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[(202)14(054)14(054)14(\))-433(and)-430.7(all)-425.2(pat)12.7(ien)12.7(ts)-428.4(wer)12(e)-440(req)12.8(ui)15(red)-430.6(to)-434.3(sig)19.8(n)-438.8(wri)13(tte)12.6(n)]TJ T* [(inf)13.9(orm)12.8(ed)-412.3(con)12.8(sen)18.8(t.)-413.6(Rad)11.8(iog)13.8(rap)12.8(hic)-407.8(exa)17.4(min)12.6(ati)12.6(on)-411.1(and)-407.6(tho)13.9(rou)14(gh)]TJ 0 -1.1174 TD [(vis)14(ual)-327.1(ins)14(pec)11.7(tio)13.7(n)-340.9(usi)19.8(ng)-336.3(a)-336.3(den)12.8(tal)-333(mi)13.7(rro)14(r)-340.9(and)-327(pro)14(be)-337.4(we)13(re)-337.4(per)12.8(-)]TJ 0 -1.1116 TD [(for)14(med)11.6(.)-383.6(For)-371.7(inc)12.7(lus)14(ion)-372.1(in)-376.7(the)-379(stu)19.8(dy,)-374.3(the)-379(sub)19.9(jec)11.5(ts)-382.3(sho)14.2(uld)-372(not)]TJ T* [(hav)12.8(e)-319(und)14(erg)12.8(one)-309.7(per)12.8(iod)19.6(ont)13.8(al)-314.5(sca)11.8(lin)13.7(g)-317.9(i)0(n)-319.1(t)0(h)15(e)-324.8(pa)13.9(st)-318.9(2)-317.9(wee)10.8(ks)-313(and)]TJ 0 -1.1174 TD [(per)12.8(iod)13.9(ont)13.8(al)-251.2(sur)14.2(ge)13.9(ry)-255.6(in)-250(th)15(e)-255.7(pas)13(t)-254.7(3)-260.3(mo)13.8(nth)13.9(s)-254.3(and)-246.4(sho)14.2(uld)-245.3(not)-245.3(hav)12.8(e)]TJ 0 -1.1116 TD [(tak)12.7(en)-377.7(any)-378.8(med)17.3(ica)11.5(tio)13.7(n)-387(\(in)13.9(cl)13.8(udi)13.8(ng)-382.3(ant)12.7(i-i)13.8(na)18.7(mma)10.4(tor)13.9(y)-381.2(and)-378.8(an-)]TJ T* [(alg)12.7(esi)12.9(c\))-176.1(or)-180.7(rec)11.7(eiv)12.7(ed)-176.2(pro)14(fes)13(sio)14(nal)-177.4(des)13(ens)13(iti)19.4(zat)11.5(ion)-176.2(the)12.7(rap)12.9(y)-179.6(i)0(n)-180.9(the)]TJ T* [(pre)12.8(vio)13.9(us)-399.4(6)-410(m)0(o)13.8(nth)13.8(s.)-401.8(The)-397.3(tee)11.5(th)-399.7(sho)14.2(win)13(g)-410(sen)18.8(sit)13.9(ivi)13.7(ty)-405.5(we)13(re)-406.5(re-)]TJ 0 -1.1174 TD [(qui)13.8(red)-407.6(to)-417(be)-412.3(wit)12.8(hou)14(t)-415.9(def)12.8(ect)11.5(ive)-407.8(res)13(tor)13.9(ati)12.6(ons)14.2(,)-418.1(c)0(a)12.8(rie)12.7(s,)-413.3(ll)13.9(ing)13.8(s,)]TJ 0 -1.1116 TD [(cra)11.7(cks)13(,)-331.7(a)0(n)13.9(d)-335.2(pul)13.8(pi)14.9(tis)13.9(.)-331.7(Pat)12.8(ien)12.7(ts)-324.7(wit)12.8(h)-329.4(poo)14(r)-335.1(o)0(r)15.1(a)0(l)-331.8(hyg)19.7(ien)12.7(e,)-328.2(sev)13(ere)]TJ T* [(per)12.8(iod)13.9(ont)13.8(iti)13.6(s,)-211.7(and)-211.8(the)-206.2(tee)11.5(th)-215.4(wit)12.8(h)-214.2(wed)11.9(ge-)12.8(sha)13(ped)-211.8(de)13.9(fec)11.7(ts)-215.2(dee)11.7(per)]TJ 0 -1.1174 TD [(tha)12.7(n)-335.2(1)-162.4(mm)-333(wer)12(e)-336.3(als)12.9(o)-335.2(exc)11.7(lu)15(ded)12.8(.)-337.5(Las)11.8(t,)-327.2(pre)12.9(gna)12.8(nt)-330.6(and)-327(lac)11.5(tat)12.6(ing)]TJ 0 -1.1116 TD [(wom)11.9(en)-337.4(\(to)-331.7(avo)12.8(id)-336.4(the)-332.9(pro)14(bab)12.8(le)-337.6(sid)14(e)-342.1(eff)12.9(ec)12.8(ts)-342(of)-336.2(the)-332.9(las)12.9(er\))-332.7(and)]TJ T* [(tho)13.8(se)-504.3(wit)12.8(h)-507.9(sys)14.4(tem)11.5(ic)-504.6(dis)14(ea)12.8(ses)-499.4(or)-509(al)13.8(ler)12.7(gie)12.7(s)-507.8(t)0(o)-503.4(des)13(ens)13(iti)13.6(zin)12.7(g)]TJ 0 -1.1174 TD [(age)11.7(nts)-262.4(wer)12(e)-278.7(als)12.9(o)-271.8(exc)11.7(lud)13.9(ed.)]TJ 1.0137 -1.1116 TD [(We)-218.7(enrolled)-224.5(48)-215.3(participants)-224.4(\(15)-216.4(male)-221.2(and)-223.3(33)-215.3(female;)-225.8(mean)]TJ -1.0137 -1.1116 TD [(age,)-452.6(43.6)-450.2(years;)-452.3(age)-454.9(range,)-449(2372)-449(years\))-457.9(with)-449(96)-451.5(dentin-)]TJ 25.504 67.9242 TD [(exposed)-274.8(teeth)-278.8(\(40)-268.2(teeth)-273(on)-272.9(the)-275.3(facial)-275.3(surface)-275.9(and)-269.4(56)-272.9(teeth)-273(on)]TJ 0 -1.1174 TD [(the)-367.5(occlusal)-363.7(surface\))-363.4(in)-365.2(this)-361.6(randomized)-367.2(controlled)-359.3(clinical)]TJ 0 -1.1116 TD [(trial.)-189(Subjects)-183.8(were)-180.4(instructed)-186.3(to)-180.9(refrain)-188.6(from)-178.4(carrying)-189.8(out)-182(any)]TJ T* [(oral)-299.4(hygiene)-298.2(measures,)-304.5(eating,)-294.9(or)-295.9(drinking)-297(water)-302.5(at)-297.2(least)-295.9(2)-168.1(h)]TJ T* [(before)-538.8(the)-528.7(evaluation.)-536.7(Detailed)-531.9(anam)-8(nesis)-530.5(interviews)-532.8(in-)]TJ 0 -1.1174 TD [(cluding)-423.8(diet,)-412.4(chewing)-420(habits)-422.5(and)-413.4(time,)-419.4(and)-419.2(frequency)-422.3(and)]TJ 0 -1.1116 TD [(degree)-390.2(of)-382.3(hypersensitivity)-388.8(were)-387.7(recorded)-386.6(before)-383.3(treatment.)]TJ T* [(Clinical)-467.7(examinations)-467.4(were)-462.6(performed)-468.4(including)-460.7(oral)-466.4(soft)]TJ 0 -1.1174 TD [(tissue)-347.5(including)-339.8(soft)-344.1(tissue)-341.7(in)-342.1(oral)-339.7(and)-344.3(the)-338.7(wear)-341.6(position)-343.1(of)]TJ 0 -1.1116 TD [(sensitive)-277.2(tooth.)-268.4(The)-270.6(vitality)-269.8(of)-272.9(all)-269.7(experimental)-272.9(and)-275.2(adjacent)]TJ T* [(teeth)-440.1(was)-442.9(checked)-438.6(through)-439.8(an)-441.1(electric)-440(pulp)-436.5(tester)-440.9(and)-436.4(re-)]TJ 0 -1.1174 TD [(corded.)-248.5(Each)-249.8(sensitive)-248.4(tooth)-247.7(was)-247.1(examined)-249.8(in)-244.2(two)-246.2(ways)-248.2(cold)]TJ 0 -1.1116 TD [(test)-368.5(and)-361.6(probing)-364.9(test.)-360.4(Cotton)-365(rolls)-362.6(and)-361.6(suction)-366(device)-367.3(were)]TJ T* [(applied)-269.5(to)-267.3(isolate)-269.4(the)-269.5(adjacent)-272.9(teeth.)-270.7(An)-262.3(ice)-270.7(stick)-265.9(was)-270.1(placed)]TJ T* [(on)-330.5(the)-332.9(tooth)-334.1(being)-329.3(tested)-331.5(for)-331.5(5)-168.1(sec,)-331.4(and)-332.8(all)-333(the)-332.9(stimuli)-331.8(were)]TJ 0 -1.1174 TD [(applied)-211.9(on)-203.8(the)-206.2(sensitive)-208.1(region)-203.7(of)-209.5(the)-200.4(experimental)-215.3(tooth.)-205(The)]TJ 0 -1.1116 TD [(patients)-420.3(were)-422.3(asked)-416.6(to)-417(describe)-421.1(the)-419.3(pain)-414.6(intensity)-420.3(ranging)]TJ T* [(from)-397.2(0)-392.8(t)0(o)-394(1)0(0)-393.9(according)-399.4(to)-394(a)-393.9(visual)-393.7(analogue)-398.3(scale)-394.8(\(VAS\).)]TJ 0 -1.1174 TD [(These)-371.7(scores)-371.4(were)-370.4(recorded)-375.1(as)-366(the)-373.2(baseline)-369.5(VAS)-367.7(score)-370.5(for)]TJ 0 -1.1116 TD [(each)-359.2(experimental)-353.5(tooth)-351.4(or)-353.5(sensitive)-357.8(point.)-349(Scores)]TJ /F8 1 Tf 20.9423 0 TD (>)Tj /F6 1 Tf .5529 0 TD [(2)-352.4(were)]TJ -21.4952 -1.1116 TD [(included)-316.7(to)-313.3(standardize)-316.3(the)-309.9(sample.)-313(After)-312.9(5)-168.1(min,)-313.4(the)-309.9(experi-)]TJ 0 -1.1174 TD [(mental)-269.6(teeth)-261.5(were)-266.8(touched)-263.6(by)-261.4(an)-262.6(explorer)-270.4(with)-259(a)-267.2(force)-261.2(of)-261.4(5)-168.1(g)]TJ 0 -1.1116 TD [(and)-286.7(the)-281.1(VAS)-281.4(was)-281.6(again)-278.7(recorded.)]TJ 1.0137 -1.1116 TD [(After)-566.3(recording)-565.2(the)-563.3(baseline)-565.3(VAS)-563.6(scores,)-564.9(participants)]TJ -1.0137 -1.1174 TD [(were)-341.6(randomly)-333.8(assigned)-333.4(to)-336.4(three)-336.2(groups:)]TJ 1.6703 -2.2232 TD [(I.)-499.8(Green)-625(laser)-618.3(\(532)-165.6(nm;)-621(MLB-200A)-623.3(Nd:)-614.8(YAG/KTP)]TJ 1.0828 -1.1116 TD [(Laser)-245(Treatment)-240.7(Instrument,)-241.5(CHONGQING)-247.4(JINGYU)]TJ 0 -1.1174 TD [(LASER)-614.4(TECHNOLOGY)-619.9(CO,)-612.3(LTD\))-618.2(and)-609.2(placebo)]TJ 0 -1.1116 TD [(\(distilled)-340.9(water\))-332.4(were)-335.9(applied)-338.6(in)-336.4(Group)-334.7(A.)]TJ -1.4169 -1.1116 TD [(II.)-500.9(NaF)-800(\(Colgate,)-804.9(NY,)-796.5(Duraphat\))-802.3(and)-799.3(green)-802.6(laser)]TJ 1.4169 -1.1174 TD [(\(532)-165.6(nm\))-338.6(without)-331.5(power)-335.8(were)-335.9(applied)-338.6(in)-336.4(Group)-334.6(B.)]TJ -1.7509 -1.1116 TD [(III.)-502(Green)-578.9(laser)-577.9(\(532)-165.6(nm\))-574.7(without)-573.4(power)-577.7(and)-574.7(placebo)]TJ 1.7509 -1.1116 TD [(\(distilled)-335.1(water\))-338.2(were)-335.9(applied)-338.6(in)-330.6(Group)-334.6(C.)]TJ -1.7394 -2.229 TD [(Each)-290.2(patient)-292.7(received)-290(an)-285.6(envelope)-288.9(with)-287.8(a)-290.2(number)-285.4(and)-292.4(the)]TJ -1.0137 -1.1116 TD [(numbers)-274.8(were)-278.3(assigned)-275.8(to)-273(one)-269.4(of)-272.9(the)-275.3(three)-272.9(above-mentioned)]TJ T* [(groups)-380.8(with)-374.2(unrestricted)-379.7(\(simple\))-379.8(randomization.)-379.9(All)-373.1(treat-)]TJ 0 -1.1174 TD [(ments)-307.3(were)-307.1(carried)-305(out)-302.9(by)-301.7(an)-302.9(experienced)-306(operator)-305(with)-305(the)]TJ 0 -1.1116 TD [(same)-439.7(methods)-436.3(and)-436.4(protocols,)-435(and)-436.4(examinations)-438.6(were)-439.6(per-)]TJ T* [(forme)-7.8(d)-605.9(b)0(y)-607(another)-609.1(dentist)-608.1(unaware)-611.1(of)-606.9(the)-603.6(grouping)-607.9(to)]TJ 0 -1.1174 TD [(minimize)-549.6(errors)-548.9(and)-545.9(avoid)-548.2(bias.)-544.6(The)-547.1(patients)-552.7(were)-549(also)]TJ 0 -1.1116 TD [(blinded)-493(to)-486.1(the)-488.4(therapy)-488.2(received.)-489.3(Each)-491.7(subject)-488.2(received)-491.6(a)]TJ T* [(single)-336.1(treatment)-337.5(and)-338.5(was)-333.4(treated)-334(without)-337.3(local)-336.4(anesthesia.)]TJ 1.0137 -1.1174 TD [(In)-244.1(Group)-248.3(A)-243.9(subjects,)-244.8(the)-246.5(sensitive)-248.4(teeth)-244.2(were)-249.5(irradiated)-245.2(by)]TJ -1.0137 -1.1116 TD [(the)-361.7(532-nm)-364.9(green)-359.1(laser)-364.8(at)-360.6(an)-360.5(intensity)-362.7(of)-359.3(15)-163.5(J/cm)]TJ 7.3823 0 0 6.5614 513.6943 236.3527 Tm (2)Tj 9.843 0 0 9.843 520.8943 231.9873 Tm (\(param-)Tj -21.1151 -1.1116 TD [(eters)-261.2(given)-260.2(in)-255.7(Table)-256.8(1\).)-259(The)-253.3(laser)-261.2(was)-258.6(placed)-257.9(at)-256.9(a)-255.7(distance)-260(of)]TJ 0 -1.1174 TD [(5)-168.1(m)0(m)-448.2(from)-443.3(the)-448.1(tooth)-449.3(surface)-448.7(and)-442.2(applied)-453.8(on)-439.9(the)-448.1(exposed)]TJ 0 -1.1116 TD [(denta)-8(l)-508.1(position)-510.1(continually)-510.3(for)-510.1(5)-168.1(min.)-509.2(The)-506.8(adjacent)-514.8(teeth)]TJ ET 313.058 168.264 239.131 .28348 re f 313.058 68.542 239.131 .28348 re f 313.058 139.635 239.131 .28348 re f 313.058 118.488 239.131 .22678 re f 313.058 87.364 239.131 .22678 re f BT /F10 1 Tf 9.845 0 0 9.845 340.044 173.9905 Tm (Table)Tj /F6 1 Tf 3.0002 0 TD (1.)Tj /F10 1 Tf 1.2496 0 TD [(Parameters)-332.7(of)-337(Light)-335.5(Equipment)]TJ /F7 1 Tf -6.9909 -2.8562 TD [(Wavelength)-2364.2(Mode)]TJ 11.8223 1.0135 TD [(Fluence)-340(rate)]TJ .5759 -1.0135 TD (\(mW/cm)Tj /F6 1 Tf 7.3837 0 0 6.5625 467.9432 150.2362 Tm (2)Tj /F7 1 Tf 9.845 0 0 9.845 471.6282 145.8708 Tm (\))Tj 2.4531 1.0135 TD [(Output)-335.3(power)]TJ 1.6988 -1.0135 TD (\(mW\))Tj /F6 1 Tf -20.2586 -1.8946 TD [(532)-170(nm)-4483.3(CW)-4871.1(47)-5697.2(150)]TJ /F7 1 Tf 0 -2.4071 TD [(Tip)-337(diameter)]TJ 0 -1.0135 TD (\(mm\))Tj 6.4611 1.0135 TD (Distance)Tj .7313 -1.0135 TD (\(mm\))Tj 4.1346 1.0135 TD [(Treatment)-340.3(time)]TJ 2.0097 -1.0135 TD [(\(min\))-3720.2(Frequency)]TJ /F6 1 Tf -13.3368 -1.8946 TD [(10)-6992.9(5)-5926.5(5)-6698.2(1)]TJ 8.7511 0 0 8.7511 321.0519 56.7496 Tm [(CW,)-333.2(continuous)-335.2(wave.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (706)Tj 49.6665 0 TD [(HU)-334.4(ET)-338.7(AL.)]TJ ET endstream endobj 34 0 obj <>stream /GS1 gs BT /F6 1 Tf 9.843 0 0 9.843 59.7543 570.8408 Tm 0 0 0 rg 0 Tc 0 Tw [(were)-347.4(covered)-345.2(with)-339.6(opaque)-343(tinfoil)-342.3(\(Fig.)-341.8(1\).)-339.7(After)-347.4(irradiation)]TJ 0 -1.1116 TD [(for)-239.4(30)-169.2(min,)-238.5(the)-235(placebo)-241.7(was)-241.3(applied)-240.7(on)-238.3(the)-235(teeth)-244.2(for)-239.4(5)-162.4(min.)-238.5(In)]TJ 0 -1.1174 TD [(Group)-340.4(B,)-339.6(patients)-339.6(received)-341.9(irradiation)-337.4(of)-342(the)-332.9(532-nm)-341.9(green)]TJ 0 -1.1116 TD [(laser,)-327.9(but)-326(the)-327.1(power)-324.3(was)-327.7(turned)-324.7(off.)-323.5(After)-324.4(30)-169.2(min,)-324.9(NaF)-322(was)]TJ T* [(carefully)-457.1(applied)-448(to)-451.6(the)-448.1(sensitive)-455.7(tooth)-449.3(to)-445.8(ensure)-452.2(that)-449.3(the)]TJ T* [(desensitizer)-374.9(made)-370.8(complete)-376.7(contact)-368.6(with)-374.2(the)-367.5(sensitive)-375.1(area)]TJ 0 -1.1174 TD [(left)-305.3(for)-308.5(5)-168.1(min.)-301.8(Thirty)-307.5(minutes)-303.9(later,)-305.2(the)-309.9(surface)-304.7(of)-307.4(the)-304.1(tested)]TJ 0 -1.1116 TD [(tooth)-570.2(was)-563.8(dried)-565.5(lightly)-566.9(with)-570(compressed)-568.2(air)-563.3(and)-568.9(rinsed)]TJ T* [(thoroughly)-379.9(with)-374.2(water.)-375.1(In)-376.5(Group)-375(C,)-374.2(the)-373.2(operator)-374.1(only)-378.9(pre-)]TJ 0 -1.1174 TD [(tended)-383.4(to)-370.9(irradi)-8(ate)-374.4(patients)-381(teeth,)-380.1(without)-377.6(laser)-376.4(activation.)]TJ 0 -1.1116 TD [(Then,)-286.7(a)-278.7(placebo)-282(was)-281.6(applied)-281(according)-284.2(to)-284.6(the)-281.1(same)-278.5(protocol)]TJ T* [(with)-362.6(NaF.)-360(All)-361.5(participants)-362.6(were)-364.7(instructed)-364.8(to)-353.7(avoid)-363.9(rinsing)]TJ 0 -1.1174 TD [(their)-306.4(mouths,)-305(chewing)-304.8(food,)-301.6(or)-301.7(brushing)-302.5(for)-302.7(at)-303(least)-307.4(30)-163.5(min,)]TJ 0 -1.1116 TD [(3)-168.1(h)0(,)-459.5(and)-453.7(12)-169.2(h,)-453.8(respectivel)-11.2(y,)-453.8(after)-462.9(the)-453.8(treatment.)-461.9(When)-457.1(the)]TJ T* [(study)-333.7(was)-333.4(terminated,)-336.3(patients)-333.9(in)-330.6(Group)-334.7(C)-330.4(were)-330.1(recalled)-336.2(to)]TJ 0 -1.1174 TD [(receive)-340.8(desensitizer)-340.4(application)-338.7(for)-331.5(DH.)]TJ 1.0137 -1.1116 TD [(During)-261(the)-263.8(study,)-262.3(patients)-259(were)-266.8(required)-258.9(to)-261.5(maintain)-266.2(good)]TJ -1.0137 -1.1116 TD [(oral)-403.1(hygiene)-407.6(\(brushing)-401.4(teeth)-405.5(twice)-400.6(a)-405.4(day)-401.9(and)-401.9(using)-402.9(dental)]TJ T* [(oss)-435.8(three)-434.1(times)-428.4(a)-434.2(day\))-431.8(and)-430.7(not)-429.7(allowed)-437.4(to)-428.5(use)-436.2(any)-430.7(anti-)]TJ 0 -1.1174 TD [(hypersensitivity)-302.4(medication)-298.4(or)-290.2(mouthwash.)-298.8(The)-293.6(participants)]TJ 0 -1.1116 TD [(were)-364.7(followed)-362.4(up)-359.3(at)-360.6(2)-358.2(weeks)-365.6(and)-361.6(3)-358.2(months)-359.1(after)-365(the)-361.7(treat-)]TJ T* [(ment.)-430.8(The)-431.9(teeth)-434.3(were)-428(examined)-434.1(with)-431.8(an)-429.6(ice)-432(stick)-427.2(and)-430.7(re-)]TJ 0 -1.1174 TD [(probing)-572.3(as)-573.4(described)-572(earlier,)-573.5(and)-574.7(the)-569(VAS)-575.1(scores)-573(were)]TJ 0 -1.1116 TD [(obtained.)-291.3(Four)-292.2(scores)-290.7(were)-289.8(recorded)-294.5(for)-285.5(each)-290.1(patient)-292.7(at)-285.7(four)]TJ T* [(time)-335.4(points:)-324.7(baseline,)-332.6(immediately)-335.4(after)-330.4(treatment,)-335.2(2)-329.4(weeks)]TJ 0 -1.1174 TD [(after)-255.6(treatment,)-254.6(and)-252.1(3)-254.5(months)-249.7(after)-255.6(treatment.)-254.6(The)-253.3(soft)-252(tissue)]TJ 0 -1.1116 TD [(and)-321.2(pulp)-321.3(vitality)-321.6(were)-324.4(examined)-324.7(repeatedly)-326.9(in)-319.1(each)-324.7(review.)]TJ T* [(Radiological)-473.3(examination)-478(of)-468.7(experimental)-468.7(teeth)-474.6(was)-471.7(con-)]TJ 0 -1.1174 TD [(ducted)-337.4(at)-337.6(the)-332.9(3)-329.4(months)-336.1(review.)]TJ /F11 1 Tf 8.9663 0 0 8.9663 59.7543 236.9763 Tm [(Statistical)-336.1(analysis)]TJ /F6 1 Tf 9.843 0 0 9.843 69.7323 220.5354 Tm [(All)-298.2(statistical)-304(analyses)-300(were)-301.3(performed)-301.4(using)-299.2(SPSS)-297.5(\(IBM)]TJ -1.0137 -1.1116 TD [(SPSS)-239.9(Statistics)-243.8(20,)-236(Armonk,)-242.5(NY\).)-238.8(The)-241.8(VAS)-241(mean)-238.3(value)-238.3(was)]TJ T* [(calculated)-362.8(to)-353.7(assess)-359.5(the)-355.9(effect)-355.7(of)-353.5(DH,)-353(and)-355.8(analysis)-362.4(of)-353.5(vari-)]TJ 0 -1.1174 TD [(ance)-284.4(was)-281.6(used)-281.8(to)-278.8(compare)-288.9(the)-281.1(consistency)-280.4(of)-284.4(VAS)-281.4(values)-279.6(at)]TJ 0 -1.1116 TD [(baseline)-248.5(and)-246.4(at)-245.4(the)-246.5(three)-244.1(points)-248.6(after)-244(intervention)-246.4(in)-244.2(different)]TJ T* [(groups.)-441.8(The)-443.4(descriptive)-442(statistics)-445.4(are)-443.3(presented)-439.5(as)-440.9(mean)]TJ /F8 1 Tf 23.7242 0 TD ()Tj /F6 1 Tf -23.7242 -1.1174 TD [(standard)-287.5(deviation.)-281(Chi-square)-285(test)-287.9(was)-281.6(taken)-284.4(to)-278.8(identify)-281(the)]TJ 0 -1.1116 TD [(relationship)-470.9(between)-473(gender)-463.9(and)-471(DH.)]TJ /F7 1 Tf 16.2769 0 TD (p)Tj /F6 1 Tf .5011 0 TD (-Value)Tj /F8 1 Tf 3.1966 0 TD ()Tj /F6 1 Tf .5529 0 TD [(0.05)-461.8(was)]TJ -20.5276 -1.1116 TD [(considered)-337(to)-336.4(indicate)-335.2(statistical)-338.5(signicance.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 59.7543 105.9023 Tm (Results)Tj /F6 1 Tf 9.843 0 0 9.843 69.7323 89.4614 Tm [(In)-595.4(this)-592(study,)-596.4(48)-589.7(participant)-10.3(s)-588.4(with)-598.8(96)-589.7(teeth)-595.6(received)]TJ -1.0137 -1.1174 TD [(treatment)-274.2(for)-268.2(DH.)-272.3(Of)-268(these,)-270.4(45)-272.9(patients)-270.5(with)-270.5(90)-267.1(teeth)-273(\()]TJ /F7 1 Tf 21.9099 0 TD (n)Tj /F8 1 Tf .6624 0 TD (=)Tj /F6 1 Tf .72 0 TD (15)Tj -23.2922 -1.1116 TD [(patients/group;)-514.6(30)-514.8(teeth/group\))-511.2(aged)-513.6(2372)-506.6(years)-514.5(\(mean:)]TJ T* [(45.8)-242.9(years\))-250.6(were)-243.7(followed)-247.2(up)-244.1(for)-245.1(2)-243(weeks)-244.7(and)-246.4(3)-243(months)-243.9(after)]TJ 25.5097 52.2463 TD [(treatment)-573.7(with)-570(a)-572.5(follow-up)-569.7(rate)]TJ /F12 1 Tf 14.3417 0 TD (*)Tj /F6 1 Tf .9964 0 TD [(93.8%.)-571(The)-570.1(age)-575.8(and)]TJ -15.3381 -1.1116 TD [(gender)-314.2(distributions)-319.8(of)-313.2(the)-315.6(three)-318.9(study)-316.5(groups)-317.4(are)-316.6(displayed)]TJ 0 -1.1174 TD [(in)-330.6(Table)-337.5(2.)]TJ 1.0137 -1.1116 TD [(The)-622(mean)-618.5(baseline)-628.7(VAS)-621.2(scores)-624.8(of)-618.5(the)-620.9(three)-624.2(groups)]TJ -1.0137 -1.1116 TD [(for)-366.1(cold)-362.8(and)-367.3(probing)-364.9(stimulation)-366.3(are)-368.5(presented)-364.7(in)-365.2(Tables)-367.2(3)]TJ T* [(and)-580.4(4.)-580.5(There)-585(was)-586.9(no)-578.2(signicant)-589.3(difference)-585.9(noted)-582.8(\(cold)]TJ 0 -1.1174 TD [(stimulation:)-707.4(6.6)]TJ /F8 1 Tf 6.9232 0 TD ()Tj /F6 1 Tf .72 0 TD (1.4/6.2)Tj /F8 1 Tf 2.949 0 TD ()Tj /F6 1 Tf .7142 0 TD (2.0/6.7)Tj /F8 1 Tf 2.949 0 TD ()Tj /F6 1 Tf .72 0 TD [(1.4,)-706(probing)-704.7(stimula-)]TJ -14.9752 -1.1116 TD [(tion:)-783.5(5.3)]TJ /F8 1 Tf 4.0433 0 TD ()Tj /F6 1 Tf .72 0 TD (1.6/5.1)Tj /F8 1 Tf 2.949 0 TD ()Tj /F6 1 Tf .7142 0 TD (1.8/5.4)Tj /F8 1 Tf 2.949 0 TD ()Tj /F6 1 Tf .72 0 TD 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[(ment)-467.7(and)-465.2(immediately)-467.8(after)-468.7(treatment)-470(in)-463.1(VAS)-465.7(scores)-469.3(for)]TJ 0 -1.1174 TD [(Group)-265.5(A)-261.2(\()]TJ /F7 1 Tf 4.2967 0 TD (p)Tj /F8 1 Tf .6681 0 TD (<)Tj /F6 1 Tf .72 0 TD (0.01/)Tj /F7 1 Tf 2.0274 0 TD (p)Tj /F8 1 Tf .6681 0 TD (<)Tj /F6 1 Tf .72 0 TD [(0.01\))-261.2(and)-263.7(Group)-265.5(B)-267.1(\()]TJ /F7 1 Tf 8.3055 0 TD (p)Tj /F8 1 Tf .6624 0 TD (<)Tj /F6 1 Tf .72 0 TD (0.01/)Tj /F7 1 Tf 2.0332 0 TD (p)Tj /F8 1 Tf .6681 0 TD (<)Tj /F6 1 Tf .72 0 TD (0.01\))Tj -22.2094 -1.1116 TD [(both)-361.6(in)-359.4(the)-361.7(probing)-359.2(and)-361.6(cold)-362.8(tests.)-361.3(This)-362.6(result)-359.1(showed)-365.6(that)]TJ T* [(low-level)-266.9(green)-267(laser)-272.7(and)-263.6(NaF)-270.1(reduced)-264.6(pain)-270.6(level)-267.3(in)-267.3(DH.)-266.6(No)]TJ T* [(change)-252(in)-255.7(sensitivity)-255.4(was)-252.8(detected)-255.6(for)-256.7(the)-252.3(placebo)-253.2(group;)-254.4(the)]TJ 0 -1.1174 TD 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[(The)11.6(ref)12.9(ore)12.8(,)-205(low)13(-en)12.8(er)14(gy)-203.8(gre)12.8(en)-199.2(lig)13.7(ht)-203.9(di)14.9(d)-208.4(not)-193.5(cau)11.7(se)-204.8(an)-199.2(inc)12.7(rea)11.7(se)-199(in)]TJ 0 -1.1174 TD [(int)13.7(ram)11.6(edu)12.8(lla)12.6(ry)-301.7(tem)17.2(per)12.8(atu)12.7(re.)-300.5(In)-301.7(our)-302.8(re)14(cen)11.7(t)-312.3(stu)19.8(dy,)-299.4(the)-298.3(532)14(-nm)]TJ 0 -1.1116 TD [(las)12.9(er)-331.6(was)-327.7(har)12.8(ml)13.7(ess)-326.6(to)-330.6(den)12.8(tal)-321.5(pul)13.8(p)-335.2(ste)12.9(m)-336.4(cel)17.3(ls,)-328.1(den)12.8(tal)-321.5(pul)13.8(p)-335.2()0(-)]TJ T* [(bro)14(bla)12.7(sts)14.2(,)-274.1(and)-269.4(rat)-263.7(den)12.8(tal)-263.9(pul)13.8(p)-277.6(tis)13.9(sue)13(.)]TJ 1.0137 -1.1174 TD [(In)-445.7(our)-446.8(previous)-441.9(study,)-446.6(we)-447.7(found)-443.2(photosensitive)-449.9(protein)]TJ -1.0137 -1.1116 TD [(Opsin4)-191.7(was)-195.2(expressed)-197.3(in)-186.6(human)-192.2(dental)-193.5(pulp)-194.6(stem)-191(cells)-192.2(and)-188.8(rat)]TJ T* [(odontoblast)-232.3(cells)-226.8(and)-229.1(that)-230.5(532)-164.6(nm)-228.1(green)-226.7(light)-230.5(could)-225.7(affect)-229(the)]TJ 0 -1.1174 TD [(expression)-278(level)-273(of)-267.1(Opsin4.)-275.8(Wang)-272.8(et)-268.4(al.)]TJ 7.3823 0 0 6.5614 216.6236 214.4692 Tm (34)Tj 9.843 0 0 9.843 226.7149 210.0472 Tm [(found)-270.4(that)-270.8(540)-164.6(nm)]TJ -16.9623 -1.1116 TD [(green)-226.7(light)-224.8(could)-219.9(regulate)-231.4(calcium)-225.8(inux)-218.6(through)-226.7(Opsin4)-226.3(and)]TJ T* [(TRPV1)-423.2(calcium)-421.6(channels)-421.2(on)-416.9(human)-422.6(adipose-derived)-424.4(stem)]TJ T* [(cells)-393.8(\(hASCs\).)-398.5(Therefore,)-392.3(we)-395.9(speculated)-395.9(there)-393.8(was)-391(similar)]TJ 0 -1.1174 TD [(process)-355.2(on)-353.5(odontoblast)-359.1(cells)-353.5(or)-353.5(myelin-free)-356.8(C-type)-354.5(sensory)]TJ 0 -1.1116 TD [(nerve)-301.5(terminals,)-305(which)-301.4(led)-298.3(to)-301.8(cell)-300.7(depolarization)-308.5(and)-298.2(reduc-)]TJ T* [(tion)-292.6(of)-295.9(ATP)-293.2(release,)-292.2(resulting)-293.5(in)-296.1(an)-291.3(immediate)-292.7(analgesic)-296.9(ef-)]TJ 0 -1.1174 TD [(fect.)-574.7(The)-575.9(540-)-574.6(and)-574.7(520-nm)-572.3(green)-572.3(light)-576.1(could)-577(stimulate)]TJ 0 -1.1116 TD [(osteoblast)-238(differentiation)-239.4(of)-232.6(hASCs)-237.4(and)-234.9(human)-232.5(bone)-236(marrow)]TJ T* [(stem)-312(cells)-313.2(\(hBMSCs\))-310.9(by)-307.5(Opsin4)-306.9(and)-309.7(TRPV1.)]TJ 7.3823 0 0 6.5614 242.3621 115.8235 Tm (35)Tj 9.843 0 0 9.843 252.7936 111.4582 Tm [(In)-307.4(addition,)]TJ -19.6118 -1.1174 TD [(our)-302.8(research)-307(group)-299.2(found)-305(that)-299.6(green)-301.5(light)-305.4(can)-299.4(accelerate)-307.4(the)]TJ 0 -1.1116 TD [(osteogenic)-602.1(differentiation)-596.5(of)-595.4(hBMSCs)-596.7(by)-589.7(activating)-596.8(the)]TJ T* [(mitogen-activat)-11.5(ed)-279.8(protein)-285.6(kinase-extracelluar)-294.3(regulated)-284.3(pro-)]TJ 0 -1.1174 TD [(tein)-426.3(kinases)-424.5(\(MAPK-ERK\))-431.2(signal)-428.3(pathway.)-423.4(Therefore,)-426.9(we)]TJ 0 -1.1116 TD [(speculate)-619.4(that)-610.6(green)-612.6(light)-610.7(may)-610.5(also)-610.3(promote)-609.2(osteob)-7.7(last)]TJ 25.5097 67.9184 TD [(differentiation)-308.5(of)-301.7(dental)-308.7(pulp)-304(stem)-300.5(cells)-307.4(to)-301.8(odontoblast)-307.2(cells)]TJ 0 -1.1174 TD [(by)-198(interaction)-200.4(of)-198(Opsin4,)-200.9(TRPV1,)-196.2(and)-200.3(MAPK-ERK)-204.5(signaling)]TJ 0 -1.1116 TD [(pathway,)-561.6(and)-557.4(produce)-557.2(reparative)-563(dentin)-561(to)-561(maintain)-559.9(the)]TJ T* [(therapeutic)-264.8(effect)-263.6(on)-261.4(DH)-263.1(for)-256.7(a)-261.4(long)-263.7(period.)]TJ 1.0137 -1.1116 TD [(However,)-257.1(further)-262.3(studies)-262.2(are)-259(required)-264.6(to)-255.8(better)-262.6(understand)]TJ -1.0137 -1.1174 TD [(the)-361.7(mechanism)-367.1(of)-359.3(532-nm)-364.9(green)-364.9(light)-363(laser.)-362.5(Besides,)-365.6(addi-)]TJ 0 -1.1116 TD [(tional)-526.5(studies)-527.1(are)-529.7(also)-529.6(needed)-528.5(to)-526.5(evaluate)-526.3(the)-528.7(long-term)]TJ T* [(stability)-397.4(of)-393.8(green)-393.7(laser)-393.6(for)-394.9(DH.)-393.3(Comparing)-399.3(the)-396.3(effects)-397(be-)]TJ 0 -1.1174 TD [(tween)-509.9(green)-514.7(light)-512.7(high-power)-508.5(laser)-514.6(and)-511.3(exploring)-512.4(which)]TJ 0 -1.1116 TD [(type)-357(of)-365(DH)-361(is)-359.2(more)-358.1(effective)-366.1(with)-362.6(green)-359.1(laser)-364.8(are)-362.7(some)-363.7(of)]TJ T* [(the)-332.9(potential)-335.3(future)-336.1(research)-341.5(directions.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 310.8472 593.6313 Tm (Conclusions)Tj /F6 1 Tf 9.843 0 0 9.843 320.8251 577.1904 Tm [(Treatments)-512.3(performed)-508.7(with)-512.4(green)-508.9(laser)-514.6(and)-505.6(NaF)-512(were)]TJ -1.0137 -1.1116 TD [(both)-384.7(equally)-384.7(effective)-389.1(in)-382.5(decreasing)-384.2(DH)-384.1(pain)-385.8(in)-382.5(the)-384.7(short-)]TJ T* [(term)-312.2(evaluation)-314.4(\(2)-313.2(weeks\))-314.8(and)-309.7(the)-315.6(effect)-315.4(of)-307.4(green)-318.8(laser)-313(was)]TJ 0 -1.1174 TD [(more)-363.9(stable)-360.3(after)-365(3)-364(months.)-362.5(Therefore,)-369.3(532-nm)-359.1(green)-364.9(laser)]TJ 0 -1.1116 TD [(was)-385.3(considered)-388.8(a)-388.2(reliable)-387(method)-389.3(for)-383.4(DH.)-387.5(However,)-389.6(addi-)]TJ T* [(tional)-538.1(studie)-7.8(s)-536.6(are)-541.2(needed)-545.7(to)-538(further)-544.6(observe)-545.5(the)-540.2(clinical)]TJ 0 -1.1174 TD [(outcomes)-242.7(of)-244.1(desensitization)-246.1(by)-244.1(using)-241.6(green)-243.9(laser)-243.9(for)-245.1(a)-238.4(longer)]TJ 0 -1.1116 TD [(follow-up)-333.5(duration.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 310.8472 476.7873 Tm [(Authors)-334(Contributions)]TJ /F6 1 Tf 9.843 0 0 9.843 320.8251 460.3463 Tm [(S.N.H.)-297.4(carried)-299.2(out)-297.2(experiments,)-302.5(analyzed)-301.6(data,)-298.3(and)-298.2(wrote)]TJ -1.0137 -1.1116 TD [(the)-517.2(article.)-521.8(L.T.Y.)-518(and)-517.1(M.Q.W.)-518.7(carried)-518.1(out)-516(experiments.)]TJ 0 -1.1174 TD [(Y.G.W.)-334.4(and)-332.8(Y.S.Z.)-338.1(conceived)-337.2(and)-332.8(designed)-333.6(the)-338.7(study.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 310.8472 414.7086 Tm [(Author)-332.4(Disclosure)-336.7(Statement)]TJ /F6 1 Tf 9.843 0 0 9.843 320.8251 398.2676 Tm [(No)-331.4(competing)-336.3(nancial)-334.9(interests)-340.5(exist.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 310.8472 374.57 Tm [(Funding)-334.6(Information)]TJ /F6 1 Tf 9.843 0 0 9.843 320.8251 358.129 Tm [(This)-374.2(study)-374.1(was)-373.8(supported)-379.6(by)-376.6(Beijing)-373.2(Municipal)-382.2(Science)]TJ -1.0137 -1.1116 TD [(&)-330.6(Technology)-337.2(Commission)-336.9(No.)-334.8(Z181100001718186.)]TJ /F4 1 Tf 8.9663 0 0 8.9663 310.8472 323.7731 Tm (References)Tj /F6 1 Tf 9.2951 0 0 9.2951 315.496 307.6724 Tm [(1.)-500.4(Ye)-396.4(W,)-394.9(Feng)-398(XP,)-395.2(Li)-398.1(R.)-395.3(The)-396.9(prevalence)-396.3(of)-399.1(dentine)-398.6(hyper-)]TJ 1.2503 -1.1223 TD [(sensitivity)-336.6(in)-335.2(Chinese)-336(adults.)-332.5(J)-334.7(Oral)-337.5(Rehabil)-336.3(2012;39:182)]TJ 0 -1.1284 TD (187.)Tj -1.2503 -1.1223 TD [(2.)-500.4(Zeola)-352(LF,)-346.7(Soares)-355.2(PV,)-352.5(Cunha-Cruz)-353.4(J.)-347(Prevalence)-356.5(of)-350.3(dentin)]TJ 1.2503 -1.1284 TD [(hypersensitivity:)-776.5(systematic)-778.7(review)-781.1(and)-773.1(meta-analysis.)]TJ 0 -1.1223 TD [(J)-334.7(Dent)-335.2(2019;81:16.)]TJ -1.2503 -1.1284 TD [(3.)-500.4(Boiko)-383.1(OV,)-387.8(Baker)-382.2(SR,)-386.2(Gibson)-385.2(BJ,)-382.4(et)-388.2(al.)-382.1(Construction)-388.6(and)]TJ 1.2503 -1.1223 TD [(validation)-458.9(of)-460(the)-455.4(quality)-460.9(of)-460(life)-457.3(measure)-459.9(for)-462.5(dentine)-459.6(hy-)]TJ 0 -1.1284 TD [(persensitivity)-508.3(\(DHEQ\).)-506.2(J)-505.5(Clin)-510.4(Periodontol)-503.3(2010;37:973)]TJ 0 -1.1223 TD (980.)Tj -1.2503 -1.1284 TD [(4.)-500.4(Brannstrom)-385.2(M.)-383.7(Dentin)-383.7(sensitivity)-385.4(and)-382.8(aspiration)-387.7(of)-386.9(odon-)]TJ 1.2503 -1.1223 TD [(toblasts.)-331.3(J)-334.7(A)0(m)-336.9(Dent)-335.1(Assoc)-334.1(1963;66:366370.)]TJ -1.2503 -1.1284 TD [(5.)-500.4(Al-Sabbagh)-424.7(M,)-420.3(Harrison)-424.9(E,)-416.9(Thomas)-426.5(MV.)-422(Patient-applied)]TJ 1.2503 -1.1223 TD [(treatment)-276.4(of)-277.1(dentinal)-282.3(hypersensitivity.)-276.9(Dent)-280.3(Clin)-278.7(North)-272.4(Am)]TJ 0 -1.1284 TD [(2009;53:6170,)-330.2(viii.)]TJ -1.2503 -1.1284 TD [(6.)-500.4(Bartold)-267.3(PM.)-270.9(Dentinal)-265.6(hypersensitivity:)-276.4(a)-266.6(review.)-268.9(Aust)-269.1(Dent)]TJ 1.2503 -1.1223 TD [(J)-334.7(2006;51:212218;)-330(quiz)-333.6(276.)]TJ -1.2503 -1.1284 TD [(7.)-500.4(Pamir)-350.7(T,)-355.9(Ozyazici)-353.9(M,)-353.2(Baloglu)-356.5(E,)-355.9(Onal)-353.4(B.)-352.6(The)-354.2(efcacy)-358.5(of)]TJ 1.2503 -1.1223 TD [(three)-456.1(desensitizing)-455.7(agents)-453.1(in)-457.1(treatment)-453.2(of)-453.9(dentine)-459.6(hyper-)]TJ 0 -1.1284 TD [(sensitivity.)-336.7(J)-328.6(Clin)-339.7(Pharm)-333(Ther)-332.3(2005;30:7376.)]TJ -1.2503 -1.1223 TD [(8.)-500.4(Oberg)-405.3(C,)-401.5(Pochapski)-407.6(MT,)-410.2(Farago)-404.9(PV,)-401.3(Granado)-409.8(CJ,)-406.8(Pilatti)]TJ 1.2503 -1.1284 TD [(GL,)-601.6(Santos)-604.2(FA.)-602.6(Evaluation)-601.7(of)-606.4(desensitizing)-608.2(agents)-599.4(on)]TJ 0 -1.1223 TD [(dentin)-687(permeability)-684.9(and)-687.8(dentinal)-684.9(tubule)-687(occlusion:)-690.4(an)]TJ 0 -1.1284 TD [(in)-347.4(vitro)-349.5(study.)-347(Gen)-353.9(Dent)-353.4(2009;57:496501;)-348.3(quiz)-345.8(502503,)]TJ 0 -1.1223 TD (535536.)Tj /F4 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(532-NM)-336(GREEN)-333.3(LASER)-342.2(FOR)-334(DENTIN)-331.7(HYPERSENSITIVITY)-25482.3(709)]TJ ET endstream endobj 54 0 obj <>stream /GS1 gs BT /F6 1 Tf 9.2951 0 0 9.2951 66.6708 725.1588 Tm 0 0 0 rg 0 Tc 0 Tw [(9.)-500.4(Orc)15.9(har)11.3(ds)12.8(on)-311.3(R,)-310(Gil)17.4(lam)-308.6(DG.)-302.4(Man)14.4(agi)14.2(ng)-311.3(de)13.8(nti)12.9(n)-311.2(hype)19.6(rse)12.2(ns)12.8(iti)13.5(v-)]TJ 1.2503 -1.1223 TD [(it)13.1(y.)-274.7(J)-273.7(A)0(m)-269.8(D)0(e)12.2(n)0(t)-274.2(A)0(s)11.2(s)0(o)12.8(c)-278.8(200)17.9(6;)12.5(137:)18.3(990)17.9(99)17.9(8;)-274.2(qui)18.4(z)-278.8(102)17.9(81)17.9(029)17.9(.)]TJ -1.7505 -1.1284 TD [(10.)-500.5(Dagostin)-273.3(A,)-270.2(Ferrari)-274.9(M.)-273.9(Effect)-277.5(of)-271(resins)-273.4(sealing)-269.7(of)-277.1(dentin)-272.3(on)]TJ 1.7505 -1.1223 TD [(the)-241.9(bond)-244.5(strength)-243.5(of)-246.6(ceramic)-244.8(restorations.)-249.2(Dent)-243.7(Mater)-248(2002;)]TJ 0 -1.1283 TD (18:304310.)Tj -1.7505 -1.1223 TD [(11.)-500.5(Whitters)-320.5(CJ,)-315.3(Hall)-316.3(A,)-319(Creanor)-317.7(SL,)-316.2(et)-321.1(al.)-315.1(A)-312.8(clinical)-322.5(study)-316.4(of)]TJ 1.7505 -1.1284 TD 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[(la)14.4(se)14.7(r)-142.7(wit)17.4(h)-140.4(a)0(n)13.8(d)-140.4(wit)17.4(ho)18(ut)-140(so)18.9(di)12.5(um)-134(u)15.1(or)15.7(id)12.5(e)-144.6(v)0(a)13.8(r)0(n)15.7(i)0(s)13.4(h)-140.4(in)-140(t)12.6(h)0(e)-138.7(t)0(r)16.3(eat)16.1(me)14.2(nt)]TJ 0 -1.1223 TD [(of)-307.6(de)13.8(nt)12.5(in)-310.8(hy)18(pe)13.8(rse)18.3(ns)12.8(i)12.6(t)0(i)13.1(v)0(i)12.5(t)0(y)18.6()0(a)-315.7(c)0(l)14.4(i)0(n)18.6(i)0(c)14.4(a)0(l)-315(a)0(n)13.8(d)-317.3(sc)14.7(an)13.8(ni)18.6(ng)-311.3(el)14.4(ect)22.2(ron)]TJ 0 -1.1284 TD [(mi)12.9(cr)17.6(os)12.8(co)13.8(py)-232.1(st)13.4(udy)17.9(.)-237.9(J)-243.2(Per)20.6(io)12.5(do)18(nt)12.5(ol)-231.5(200)17.9(5;)18.6(76:)18.4(11)18(40)24(114)17.9(7.)]TJ -1.7505 -1.1223 TD [(22.)-500.5(Al)-483.1(Ha)12.2(bas)14.5(hne)13.7(h)-488.1(R)0(,)-480.7(Far)14.5(as)14.7(in)-481.6(R,)-480.7(Kha)12.1(der)-476.6(Y.)-483.6(The)-476.2(ef)11.5(fe)11.5(ct)-485.8(of)-478.3(a)]TJ 1.7505 -1.1284 TD [(tri)16.7(clo)14.2(san)14.6(/co)14.2(pol)18.4(yme)14.1(r/)13.2(uor)15.5(id)12.5(e)-205.6(t)0(o)12.5(o)0(t)12.5(hpa)13.7(ste)-192.2(on)-195.5(pl)12.5(aqu)13.7(e)-205.6(f)0(o)15.7(rma)11.8(ti)13.1(on,)]TJ 0 -1.1223 TD [(gi)12.5(ngi)12.3(vi)12.5(tis)13.8(,)-292.8(a)0(n)13.8(d)-292.9(den)13.7(ti)13.1(n)-292.9(hyp)17.9(ers)12.2(en)13.8(sit)13.8(ivi)12.9(ty)12.5(:)-292.3(a)-291(sin)13.2(gl)12.5(e-)11.5(bli)12.9(nde)13.7(d)-292.9(r)0(a)11.5(n)0(-)]TJ 0 -1.1284 TD [(dom)18.3(ized)-264.6(cli)14.8(ni)12.5(cal)-264.4(stu)13.2(dy.)-262.6(Qui)16.9(nte)14.2(sse)15.4(nce)-271.1(In)15.7(t)-280.1(201)17.9(7;)12.5(48:)12.3(123)17.9(13)17.9(0.)]TJ -1.7505 -1.1223 TD [(23.)-500.5(Suri)-365.1(I,)-368.5(Singh)-362.9(P,)-363(Shakir)-369.6(QJ,)-367(Shetty)-366.7(A,)-361.6(Bapat)-373.2(R,)-364.9(Thakur)-363(R.)]TJ 1.7505 -1.1284 TD [(A)-343.3(comparative)-348.5(evaluation)-347.8(to)-341.3(assess)-347.3(the)-345.6(efcacy)-346.3(of)-344.2(5%)-344.3(so-)]TJ 0 -1.1223 TD 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