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[(Af)20(te)13.8(r)-340.9(7)-340.9(d)0(a)19.7(y)0(s)15.3()-340.9(in)20.7(cu)19.7(ba)19.7(ti)14.8(on)-330.5(wi)19.8(th)-330.6(os)15.3(te)19.6(og)20.8(en)19.7(ic)-337.6(m)15(e)0(d)13.9(i)0(u)20.7(m)0(,)-334.1(t)0(h)20.7(e)-342.1(al)19.5(-)]TJ -1.0137 -1.1116 TD [(ka)13.9(li)20.6(ne)-469.9(ph)20.8(os)21(ph)20.8(at)13.8(as)19.9(e)-480.3(\()0(A)20(L)0(P)19.8(\))-479.1(ac)18.5(ti)20.6(vi)15(ty)-468.9(of)-468.7(pe)19.7(ri)20.7(od)20.8(on)15.1(ta)19.5(l)-479.3(l)0(i)20.6(g)0(a)19.7(m)0(e)18.4(n)0(t)]TJ 0 -1.1174 TD [(ce)12.8(ll)14.8(s)-237(w)0(a)18.8(s)-237(me)18.4(as)14.1(ur)15.1(ed)-228(us)15.3(in)15(g)-231.5(t)0(h)14.9(e)-232.6(Al)14.1(ka)13.9(li)14.8(ne)-222.2(Ph)15.2(os)15.3(ph)15.1(at)13.8(as)14.1(e)-232.7(A)0(s)14.4(s)0(a)14.1(y)-231.5(Ki)14.1(t)]TJ 0 -1.1116 TD -.019 Tc [(\(B)-3.8(eyotim)-4(e,)-212.5(Shanghai,)-212.5(C)-3.8(hi)]TJ 9.9355 0 TD -.0154 Tc [(n)6.5(a)-.4(\))6.6(.)-214.7(A)5.7(f).8(t)6.4(e)-.4(r)-212.3(r)6.6(ea)5.4(ct)6.4(io)6.5(n)-212.3(w)-.1(i)6.4(t).6(h)]TJ /F11 1 Tf 9.1291 0 TD 0 Tc (p)Tj /F6 1 Tf .4781 0 TD -.0166 Tc [(-n)5.3(it)5.2(rop)5.3(heny)5.3(l)]TJ -19.5427 -1.1116 TD 0 Tc [(ph)15.1(os)15.3(ph)15.1(at)13.8(e,)-282.2(th)20.7(e)-290.2(a)0(b)13.9(s)0(o)15.3(r)0(b)15.1(a)0(n)13.9(c)0(e)-281(a)0(t)-280(4)0(0)15.1(5)-156.6(nm)-279.9(wa)13.1(s)-283.1(m)0(e)12.7(a)0(s)14.1(u)0(r)15.1(e)0(d)-279.8(t)0(o)-278.8(d)0(e)13.9(t)0(e)13.8(c)0(t)]TJ 0 -1.1174 TD [(th)15(e)-411.2(A)0(L)13(P)-409.9(ac)12.8(ti)14.8(vi)20.7(ty)15(.)-412.4(A)0(f)14.2(t)0(e)13.8(r)-410(21)-399.6(da)13.9(ys)15.3()-410(o)0(s)15.3(t)0(e)13.8(o)0(g)20.8(e)0(n)13.9(i)0(c)-406.7(i)0(n)20.7(d)0(u)15.1(c)0(t)13.8(i)0(o)15(n)0(,)-402(4)0(%)]TJ 0 -1.1116 TD [(pa)13.9(ra)14(fo)15.1(rm)13.9(al)13.8(de)19.7(hy)15.1(de)-389.3(wa)13(s)-398.3(u)0(s)15.3(e)0(d)-389.3(t)0(o)-388.2()0(x)-387.9(t)0(h)15(e)-399.7(pe)19.7(ri)15(od)15.1(on)15.1(ta)13.8(l)-392.9(l)0(i)14.8(g)0(a)13.9(m)0(e)12.7(n)0(t)]TJ T* [(ce)12.8(ll)14.8(s)-156.4(f)0(o)15.1(r)-156.6(30)-152(mi)13.7(n)-156.6(a)0(n)19.7(d)-156.6(1%)-153(al)19.5(iz)13.8(ar)14(in)-146.3(re)14(d)-156.6(S)-156.4(\(S)15.3(ig)15(ma)12.7(-A)14.2(ld)20.7(ri)15(ch)13.9(\))-156.6(s)0(o)15.3(l)0(u)14.9(t)0(i)14.8(o)0(n)]TJ 0 -1.1174 TD [(wa)13(s)-237(u)0(s)15.3(e)0(d)-233.7(t)0(o)-227(s)0(t)15.1(a)0(i)13.8(n)-237.2(th)15(e)-238.4(c)0(e)12.8(l)0(l)14.8(s)0(.)-229(T)0(h)13.9(e)-238.4(10)20.8(%)-238.3(c)0(e)12.8(t)0(y)15(l)0(p)15(y)0(r)15.1(i)0(d)15(i)0(n)20.7(i)0(u)14.9(m)-238.5(ch)13.9(lo)14.9(ri)15(de)]TJ 0 -1.1116 TD [(\(S)15.3(ig)15(ma)12.7(-A)14.2(ld)15(ri)15(ch)19.7(\))-323.6(w)0(a)13(s)-323.4(us)15.3(ed)-314.4(to)-313.3(so)15.3(lu)15(bi)20.7(li)14.8(ze)-315.5(th)15(e)-324.8(s)0(t)15.1(a)0(i)19.5(n)0(e)13.9(d)-323.6(ce)12.8(ll)14.8(s)-317.7(a)0(n)13.9(d)]TJ T* [(qu)15.1(an)13.9(ti)14.8(fy)-221(th)15(e)-226.9(a)0(l)13.8(i)0(z)13.8(a)0(r)13.9(i)0(n)-221.2(r)0(e)14(d)0(-)20.9(s)0(t)15.1(a)0(i)13.8(n)0(e)13.9(d)-231.5(no)20.8(du)15.1(le)13.8(s,)-223.2(an)19.7(d)-231.5(i)0(t)-221.3(w)0(a)13(s)-225.5(me)12.7(as)14.1(ur)15.1(ed)]TJ T* [(wi)14.1(th)-457.3(th)15(e)-463(a)0(b)13.9(s)0(o)15.3(r)0(b)15.1(a)0(n)13.9(c)0(e)-459.5(a)0(t)-458.5(5)0(9)20.8(0)-162.4(nm)19.6(.)-464.2(T)0(h)13.9(e)-468.8(AL)18.8(P)-467.5(a)0(n)13.9(d)-461.9(os)15.3(te)13.8(oc)13.9(al)19.5(ci)13.8(n)]TJ 0 -1.1174 TD [(\(O)14.2(CN)13.2(\))-289(m)0(R)12.8(N)0(A)-280.4(w)0(a)18.8(s)-288.9(ev)13.9(al)13.8(ua)13.9(te)13.8(d)-283.3(b)0(y)-278.7(R)0(T)12.8(-)0(P)15.3(C)0(R)13(.)-285.7(Th)13.9(e)-290.2(p)0(r)20.9(i)0(m)13.7(e)0(r)13.9(s)-288.9(us)15.3(ed)]TJ 0 -1.1116 TD [(ar)14(e)-255.7(l)0(i)14.8(s)0(t)15.1(e)0(d)-245.3(i)0(n)-244.2(T)0(a)18.5(b)0(l)14.9(e)-255.7(2.)]TJ /F2 1 Tf 8.9663 0 0 8.9663 313.0582 190.2614 Tm [(Statistical)-342.4(analysis)]TJ /F6 1 Tf 9.843 0 0 9.843 323.0361 173.8204 Tm [(In)-416.9(the)-419.3(present)-424.6(study,)-417.8(all)-419.4(the)-419.3(experiments)-420.1(repeated)-422.5(three)]TJ -1.0137 -1.1116 TD [(times)-8(.)-291.4(The)-293.6(data)-294.8(were)-295.6(analyzed)-295.8(with)-293.5(the)-292.6(independen)-8.9(t)-289.2(sample)]TJ /F11 1 Tf T* (t)Tj /F6 1 Tf .2822 0 TD [(-test)-283.2(and)-280.9(one-way)-281.6(ANOVA)-280.6(method)-279.8(using)-281.9(the)-275.3(SPSS)-280.2(version)]TJ -.2822 -1.1174 TD [(20.0)-392.6(\(IBM)-386.4(Corp.,)-392.4(Armonk,)-386.5(NY,)-387.5(USA\).)-395.3(The)]TJ /F11 1 Tf 18.5923 0 TD (p)Tj /F6 1 Tf .5011 0 TD (-value)Tj /F10 1 Tf 2.8971 0 TD (<)Tj /F6 1 Tf .5529 0 TD (0.05)Tj -22.5435 -1.1116 TD [(was)-339.2(set)-332.7(as)-337.2(signicant)-335.9(difference.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 313.0582 111.3448 Tm (Results)Tj /F2 1 Tf 0 -1.8336 TD [(Inammatory)-339(cytokines)-334.3(expression)-329.6(in)-336.5(periodontal)]TJ 0 -1.2203 TD [(ligament)-339.3(cells)]TJ /F6 1 Tf 9.843 0 0 9.843 323.0361 67.5212 Tm [(After)-566.3(being)-565.5(treated)-564.4(with)-564.2(10)]TJ /F7 1 Tf 12.2797 0 TD (l)Tj /F6 1 Tf .5529 0 TD [(g/mL)-565.7(LPS,)-560.5(RT-PCR)-563.6(re-)]TJ -13.8463 -1.1116 TD [(sults)-552.5(showed)-549.9(that)-553(the)-551.8(periodontal)-550.5(ligament)-554.2(cells)-549.3(mRNA)]TJ ET 62.022 719.49 490.167 .22668 re f 62.022 557.461 490.167 .28345 re f 62.022 700.781 490.167 .22681 re f BT /F9 1 Tf 9.845 0 0 9.845 131.244 725.1588 Tm (Table)Tj /F6 1 Tf 3.0002 0 TD (2.)Tj /F9 1 Tf 1.2496 0 TD [(Primers)-336(Used)-332.7(for)-332.2(Reverse-Transcription)-342.6(Polymerase)-332.5(Chain)-336.5(Reaction)]TJ /F11 1 Tf -11.281 -1.8427 TD [(Gene)-17254(Primer)-331.4(sequence)-16527.9(Product)-331.7(size)-339(\(bp\))]TJ /F7 1 Tf 0 -1.9003 TD (b)Tj /F6 1 Tf .5528 0 TD [(-actin)-10587.1(Forward:)-332.4(CCTGGCACCCAGCACAAT)-15784.3(144)]TJ 12.8761 -1.0077 TD [(Reverse:)-334.9(GGGCCGGACTCGTCATACT)]TJ -13.4289 -1.3187 TD (TNF-)Tj /F7 1 Tf 2.217 0 TD (a)Tj /F6 1 Tf 11.2119 0 TD [(Forward:)-332.4(GGCTCCAGGCGGTGCTTGTTC)-13942.3(190)]TJ 0 -1.0077 TD [(Reverse:)-334.9(CAGGCTTGTCACTCGGGGTTCG)]TJ -13.4289 -1.3187 TD [(IL-6)-11648.9(Forward:)-332.4(GGTGTTGCCTGCTGCCTTCC)-14816.3(193)]TJ 13.4289 -1.0135 TD [(Reverse:)-334.9(TGCCTCTTTGCTGCTTTCACAC)]TJ -13.4289 -1.313 TD (IL-1)Tj /F7 1 Tf 1.7794 0 TD (b)Tj /F6 1 Tf 11.6495 0 TD [(Forward:)-332.4(GGCAGGCCGCGTCAGTTG)-15732.3(198)]TJ 0 -1.0135 TD [(Reverse:)-334.9(CCCGGACGTGCAGTTCAGT)]TJ -13.4289 -1.313 TD [(OCN)-11326.9(Forward:)-332.4(AGCAAAGGTGCAGCCTTTGT)-14452.3(261)]TJ 13.4289 -1.0135 TD [(Reverse:)-334.9(GCGCCTGGGTCTCTTCACT)]TJ -13.4289 -1.313 TD [(ALP)-11544.9(Forward:)-332.4(CCACGTCTTCACATTTGGTG)-14764.3(196)]TJ 13.4289 -1.0135 TD [(Reverse:)-334.9(AGACTGCGCCTGGTAGTTGT)]TJ 8.7511 0 0 8.7511 70.0157 545.6691 Tm [(ALP,)-327.8(alkaline)-340.2(phosphatase;)-333.6(IL-1)]TJ /F7 1 Tf 13.2677 0 TD (b)Tj /F6 1 Tf .5571 0 TD [(,)-333.1(interleukin-1)]TJ /F7 1 Tf 5.7657 0 TD (b)Tj /F6 1 Tf .5507 0 TD [(;)-334.4(IL-6,)-328.1(interleukin-6;)-333.2(OCN,)-336.5(osteocalcin;)-333.9(TNF-)]TJ /F7 1 Tf 18.8067 0 TD (a)Tj /F6 1 Tf .4988 0 TD [(,)-333.1(tumor)-332.4(necrosis)-336.9(factor-)]TJ /F7 1 Tf 9.6009 0 TD (a)Tj /F6 1 Tf .4988 0 TD (.)Tj ET 62.022 261.241 239.131 .28345 re f 62.022 68.372 239.131 .28348 re f 62.022 232.611 239.131 .28343 re f BT /F9 1 Tf 9.845 0 0 9.845 69.6756 286.866 Tm (Table)Tj /F6 1 Tf 3.0002 0 TD (3.)Tj /F9 1 Tf 1.2496 0 TD [(Experimental)-338.7(Groups)-337(\(Normal,)-334.2(Starved,)]TJ -2.5683 -1.0135 TD [(or)-330(Inamed)-339.1(Periodontal)-333.8(Ligament)-333.5(Cells\))]TJ -.2188 -1.0077 TD [(According)-333(to)-335.8(the)]TJ /F6 1 Tf 8.4363 0 TD (808)Tj /F9 1 Tf 1.6642 0 TD [(nm)-338.1(Laser)-334(Parameters)]TJ /F11 1 Tf -2.4531 -1.8427 TD [(Energy)-331.8(density)]TJ 1.503 -1.0135 TD [(\()-127.7(J/cm)]TJ /F6 1 Tf 7.3837 0 0 6.5625 197.348 243.2125 Tm (2)Tj /F11 1 Tf 9.845 0 0 9.845 201.033 238.8472 Tm (\))Tj 3.697 1.0135 TD (Power)Tj -.7141 -1.0135 TD (\(mW/cm)Tj /F6 1 Tf 7.3837 0 0 6.5625 263.2251 243.2125 Tm (2)Tj /F11 1 Tf 9.845 0 0 9.845 266.9102 238.8472 Tm (\))Tj 1.4742 1.0135 TD (Time)Tj .0288 -1.0135 TD (\(sec\))Tj /F6 1 Tf -22.3144 -1.8946 TD [(Starvation)-335.1(group)]TJ .9905 -1.0135 TD [(\(pretreated)-338.4(without)]TJ T* [(FBS)-337.6(for)-331.2(24)-169(h\))]TJ 11.9317 2.027 TD 5.201 Tc [(12)5201(0)1784.2(5)5201(0)]TJ 0 -1.0135 TD 0 Tc [(3)-9116.8(150)]TJ T* [(5)-9116.8(250)]TJ -.501 -1.0135 TD [(10)-9117.8(500)]TJ -2.2861 -1.0077 TD [(Nonirradiated)-2920()-3163.4()]TJ -10.135 -1.3187 TD [(Inammation)-338.2(group)]TJ .9905 -1.0135 TD [(\(pretreated)-338.4(with)]TJ 0 -1.0077 TD (10)Tj /F7 1 Tf 1.169 0 TD (l)Tj /F6 1 Tf .5528 0 TD [(g/mL)-334.7(LPS)]TJ -1.7218 -1.0135 TD [(for)-337(3)-168(h)0(\))]TJ 11.9317 3.0347 TD 5.201 Tc [(12)5201(0)1784.2(5)5201(0)]TJ 0 -1.0135 TD 0 Tc [(3)-9116.8(150)]TJ 0 -1.0077 TD [(5)-9116.8(250)]TJ -.501 -1.0135 TD [(10)-9117.8(500)]TJ -2.2861 -1.0135 TD [(Nonirradiated)-2920()-3163.4()]TJ -10.135 -1.313 TD [(Normal)-337.5(group)-7191.6(1)-5201(2)0(0)-3416.8(5)0(0)]TJ 12.9222 -1.0135 TD [(3)-9116.8(150)]TJ T* [(5)-9116.8(250)]TJ -.501 -1.0077 TD [(10)-9117.8(500)]TJ -2.2861 -1.0135 TD [(Nonirradiated)-2920()-3163.4()]TJ 8.7511 0 0 8.7511 70.0157 56.5795 Tm [(FBS,)-331.7(fetal)-335.9(bovine)-329.8(serum;)-330.8(LPS,)-338.3(lipopolysaccharide.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (698)Tj 47.9403 0 TD [(WANG)-332.6(ET)-338.7(AL.)]TJ ET endstream endobj 52 0 obj <>stream /GS1 gs BT /F6 1 Tf 9.843 0 0 9.843 59.7543 546.8597 Tm 0 0 0 rg 0 Tc 0 Tw [(expression)-485.3(of)-486(TNF-)]TJ /F7 1 Tf 8.2997 0 TD (a)Tj /F6 1 Tf .5011 0 TD [(,)-481.5(IL-1)]TJ /F7 1 Tf 2.5112 0 TD (b)Tj /F6 1 Tf .5529 0 TD [(,)-481.5(and)-482.5(IL-6)-483.6(was)-483.2(raised)-481.1(up)-480.3(re-)]TJ -11.865 -1.1116 TD [(markably)-265.9(at)-268.4(1,)-263.7(3,)-263.7(and)-263.6(6)-168.1(h)-260.3(\()]TJ /F11 1 Tf 10.7188 0 TD (p)Tj /F10 1 Tf .6681 0 TD (<)Tj /F6 1 Tf .7142 0 TD [(0.05\),)-264.7(and)-269.4(the)-263.8(most)-264.8(signicant)]TJ -12.1011 -1.1116 TD [(increase)-295.6(was)-293.1(observed)-293.1(at)-291.5(3)-168.1(h)-289.1(for)-291.2(all)-292.7(three)-295.9(cytokines)-294.5(\(Fig.)-290(1\).)]TJ 0 -1.1174 TD [(In)-405.3(the)-402(following)-408.6(experiments,)-406.2(pretreatment)-405.3(with)-403(10)]TJ /F7 1 Tf 21.5643 0 TD (l)Tj /F6 1 Tf .5529 0 TD (g/mL)Tj -22.1173 -1.1116 TD [(LPS)-390.1(for)-383.4(3)-168.1(h)-387(was)-385.3(used)-385.5(to)-388.2(induce)-383.4(inamed)-391.4(periodontal)-389.2(liga-)]TJ T* [(ment)-335.2(cells.)]TJ /F2 1 Tf 8.9663 0 0 8.9663 59.7543 467.8298 Tm [(Photobiomodulation)-337(effect)-335.1(of)-336.7(808)-165(nm)-334.8(laser)]TJ 0 -1.2203 TD [(on)-337.6(the)-328.5(periodontal)-340.4(ligament)-332.9(cells)-332.5(proliferation.)]TJ /F6 1 Tf 9.843 0 0 9.843 69.7323 440.4471 Tm [(In)-324.7(the)-321.4(present)-326.7(study,)-325.7(the)-321.4(proliferation)-328.1(of)-318.9(normal,)-329.3(starved,)]TJ -1.0137 -1.1116 TD [(and)-263.7(inamed)-264.7(periodontal)-268.2(ligament)-260.4(cells)-267.1(was)-264.3(measured)-266.7(using)]TJ 0 -1.1174 TD [(the)-298.3(CCK-8)-296.4(assay.)-298.9(Under)-295.5(normal)-297.1(conditions,)-292.3(the)-298.3(cells)-295.9(prolif-)]TJ 0 -1.1116 TD [(erated)-280.9(stably)-272.8(within)-272.8(7)-277.6(days)-270.3(after)-278.6(laser)-278.4(irradiation.)-277.5(Compared)]TJ T* [(with)-316.6(nonirradiated)-317.6(cells,)-316.6(3)-312.1(and)-315.5(5)-168.1(J/cm)]TJ 7.3823 0 0 6.5614 210.444 400.9889 Tm (2)Tj 9.843 0 0 9.843 217.2472 396.6235 Tm [(irradiation)-320.2(increased)]TJ -16.0005 -1.1174 TD [(cell)-375.6(activity)-368.8(at)-372.1(5)-364(and)-373.1(7)-369.7(days)-368.2(\()]TJ /F11 1 Tf 12.5734 0 TD (p)Tj /F10 1 Tf .6624 0 TD (<)Tj /F6 1 Tf .72 0 TD [(0.05\),)-368.3(and)-373.1(3)-168.1(J/cm)]TJ 7.3823 0 0 6.5614 266.8535 390.0471 Tm (2)Tj 9.843 0 0 9.843 274.1668 385.6251 Tm (irradi-)Tj -21.7832 -1.1116 TD -.0161 Tc [(at)5.7(io)5.8(n)-241.8(s).3(i)5.7(g).1(n)5.8(i)0()6(c)-1.1(antl)5.7(y)-241.8(p)5.8(ro)5.8(mo)5.8(ted)-241.8(p)5.8(rol)5.7(if)5.9(er)5.9(at)5.7(io)5.8(n)-241.8(a)-1.1(t)-236.2(7)-241.8(d)5.8(a)-1.1(y)5.8(s)-241.6(\()]TJ /F11 1 Tf 20.2281 0 TD 0 Tc (p)Tj /F10 1 Tf .6451 0 TD (<)Tj /F6 1 Tf .7027 0 TD -.0162 Tc [(0)5.7(.)3.4(00)5.7(1\).)]TJ -21.5759 -1.1116 TD 0 Tc [(Under)-353.1(the)-355.9(starved)-349.8(condition,)-354.7(the)-350.2(periodontal)-354.6(ligament)-358.3(cells)]TJ T* [(continued)-352.3(to)-353.7(proliferate)-350(after)-353.5(laser)-353.3(irradiation,)-352.4(although)-350.1(the)]TJ 0 -1.1174 TD [(proliferation)-287.8(rate)-289(was)-287.4(lower)-284.1(than)-282.2(that)-288.1(under)-283.1(the)-286.8(normal)-285.6(con-)]TJ 0 -1.1116 TD [(dition.)-390.6(After)-393.5(irradiation)-389.3(at)-389.4(3)-392.8(and)-390.4(5)-162.4(J/cm)]TJ 7.3823 0 0 6.5614 221.896 335.2251 Tm (2)Tj 9.843 0 0 9.843 225.581 330.8597 Tm [(,)-389.3(cell)-387.1(activity)-391.8(was)]TJ -16.8471 -1.1116 TD [(increased)-290.9(compared)-284.2(with)-287.8(nonirradiated)-288.8(cells)-284.4(at)-285.7(5)-283.3(and)-286.7(7)-283.3(days)]TJ 0 -1.1174 TD (\()Tj /F11 1 Tf .4896 0 TD (p)Tj /F10 1 Tf .6508 0 TD (<)Tj /F6 1 Tf .7027 0 TD -.0157 Tc [(0.05\))-15.7(.)-221.8(U)-.4(n)-15.7(d)10.9(er)-235.6(the)-236.8(i).4(n)-15.7(a)9.9(med)-235.7(con)-15.7(d)10.9(itio)-15.7(n)10.9(,)-232.2(s)-15.7(i)11(mila)-15.7(r)-220.6(t)-15.7(o)-219.6(t)-15.7(h)10.8(e)-236.8(star)-15.7(v)10.9(e)-.7(d)]TJ -1.8431 -1.1116 TD 0 Tc [(condition,)-354.7(5)-168.1(J/cm)]TJ 7.3823 0 0 6.5614 128.2393 302.3432 Tm (2)Tj 9.843 0 0 9.843 135.3826 297.9779 Tm [(irradiation)-360.5(signicantly)-349.8(promo)-6.7(ted)-350.2(prolif-)]TJ -7.6834 -1.1116 TD [(eration)-338.6(of)-330.5(periodontal)-337.3(ligament)-341.1(cells)-336.2(\(Fig.)-330.3(2\).)]TJ /F2 1 Tf 8.9663 0 0 8.9663 59.7543 262.7716 Tm [(Photobiomodulation)-337(effect)-335.1(of)-336.7(808)-165(nm)-334.8(laser)]TJ 0 -1.2203 TD [(on)-337.6(the)-328.5(migration)-341.4(of)-330.4(periodontal)-334(ligament)-339.3(cells)]TJ /F6 1 Tf 9.843 0 0 9.843 69.7323 235.3889 Tm [(To)-383.5(study)-385.6(the)-384.7(effect)-384.5(of)-382.3(808)-170.3(nm)-383.6(laser)-382.1(on)-382.3(the)-384.7(migration)-387(of)]TJ -1.0137 -1.1116 TD [(normal,)-490.6(starved,)-485.7(and)-482.5(inamed)-489.3(periodontal)-487.1(ligament)-485.1(cells,)]TJ 25.5097 32.7554 TD [(the)-315.6(cells)-324.7(were)-318.6(scratched)-319.7(using)-322.2(WoundMaker.)-319.4(Images)-321(of)-319(the)]TJ 0 -1.1116 TD [(migrating)-490.7(cells)-497.5(and)-494(the)-488.4(relative)-496.5(width)-496.2(of)-491.7(the)-494.2(scratch)-494.9(are)]TJ T* [(shown)-311.4(in)-313.3(Fig.)-317.7(3.)-309.8(Under)-318.5(the)-315.6(normal)-314.4(condition,)-314.4(the)-315.6(migration)]TJ 0 -1.1174 TD [(width)-260.1(of)-267.1(periodontal)-262.5(ligament)-266.2(cells)-267.1(was)-264.3(promoted)-264.7(after)-267.1(laser)]TJ 0 -1.1116 TD [(irradiation,)-283.3(especially)-286.6(at)-280(3)-168.1(J/cm)]TJ 7.3823 0 0 6.5614 434.7778 507.4014 Tm (2)Tj 9.843 0 0 9.843 441.2408 503.0361 Tm [(compared)-284.2(with)-282(the)-286.8(nonirra-)]TJ -13.2473 -1.1116 TD [(diated)-320.2(cells)-324.7(\()]TJ /F11 1 Tf 5.4429 0 TD (p)Tj /F10 1 Tf .6624 0 TD (<)Tj /F6 1 Tf .72 0 TD [(0.001\).)-323.4(While)-320.2(for)-320(the)-321.4(starved)-326.7(and)-321.2(inamed)]TJ -6.8253 -1.1174 TD [(periodontal)-475.6(ligament)-473.5(cells,)-477.9(5)-162.4(J/cm)]TJ 7.3823 0 0 6.5614 450.3117 485.518 Tm (2)Tj 9.843 0 0 9.843 458.6455 481.0959 Tm [(signicantly)-476.5(promoted)]TJ -15.0156 -1.1116 TD [(cells)-336.2(migration)-335.2(\()]TJ /F11 1 Tf 6.9174 0 TD (p)Tj /F10 1 Tf .6624 0 TD (<)Tj /F6 1 Tf .72 0 TD (0.01\).)Tj /F2 1 Tf 8.9663 0 0 8.9663 310.8472 445.9463 Tm [(Photobiomodulation)-337(effect)-328.8(of)-336.7(808)-165(nm)-334.8(laser)]TJ 0 -1.2266 TD [(on)-331.3(the)-334.8(periodontal)-334(ligament)-332.9(cells)-338.8(inammation)]TJ /F6 1 Tf 9.843 0 0 9.843 320.8251 418.507 Tm [(To)-441.1(nd)-446.6(out)-441.2(the)-442.3(anti-inammator)-11.3(y)-438.8(effect)-447.9(of)-445.7(the)-442.3(808)-170.3(nm)]TJ -1.0137 -1.1116 TD [(laser,)-322.2(the)-315.6(nonstimulated)-323.5(periodontal)-320.1(ligament)-323.8(cells)-318.9(were)-324.3(set)]TJ T* [(as)-256.6(a)-261.4(negative)-260.2(control)-262.5(group,)-256.6(while)-261.2(10)]TJ /F7 1 Tf 15.0616 0 TD (l)Tj /F6 1 Tf .5529 0 TD [(g/mL)-260.4(LPS-stimulated)]TJ -15.6146 -1.1174 TD [(cel)11.5(ls)-226.8(we)13(re)-228(dee)11.7(med)-224.6(as)-222(pos)14.2(iti)13.6(ve)-228(con)12.8(tro)13.9(l)-231.6(gro)14(up.)-218.7(The)-224.5(stu)14(dy)-226.8(fou)14(nd)]TJ 0 -1.1116 TD [(that)-357.2(the)-361.7(mRNA)-359.8(expression)-358.6(of)-359.3(TNF-)]TJ /F7 1 Tf 14.7448 0 TD (a)Tj /F6 1 Tf .5011 0 TD [(,)-354.8(IL-1)]TJ /F7 1 Tf 2.3903 0 TD (b)Tj /F6 1 Tf .5529 0 TD [(,)-354.8(and)-355.8(IL-6)-362.6(was)]TJ -18.1891 -1.1116 TD [(decreased)-263.2(after)-255.6(the)-263.8(density)-256.6(of)-255.6(1,)-258(3,)-258(5,)-258(or)-255.6(10)-169.2(J/cm)]TJ 7.3823 0 0 6.5614 500.0313 368.107 Tm (2)Tj 9.843 0 0 9.843 506.2676 363.7416 Tm (irradiation,)Tj -19.8537 -1.1116 TD [(compared)-457(with)-454.8(the)-459.6(nonirradiated)-461.6(group)-454.7(\()]TJ /F11 1 Tf 17.4346 0 TD (p)Tj /F10 1 Tf .6624 0 TD (<)Tj /F6 1 Tf .72 0 TD [(0.01\),)-454.7(with)-460.6(a)]TJ -18.817 -1.1174 TD [(signicant)-335.9(decrease)-336.9(at)-337.6(the)-332.9(3)-168.1(J/cm)]TJ 7.3823 0 0 6.5614 443.6219 346.1668 Tm (2)Tj 9.843 0 0 9.843 450.5952 341.8015 Tm [(energy)-337.2(density)-331.5(\(Fig.)-336.1(4\).)]TJ /F2 1 Tf 8.9663 0 0 8.9663 310.8472 317.5936 Tm [(Photobiomodulation)-337(effect)-328.8(of)-336.7(808)-165(nm)-334.8(laser)]TJ 0 -1.2266 TD [(on)-331.3(the)-334.8(osteogenesis)-333.5(of)-330.4(periodontal)-340.4(ligament)-332.9(cells)]TJ /F6 1 Tf 9.843 0 0 9.843 320.8251 290.1543 Tm [(The)-483.7(photobiomodulation)-483.7(effect)-488.2(of)-486(808)-164.6(nm)-481.5(laser)-485.8(on)-486(the)]TJ -1.0137 -1.1116 TD [(osteogenic)-371.7(differentiation)-377.7(of)-365(normal,)-375.4(starved,)-370.5(and)-373.1(inamed)]TJ T* [(periodontal)-314.3(ligament)-312.3(cells)-313.2(was)-310.4(evaluated)-314.3(with)-310.8(the)-309.9(early)-313.2(and)]TJ 0 -1.1174 TD [(later)-359.4(osteogenic)-365.9(differentiation.)-369.6(When)-359.2(the)-361.7(periodontal)-366.1(liga-)]TJ 0 -1.1116 TD [(ment)-375.5(cells)-370.8(were)-376.2(irradiated)-377.7(after)-376.5(the)-373.2(808)-164.6(nm)-377.8(laser,)-374(the)-373.2(ALP)]TJ T* [(activity)-276.6(and)-275.2(mRNA)-273.4(expression)-278(of)-272.9(ALP)-275.9(and)-275.2(OCN,)-280.2(as)-273.9(well)-277.4(as)]TJ T* [(mineralized)-283.3(nodules)-279.5(were)-284(increased)-279.4(\()]TJ /F11 1 Tf 15.2171 0 TD (p)Tj /F10 1 Tf .6681 0 TD (<)Tj /F6 1 Tf .72 0 TD [(0.05\);)-279.7(furthermore,)]TJ ET q 489.531 0 0 106.696 60.265 625.549 cm /Im1 Do Q BT /F8 1 Tf 9.845 0 0 9.845 59.7543 608.7683 Tm [(FIG.)-405.8(1.)]TJ /F6 1 Tf 4.1865 0 TD [(RT)18.9(-P)15.5(CR)-332.2(an)19.9(al)19.7(ys)21.2(is)-330.2(sh)15.5(ow)20.2(ed)-331.4(IL)19.9(-1)]TJ /F7 1 Tf 12.3751 0 TD (b)Tj /F6 1 Tf .5471 0 TD [(,)-337.4(I)0(L)19.9(-)0(6)15.3(,)-337.4(an)19.9(d)-346.5(T)0(N)19.1(F)0(-)]TJ /F7 1 Tf 6.8699 0 TD (a)Tj /F6 1 Tf .8407 0 TD [(in)20.9(cr)19.9(ea)18.7(se)14.3(d)-340.7(s)0(i)21(g)0(n)21.1(i)0()21(c)0(a)12.9(n)0(t)20.9(l)0(y)-330.4(a)0(f)19.9(t)0(e)19.7(r)-340.7(pr)15.3(et)19.7(re)19.9(at)19.7(me)18.7(nt)-330.4(wi)14.3(th)-330.4(LP)20.1(S.)-332.4(Al)20.1(l)-340.9(t)0(e)19.7(s)0(t)21(e)0(d)]TJ -24.8193 -1.0135 TD [(cy)14.1(to)20.9(ki)20.9(ne)-164.4(le)19.7(ve)19.9(ls)-169(we)19.1(re)-164.4(in)20.9(cr)19.9(ea)12.9(se)20.1(d)-173.7(a)0(t)-164.6(1)0(,)-165.6(3)0(,)-165.6(a)0(n)19.9(d)-173.8(6)-156.5(h)0(,)-165.6(w)0(i)20.1(t)0(h)-163.4(t)0(h)20.9(e)-180.7(hi)20.9(gh)21.1(es)20.1(t)-173.9(l)0(e)19.7(v)0(e)14.1(l)0(s)-163.2(a)0(t)-164.6(3)-156.5(h.)-165.6(Th)19.9(e)-174.9(a)0(s)20(t)0(e)13.9(r)0(i)20.9(s)0(k)21.2(s)-173.6(in)20.9(di)15.1(ca)18.7(te)-164.6(si)21(gn)21.1(i)15.3(ca)18.7(nt)-163.4(di)20.9(ff)21(er)14.1(en)19.9(ce)18.7(s)-173.6(b)0(e)19.9(t)0(w)20.1(e)0(e)13(n)]TJ 0 -1.0077 TD [(gr)15.3(ou)21.1(ps)-330(\(m)14.1(ea)18.7(n)]TJ /F10 1 Tf 5.6434 0 TD ()Tj /F6 1 Tf .7083 0 TD [(SD)20.4(,)]TJ /F11 1 Tf 1.8427 0 TD (n)Tj /F10 1 Tf .6565 0 TD (=)Tj /F6 1 Tf .7083 0 TD [(3,)-332.6(*)]TJ /F11 1 Tf 1.5721 0 TD (p)Tj /F10 1 Tf .6565 0 TD (<)Tj /F6 1 Tf .7083 0 TD [(0.)18.7(05)21.1(,)-343.1(*)0(*)]TJ /F11 1 Tf 3.2881 0 TD (p)Tj /F10 1 Tf .6565 0 TD (<)Tj /F6 1 Tf .7083 0 TD [(0.)18.7(01)21.1(,)-343.1(*)0(*)21.1(*)0(*)]TJ /F11 1 Tf 4.2613 0 TD (p)Tj /F10 1 Tf .6565 0 TD (<)Tj /F6 1 Tf .7083 0 TD [(0.)18.7(00)21.1(01)21.1(\).)]TJ /F8 1 Tf 3.6106 0 TD [(\(A)20.2(\))]TJ /F6 1 Tf 1.7045 0 TD -.0203 Tc [(T)-20.3(h)-.4(e)-368(m)-20.3(RN)-20.3(A)-352.2(e)-20.3(x)-6.2(p)-20.3(re)-20.3(ss)-20.3(io)-20.3(n)-356.3(o)-20.3(f)-350.5(I)-20.3(L)-6.2(-)-20.3(1)]TJ /F7 1 Tf 12.5306 0 TD 0 Tc (b)Tj /F6 1 Tf .5413 0 TD (;)Tj /F8 1 Tf .6219 0 TD [(\(B)14.3(\))]TJ /F6 1 Tf 1.6585 0 TD [(Th)19.9(e)-347.7(m)0(R)18.9(N)0(A)-331.9(e)0(x)19.9(-)]TJ -43.4425 -1.0135 TD [(pr)15.3(es)20.1(si)21(on)-318.7(of)-324.5(IL)19.9(-6)21(;)]TJ /F8 1 Tf 7.1003 0 TD [(\(C)20.2(\))]TJ /F6 1 Tf 1.693 0 TD [(Th)19.9(e)-330.4(m)0(R)18.9(N)0(A)-326.1(e)0(x)19.9(p)0(r)21.1(e)0(s)20.1(s)0(i)21(o)0(n)-324.5(o)0(f)-318.7(T)0(N)19.1(F)0(-)]TJ /F7 1 Tf 12.9107 0 TD (a)Tj /F6 1 Tf .4895 0 TD .3316 Tc [(.I)331.6(L)351.5(-)331.6(1)]TJ /F7 1 Tf 2.3207 0 TD 0 Tc (b)Tj /F6 1 Tf .5413 0 TD -.0205 Tc [(,)-352.1(i)-20.5(nt)-20.5(er)-20.5(l)-5.4(e)-20.5(uk)-20.5(in)-20.5(-1)]TJ /F7 1 Tf 5.6376 0 TD 0 Tc (b)Tj /F6 1 Tf .5413 0 TD [(;)-335.2(I)0(L)19.9(-)0(6)21(,)-331.6(in)20.9(te)19.7(rl)20.9(eu)19.9(ki)20.9(n-)15.3(6;)-318.9(LP)20.1(S,)-320.9(li)20.7(po)21.1(po)21.1(ly)15.1(sa)20.1(cc)18.7(ha)19.9(ri)20.9(de)19.9(;)]TJ -31.2343 -1.0135 TD [(RT)18.9(-P)15.5(CR)19.1(,)-268.3(r)0(e)19.9(v)0(e)19.9(r)0(s)15.5(e)0(-)19.9(t)0(r)20.9(a)0(n)19.9(s)0(c)20.1(r)0(i)15.1(p)0(t)20.9(i)0(o)20.9(n)-271.6(po)21.1(ly)20.9(me)18.7(ra)19.9(se)-262.1(ch)19.9(ai)13.9(n)-265.9(r)0(e)19.9(a)0(c)13(t)0(i)20.7(o)0(n)21.1(;)-271.8(SD)20.4(,)-268.3(s)0(t)21(a)0(n)14.1(d)0(a)19.9(r)0(d)-261.1(d)0(e)19.9(v)0(i)20.9(a)0(t)19.7(i)0(o)20.9(n)0(;)-261.3(T)0(N)19.1(F)0(-)]TJ /F7 1 Tf 35.0004 0 TD (a)Tj /F6 1 Tf .4895 0 TD [(,)-274(t)0(u)20.9(m)0(o)19.9(r)-271.6(ne)19.9(cr)19.9(os)21.2(is)-261.1(fa)19.9(ct)13.9(or)21(-)]TJ /F7 1 Tf 9.2367 0 TD (a)Tj /F6 1 Tf .4895 0 TD (.)Tj ET q 1 i 59.754 208.46 m 550.091 208.46 l 550.091 103.181 l 59.754 103.181 l W n q 490.48 0 0 105.279 59.754 103.181 cm /Im2 Do Q Q BT /F8 1 Tf 9.845 0 0 9.845 59.7543 86.4567 Tm [(FIG.)-469.2(2.)]TJ /F6 1 Tf 4.2498 0 TD [(CCK-8)-468.4(assay)-473.4(showed)-468.4(the)-465(proliferation)-470.8(of)-468.4(periodontal)-468.7(ligament)-472.6(cells.)]TJ /F8 1 Tf 29.5759 0 TD (\(A\))Tj /F6 1 Tf 1.8543 0 TD [(Under)-467.6(normal)-469.1(conditions,)-469.7(3)-168(J/cm)]TJ 7.3837 0 0 6.5625 546.2361 90.822 Tm (2)Tj 9.845 0 0 9.845 59.7543 76.4787 Tm [(signicantly)-400.4(promoted)-396.2(the)-395.9(proliferation)-396(of)-393.6(periodontal)-393.8(ligament)-397.8(cells)-399.1(\()]TJ /F11 1 Tf 29.478 0 TD (p)Tj /F10 1 Tf .6622 0 TD (<)Tj /F6 1 Tf .7198 0 TD (0.001\);)Tj /F8 1 Tf 3.2593 0 TD (\(B\))Tj /F6 1 Tf 1.7276 0 TD [(Under)-398.5(starved)-395.1(conditions,)-394.8(5)-168(J/cm)]TJ 7.3837 0 0 6.5625 546.2361 80.8441 Tm (2)Tj 9.845 0 0 9.845 59.7543 66.5575 Tm [(enhanced)-352.4(the)-355.6(proliferation)-349.9(of)-353.3(periodontal)-347.7(ligament)-351.7(cells)-353(\()]TJ /F11 1 Tf 23.7598 0 TD (p)Tj /F10 1 Tf .668 0 TD (<)Tj /F6 1 Tf .7198 0 TD (0.01\);)Tj /F8 1 Tf 2.7123 0 TD (\(C\))Tj /F6 1 Tf 1.7333 0 TD [(Under)-352.5(inamed)-350.2(conditions,)-354.5(5)-168(J/cm)]TJ 7.3837 0 0 6.5625 489.4298 70.9228 Tm (2)Tj 9.845 0 0 9.845 496.5731 66.5575 Tm [(promoted)-350.2(the)]TJ -44.3696 -1.0135 TD [(proliferation)-338.4(of)-336(periodontal)-336.2(ligament)-334.4(cells)-335.7(\()]TJ /F11 1 Tf 17.9609 0 TD (p)Tj /F10 1 Tf .668 0 TD (<)Tj /F6 1 Tf .7141 0 TD [(0.05\).)-333.2(CCK-8,)-339.4(cell)-334.9(counting)-331.9(kit-8.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(PHOTOBIOMODULATION)-340.2(FOR)-334(PERIODONTAL)-337.8(LIGAMENT)-339.2(CELLS)-21653.2(699)]TJ ET endstream endobj 54 0 obj <>stream Adobed         s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjzm!1AQa"q2#BRbr3$4CS%cs5DT &6E'dtU7()󄔤euFVfvGWgw8HXhx9IYiy*:JZjz 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[(dance)-435.2(with)-431.8(the)-430.8(diaphasic)-439.7(doseresponse)-431.9(rule)-437.6(of)-428.4(photobio-)]TJ T* -.0158 Tc [(mod)-15.8(u)10.8(lati)-15.8(o)10.7(n)-333.7(\(A)-15.8(r)10(ndt)-15.8()10.7(S).5(ch)-15.8(u)10.8(l).3(z)-334.8(c)-.8(u)-15.8(r)10.8(ve\))-15.8(.)]TJ 7.3823 0 0 6.5614 194.9102 510.3495 Tm -.0162 Tc (25)Tj 9.843 0 0 9.843 205.3417 505.9841 Tm [(The)-335.1(p).1(h)-16.1(o)10.5(tobi)-16.1(o)10.4(m)-1.1(odu)-16.1(l)10.4(a)-1.1(ti)-16.1(o)10.4(n)]TJ -14.5605 -1.1174 TD 0 Tc [(of)-244.1(808)-164.6(nm)-239.6(laser)-243.9(promoted)-241.7(the)-240.7(proliferation)-247.5(of)-238.3(the)-246.5(normal)-239.5(and)]TJ 0 -1.1116 TD [(stress)-398.9(condition)-397.4(periodontal)-400.7(ligament)-398.7(cells)-399.6(and)-396.1(it)-394.1(followed)]TJ T* [(the)-332.9(rule)-334(of)-336.2(diaphasic)-336(doseresponse.)]TJ 1.0137 -1.1174 TD .0119 Tc [(Wou)5(n)-.7(d)-357.8(h)5(ealin)5(g)-357.8(i)-.8(s)-357.6(a)-359(h)5(i)-.8(gh)5(ly)-357.8(coo)5(rdi)4.9(nated)-357.8(pro)5(cess)-357.6(t)4.9(h)-.7(at)-357.9(r)5.1(e)-1.9(-)]TJ -1.0137 -1.1116 TD .0125 Tc [(es)5.8(tabl)5.5(ish)5.6(e)-1.3(s)-276.4(t)5.5(he)-277.7(i)5.5(n)-.1(t)5.5(e)-1.3(g)5.6(r)-.1(it)5.5(y)-276.6(o)-.1(f)-270.8(v)-.1(ar)5.7(io)5.6(us)-276.4(t)5.5(i)-.2(ss)5.8(ues.)-273.2(Th)5.6(e)-277.7(p)-.1(eri)5.5(odo)5.6(nt)5.5(al)]TJ T* .0116 Tc [(li)4.6(gament)-231.5(cell)4.6(s)-237(m)3.5(igr)4.8(a)-2.2(t)4.6(i)-1.1(o)4.7(n)-237.2(to)-231.4(th)4.7(e)-238.3(r)4.8(oo)4.7(t)-237.3(s)-.8(u)4.7(r)-1(f)4.8(a)-2.2(ce)-238.3(i)4.6(s)-237(a)-238.3(p)4.7(rerequ)4.7(isi)4.6(t)-1.1(e)]TJ T* 0 Tc [(s)-12.4(t)-7(e)-13.8(p)-634.7(fo)20.9(r)-617.4(p)0(e)19.7(r)0(i)15(o)0(d)20.8(o)0(n)20.8(t)0(a)19.6(l)-617.5(li)20.6(ga)19.7(me)18.4(nt)-607.1(re)14(ge)19.7(ne)19.7(ra)19.7(ti)20.6(on)20.8(.)-619.7(T)0(s)19.8(u)0(k)20.8(a)-618.5(et)-608.3(al)19.6(.)]TJ 0 -1.1174 TD [(co)19.7(n)21(rm)13.9(ed)-325.9(th)20.7(at)-331.8(Nd)20(:Y)19.8(AG)-332.2(ir)20.7(ra)19.7(di)20.7(at)13.8(ed)-325.9(at)-331.8(10)20.8(.3)18.5(4)-156.6(J)0(/)20.9(c)0(m)]TJ 7.3823 0 0 6.5614 253.7574 422.6456 Tm (2)Tj 9.843 0 0 9.843 260.7873 418.2802 Tm [(st)20.9(im)19.5(ul)14.9(at)19.6(ed)]TJ -20.1935 -1.1116 TD [(os)21(te)13.8(ob)20.8(la)19.6(st)-509(ce)18.5(ll)-509.3(mi)19.5(gr)20.9(at)13.8(io)20.7(n)-519.5(a)0(n)19.7(d)-519.5(in)20.7(cr)19.7(ea)18.5(se)14.1(d)-519.5(t)0(h)20.7(e)-520.6(ad)19.7(en)19.7(os)21(in)20.7(e)-520.6(t)0(r)15(i)0(-)]TJ T* [(ph)20.8(os)15.3(ph)20.8(at)19.5(e)-342.1(\()0(A)14.2(T)15(P\))-336.1(pr)20.9(od)15.1(uc)19.7(ti)20.6(on)20.8(.)]TJ 7.3823 0 0 6.5614 176.8818 400.7621 Tm -.0162 Tc (26)Tj 9.843 0 0 9.843 187.5401 396.3968 Tm 0 Tc [(Yi)19.8(n)-346.7(e)0(t)-331.8(a)0(l)19.5(.)-343.3(fo)15.1(un)20.8(d)-340.9(t)0(h)15(a)0(t)-331.8(i)0(r)20.7(r)0(a)19.7(d)0(i)14.9(a)0(-)]TJ -12.752 -1.1174 TD [(ti)20.6(on)-439.9(wi)19.8(th)-440.1(th)15(e)-445.8(w)0(a)18.8(v)0(e)13.9(l)0(e)19.5(n)0(g)20.8(t)0(h)-440.1(o)0(f)-439.9(6)0(6)20.8(0)-156.6(nm)-441.2(im)19.5(pr)20.9(ov)20.8(ed)-441.1(th)20.7(e)-451.5(c)0(e)18.5(l)0(l)20.6(u)0(l)14.9(a)0(r)]TJ 0 -1.1116 TD [(re)19.7(pa)19.7(ir)-595.5(ca)18.5(pa)13.9(ci)19.5(ty)-589.8(by)-595.4(al)19.5(te)13.8(ri)20.7(ng)-595.4(th)20.7(e)-607(e)0(x)19.7(p)0(r)20.9(e)0(s)19.9(s)0(i)20.9(o)0(n)-595.4(o)0(f)-595.4(h)0(e)19.7(p)0(a)19.7(t)0(o)15(c)0(y)19.7(t)0(e)]TJ T* [(gr)20.9(ow)20(th)-601.3(fa)19.7(ct)19.5(or)-595.4(\(H)20(GF)14.4(\))-605.8(a)0(n)19.7(d)-605.9(pl)20.7(at)19.5(el)19.6(et)-596.7(de)19.7(ri)15(ve)19.7(d)-605.9(g)0(r)20.9(o)0(w)20(t)0(h)-595.6(f)0(a)19.7(c)0(t)13.8(o)0(r)]TJ 0 -1.1174 TD [(\(P)21(DG)13.3(F\))21(.)]TJ 7.3823 0 0 6.5614 95.3575 356.9385 Tm (27)Tj 9.843 0 0 9.843 108.7937 352.5164 Tm [(Ev)19.6(an)19.7(s)-622.9(a)0(n)19.7(d)-617.4(Ab)20(ra)14(ha)19.7(ms)19.8(e)-618.5(s)0(h)21(o)0(w)14.2(e)0(d)-608.1(t)0(h)20.7(a)0(t)-614(6)0(3)20.8(2)0(.)18.5(8)-156.6(nm)]TJ -4.7518 -1.1116 TD [(ph)20.8(ot)20.7(ob)15.1(io)20.7(mo)19.6(du)20.8(la)19.6(ti)20.6(on)-232.6(at)-233.9(an)-228(en)13.9(er)19.7(gy)-226.8(of)-232.6(5)-156.6(J)0(/)15.1(c)0(m)]TJ 7.3823 0 0 6.5614 227.7921 345.9401 Tm (2)Tj 9.843 0 0 9.843 233.9149 341.5747 Tm [(in)20.7(cr)19.7(ea)18.5(se)19.9(d)-243(t)0(h)20.7(e)-244.2(ce)18.5(ll)]TJ -17.4634 -1.1116 TD [(mi)19.5(gr)20.9(at)13.8(io)20.7(n)-767.1(a)0(n)19.7(d)-767.1(ha)19.7(pt)20.7(ot)20.7(ax)19.7(is)-762.4(of)-756.7(wo)20(un)20.8(de)19.7(d)-767.1(h)0(u)20.8(m)0(a)18.4(n)-767.1(sk)15.3(in)-756.8(-)]TJ T* [(br)20.9(ob)15.1(la)19.5(st)20.9(s.)]TJ 7.3823 0 0 6.5614 99.0992 324.0566 Tm -.0162 Tc (28)Tj 9.843 0 0 9.843 110.8913 319.6913 Tm 0 Tc [(In)-445.7(th)20.7(e)-457.3(p)0(r)15.1(e)0(s)19.9(e)0(n)19.7(t)-456.2(st)20.9(ud)15.1(y,)-442.3(ph)15.1(ot)15(ob)15.1(iom)12.6(odu)14(lat)12.6(ion)-452.7(wit)12.8(h)]TJ -4.9649 -1.1174 TD [(808)-153.1(nm)-458.4(las)12.9(er)-458.3(pro)14(mot)12.6(ed)-458.4(the)-453.8(pe)13.9(rio)13.9(don)14(tal)-454(lig)13.7(ame)10.4(nt)-457.3(cel)11.5(ls)-457.1(mi-)]TJ 0 -1.1116 TD [(gra)12.8(tio)13.7(n)-617.4(u)0(n)15.1(der)-609.2(nor)14(mal)11.5(,)-614(sta)12.9(rve)12.8(d,)-609.3(and)-609.2(in)14(am)12.7(ed)-613.9(conditions,)]TJ T* [(conrming)-467.3(that)-460.8(photobiomo)-6.8(dulation)-465.4(could)-461.8(be)-464.1(the)-465.4(precon-)]TJ 0 -1.1174 TD [(dition)-525.4(of)-526.3(the)-528.7(periodontal)-527.4(ligament)-531.1(cells)-526.3(before)-533(tooth)-524.1(re-)]TJ 0 -1.1116 TD [(plantation,)-339.8(thus)-332.6(promoting)-333.9(the)-332.9(tissue)-335.9(regeneration.)]TJ 1.0137 -1.1116 TD [(The)-408.8(most)-408.8(common)-413.4(complications)-411(of)-411.1(replanted)-411(teeth)-411.3(are)]TJ -1.0137 -1.1174 TD [(inammatory)-495(and)-494(replacement)-497.4(resorption.)-493.7(Alleviating)-494(the)]TJ 0 -1.1116 TD [(inammation)-351.2(of)-347.7(periodontal)-348.9(ligament)-346.8(cells)-353.5(is)-347.7(important)-346.7(for)]TJ T* [(the)-344.4(prognosis)-337.9(of)-342(avulsed)-344(teeth.)-345.6(In)-336.2(the)-344.4(current)-344.2(study,)-342.9(the)-338.7(re-)]TJ 0 -1.1174 TD [(sults)-391.3(showed)-388.6(that)-391.7(the)-390.5(mRNA)-394.3(expression)-393.2(of)-388.1(TNF-)]TJ /F7 1 Tf 20.5679 0 TD (a)Tj /F6 1 Tf .5011 0 TD [(,)-389.3(IL-1)]TJ /F7 1 Tf 2.4191 0 TD (b)Tj /F6 1 Tf .5529 0 TD (,)Tj -24.041 -1.1116 TD [(and)-505.6(IL-6)-512.4(in)-503.4(the)-505.7(inamed)-512.3(periodontal)-510.1(ligament)-508.1(cells)-509(was)]TJ T* [(suppressed)-410.1(after)-411.1(photobiomodulation)-408.8(of)-405.3(808)-164.6(nm)-406.6(laser.)-408.6(The)]TJ T* -.0167 Tc [(an)5.2(ti-i)5.1(n)-.5(ammator)5.3(y)-282.7(effect)-282.9(o)5.2(f)-282.7(th)5.2(e)-283.9(p)5.2(hoto)5.2(b)-.5(io)5.2(mod)5.2(u)-.5(lation)-277(o)-.5(f)-276.9(808)-161.8(nm)]TJ 0 -1.1174 TD 0 Tc [(las)12.9(er)-239.5(was)-229.8(sim)12.8(ila)12.6(r)-243(t)0(o)-238.5(tha)12.7(t)-237.4(i)0(n)-238.5(the)-235(afo)12.8(rem)17.4(ent)12.7(ion)13.8(ed)-239.5(stu)14(die)12.7(s.)-234.7(Vil)12.8(ela)]TJ 0 -1.1116 TD [(et)-280(al.)-283.4(found)-281.9(that)-276.5(numbers)-286.3(of)-278.6(inammatory)-281.9(cells)-284.4(and)-280.9(necrotic)]TJ T* [(areas)-354.4(were)-353.2(reduced)-351(after)-353.5(685)-164.6(nm)-349(laser)-353.3(irradiation.)]TJ 7.3823 0 0 6.5614 262.9417 148.7055 Tm (29)Tj 9.843 0 0 9.843 273.77 144.3401 Tm (Boschi)Tj -21.5125 -1.1174 TD [(et)-326(al.)-323.7(showed)-325.2(that)-322.6(irradiated)-325.9(with)-328.1(660)-164.6(nm)-320.2(laser)-330.3(signicantly)]TJ 0 -1.1116 TD [(red)12.8(uce)11.7(d)-231.5(t)0(h)15(e)-232.6(IL-)12.8(6)-231.5(and)-217.6(TNF)12.1(-)]TJ /F7 1 Tf 10.69 0 TD (a)Tj /F6 1 Tf .7315 0 TD [(exp)12.8(res)13(sio)14(n.)]TJ 7.3823 0 0 6.5614 218.4944 126.7653 Tm (30)Tj 9.843 0 0 9.843 228.1322 122.3999 Tm [(Rec)10.6(en)13.9(t)-231.6(stu)14(die)12.7(s)-231.3(had)]TJ -16.8759 -1.1116 TD [(shown)-380.6(that)-374.4(IL-6)-379.9(and)-373.1(Galectin-3)-384.4(could)-375.4(be)-377.7(early)-376.5(biomarkers)]TJ 0 -1.1174 TD [(for)-510.1(the)-517.2(detection)-514.9(of)-509(periodontitis)-517(in)-509.2(serum)-514.5(and)-511.3(saliva.)]TJ 7.3823 0 0 6.5614 291.855 104.8819 Tm (5,6)Tj 9.843 0 0 9.843 62.022 89.5181 Tm [(Photobiomodulation)-425.9(reduced)-420.1(the)-425.1(inammation)-420.3(reaction)-427.2(by)]TJ 0 -1.1116 TD [(activating)-441.2(signaling)-437.5(pathways)-438.2(and)-436.4(downregulating)-439.4(the)-436.6(ex-)]TJ 0 -1.1174 TD [(pression)-366.8(of)-365(inammatory)-362.6(cytokines.)-367.1(The)-362.8(mechanism)-367.1(of)-365(in-)]TJ 0 -1.1116 TD [(ammation)-320.1(alleviation)-327.3(by)-313.2(photobiomo)-6.8(dulation)-315.6(may)-322.5(involve)]TJ 25.504 67.9184 TD [(the)-338.7(cAMP/NF-)]TJ /F7 1 Tf 6.0592 0 TD (j)Tj /F6 1 Tf .5472 0 TD [(B)-336.2(signaling)-339.6(pathway)]TJ 7.3823 0 0 6.5614 460.8566 729.5242 Tm (17)Tj 9.843 0 0 9.843 471.5715 725.1588 Tm [(or)-336.2(the)-332.9(C-Raf/Erk1/2)]TJ -16.1041 -1.1174 TD [(signal)-7.8(ing)-331.7(pathway;)]TJ 7.3823 0 0 6.5614 388.7432 718.5825 Tm (31)Tj 9.843 0 0 9.843 399.4581 714.1605 Tm [(this)-332.8(requires)-333.5(further)-337.2(research.)]TJ -7.7641 -1.1116 TD [(Periodontal)-521.5(ligament)-519.6(cells)-514.7(osteogenic)-521.4(differentiation)-521.7(is)]TJ -1.0137 -1.1116 TD [(an)-441.1(important)-444.6(healing)-436.5(proces)-8.7(s)-438.6(after)-439.9(tooth)-437.7(replantation,)-446.8(and)]TJ T* [(it)-399.9(is)-399.6(helpful)-395(for)-400.7(the)-396.3(replanted)-399.5(teeth)-399.7(to)-399.7(be)-395(early)-399.6(retained)-398.4(in)]TJ 0 -1.1174 TD [(the)-379(alveolar)-381.1(socket.)-375.2(The)-374.3(inammation)-380(and)-373.1(nutritional)-382.5(de-)]TJ 0 -1.1116 TD [(ciency)-551.6(was)-552.3(harmful)-551.6(to)-549.5(the)-546(osteogenic)-550.2(potential)-554.2(of)-549.3(peri-)]TJ T* [(odontal)-395(ligament)-398.7(cells.)-391.5(Only)-391.3(a)-393.9(few)-397(studies)-388.9(have)-398.4(examined)]TJ 0 -1.1174 TD [(the)-390.5(effect)-396.1(of)-388.1(photobiomodulation)-391.5(on)-388.1(the)-384.7(osteogenic)-394.7(differ-)]TJ 0 -1.1116 TD [(entiation)-398.7(of)-393.8(periodontal)-400.7(ligament)-398.7(cells)-393.8(under)-398.3(inamed)-397.1(and)]TJ T* [(starve)-8.8(d)-381.2(conditions.)-384.4(Amarol)-384.4(et)-383.6(al.)-381.3(found)-385.6(that)-380.2(photobiomod-)]TJ 0 -1.1174 TD [(ulation)-320.3(with)-310.8(808)-170.3(nm)-314.4(laser)-313(could)-317.8(regulate)-317.8(bone)-310.8(marrow)-320.8(stro-)]TJ 0 -1.1116 TD [(mal)-334.1(cells)-336.2(differentiation)-337.3(and)-332.8(enhance)-334.9(osteogenesis.)]TJ 7.3823 0 0 6.5614 517.9463 597.9967 Tm (32)Tj 9.843 0 0 9.843 528.6046 593.6313 Tm (Wang)Tj -21.8984 -1.1116 TD [(et)-475.8(al.)-473.5(investigated)-477.8(the)-471.1(osteogenesis)-477.2(of)-468.7(induced)-476.7(inamma-)]TJ T* [(tion)-534.6(bone)-529.7(marrow)-533.9(stromal)-528.5(cells)-532(with)-535.4(1064)-165.7(nm)-527.6(laser)-537.6(and)]TJ 0 -1.1174 TD [(found)-322.3(that)-316.8(at)-320.3(an)-314.4(energy)-319.9(of)-318.9(8)-162.4(J/cm)]TJ 7.3823 0 0 6.5614 446.4566 565.1148 Tm (2)Tj 9.843 0 0 9.843 453.2597 560.7495 Tm [(promoted)-316.6(the)-321.4(osteogene-)]TJ -14.2437 -1.1116 TD [(sis)-360.1(of)-353.5(the)-355.9(inamed)-356.8(cells.)]TJ 7.3823 0 0 6.5614 412.8944 554.1731 Tm (33)Tj 9.843 0 0 9.843 423.7794 549.8077 Tm [(In)-353.5(the)-355.9(current)-361.5(study,)-354.5(our)-354.6(results)]TJ -11.2487 -1.1116 TD [(conrmed)-386.6(that)-386(photobiomodulation)-385.7(with)-379.9(808)-164.6(nm)-383.6(laser)-387.9(pro-)]TJ 0 -1.1174 TD [(moted)-514.9(osteogenic)-509.9(differentiation)-515.9(of)-509(starved)-511(and)-505.6(inamed)]TJ 0 -1.1116 TD [(periodontal)-515.9(ligament)-513.9(cells.)-512.4(It)-509.2(was)-512(speculated)-516.8(that)-512.7(photo-)]TJ T* [(biomodulat)-8(ion)-533.3(could)-536.7(increase)-537.5(the)-534.5(concentration)-543.5(of)-532.1(intra-)]TJ 0 -1.1174 TD [(cellular)-289.1(calcium)-289.1(ions.)-278.5(Un)14.2(de)19.7(r)-219.9(t)0(h)20.7(e)-221.1(ci)19.5(rc)19.7(um)19.6(st)20.9(an)19.7(ce)-211.9(of)-209.5(in)15(du)20.8(ct)19.5(io)20.7(n)-220(o)0(f)]TJ 0 -1.1116 TD [(os)15.3(te)19.6(og)20.8(en)19.7(ic)-280(di)20.7(ff)20.9(er)19.7(en)13.9(ti)20.6(at)19.5(io)20.7(n,)-275.2(in)20.7(tr)15(ac)18.5(el)19.5(lu)20.7(la)19.6(r)-289.1(c)0(a)18.5(l)0(c)19.6(i)0(u)20.7(m)-284.5(io)15(ns)-272.7(we)18.8(re)-279.8(re)19.7(-)]TJ T* [(le)13.8(as)19.9(ed)-251(ou)20.8(ts)20.9(id)15(e)-261.4(o)0(f)-249.8(t)0(h)20.7(e)-261.4(ce)18.5(ll)20.6(s)-260.1(a)0(n)13.9(d)-260.3(gr)20.9(ad)19.7(ua)19.7(ll)20.6(y)-260.3(a)0(c)18.5(c)0(u)13.9(m)15(ul)15(at)19.5(ed)-251(to)-250(fo)20.9(rm)]TJ 0 -1.1174 TD 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[(pathological)-353.6(evaluation)-347.8(of)-350.3(the)-351.7(effects)-346.2(of)-350.3(variable)-350.4(extraoral)]TJ 0 -1.1284 TD [(dry)-393.1(times)-386.7(and)-388.9(enamel)-396.7(matrix)-390.1(proteins)-389.9(\(enamel)-393.1(matrix)-390.1(de-)]TJ 0 -1.1223 TD [(rivatives\))-341.3(application)-347.4(on)-335.7(replanted)-344.5(dogs)-337.6(teeth.)-343.5(Dent)-335.1(Trau-)]TJ 0 -1.1284 TD [(matol)-338.8(2015;31:2934.)]TJ -1.2503 -1.1223 TD [(5.)-500.4(Isola)-329(G,)-325.1(Polizzi)-327.8(A,)-325.1(Alibrandi)-324.9(A,)-325.1(Williams)-329.4(RC,)-327.1(Lo)-325.4(Giudice)]TJ 1.2503 -1.1284 TD [(A.)-447(Analysis)-449.3(of)-447.8(galectin-3)-447.7(levels)-452.5(as)-448.8(a)-443.5(source)-449.9(of)-447.9(coronary)]TJ 0 -1.1223 TD [(heart)-450(disease)-450.4(risk)-446.7(during)-447.9(periodontitis.)-443.9(J)-450.6(Periodontal)-446.6(Res)]TJ 0 -1.1284 TD (2021;56:597605.)Tj -1.2503 -1.1223 TD [(6.)-500.4(Isola)-274.2(G,)-270.2(Lo)-270.5(Giudice)-272.1(A,)-270.2(Polizzi)-272.9(A,)-270.2(Alibrandi)-270(A,)-270.2(Murabito)-268.1(P,)]TJ 1.2503 -1.1284 TD [(Indelicato)-856.4(F.)-850.9(Identication)-853(of)-850.4(the)-851.9(different)-851.1(salivary)]TJ 0 -1.1223 TD [(Interleukin-6)-271.7(proles)-265.1(in)-268.1(patients)-269.2(with)-263.3(periodontitis:)-272.6(a)-266.6(cross-)]TJ 0 -1.1284 TD [(sectional)-340.7(study.)-334.8(Arch)-331.9(Oral)-337.5(Biol)-333.6(2021;122:104997.)]TJ -1.2503 -1.1223 TD [(7.)-500.4(Matarese)-536.5(G,)-526.3(Isola)-530.3(G,)-526.3(Anastasi)-532.8(GP,)-529.4(et)-528.5(al.)-528.5(Transforming)]TJ 1.2503 -1.1284 TD [(growth)-278.7(factor)-275.6(beta)-270.7(1)-274.6(and)-273(vascular)-276.9(endothelial)-274.2(growth)-278.7(factor)]TJ 0 -1.1223 TD [(levels)-513.5(in)-505.9(the)-510.3(pathogenesis)-511.6(of)-502.7(periodontal)-510.7(disease.)-511.5(Eur)-510.9(J)]TJ 0 -1.1284 TD [(Inamm)-338.8(2013;11:479488.)]TJ -1.2503 -1.1284 TD [(8.)-500.4(Barbakow)-561.1(FH,)-559.9(Cleaton-Jones)-561.5(PE,)-560.2(Austin)-555.4(JC,)-559.3(Vieira)-561(E.)]TJ 1.2503 -1.1223 TD [(Effects)-349.9(of)-344.2(thyrocalcitonin,)-349.8(acidulated)-352(sodium)-340.5(uoride,)-351.5(and)]TJ 0 -1.1284 TD [(neutral)-376.6(sodium)-377.1(uoride)-375.8(on)-372.3(the)-376.1(mobility)-376.6(of)-374.7(experimentally)]TJ 0 -1.1223 TD [(replanted)-338.4(teeth.)-337.4(J)-334.7(Endod)-332(1980;6:823828.)]TJ -1.2503 -1.1284 TD [(9.)-500.4(Selvig)-305.7(KA,)-302.4(Bjorvatn)-310.2(K,)-300.7(Bogle)-301.9(GC,)-305.6(Wikesjo)]TJ 18.7551 .0244 TD ()Tj .7197 -.0244 TD [(UM.)-306.2(Effect)-301.9(of)]TJ -18.2245 -1.1223 TD [(stannous)-552(uoride)-552.7(and)-547.5(tetracycline)-559.5(on)-549.2(periodontal)-553.4(repair)]TJ 0 -1.1284 TD [(after)-330.4(delayed)-330.2(tooth)-328.9(replantation)-331.5(in)-329.1(dogs.)-323(Scand)-329.2(J)-328.6(Dent)-329.1(Res)]TJ 0 -1.1223 TD (1992;100:200203.)Tj -1.7505 -1.1284 TD [(10.)-500.5(Yuan)-293(XJ,)-293.8(Wang)-295.8(YY,)-290.2(Shi)-289.4(BQ,)-293.4(Zhao)-293.3(YM.)-294(Effect)-295.8(of)-289.3(propolis)]TJ 1.7505 -1.1223 TD [(on)-360.1(preserving)-360.7(human)-364.4(periodontal)-364.4(ligament)-361.2(cells)-360.9(and)-358.4(regu-)]TJ 0 -1.1284 TD [(lating)-424.2(pro-inammatory)-421(cytokines.)-422.5(Dent)-426.6(Traumatol)-421(2018;)]TJ 0 -1.1223 TD (34:245253.)Tj -1.7505 -1.1284 TD [(11.)-500.5(Levin)-299(L,)-301(Bryson)-299.9(EC,)-293.7(Caplan)-300.2(D,)-300.7(Trope)-301.9(M.)-298.3(Effect)-295.8(of)-301.5(topical)]TJ 1.7505 -1.1223 TD [(alendronate)-288(on)-286.9(root)-282.9(resorption)-282.7(of)-283.2(dried)-287.2(replanted)-283.5(dog)-287.1(teeth.)]TJ 0 -1.1284 TD [(Dent)-335.1(Traumatol)-335.6(2001;17:120126.)]TJ -1.7505 -1.1223 TD [(12.)-500.5(Qian)-280.2(H,)-276.3(Ding)-282.1(Y,)-276.3(Wu)-279.1(Y,)-276.3(Li)-282.2(S.)-277.6(The)-274.9(effects)-285.2(of)-277.1(three)-279.2(modied)]TJ 1.7505 -1.1284 TD [(hanks)-470.1(balanced)-474.9(salt)-472.4(solutions)-473.6(on)-469.9(root)-465.9(resorption)-471.8(of)-472.3(late)]TJ 0 -1.1223 TD [(replanted)-576.2(teeth:)-568.7(a)-571.6(pilot)-572.3(study.)-566.6(J)-572.6(Craniomaxillofac)-574.8(Surg)]TJ 0 -1.1284 TD (2018;46:808814.)Tj -1.7505 -1.1223 TD [(13.)-500.5(Rincon)-308.1(JC,)-309.2(Haase)-306.8(HR,)-305.6(Bartold)-310(PM.)-301.4(Effect)-308(of)-307.6(emdogain)-307.4(on)]TJ 1.7505 -1.1284 TD [(human)-303.4(periodontal)-297.3(broblasts)-300.7(in)-298.6(an)-303.4(in)-298.6(vitro)-300.8(wound-healing)]TJ 0 -1.1223 TD [(model.)-333.4(J)-334.7(Periodontal)-336.8(Res)-337.9(2003;38:290295.)]TJ -1.7505 -1.1284 TD [(14.)-500.5(Guzma)]TJ 4.2634 .0427 TD ()Tj .3843 -.0427 TD (n-Mart)Tj 2.763 .0427 TD ()Tj .2989 -.0427 TD [(nez)-777.3(N,)-776.4(Silva-Herzog)-778.6(FD,)-773.3(Me)]TJ 13.2719 .0427 TD ()Tj .3843 -.0427 TD [(ndez)-777.5(GV,)]TJ -19.6151 -1.1223 TD (Mart)Tj 1.9274 .0366 TD ()Tj .305 -.0366 TD (n-Pe)Tj 1.4455 .0366 TD ()Tj .3843 -.0366 TD [(rez)-273.4(S,)-271.5(Cerda-Cristerna)-279.8(BI,)-269.7(Cohenca)-274.6(N.)-270.2(The)-268.8(effect)]TJ -4.0621 -1.1284 TD [(of)-246.6(emdogain)-246.4(and)-248.6(24%)-246.9(edta)-246.3(root)-246.3(conditioning)-247.6(on)-244.3(periodontal)]TJ 0 -1.1223 TD [(healing)-337.6(of)-332(replanted)-332.3(dogs)-331.5(teeth.)-331.3(Dent)-335.1(Traumatol)-335.6(2009;25:)]TJ 0 -1.1284 TD (4350.)Tj -1.7505 -1.1223 TD [(15.)-500.5(Posten)-427.4(W,)-431.5(Wrone)-426.4(DA,)-430.5(Dover)-429.7(JS,)-423.2(Arndt)-431(KA,)-424.4(Silapunt)-427.4(S,)]TJ 1.7505 -1.1284 TD [(Alam)-639.7(M.)-639.9(Low-level)-636.5(laser)-638.2(therapy)-639.4(for)-639.4(wound)-636.6(healing:)]TJ 0 -1.1223 TD [(mechanism)-310.5(and)-309.6(efcacy.)-309.8(Dermatol)-316.9(Surg)-304.7(2005;31:334340.)]TJ -1.7505 -1.1284 TD [(16.)-500.5(Choi)-407.3(EJ,)-410(Yim)-409.6(JY,)-409.7(Koo)-410.7(KT,)-406.4(et)-406.5(al.)-412.6(Biological)-408.8(effects)-413.3(of)-405.2(a)]TJ 1.7505 -1.1223 TD [(semiconductor)-362(diode)-352(laser)-357.7(on)-354(human)-352.2(periodontal)-358.3(ligament)]TJ 0 -1.1284 TD [(broblasts.)-337.4(J)-334.7(Periodontal)-336.8(Implant)-335.3(Sci)-330.2(2010;40:105110.)]TJ 25.263 70.9097 TD [(17.)-500.5(Lee)-236.4(JH,)-232.8(Chiang)-235(MH,)-239.1(Chen)-235.2(PH,)-236.6(Ho)-233.6(ML,)-233.3(Lee)-236.4(HE,)-235.6(Wang)-240.9(YH.)]TJ 1.7505 -1.1223 TD [(Anti-inammatory)-541.2(effects)-547.4(of)-539.3(low-level)-548.6(laser)-540.6(therapy)-541.8(on)]TJ 0 -1.1284 TD [(human)-474.1(periodontal)-474.2(ligament)-477.1(cells:)-476.3(in)-475.5(vitro)-477.6(study.)-475.1(Lasers)]TJ 0 -1.1223 TD [(Med)-333.3(Sci)-336.3(2018;33:469477.)]TJ -1.7505 -1.1283 TD [(18.)-500.5(de)-522.9(Oliveira)-524.1(TS,)-523.6(Serra)-522.9(AJ,)-525.6(Manchini)-526.1(MT,)-526(et)-522.4(al.)-522.4(Effects)]TJ 1.7505 -1.1223 TD [(of)-545.4(low)-550.4(level)-550.8(laser)-552.8(therapy)-547.9(on)-549.2(attachment,)-552.9(proliferation,)]TJ 0 -1.1284 TD [(and)-651.2(gene)-655.5(expression)-656.4(of)-655.2(vegf)-653.6(and)-657.3(vegf)-653.6(receptor)-658.3(2)-652.7(o)0(f)]TJ 0 -1.1223 TD [(adipocyte-derived)-435.1(mesenchymal)-437(stem)-435.9(cells)-434(cultivated)-438.7(un-)]TJ 0 -1.1284 TD [(der)-470.5(nutritional)-474.9(deciency.)-478(Lasers)-481.4(Med)-473.5(Sci)-470.5(2015;30:217)]TJ 0 -1.1223 TD (223.)Tj -1.7505 -1.1284 TD [(19.)-500.5(Huang)-342(YY,)-345.1(Sharma)-343.4(SK,)-340.3(Carroll)-342.9(J,)-347(Hamblin)-340.7(MR.)-346(Biphasic)]TJ 1.7505 -1.1223 TD [(dose)-327.2(response)-327.3(in)-329.1(low)-330.8(level)-331.2(light)-328.4(therapyan)-327(update.)-332(Dose)]TJ 0 -1.1284 TD [(Response)-335.8(2011;9:602618.)]TJ -1.7505 -1.1284 TD [(20.)-500.5(Martens)-369.4(LC.)-373(Laser)-378.4(physics)-368.8(and)-376.7(a)-370.3(review)-372.5(of)-374.7(laser)-369.8(applica-)]TJ 1.7505 -1.1223 TD [(tions)-541.5(in)-542.5(dentistry)-542(for)-547.9(children.)-541.5(Eur)-547.5(Arch)-539.3(Paediatr)-548.5(Dent)]TJ 0 -1.1284 TD (2011;12:6167.)Tj -1.7505 -1.1223 TD [(21.)-500.5(Mustafa)-735.4(FH,)-736.7(Jaafar)-736.9(MS.)-734.4(Comparison)-730.6(of)-734.5(wavelength-)]TJ 1.7505 -1.1284 TD [(dependent)-300(penetration)-307.6(depths)-302.5(of)-301.5(lasers)-308.1(in)-298.6(different)-308.3(types)-302.3(of)]TJ 0 -1.1223 TD [(skin)-298(in)-292.5(photodynamic)-301.4(therapy.)-297.9(Indian)-299.6(J)-298.1(Phys)-295.4(2012;87:203)]TJ 0 -1.1284 TD (209.)Tj -1.7505 -1.1223 TD [(22.)-500.5(da)-352.1(Silva)-360.4(PCS,)-352.6(Marques)-357.8(NP,)-358.6(Farina)-355.5(MT,)-355.3(et)-357.7(al.)-351.6(Laser)-360.1(treat-)]TJ 1.7505 -1.1284 TD [(ment)-412.4(contributes)-412.3(to)-414.5(maintain)-410(membrane)-417.8(integrity)-414.2(in)-408.4(stem)]TJ 0 -1.1223 TD [(cells)-379.2(from)-376.8(human)-376.6(exfoliated)-374.5(deciduous)-380.3(teeth)-380(\(shed\))-374.8(under)]TJ 0 -1.1284 TD [(nutritional)-334.6(decit.)-334.4(Lasers)-335(Med)-339.4(Sci)-330.2(2019;34:1521.)]TJ -1.7505 -1.1223 TD [(23.)-500.5(Trope)-661.8(M.)-670.4(Clinical)-664.7(management)-669.5(of)-667.4(the)-662.8(avulsed)-666.7(tooth:)]TJ 9.2951 0 0 9.2951 327.118 463.6345 Tm [(present)-516.5(strategies)-519.1(and)-523.1(future)-515.4(directions.)-522(Dent)-518.1(Traumatol)]TJ T* (2002;18:111.)Tj -1.7505 -1.1284 TD [(24.)-500.5(Tagliani)-412.3(MM,)-413.6(Oliveira)-420.4(CF,)-416.7(Lins)-409.7(EMM,)-415.7(et)-418.7(al.)-412.6(Nutritional)]TJ 1.7505 -1.1223 TD [(stress)-382.3(enhances)-389.2(cell)-386(viability)-386.9(of)-380.8(odontoblastlike)-385(cells)-385.3(sub-)]TJ 0 -1.1284 TD [(jected)-238(to)-237.6(low)-239.3(level)-239.8(laser)-241.8(irradiation.)-244.2(Laser)-238.1(Phys)-240.5(Lett)-237.3(2010;7:)]TJ 0 -1.1223 TD (247251.)Tj -1.7505 -1.1284 TD [(25.)-500.5(Huang)-354.2(YY,)-357.3(Chen)-357.2(AC,)-360.5(Carroll)-361.2(JD,)-354.8(Hamblin)-359(MR.)-358.2(Biphasic)]TJ 1.7505 -1.1223 TD [(dose)-424.7(response)-431(in)-426.7(low)-428.4(level)-428.8(light)-425.9(therapy.)-426(Dose)-432.4(Response)]TJ 0 -1.1284 TD (2009;7:358383.)Tj -1.7505 -1.1223 TD [(26.)-500.5(Tsuka)-292.6(Y,)-300.7(Kunimatsu)-297.4(R,)-297.8(Gunji)-293.9(H,)-294.6(et)-296.7(al.)-296.8(Effects)-301.2(of)-295.4(Nd:YAG)]TJ 1.7505 -1.1284 TD [(low-level)-451(laser)-449.1(irradiation)-451.5(on)-445.5(cultured)-449.9(human)-449.7(osteoblasts)]TJ 0 -1.1223 TD [(migration)-402.1(and)-407.2(atp)-400.5(production:)-409(in)-402.3(vitro)-404.4(study.)-401.9(Lasers)-408.2(Med)]TJ 0 -1.1284 TD [(Sci)-330.2(2019;34:5560.)]TJ -1.7505 -1.1223 TD [(27.)-500.5(Yin)-257.6(K,)-251.9(Zhu)-258.5(R,)-255.1(Wang)-259.2(S,)-259.3(Zhao)-256.7(RC.)-253.9(Low-level)-264.4(laser)-260.1(effect)-255.4(on)]TJ 1.7505 -1.1284 TD [(proliferation,)-295.6(migration,)-292.4(and)-291.3(antiapoptosis)-292.9(of)-289.3(mesenchymal)]TJ 0 -1.1223 TD [(stem)-332.2(cells.)-336.5(Stem)-336(Cells)-337(Dev)-329.5(2017;26:762775.)]TJ -1.7505 -1.1284 TD [(28.)-500.5(Evans)-347.5(DH,)-345.1(Abrahamse)-352(H.)-343.3(Efcacy)-350.1(of)-344.2(three)-352.4(different)-344.9(laser)]TJ 1.7505 -1.1223 TD [(wavelengths)-550.5(for)-547.9(in)-548.6(vitro)-550.8(wound)-545.1(healing.)-551.2(Photodermatol)]TJ 0 -1.1284 TD [(Photoimmunol)-331.4(Photomed)-336.6(2008;24:199210.)]TJ -1.7505 -1.1223 TD [(29.)-500.5(Vilela)-448.3(RG,)-452(Gjerde)-451.8(K,)-447(Frigo)-450.6(L,)-447.3(et)-455.3(al.)-449.2(Histomorphometric)]TJ 1.7505 -1.1284 TD [(analysis)-628.8(of)-624.7(inammatory)-629.2(response)-626.1(and)-626.8(necrosis)-631.7(in)-627.9(re-)]TJ T* [(implanted)-251.5(central)-252.7(incisor)-249.5(of)-252.7(rats)-249.6(treated)-252.7(with)-251.1(low-level)-249.8(laser)]TJ 0 -1.1223 TD [(therapy.)-334.5(Lasers)-335(Med)-333.3(Sci)-336.3(2012;27:551557.)]TJ -1.7505 -1.1284 TD [(30.)-500.5(Boschi)-289(ES,)-285.7(Leite)-290.4(CE,)-287.6(Saciura)-292.7(VC,)-287.3(et)-290.6(al.)-284.6(Anti-inammatory)]TJ 1.7505 -1.1223 TD [(effects)-517(of)-521(low-level)-518.1(laser)-516.2(therapy)-517.4(\(660)-167.6(nm\))-520.8(in)-512(the)-522.5(early)]TJ 0 -1.1284 TD [(phase)-392.5(in)-384(carrageenan-induced)-402.7(pleurisy)-389.9(in)-390.1(rat.)-390.7(Lasers)-389.9(Surg)]TJ 0 -1.1223 TD [(Med)-333.3(2008;40:500508.)]TJ -1.7505 -1.1284 TD [(31.)-500.5(Lim)-342.9(W,)-340(Choi)-340.2(H,)-343.3(Kim)-342.6(J,)-340.9(et)-345.5(al.)-339.5(Anti-inammatory)-346.1(effect)-346.9(of)]TJ 1.7505 -1.1223 TD [(635)-165.1(nm)-487.8(irradiations)-499.6(on)-488.2(in)-487.6(vitro)-495.9(direct/indirect)-495.9(irradiation)]TJ 0 -1.1284 TD [(model.)-333.4(J)-334.7(Oral)-331.4(Pathol)-336.2(Med)-333.3(2015;44:94102.)]TJ -1.7505 -1.1223 TD [(32.)-500.5(Amaroli)-410.1(A,)-410.4(Agas)-408(D,)-410.4(Laus)-408.3(F,)-411.8(et)-406.5(al.)-412.6(The)-409.1(effects)-413.3(of)-411.3(photo-)]TJ 1.7505 -1.1284 TD [(biomodulation)-558.4(of)-557.6(808)-171.2(nm)-554.9(diode)-559.4(laser)-565(therapy)-560.1(at)-558.9(higher)]TJ 0 -1.1223 TD [(uence)-418.9(on)-421.1(the)-418.8(in)-420.6(vitro)-416.6(osteogenic)-420.7(differentiation)-427.5(of)-417.4(bone)]TJ 0 -1.1284 TD [(marrow)-334.1(stromal)-334.4(cells.)-336.5(Front)-334.7(Physiol)-331.2(2018;9:123.)]TJ -1.7505 -1.1223 TD [(33.)-500.5(Wang)-423.9(L,)-423(Wu)-425.5(F,)-424(Liu)-422.6(C,)-425.8(et)-424.8(al.)-424.8(Low-level)-423(laser)-430.8(irradiation)]TJ 1.7505 -1.1284 TD [(modulates)-354.9(the)-351.7(proliferation)-356.5(and)-352.3(the)-351.7(osteogenic)-353.6(differentia-)]TJ 0 -1.1223 TD [(tion)-249.5(of)-252.7(bone)-254.9(marrow)-254.8(mesenchymal)-254(stem)-253(cells)-257.2(under)-251.2(healthy)]TJ 0 -1.1284 TD [(and)-297.4(inammatory)-299.9(condition.)-302.7(Lasers)-298.4(Med)-296.7(Sci)-299.7(2019;34:169)]TJ 0 -1.1223 TD (178.)Tj /F4 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(PHOTOBIOMODULATION)-340.2(FOR)-334(PERIODONTAL)-337.8(LIGAMENT)-339.2(CELLS)-21653.2(703)]TJ ET endstream endobj 78 0 obj <>stream /GS1 gs BT /F6 1 Tf 9.2951 0 0 9.2951 62.022 725.1588 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