%PDF-1.3 % 2 0 obj <> endobj 22 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 41 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 42 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 14 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 7 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 10 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 6 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 39 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 35 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 29 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 37 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 32 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 21 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 23 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 13 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 38 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 31 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 3 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 9 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 5 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 46 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 34 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 12 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 25 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 44 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 1 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 28 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 19 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 27 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 4 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 26 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 33 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 11 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 17 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 30 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 16 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 40 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 15 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 36 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 24 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 45 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 20 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 8 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 53/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0q-Br44C@B 9 s (P endstream endobj 43 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 55/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5T0P02S04S  @$P5 )1 endstream endobj 18 0 obj <>>>/Subtype/Form/BBox[0 0 612 792]/Matrix [1 0 0 1 0 0]/Length 54/FormType 1/Filter/FlateDecode>>stream xs w3T04PI2P0T5TR Ɩf !\!Y\ !p)P endstream endobj 47 0 obj <>stream Acrobat Distiller 8.1.0 (Windows); modified using iText 4.2.0 by 1T3XT Arbortext Advanced Print Publisher 9.0.114/W 2014-10-06T06:56:50-07:00 2014-09-30T14:09+05:30 application/pdf untitled uuid:80d98c67-dd22-4061-a373-1c5f04a3e39d uuid:1895de0c-6a1a-42be-a923-7ef2bf4c512f endstream endobj 48 0 obj <>stream x+| endstream endobj 49 0 obj <>stream xS**T0T0BilU!D. rej endstream endobj 50 0 obj <>stream x+| endstream endobj 51 0 obj <>stream xS**T0T0Bih] 9D. qaj endstream endobj 52 0 obj <>stream x+| endstream endobj 53 0 obj <>stream xS**T0T0Bil])D. qgj endstream endobj 54 0 obj <>stream x+| endstream endobj 55 0 obj <>stream xS**T0T0Bid]1D. pa endstream endobj 56 0 obj <>stream x+| endstream endobj 57 0 obj <>stream xS**T0T0Bid]D. qdj endstream endobj 58 0 obj <>stream x+| endstream endobj 59 0 obj <>stream xS**T0T0BiU!D. _e1 endstream endobj 60 0 obj <>stream x+| endstream endobj 61 0 obj <>stream xS**T0T0BiUD* 8 endstream endobj 62 0 obj <>stream x+| endstream endobj 63 0 obj <>stream xS**T0T0Bil]D. rs endstream endobj 64 0 obj <>stream x+| endstream endobj 65 0 obj <>stream xS**T0T0BiUD* : endstream endobj 66 0 obj <>stream x+| endstream endobj 67 0 obj <>stream xS**T0T0BiU)D* 9V endstream endobj 68 0 obj <>stream x+| endstream endobj 69 0 obj <>stream xS**T0T0Bil]D. pa endstream endobj 70 0 obj <>stream x+| endstream endobj 71 0 obj <>stream xS**T0T0Bih] D. pa endstream endobj 72 0 obj <>stream x+| endstream endobj 73 0 obj <>stream xS**T0T0Bih]D. r^j endstream endobj 74 0 obj <>stream x+| endstream endobj 75 0 obj <>stream xS**T0T0Bid]%D. rs endstream endobj 76 0 obj <>stream x+| endstream endobj 77 0 obj <>stream xS**T0T0Bib] D. qjj endstream endobj 78 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 87 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 88 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 80 0 obj <>stream /GS1 gs BT /F3 1 Tf 9.843 0 0 9.843 62.022 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(three-dimensional)-243.7(\(3D\))-241.4(diamond)-240.6(and)-234.8(graphite.)-239.4(Graphene)-243.5(has)]TJ 0 -1.1174 TD [(been)-381.1(discussed)-374.6(in)-376.7(theory)-382.2(for)-371.9(about)-381.2(60)-376.6(years.)-373.9(In)-376.5(2004,)-376.5(gra-)]TJ 0 -1.1116 TD [(phene)-428.3(was)-431.4(rst)-430.4(isolated)-431.8(by)-428.4(Novoselov)-432.3(and)-424.9(Geim.)]TJ 7.3823 0 0 6.5614 267.5905 707.5841 Tm (13)Tj 9.843 0 0 9.843 279.1558 703.2188 Tm (Since)Tj -22.0597 -1.1116 TD [(then,)-539(graphene)-536.4(has)-539.9(attracted)-539.1(much)-536.7(interest)-541.2(from)-535.5(various)]TJ T* [(scientic)-284.1(elds,)-280.6(and)-275.2(its)-279.8(discovery)-282.9(won)-274.9(the)-281.1(2010)-275.1(Nobel)-278.4(Prize)]TJ 0 -1.1174 TD [(in)-336.4(physics.)]TJ 1.0137 -1.1116 TD [(Graphene)-376(is)-376.5(a)-376.6(one-atom-thick)-377.6(sheet)-376.4(of)-376.5(carbon)-377.5(atoms)-376.5(ar-)]TJ -1.0137 -1.1116 TD [(ranged)-446.6(in)-445.8(a)-440(2)0(D)-446.6(honeycomb)-445.5(structure.)-447.7(The)-449.2(strong)-444.2(carbon-)]TJ 0 -1.1174 TD [(carbon)-515.8(bonding)-514.7(in)-509.2(the)-517.2(plane,)-512.5(the)-517.2(aromatic)-514.9(structure,)-516.8(the)]TJ 0 -1.1116 TD [(presence)-393.4(of)-382.3(free)]TJ /F9 1 Tf 7.0672 0 TD (p)Tj /F3 1 Tf .9388 0 TD [(electrons,)-391.2(and)-384.6(reactive)-393.8(sites)-386.7(for)-389.1(surface)]TJ -8.006 -1.1116 TD [(reactions)-422.4(make)-416.9(graphene)-421.2(a)-417(unique)-416.8(material)-422.8(with)-414.5(excellent)]TJ 0 -1.1174 TD [(properties:)-573.3(the)-569(thinnest)-568.9(material)-572.6(ever)-571.1(measured;)-573.2(a)-566.7(large)]TJ 0 -1.1116 TD [(specic)-247.1(surface)-241.3(area)-244(\(2600)-166.7(m)]TJ 7.3823 0 0 6.5614 176.5984 597.9967 Tm (2)Tj 9.843 0 0 9.843 182.6645 593.6313 Tm (g)Tj /F8 1 Tf 7.3823 0 0 6.5614 188.7874 597.9967 Tm (-)Tj /F3 1 Tf .7219 0 TD (1)Tj 9.843 0 0 9.843 197.8015 593.6313 Tm (\))Tj 7.3823 0 0 6.5614 201.0897 597.9967 Tm (15)Tj 9.843 0 0 9.843 208.5165 593.6313 Tm [(;)-237.4(a)-244.2(Youngs)-238.7(modulus)-245(of)]TJ -14.8831 -1.1116 TD [(1)-358.2(TPa)-362.6(and)-355.8(intrin)-7(sic)-355.7(strength)-361.3(of)-359.3(130)-360.4(GPa,)-360(which)-364.8(is)-359.2(close)-359.1(to)]TJ T* [(that)-622.1(predicted)-629.9(by)-624.2(theory)]TJ 7.3823 0 0 6.5614 167.1873 576.1132 Tm (16,17)Tj 9.843 0 0 9.843 183.7984 571.7479 Tm [(;)-623.3(a)-624.3(high)-620.8(room)-627.6(temperature)]TJ -12.3718 -1.1174 TD [(electron)-565.5(mobility)-563.5(of)-560.9(2.5)]TJ /F8 1 Tf 10.5806 0 TD ()Tj /F3 1 Tf .72 0 TD (10)Tj 7.3823 0 0 6.5614 183.0614 565.1148 Tm (5)Tj 9.843 0 0 9.843 192.3023 560.7495 Tm (cm)Tj 7.3823 0 0 6.5614 204.3779 565.1148 Tm (2)Tj 9.843 0 0 9.843 213.6188 560.7495 Tm (V)Tj /F8 1 Tf 7.3823 0 0 6.5614 221.896 565.1148 Tm (-)Tj /F3 1 Tf .7219 0 TD (1)Tj 9.843 0 0 9.843 236.4661 560.7495 Tm (s)Tj /F8 1 Tf 7.3823 0 0 6.5614 241.455 565.1148 Tm (-)Tj /F3 1 Tf .7219 0 TD (1)Tj 9.843 0 0 9.843 256.0251 560.7495 Tm (\(theoretical)Tj -19.7097 -1.1116 TD (limit)Tj /F9 1 Tf 2.2981 0 TD (*)Tj /F3 1 Tf .9964 0 TD (2)Tj /F8 1 Tf .6681 0 TD ()Tj /F3 1 Tf .72 0 TD (10)Tj 7.3823 0 0 6.5614 117.9212 554.1731 Tm (5)Tj 9.843 0 0 9.843 125.4614 549.8077 Tm (cm)Tj 7.3823 0 0 6.5614 137.5937 554.1731 Tm (2)Tj 9.843 0 0 9.843 145.0771 549.8077 Tm (V)Tj /F8 1 Tf 7.3823 0 0 6.5614 153.411 554.1731 Tm (-)Tj /F3 1 Tf .7219 0 TD (1)Tj 9.843 0 0 9.843 166.2236 549.8077 Tm (s)Tj /F8 1 Tf 7.3823 0 0 6.5614 171.2692 554.1731 Tm (-)Tj /F3 1 Tf .7219 0 TD (1)Tj 9.843 0 0 9.843 180.2834 549.8077 Tm (\))Tj 7.3823 0 0 6.5614 183.5716 554.1731 Tm (18,19)Tj 9.843 0 0 9.843 200.1826 549.8077 Tm [(;)-392.9(very)-385.7(high)-390.4(thermal)-391.6(con-)]TJ -14.0364 -1.1116 TD [(ductivity,)-303(reaching)-300.4(5000)-303.9(W)-297.1(m)]TJ /F8 1 Tf 7.3823 0 0 6.5614 183.4582 543.2313 Tm (-)Tj /F3 1 Tf .7142 0 TD (1)Tj 9.843 0 0 9.843 195.4204 538.866 Tm (K)Tj /F8 1 Tf 7.3823 0 0 6.5614 203.6976 543.2313 Tm (-)Tj /F3 1 Tf .7219 0 TD (1)Tj 9.843 0 0 9.843 212.7117 538.866 Tm [(;)-300.7(optical)-304.2(adsorption)-300.2(of)]TJ -15.3093 -1.1174 TD (exactly)Tj /F9 1 Tf 3.2312 0 TD .1622 Tc (p&)Tj /F3 1 Tf 1.8834 0 TD 0 Tc (2.3%)Tj 7.3823 0 0 6.5614 132.8881 532.2329 Tm (20,21)Tj 9.843 0 0 9.843 149.4992 527.8676 Tm [(;)-323.8(and)-321.2(complete)-330.6(impermeability)-327.3(to)-319.1(any)]TJ -8.8872 -1.1116 TD (gases.)Tj 7.3823 0 0 6.5614 85.833 521.2912 Tm (22)Tj 9.843 0 0 9.843 95.5842 516.9258 Tm [(Its)-245.1(room)-247.5(temperature)-248.6(quantum)-240.6(Hall)-248.6(Effect)-246.3(and)-240.6(room)]TJ -3.4097 -1.1116 TD [(temperature)-358(ferromagnetism)-355.4(are)-356.9(also)-351.1(reported.)]TJ 7.3823 0 0 6.5614 249.0519 510.3495 Tm [(23,2)-8.6(4)]TJ 9.843 0 0 9.843 269.1779 505.9841 Tm [(In)-347.7(addi-)]TJ -21.046 -1.1174 TD [(tion,)-307.6(graphene)-311.8(can)-310.9(be)-308.6(synthesized)-309.2(in)-307.6(a)-313.3(relatively)-308.7(pure)-310.8(form,)]TJ 0 -1.1116 TD [(meaning)-374.3(that)-374.4(biological)-376.7(cell)-375.6(testing)-371.9(would)-375.1(be)-372(less)-373.9(affected)]TJ T* [(by)-399.6(impurities.)]TJ 7.3823 0 0 6.5614 118.3748 477.4676 Tm (2529)Tj 9.843 0 0 9.843 140.8251 473.1022 Tm [(However,)-406.8(some)-404(of)-399.6(these)-405.2(characteristics)]TJ -8.006 -1.1174 TD [(have)-502.1(been)-502.1(achieved)-503.2(only)-499.9(for)-498.6(the)-505.7(highest-quality)-503.1(samples)]TJ 0 -1.1116 TD [(\(mechanically)-378.8(exfoliated)-377.7(graphene)]TJ 7.3823 0 0 6.5614 201.2598 455.5274 Tm (13)Tj 9.843 0 0 9.843 208.6299 451.1621 Tm [(\))-375.4(and)-373.1(for)-371.9(graphene)-375.1(de-)]TJ -14.8946 -1.1116 TD [(posited)-429.4(on)-428.4(special)-431.7(substrates)-427.7(such)-431.6(as)-423.6(hexagonal)-434(boron)-425.9(ni-)]TJ T* (tride.)Tj 7.3823 0 0 6.5614 82.6582 433.644 Tm (18,30)Tj 9.843 0 0 9.843 102.1039 429.2786 Tm [(Equivalent)-285.6(characteris)-12.2(tics)-282.1(have)-289(not)-285.7(been)-289(observed)]TJ -4.0721 -1.1174 TD [(on)-336.3(graphene)-334.8(prepared)-334.8(using)-333.7(other)-335.1(techniques.)]TJ 1.0137 -1.1116 TD -.0216 Tc [(The)-398.2(m)-.9(a)-6.6(r).4(ke)-6.6(t)-391.4(f)-5.4(or)-397(gr)-5.4(aph)-5.4(e)-.8(ne)-398.2(ap)-5.4(pli)-5.5(cat)-5.5(ion)-5.4(s)-391.1(i)-5.5(s)-396.9(ess)-5.2(e)-.8(n)-5.4(tia)-6.6(lly)-397.1(dr)-5.4(ive)-6.6(n)]TJ -1.0137 -1.1116 TD [(by)-310.8(p)-5.5(r).3(og)-5.5(re)-6.7(ss)-310.6(in)-310.8(t)-5.6(h).2(e)-311.9(p).2(r)-5.5(odu)-5.5(cti)-5.6(o).2(n)-310.8(o).2(f)-310.7(g)-5.5(rap)-5.5(h).2(en)-5.5(e)-311.9(w)-.6(it)-5.6(h)-310.8(p).2(ro)-5.5(per)-5.5(tie)-6.7(s)-310.6(t).1(ha)-6.7(t)]TJ 0 -1.1174 TD [(ar)-5.4(e)-277.3(a)-6.6(ppr)-5.4(opr)-5.4(iat)-5.5(e)-277.3(f)-5.4(o).3(r)-276.1(i)-5.5(ts)-281.7(sp)-5.4(eci)-5.5(c)-277.3(a)-6.6(ppl)-5.5(ica)-6.6(tio)-5.4(n.)-278.5(Cu)-5.4(rr)-5.4(ent)-5.5(l).2(y,)-278.5(g)-5.4(r).4(ap)-5.4(he)-6.6(ne)]TJ 0 -1.1116 TD -.0203 Tc [(ca)-5.3(n)-349.7(b)1.6(e)-350.9(p)-4.1(repare)-5.3(d)-349.7(u)1.6(sing)-355.5(mechanical)-355.6(exfoliation,)]TJ 7.3823 0 0 6.5614 240.7747 378.8219 Tm -.0239 Tc (13)Tj 9.843 0 0 9.843 251.2629 374.4566 Tm -.0215 Tc [(che)-6.5(m)-.8(ic)-6.5(al)-351(va)-6.5(-)]TJ -19.2259 -1.1116 TD [(po)-5.3(r)-339.3(d)-5.3(epo)-5.3(s).6(it)-5.4(ion)-345.1(\().5(CV)-6.2(D\))-5.3(,)]TJ 7.3823 0 0 6.5614 148.9322 367.8802 Tm -.0239 Tc (31)Tj 9.843 0 0 9.843 159.307 363.5149 Tm -.0216 Tc [(ep)-5.4(ita)-6.6(xia)-6.6(l)-339.6(gr)-5.4(owt)-5.5(h).3(,)]TJ 7.3823 0 0 6.5614 223.9936 367.8802 Tm -.0239 Tc (32)Tj 9.843 0 0 9.843 234.3684 363.5149 Tm -.0203 Tc [(and)-343.9(c).5(he)-5.3(mica)-5.3(l)-338.3(e).5(x-)]TJ -17.5095 -1.1174 TD -.0217 Tc [(f)-5.5(o).2(li)-5.6(ati)-5.6(on.)]TJ 7.3823 0 0 6.5614 96.0378 356.9385 Tm -.0239 Tc (33)Tj 9.843 0 0 9.843 106.696 352.5164 Tm -.0214 Tc [(A)-6.1(m)-.7(on)-5.2(g)-373.8(t).4(he)-6.4(m,)-370.4(C)-6.2(V)-.3(D)-374.7(h).5(a)-6.4(s)-373.6(emer)-5.2(ged)-373.8(a)-6.4(s)-373.6(a)-.6(n)-373.8(i).4(m)-6.4(por)-5.2(tan)-5.2(t)]TJ -4.5386 -1.1116 TD -.0217 Tc [(an)-5.5(d)-402.9(t).1(he)-404.1(mo)-5.5(st)-403.1(su)-5.5(cce)-6.7(ss)-5.3(ful)-403.1(m)-1(e)-6.7(t).1(ho)-5.5(d)-402.9(f).3(or)-402.9(t)-5.6(h).2(e)-404.1(p).2(ro)-5.5(duc)-6.7(ti)-5.6(on)-402.9(of)-402.9(la)-6.7(rge)-6.7(-)]TJ T* [(s)-5.2(cal)-5.5(e)-242.7(a)-.8(n)-5.4(d)-241.6(hi)-5.5(gh)-5.4(-qu)-5.4(a)-.8(li)-5.5(ty)-247.3(gra)-6.6(phe)-6.6(ne)-242.7(s)-5.2(h).3(e)-6.6(e)-.8(ts)-247.1(fo)-5.4(r)-241.5(v)-5.4(ari)-5.5(ous)-247.1(ap)-5.4(pli)-5.5(cat)-5.5(ion)-5.4(s).5(,)]TJ T* -.0197 Tc [(including)-331.8(b)-3.5(one)-338.7(tissue)-333(e)1.1(ngineering,)-334.1(as)-331.6(the)-333(m)-4.7(ethod)-331.8(w)-4.4(as)-331.6(rst)-331.9(re)-4.7(-)]TJ 0 -1.1174 TD -.0217 Tc [(po)-5.5(rt)-5.6(ed)-402.9(in)-402.9(2)-5.5(009)-5.5(.)]TJ 7.3823 0 0 6.5614 122.4566 313.0582 Tm -.0294 Tc [(34)-5.5(,3)-5.5(5)]TJ 9.843 0 0 9.843 142.0724 308.6928 Tm -.0182 Tc [(Af)3.8(ter)-399.4(g)3.7(ro)3.7(wt)3.6(h)-399.4(o)3.7(f)-399.4(l)-2.1(ar)3.8(ge-s)3.9(cal)3.6(e)-400.6(g)3.7(r)-2(ap)3.7(hen)3.7(e)-400.6(by)]TJ -8.1327 -1.1116 TD -.02 Tc [(CV)-4.7(D)-361.8(o)1.9(n)-360.9(c)-5(opper)-360.9(foils)-360.7(o)1.9(r)-360.9(n)-3.8(ic)-5(kel)-361()-3.7(lm,)-363.3(t)1.8(he)-362.1(coppe)-5(r)-360.9(or)-360.9(nickel)-361(are)]TJ T* -.0195 Tc [(etche)-4.5(d)-458.3(and)-458.3(t)2.3(he)-459.5(graphene)-465.3(can)-458.3(be)-459.5(tr)]TJ 14.1631 0 TD -.0217 Tc [(ans)-5.3(f).3(e)-6.7(rre)-6.7(d)-460.5(t).1(o)-466.3(d).2(is)-5.3(ti)-5.6(nct)-466.4(s).4(ub)-5.5(-)]TJ -14.1631 -1.1174 TD -.0215 Tc [(s)-5.1(t).3(ra)-6.5(tes)-350.7(u).4(s)-5.1(i).3(n)-5.3(g)-345.1(p)-5.3(o).4(ly)-5.3(met)-5.4(hyl)-5.4(met)-5.4(h).4(ac)-6.5(ryl)-5.4(a)-.7(te)-6.5(,)-347.5(a)-.7(c)-6.5(c)-.7(or)-5.3(din)-5.3(g)-350.9(to)-350.9(the)-352.1(e)-.7(x)-5.3(p).4(er)-5.3(-)]TJ 0 -1.1116 TD -.0178 Tc [(i)4(m)-2.8(en)4.1(tal)-410.7(d)4.1(es)4.3(ig)4.1(n)4.1(.)]TJ 7.3823 0 0 6.5614 121.2661 269.2346 Tm -.0239 Tc (36)Tj 9.843 0 0 9.843 132.3779 264.8692 Tm -.0197 Tc [(By)-412.5(contrast,)-414.8(m)1(echanical)-418.3(exfoliation)-412.5(s)-3.3(uffers)]TJ -7.1478 -1.1116 TD -.0217 Tc [(f)-5.5(r).3(om)-294.7(low)-294.4(y).2(ie)-6.7(lds)-5.3(,)-290.1(mak)-5.5(i).1(n)-5.5(g)-287.7(it)-293.6(di)-5.6(fc)-6.7(u).2(lt)-293.6(to)-293.5(app)-5.5(l).1(y)-287.7(t)-5.6(o)-287.7(i)-5.6(ndu)-5.5(st)-5.6(ria)-6.7(l).1(-s)-5.3(cal)-5.6(e)]TJ 0 -1.1174 TD [(pr)-5.6(od)-5.6(uct)-5.7(i)0(on)-5.6(.)]TJ 7.3823 0 0 6.5614 105.1086 247.3511 Tm -.0315 Tc (15)Tj 9.843 0 0 9.843 72 231.9873 Tm 0 Tc [(Graphene)-439.4(oxide)-444.5(\(GO\))-438.1(is)-439.9(an)-441.1(oxidized)-437.6(derivative)-441.1(of)-439.9(gra-)]TJ -1.0137 -1.1116 TD (phene.)Tj 7.3823 0 0 6.5614 88.1008 225.411 Tm (37)Tj 9.843 0 0 9.843 98.3055 221.0456 Tm [(The)-287.9(most)-287.8(widely)-291.1(used)-293.4(approach)-288.7(to)-290.3(GO)-286.2(synthesis)-293(is)]TJ -3.6862 -1.1174 TD [(based)-497.2(on)-497.5(the)-499.9(principle)-496.4(rst)-499.5(introduced)-497.4(by)-497.5(Hummers)-495.8(and)]TJ 0 -1.1116 TD [(Offeman)-634.1(\(commonly)-629.9(referred)-634.2(to)-624.4(as)-631(Hummers)-634(method\),)]TJ T* [(which)-341.7(involves)-344.1(the)-338.7(oxidation)-339.8(of)-342(graphite)-345.4(by)-336.3(treatment)-343.3(with)]TJ T* [(potassium)-513.3(permanganate)-515.7(and)-511.3(sulfuric)-511.1(acid.)]TJ 7.3823 0 0 6.5614 240.9448 181.5874 Tm (38)Tj 9.843 0 0 9.843 253.3605 177.222 Tm [(Many)-507.6(tech-)]TJ -19.439 -1.1174 TD [(niques)-364.8(have)-358.1(been)-363.8(used)-362.5(in)-359.4(the)-361.7(fabrication)-367.3(of)-359.3(GO)-361(thin)-361.8(lms,)]TJ 0 -1.1116 TD [(such)-1030.6(as)-1022.6(spin)-1029.6(coating,)]TJ 7.3823 0 0 6.5614 166.5637 159.6472 Tm (39,40)Tj 9.843 0 0 9.843 193.3228 155.2818 Tm [(LangmuirBlodgett)-1027.2(tech-)]TJ -13.3395 -1.1116 TD (niques,)Tj 7.3823 0 0 6.5614 90.2551 148.7055 Tm (41,42)Tj 9.843 0 0 9.843 111.5149 144.3401 Tm [(ow-directed)-472.6(assembly,)]TJ 7.3823 0 0 6.5614 207.8929 148.7055 Tm (43)Tj 9.843 0 0 9.843 219.9117 144.3401 Tm (evaporation-induced)Tj -16.0408 -1.1174 TD [(self-assemblies)-811(on)-802.8(water,)]TJ 7.3823 0 0 6.5614 172.4031 137.707 Tm (44)Tj 9.843 0 0 9.843 187.7102 133.3417 Tm [(and)-805.1(the)-799.4(bubble-depo)-8.8(sition)]TJ -12.7693 -1.1116 TD (method.)Tj 7.3823 0 0 6.5614 94.1102 126.7653 Tm (45)Tj 9.843 0 0 9.843 106.1291 122.3999 Tm [(GO)-464.7(conta)-8(ins)-464(a)-468.8(range)-468.6(of)-468.7(reactive)-468.7(oxygen)-468.6(func-)]TJ -4.4811 -1.1116 TD [(tional)-497.7(groups,)-499.4(including)-501(epoxide,)-503.2(carboxyl,)-498.5(and)-499.8(hydroxyl)]TJ 0 -1.1174 TD [(groups.)-315.1(They)-317.8(are)-316.6(presented)-324.3(on)-313.2(the)-315.6(basal)-318.8(plane)-319(and)-315.5(edges)-318.7(of)]TJ 0 -1.1116 TD [(GO)-453.2(and)-459.5(enable)-453.7(greater)-460.5(interactions)-454.7(with)-454.8(proteins)-459.3(through)]TJ T* [(covalent,)-442.2(electrostatic,)-444.4(and)-436.4(hydrogen)-441.9(bonding.)-437.5(GO)-435.9(sheets,)]TJ 0 -1.1174 TD [(because)-438.4(of)-434.1(their)-438.9(derivatization,)-438.8(are)-437.6(more)-433(hydrophilic,)-437.5(and)]TJ 0 -1.1116 TD [(the)-407.8(hydrogen)-413.1(bonds)-402.7(betwe)-8.8(en)-406.5(their)-410.1(polar)-409.9(functional)-405.4(groups)]TJ 25.504 67.9184 TD [(and)-257.9(water)-262.2(molecules)-262.4(offer)-260(reasonable)-257.5(colloidal)-260.4(dispersibility)]TJ 0 -1.1174 TD [(under)-334.9(appropriate)-338.3(pH)-337.1(conditions.)]TJ 7.3823 0 0 6.5614 446.0031 718.5825 Tm (46)Tj 9.843 0 0 9.843 323.0361 703.2188 Tm [(Reduced)-346.3(graphene)-346.3(oxide)-340.9(\(rGO\))-341.2(can)-345.4(be)-337.4(obtained)-345.5(by)-342(ther-)]TJ -1.0137 -1.1116 TD [(mal,)-493.1(chemical,)-490.7(and)-488.3(UV)-487.8(treatment)-493(of)-486(GO)-487.8(under)-484.7(reducing)]TJ T* [(conditions)-398.3(with)-391.4(hydrazine)-393.6(or)-388.1(other)-392.7(reducing)-391.4(agents.)]TJ 7.3823 0 0 6.5614 524.5227 685.7006 Tm (47)Tj 9.843 0 0 9.843 535.7479 681.3352 Tm [(It)-388.2(is)]TJ -22.6241 -1.1174 TD [(mainly)-412.4(produced)-414.3(to)-405.5(restore)-413.1(the)-413.5(electrical)-414.7(conductivity)-413.5(and)]TJ 0 -1.1116 TD [(optical)-390.6(absorbance)-389.8(of)-382.3(GO)-384.1(while)-387.9(reducing)-385.6(the)-384.7(oxygen)-387.9(con-)]TJ T* [(tent,)-337.6(surface)-339.2(charge,)-336(and)-332.8(hydrophilicity.)]TJ 7.3823 0 0 6.5614 473.5558 651.4014 Tm (48)Tj 9.843 0 0 9.843 323.0361 637.455 Tm [(For)-423.6(better)-423.9(utilization)-424.2(of)-422.6(graphene)-427(in)-422.8(biology)-416.9(and)-424.9(medi-)]TJ -1.0137 -1.1116 TD [(cine,)-338.6(appropriate)-338.3(functionalization)-340.9(of)-336.2(pristine)-338.4(graphene)-340.6(and)]TJ T* [(the)-304.1(immobilization)-303.2(of)-301.7(biomaterials)-300.5(on)-301.7(it)-302(are)-299.3(necessary.)-305.6(This)]TJ 0 -1.1174 TD [(is)-595.4(important)-600.2(in)-589.8(biocompatibility,)-601.5(because)-593.9(the)-597.8(functional)]TJ 0 -1.1116 TD [(groups)-398(can)-397.3(create)-403(defects)-397(on)-399.6(the)-396.3(graphene)-398.2(surface)-396.8(and)-396.1(re-)]TJ T* [(duce)-432.9(the)-430.8(strong)-432.7(hydrophobic)-433.8(interaction)-430.8(of)-434.1(graphene)-432.7(with)]TJ T* [(cells)-468.7(and)-471(tissues.)]TJ 7.3823 0 0 6.5614 383.3574 576.1132 Tm (49)Tj 9.843 0 0 9.843 395.3196 571.7479 Tm [(Biomolecules)-474.2(such)-466.1(as)-463.9(proteins,)-468.5(DNA,)]TJ -8.3573 -1.1174 TD [(and)-494(small)-491.8(molecules)-492.8(have)-490.5(been)-490.5(reported)-495(to)-486.1(functionalize)]TJ 0 -1.1116 TD [(graphene.)-395.8(The)-391.6(biological)-394(activity)-391.8(of)-393.8(graphene-based)-395.4(mate-)]TJ T* [(rials)-427.2(can)-426.1(be)-423.8(associated)-430.2(with)-426(their)-421.6(capacities)-431.7(to)-422.8(affect)-430.6(mo-)]TJ 0 -1.1174 TD [(lecular)-339.7(processes)-335.3(and)-338.5(functions.)]TJ 7.3823 0 0 6.5614 441.0707 532.2329 Tm (50)Tj 9.843 0 0 9.843 323.0361 516.9258 Tm [(Based)-348.5(on)-347.8(current)-349.9(experiments)-350.9(with)-345.3(regard)-348.7(to)-347.9(cell)-346.8(behav-)]TJ -1.0137 -1.1116 TD [(iors)-447.8(in)-451.6(these)-445.5(materials)-452.5(\(Table)-448(1\),)-449.1(the)-448.1(applications)-449(of)-451.4(gra-)]TJ 0 -1.1174 TD [(phene)-244(and)-240.6(its)-239.5(derivatives)-240.4(can)-241.8(be)-239.5(categorized)-242.8(into)-240.8(three)-238.3(types:)]TJ 0 -1.1116 TD [(G)-266.9(sheet,)]TJ 7.3823 0 0 6.5614 345.5432 488.4093 Tm (4,5,51)Tj 9.843 0 0 9.843 366.633 484.0439 Tm [(GO)-263.1(akes,)]TJ 7.3823 0 0 6.5614 408.8125 487.4456 Tm [(6,8,9,11,1)-8.7(2,52,53)]TJ 9.843 0 0 9.843 463.181 484.0439 Tm [(and)-263.6(rGO)-270(akes,)-264.3(which)]TJ -15.2517 -1.1116 TD [(are)-391.5(directly)-391.6(reduced)-391.3(from)-385.7(GO.)]TJ 7.3823 0 0 6.5614 437.7259 477.4676 Tm [(7,10)-8.6(,54)]TJ 9.843 0 0 9.843 463.7479 473.1022 Tm [(Although)-390.1(GO)-389.8(or)-382.3(rGO)]TJ -15.3093 -1.1174 TD [(lms)-241.6(and)-240.6(sheets)-239.1(have)-242.9(been)-237.1(used)-241.5(in)-238.5(different)-242.8(experiments,)-244.9(the)]TJ 0 -1.1116 TD [(main)-271.9(form)-270.5(of)-267.1(a)-273(single)-267(layer)-272.9(of)-267.1(GO)-274.6(or)-267.1(rGO)-270(lm)-269.4(or)-267.1(sheet)-272.7(is)-267.1(as)]TJ T* [(a)-359.4(ake)-357.9(or)-353.5(microake)-360.2(with)-356.9(a)-353.6(diameter)-359.3(less)-356.7(than)-357(several)-362.4(mi-)]TJ T* (crometers.)Tj 7.3823 0 0 6.5614 354.5007 433.644 Tm [(57,)-8.6(10,5153)]TJ 9.843 0 0 9.843 400.0251 429.2786 Tm [(However,)-499(CVD-grown)-497.3(graphene)-496.1(can)]TJ -8.8354 -1.1174 TD [(be)-435.3(formed)-440.9(as)-435.1(a)-434.2(large-scale)-438.4(sheet)-439.8(as)-435.1(long)-436.5(as)-435.1(a)-434.2(sufciently)]TJ 0 -1.1116 TD [(large)-284.4(substrate)-282.8(is)-284.4(used)-281.8(for)-279.7(growing)-279.4(the)-281.1(product,)-283.1(Currently,)-280.7(it)]TJ T* [(is)-238.3(easy)-236.9(to)-232.7(coat)-237.2(scaffolds)-236.5(or)-232.6(substrates)-237.6(with)-235.9(a)-232.7(planar)-239.4(or)-232.5(regular)]TJ 0 -1.1174 TD [(surface.)-394.5(However,)-389.6(GO)-389.8(and)-384.6(rGO)-390.9(can)-385.8(be)-389.3(easily)-389.1(coated)-390.4(onto)]TJ 0 -1.1116 TD [(scaffolds)-420.9(with)-414.5(irregular)-415.6(or)-411.1(3D)-417.8(structures,)-414(and)-413.4(they)-414.6(can)-414.6(be)]TJ T* [(easily)-452.5(grafted)-447.8(with)-443.3(other)-450.3(chemicals)-447.8(and)-448(form)-443.3(new)-448.8(hybrid)]TJ 0 -1.1174 TD [(surfaces)-340.1(or)-336.2(materials.)]TJ 7.3823 0 0 6.5614 398.8912 356.9385 Tm [(810,)-7.8(12,52,53)]TJ 9.843 0 0 9.843 323.0361 341.5747 Tm [(Graphene)-399(and)-390.4(its)-395(derivatives,)-399.3(owing)-392.4(to)-394(their)-392.8(unique)-393.8(op-)]TJ -1.0137 -1.1116 TD [(tical,)-386(mechanical,)-384.6(chemical,)-387(and)-378.8(electrical)-385.9(properties,)-385.4(have)]TJ T* [(been)-358.1(extensively)-355.6(studied)-354.5(by)-353.5(materials)-354.6(scientists,)-356.5(physicists,)]TJ 0 -1.1174 TD [(and)-304(chemists.)]TJ 7.3823 0 0 6.5614 367.3133 313.0582 Tm (31)Tj 9.843 0 0 9.843 377.6881 308.6928 Tm [(Their)-301.7(uses)-304.7(are)-305.1(expanding)-306.1(beyond)-301.5(electronic)]TJ -6.5661 -1.1116 TD [(and)-309.7(chemical)-302.9(applications)-310.8(toward)-308.2(biomedical)-304.1(areas,)-306(such)-304.9(as)]TJ T* [(drug)-413.3(delivery,)-412.2(cancer)-414.4(therapies,)-414.3(biosensing,)-412.9(and)-413.4(tissue)-416.6(en-)]TJ 0 -1.1174 TD [(ginee)-8(ring.)]TJ 7.3823 0 0 6.5614 352.8566 280.1763 Tm [(55,5)-8.6(6)]TJ /F5 1 Tf 8.9663 0 0 8.9663 313.0582 248.4283 Tm [(Biocompatibility)-339(or)-335.1(Toxicity)-337.2(of)-330.2(Graphene)]TJ 0 -1.2203 TD [(and)-338.2(Its)-332.5(Derivatives)]TJ /F3 1 Tf 9.843 0 0 9.843 323.0361 221.0456 Tm [(So)-445.5(far,)-451.3(only)-448(a)-445.8(limited)-448.4(number)-446.7(of)-445.7(publications)-453.6(have)-444.5(at-)]TJ -1.0137 -1.1174 TD [(tempted)-357.1(to)-353.7(address)-355.2(the)-350.2(interactions)-356.8(of)-353.5(graphene)-352.1(and)-355.8(its)-354.7(de-)]TJ 0 -1.1116 TD [(rivatives)-294.6(with)-287.8(living)-289.2(systems.)]TJ 7.3823 0 0 6.5614 429.8456 203.4708 Tm (57,58)Tj 9.843 0 0 9.843 449.3479 199.1054 Tm [(However,)-291.7(existing)-286.6(studies)]TJ -13.8463 -1.1116 TD [(with)-431.7(regard)-429.3(to)-428.5(the)-430.8(biocompatible)-434.3(effects)-431.5(of)-428.4(G)-428.2(and)-430.7(its)-423.8(de-)]TJ T* [(rivatives)-340.7(often)-335.1(show)-333.4(contradictory)-340.7(or)-330.5(inconclusive)-339.5(results.)]TJ 1.0137 -1.1174 TD [(Most)-396.9(of)-393.8(the)]TJ /F4 1 Tf 5.2989 0 TD [(in)-388.2(vitro)]TJ /F3 1 Tf 3.4616 0 TD [(studies)-394.6(have)-398.4(reported)-397.1(that)-391.7(cell)-398.7(via-)]TJ -9.7742 -1.1116 TD [(bility)-398.8(decreases)-401.2(after)-399.6(exposure)-396.8(to)-399.7(graphene)-398.2(and)-396.1(its)-395(deriva-)]TJ T* [(tives)-381.1(at)-377.9(concentrations)-377.3(around)-382.1(10)]TJ /F9 1 Tf 13.9327 0 TD (m)Tj /F3 1 Tf .5529 0 TD .3755 Tc [(gm)375.5(L)]TJ /F8 1 Tf 7.3823 0 0 6.5614 479.2251 148.7055 Tm 0 Tc (-)Tj /F3 1 Tf .7219 0 TD (1)Tj 9.843 0 0 9.843 488.2392 144.3401 Tm (.)Tj 7.3823 0 0 6.5614 490.7337 148.7055 Tm (5962)Tj 9.843 0 0 9.843 512.9006 144.3401 Tm [(Chng)-379.8(and)]TJ -20.303 -1.1174 TD [(Pumera)-372.8(investigated)-368.4(the)-367.5(cytotoxic)-369.7(effects)-368.2(of)-365(GOs)-367.7(prepared)]TJ 0 -1.1116 TD [(by)-393.9(different)-398.3(oxidative)-392.8(treatments)-396(\(the)-397.3(Staudenmaier,)-397(Hoff-)]TJ T* [(mann,)-436.5(Hummers,)-430.1(and)-430.7(Tour)-431.8(methods\).)-435(The)-426.1(results)-434.9(showed)]TJ 0 -1.1174 TD [(differing)-316.5(cytotoxicities)-313.2(of)-307.4(GO.)-306.9(The)-310.9(extent)-314.5(of)-307.4(oxidation)-311(may)]TJ 0 -1.1116 TD [(play)-311(a)-307.5(critical)-312.3(role)-310.9(in)-307.6(toxicity)-304.2(imparted)-312.1(by)-307.5(GOs,)-307.8(which)-312.9(may)]TJ T* [(stem)-265.9(from)-264.8(the)-258(oxygen)-267(content)-263.7(\(C/O)-259.8(ratio\))-267.1(and)-257.9(the)-263.8(amount)-262.6(of)]TJ 0 -1.1174 TD [(carbonyl)-287.7(groups)-277.1(present.)]TJ 7.3823 0 0 6.5614 410.8534 72 Tm (63)Tj 9.843 0 0 9.843 421.0015 67.5779 Tm [(Furthermore,)-283.9(Liao)]TJ /F4 1 Tf 7.6662 0 TD [(et)-280(al.)]TJ /F3 1 Tf 2.3154 0 TD (reported)Tj -20.948 -1.1116 TD [(that)-351.4(the)-344.4(particle)-352.5(size,)-349.9(particulate)-351.3(state,)-345.4(oxygen)-347.6(content,)-353.5(and)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (478)Tj 49.6032 0 TD [(GU)-334.7(ET)-338.7(AL.)]TJ ET endstream endobj 89 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 92 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 93 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 90 0 obj <>stream 0 0 0 1 k /GS1 gs 117.638 56.636 .28346 702.312 re f 146.608 56.636 .22678 702.312 re f BT /F7 1 Tf 0 9.845 -9.845 -0 112.1953 265.2661 Tm 0 Tc 0 Tw (Table)Tj /F3 1 Tf 3.0002 0 TD (1.)Tj /F7 1 Tf 1.2496 0 TD [(The)-333.5(Cell)-333.2(Behaviors)-333(on)-337(Graphene)-334.5(and)-332(Its)-336.8(Derivatives)]TJ /F4 1 Tf -25.4413 -1.8658 TD (Graphene)Tj 0 -1.0077 TD (types)Tj 11.1773 1.0077 TD (Preparation)Tj .7832 -1.0077 TD (methods)Tj 7.8662 1.0077 TD (Application)Tj 1.0711 -1.0077 TD [(modes)-5108.8(Cell)-334.7(types)-5817.7(Outcomes)]TJ 29.6507 1.0077 TD (Possible)Tj -.7429 -1.0077 TD [(mechanisms)-8570.9(Reference)]TJ /F3 1 Tf -49.8057 -1.9118 TD [(G)-8656.9(CVD)-7272.9(Sheet)-5495.2(Human)-336.3(OB,)-329.6(hMSCs)-881.7(The)-333.5(cells)-335.7(on)-330.2(G)-335.8(adhered)]TJ 36.4977 -1.0077 TD [(and)-332.4(proliferated)]TJ 0 -1.0135 TD [(better)-336.9(than)-333.5(on)-330.2(an)]TJ T* (SiO)Tj 0 7.3837 -6.5625 -0 190.8283 431.2062 Tm (2)Tj 0 9.845 -9.845 -0 189.1842 438.1794 Tm (substrate)Tj 7.4228 3.0348 TD [(The)-333.6(electrical)-338.9(conductivity)-337.4(of)]TJ .9098 -1.0077 TD [(G)-335.8(i)0(s)-330.2(o)0(f)-336(particular)]TJ 0 -1.0135 TD [(importance,)-335(because)]TJ T* [(electricity)-338.9(as)-331.2(well)-340.3(as)]TJ T* [(cocktails)-335.3(of)-336(growth)-335.2(factors)]TJ 0 -1.0077 TD [(and)-332.4(substrate)-339.5(properties)-334.9(is)]TJ 0 -1.0135 TD [(able)-334.7(to)-336.2(stimulate)-335.4(cell)]TJ T* [(growth)-335.2(and)-332.4(differentiation.)]TJ 12.1102 7.083 TD (Kalbacova)Tj /F4 1 Tf 4.6241 0 TD [(et)-331.6(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 154.9417 705.5431 Tm (51)Tj 0 9.845 -9.845 -0 239.0172 56.6362 Tm [(G)-8656.9(CVD)-7272.9(Sheet)-5495.2(hMSCs)-6127.7(G)-330.1(provides)-337.3(a)-336.2(promising)]TJ 36.4977 -1.0077 TD (biocompatible)Tj 0 -1.0135 TD [(scaffold)-321.2(that)-316.4(does)-315.9(not)]TJ T* [(curb)-333.4(the)-332.6(proliferation)]TJ T* [(of)-330.2(hMSCs.)-338(The)]TJ 0 -1.0077 TD (osteogenic)Tj 0 -1.0135 TD [(differentiation)-336(rate)]TJ T* [(induced)-331.9(by)-336(G)]TJ 0 -1.0077 TD [(is)-330.2(comparable)]TJ 0 -1.0135 TD [(to)-330.4(BMP-2.)]TJ 9.6801 9.1043 TD [(Surface)-332.8(morphology;)-334.9(lateral)]TJ .9098 -1.0077 TD (stress)Tj 12.1102 1.0077 TD (Nayak)Tj /F4 1 Tf 2.9484 0 TD [(et)-331.6(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 234.5952 689.0455 Tm (4)Tj 0 9.845 -9.845 -0 338.6267 56.6362 Tm [(G,)-333.4(GO)-6637.5(CVD)-7272.9(Sheet)-5495.2(hMSCs)-6127.7(The)-333.5(strong)-334.2(noncovalent)]TJ 36.4977 -1.0135 TD [(binding)-329.8(abilities)-340.2(of)-330.2(G)]TJ 0 -1.0077 TD [(enable)-332.1(it)-336.3(to)-336.2(act)-333.7(as)-331.2(a)]TJ 0 -1.0135 TD (preconcentration)Tj T* [(platform)-333.1(for)]TJ T* [(osteogenic)-336.1(inducers,)]TJ 0 -1.0077 TD [(which)-335.4(accelerate)-340.9(the)]TJ 0 -1.0135 TD [(osteogenesis)-337.7(of)]TJ T* [(MSCs.)-331.3(However,)-336.8(G)]TJ 0 -1.0077 TD (suppresses)Tj 0 -1.0135 TD [(adipogenesis)-337.9(of)]TJ T* [(MSCs.)-331.3(GO)-337.6(does)-333.2(not)]TJ T* [(interfere)-335.3(with)]TJ 0 -1.0077 TD [(adipogenesis)-337.9(of)]TJ 0 -1.0135 TD (MSCs.)Tj 9.6801 14.166 TD [(G)-330.1(has)-338(the)-332.6(ability)-337(to)-330.4(bind)]TJ .9098 -1.0135 TD [(dexamethasone)-336.6(and)]TJ /F9 1 Tf 0 -1.0077 TD (b)Tj /F3 1 Tf .5528 0 TD [(-glycerolphosphate,)-296.9(which)]TJ -.5528 -1.0135 TD [(is)-336(good)-332.2(for)-331.2(osteogenesis.)]TJ T* [(Insulin)-335.3(is)-330.2(denatured)-340.8(on)]TJ T* [(adsorption)-333.7(of)-336(G)-330.1(through)-335.3(a)]TJ 0 -1.0077 TD (strong)Tj /F9 1 Tf 2.8332 0 TD (p)Tj /F3 1 Tf .5528 0 TD (-)Tj /F9 1 Tf .334 0 TD (p)Tj /F3 1 Tf .8811 0 TD [(interaction.)-341(GO)]TJ -4.6011 -1.0135 TD [(does)-333.2(not)-337.1(interfere)-335.3(with)]TJ T* [(adipogenesis)-337.9(due)-332.4(to)]TJ 0 -1.0077 TD [(electrostatic)-341.9(binding)-329.8(with)]TJ 0 -1.0135 TD (insulin.)Tj 12.1102 10.1178 TD (Lee)Tj /F4 1 Tf 1.8427 0 TD [(et)-331.6(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 334.2613 678.1605 Tm (5)Tj 0 9.845 -9.845 -0 499.0109 713.4235 Tm (\()Tj /F4 1 Tf .334 0 TD (continued)Tj /F3 1 Tf 3.9619 0 TD (\))Tj /F5 1 Tf 8.9663 0 0 8.9663 297.4109 34.2425 Tm (479)Tj ET endstream endobj 94 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 96 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 97 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 95 0 obj <>stream 0 0 0 1 k /GS1 gs 89.178 57.033 .22678 702.312 re f 115.654 57.033 .22678 702.312 re f BT /F7 1 Tf 0 9.845 -9.845 -0 83.6787 359.8865 Tm 0 Tc 0 Tw (Table)Tj /F3 1 Tf 3.0002 0 TD [(1.)-499.6(\()]TJ /F7 1 Tf 1.5836 0 TD (Continued)Tj /F3 1 Tf 4.8948 0 TD (\))Tj /F4 1 Tf -40.2407 -1.6181 TD (Graphene)Tj 0 -1.0135 TD (types)Tj 11.1773 1.0135 TD (Preparation)Tj .7832 -1.0135 TD (methods)Tj 7.8719 1.0135 TD (Application)Tj 1.0653 -1.0135 TD [(modes)-5108.8(Cell)-334.7(types)-5817.7(Outcomes)]TJ 29.6507 1.0135 TD (Possible)Tj -.7429 -1.0135 TD [(mechanisms)-8570.9(Reference)]TJ /F3 1 Tf -49.8057 -1.9061 TD [(GO)-7938.9(Modied)-337.1(Hummers)]TJ 10.2848 -1.0135 TD (method)Tj 8.4651 1.0135 TD [(Nanosheets)-3112.2(hASCs)-6294.8(The)-333.5(GO)-331.9(lm)-338.1(proved)-329.6(to)]TJ 17.7478 -1.0135 TD [(be)-331.4(a)-336.2(suitable)]TJ T* [(environment)-337.2(for)-331.2(the)]TJ 0 -1.0077 TD (time-dependent)Tj 0 -1.0135 TD [(viability)-333.4(of)-336(hASCs.)]TJ T* [(The)-333.5(enhanced)]TJ 0 -1.0077 TD [(differentiation)-336(of)]TJ 0 -1.0135 TD [(hASCs)-334.7(included)]TJ T* (osteogenesis,)Tj T* [(adipogenesis,)-335.5(and)]TJ 0 -1.0077 TD [(epithelial)-336.8(genesis;)]TJ 0 -1.0135 TD [(while)-335.5(the)]TJ T* (chondrogenic)Tj T* [(differentiation)-336(of)]TJ 0 -1.0077 TD [(hASCs)-334.7(was)]TJ 0 -1.0135 TD [(decreased,)-340.4(compared)]TJ T* [(tissue)-335.4(culture)]TJ 0 -1.0077 TD [(polystyrene)-335.9(as)-337(a)]TJ 0 -1.0135 TD [(control)-336.7(substrate.)]TJ 9.6801 18.2143 TD [(It)-330.4(is)-336(hypothesized)-338(that)-333.7(a)]TJ .9099 -1.0135 TD [(combination)-337.4(of)-330.2(factors,)]TJ T* [(including)-333.1(nanoscale)]TJ 0 -1.0077 TD [(structure,)-337.3(strong)-334.2(stiffness,)]TJ 0 -1.0135 TD [(roughness,)-335.6(reactive)-335.4(oxygen)]TJ T* [(functional)-335.2(groups,)-337.4(and)]TJ 0 -1.0077 TD [(adsorption)-333.7(of)-336(biomolecules)]TJ 0 -1.0135 TD [(on)-336(GO)-331.9(lms,)-336.6(affects)-332.9(the)]TJ T* [(hASCs)-334.7(behaviors.)]TJ 12.1102 8.0965 TD (Kim)Tj /F4 1 Tf 2.1134 0 TD [(et)-331.6(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 123.9874 681.2219 Tm (6)Tj 0 9.845 -9.845 -0 317.6503 57.0331 Tm [(rGO)-7605.9(Modied)-337.1(Hummers)]TJ 10.2848 -1.0135 TD [(method;)-337.8(Spin)]TJ 0 -1.0077 TD (coating)Tj 8.4651 2.0212 TD [(Film)-5827.2(hFOB)-6679.8(rGO)-332.9(is)-336(biocompatible)]TJ 17.7478 -1.0135 TD [(with)-333.4(hFOB,)-337.2(whereas)]TJ 0 -1.0077 TD [(single-walled)-340.2(carbon)]TJ 0 -1.0135 TD [(nanotube)-332.9(network)-337.3(is)]TJ T* [(inhibitory)-333.1(to)-336.2(the)]TJ T* [(proliferation)-338.4(of)]TJ 0 -1.0077 TD (hFOB.)Tj 9.6801 6.0695 TD [(The)-333.5(distinct)-337.9(nanotopographic)]TJ .9099 -1.0135 TD [(features)-339.7(of)-330.2(these)-335.5(two)-338(kinds)]TJ 0 -1.0077 TD [(of)-336(nanocarbon)-335.9(substrates)]TJ 0 -1.0135 TD [(cause)-336.5(the)-332.6(difference.)]TJ 12.1102 3.0348 TD (Agarwal)Tj /F4 1 Tf 3.7776 0 TD [(et)-337.3(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 313.285 697.6628 Tm (54)Tj 0 9.845 -9.845 -0 387.3826 57.0331 Tm (GO-CaCO)Tj 0 7.3837 -6.5625 -0 389.0267 99.0425 Tm (3)Tj 0 9.845 -9.845 -0 397.3605 65.9905 Tm (G-CaCO)Tj 0 7.3837 -6.5625 -0 399.0046 100.97 Tm (3)Tj 0 9.845 -9.845 -0 407.2818 65.9905 Tm (GO-HA)Tj 0 -1.0135 TD (G-HA)Tj 8.4651 3.0348 TD [(Modied)-337.1(Hummers)]TJ .9098 -1.0135 TD (method)Tj 8.4651 1.0135 TD [(Film)-5827.2(Mouse)-335(OB)-4679.7(Compared)-334.9(with)-333.4(bare)]TJ 17.7478 -1.0135 TD [(GO)-308.8(and)-309.3(G)-307(lms,)-307.8(GO/)]TJ 0 -1.0077 TD (G-CaCO)Tj 0 7.3837 -6.5625 -0 408.9259 451.3322 Tm (3)Tj 0 9.845 -9.845 -0 407.2818 458.3054 Tm (composites)Tj -4.2613 -1.0135 TD [(exhibited)-334.3(remarkably)]TJ T* [(enhanced)-335.1(HA)]TJ T* [(formation)-334.1(when)]TJ 0 -1.0077 TD [(incubated)-335.2(in)-336.1(a)]TJ 0 -1.0135 TD [(simulated)-335.2(body)-332.2(uid)]TJ T* [(solution.)-334.1(The)-333.5(GO/G-)]TJ T* [(HA)-331.9(composites)]TJ 0 -1.0077 TD [(supported)-332.6(high)]TJ 0 -1.0135 TD [(viability)-333.4(of)-336(OB)-332(with)]TJ T* [(an)-331.4(elongated)]TJ T* (morphology.)Tj 9.6801 13.1583 TD [(GO/G-HA)-333.7(hybrid)-334.4(materials)]TJ .9099 -1.0135 TD [(induce)-336.7(a)-330.4(3)0(D)-336.8(matrix)]TJ 0 -1.0077 TD [(adhesion)-338.5(of)-330.2(OB)-337.8(with)-333.4(high)]TJ 0 -1.0135 TD [(cell)-334.9(viability)-333.4(and)-338.1(provide)-330.7(a)]TJ T* [(similar)-337.9(microenvironment)]TJ T* [(to)-336.2(that)-333.7(found)]TJ /F4 1 Tf 5.6261 0 TD [(in)-330.4(vivo)]TJ /F3 1 Tf 6.4841 5.0618 TD (Kim)Tj /F4 1 Tf 2.1134 0 TD [(et)-331.6(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 383.0172 681.2219 Tm (52)Tj 0 9.845 -9.845 -0 537.8455 713.8203 Tm (\()Tj /F4 1 Tf .334 0 TD (continued)Tj /F3 1 Tf 3.9619 0 TD (\))Tj /F5 1 Tf 8.9663 0 0 8.9663 299.6786 34.2425 Tm (480)Tj ET endstream endobj 98 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 100 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 101 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 99 0 obj <>stream 0 0 0 1 k /GS1 gs 101.083 56.636 .22678 702.312 re f 127.559 56.636 .28346 702.312 re f BT /F7 1 Tf 0 9.845 -9.845 -0 95.5842 359.4897 Tm 0 Tc 0 Tw (Table)Tj /F3 1 Tf 3.0002 0 TD [(1.)-499.6(\()]TJ /F7 1 Tf 1.5836 0 TD (Continued)Tj /F3 1 Tf 4.8948 0 TD (\))Tj /F4 1 Tf -40.2407 -1.6182 TD (Graphene)Tj 0 -1.0135 TD (types)Tj 11.1773 1.0135 TD (Preparation)Tj .7832 -1.0135 TD (methods)Tj 7.8662 1.0135 TD (Application)Tj 1.0711 -1.0135 TD [(modes)-5108.8(Cell)-334.7(types)-5817.7(Outcomes)]TJ 29.6507 1.0135 TD (Possible)Tj -.7429 -1.0135 TD [(mechanisms)-8570.9(Reference)]TJ /F3 1 Tf -49.8057 -1.9061 TD [(FRGO)-6720.9(Hummers)-334.5(method;)]TJ 10.2848 -1.0135 TD (low-temperature)Tj T* [(thermal)-339(reduction)]TJ T* (method)Tj 8.4651 3.0405 TD [(Film)-5827.2(OB)-7731.8(The)-333.5(surface)-338.5(oxygen)]TJ 17.7478 -1.0135 TD [(content)-332.1(of)-336(FRGO)]TJ T* (signicantly)Tj T* [(inuences)-248.3(the)-246.2(cellular)]TJ 0 -1.0077 TD [(behaviors,)-337.1(with)-333.4(the)]TJ 0 -1.0135 TD [(best)-333.4(performance)-339.2(for)]TJ T* [(cell)-334.9(attachment,)]TJ 0 -1.0077 TD [(proliferation,)-336(calcium)]TJ 0 -1.0135 TD [(deposition,)-331.5(and)]TJ T* [(collagen)-334.3(secretion)]TJ T* [(being)-334.5(obtained)-333.1(in)]TJ 0 -1.0077 TD [(moderately)-337.4(reduced)]TJ 0 -1.0135 TD [(FRGO.)-332.3(Cell)]TJ T* (performance)Tj T* (signicantly)Tj 0 -1.0077 TD [(decreased)-337.1(as)-337(the)]TJ 0 -1.0135 TD [(FRGO)-334.7(was)-333(highly)]TJ T* [(reduced.)-336.3(Moderate)]TJ 0 -1.0077 TD [(performance)-339.2(was)]TJ 0 -1.0135 TD [(found)-333.2(in)-330.4(nonreduced)]TJ T* [(pure)-333.4(GO)-331.9(and)-338.1(control)]TJ T* [(glass)-334.2(slides.)]TJ 9.6801 21.2548 TD [(Enhancement)-277.2(of)-272.6(cell)-277.3(adhesion)]TJ .9098 -1.0135 TD [(and)-332.4(proliferation)-338.4(may)-333.5(be)]TJ T* [(induced)-331.9(by)-336(enhanced)]TJ T* [(extracellular)-336.2(matrix)-336.9(protein)]TJ 0 -1.0077 TD [(adsorption)-333.7(in)-336.2(moderately)]TJ 0 -1.0135 TD [(reduced)-332.9(FRGO)-340.4(by)]TJ T* [(noncovalent)-337.2(interactions.)]TJ 12.1102 6.0753 TD (Shi)Tj /F4 1 Tf 1.6642 0 TD [(et)-337.3(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 135.8929 676.4597 Tm (7)Tj 0 9.845 -9.845 -0 359.433 56.6362 Tm [(Nylon)-334.2(6,)-332.6(6-GO)]TJ .9098 -1.0135 TD (hybrid)Tj 8.4651 1.0135 TD [(Hybrid)-335.2(Nylon)-334.2(6,6)]TJ .9098 -1.0135 TD [(with)-333.4(0.25)-167.6(wt%)]TJ T* [(graphene)-339.7(oxide.)]TJ 8.4651 2.027 TD [(Film)-5827.2(Mouse)-335(pre-OB)-3066.7(The)-276(cell)-277.3(attachment)-281.2(and)]TJ 17.7478 -1.0135 TD [(proliferation)-338.4(on)]TJ T* [(Nylon)-334.2(6,)-332.6(6-GO)]TJ T* [(hybrid)-334.4(polymer)]TJ 0 -1.0077 TD [(greatly)-332.1(exceed)-338.9(those)]TJ 0 -1.0135 TD [(of)-330.2(Nylon)-334.2(6,6.)]TJ 9.6801 5.0618 TD [(The)-333.6(incorporation)-338.2(of)-330.2(GO)-337.6(in)]TJ .9098 -1.0135 TD [(Nylon)-334.2(6,6)-333.6(matrix)-336.9(modies)]TJ T* [(the)-332.6(physiochemical)]TJ T* [(properties)-334.9(of)-336(the)-332.6(surface,)]TJ 0 -1.0077 TD [(including)-333.1(chemistry)-335.1(and)]TJ 0 -1.0135 TD [(wettability,)-335.2(favoring)]TJ T* [(attachment,)-336.4(cell-substrate)]TJ T* [(interactions,)-336(and)-332.4(biological)]TJ 0 -1.0077 TD [(response)-338.2(required)-332.9(for)-337(cell)]TJ 0 -1.0135 TD [(attachment)-338.8(and)]TJ T* [(proliferation.)-336(Furthermore,)]TJ 0 -1.0077 TD [(the)-251.9(negative)-253.6(polarity)-251.5(of)-249.6(G)-255.2(i)0(s)]TJ 0 -1.0135 TD [(instrumental)-338.4(in)-330.4(favorably)]TJ T* [(inuencing)-334.9(biological)]TJ T* (function.)Tj 12.1102 14.1718 TD [(Misra)-335.2(and)-332.4(Chaudhari)]TJ 0 7.3837 -6.5625 -0 355.0676 724.3085 Tm (53)Tj 0 9.845 -9.845 -0 519.8739 713.4235 Tm (\()Tj /F4 1 Tf .334 0 TD (continued)Tj /F3 1 Tf 3.9619 0 TD (\))Tj /F5 1 Tf 8.9663 0 0 8.9663 297.4109 34.2425 Tm (481)Tj ET endstream endobj 102 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 104 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 105 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 103 0 obj <>stream 0 0 0 1 k /GS1 gs 92.013 56.58 .22678 702.312 re f 118.488 56.58 .22678 702.312 re f BT /F7 1 Tf 0 9.845 -9.845 -0 86.5134 359.433 Tm 0 Tc 0 Tw (Table)Tj /F3 1 Tf 3.0002 0 TD [(1.)-499.6(\()]TJ /F7 1 Tf 1.5836 0 TD (Continued)Tj /F3 1 Tf 4.8948 0 TD (\))Tj /F4 1 Tf -40.2407 -1.6182 TD (Graphene)Tj 0 -1.0135 TD (types)Tj 11.1773 1.0135 TD (Preparation)Tj .7832 -1.0135 TD (methods)Tj 7.8662 1.0135 TD (Application)Tj 1.0711 -1.0135 TD [(modes)-5108.8(Cell)-334.7(types)-5817.7(Outcomes)]TJ 29.6507 1.0135 TD (Possible)Tj -.7429 -1.0135 TD [(mechanisms)-8570.9(Reference)]TJ /F3 1 Tf -49.8056 -1.9061 TD (Chitosan-GO)Tj .9098 -1.0135 TD (scaffolds)Tj 8.4651 1.0135 TD [(Covalent)-334.1(linking)-335.7(of)]TJ .9099 -1.0135 TD [(the)-338.3(carboxyl)]TJ T* [(groups)-276.4(of)-272.6(GO)-274.3(with)]TJ 0 -1.0077 TD [(the)-338.3(amino)-329.9(groups)]TJ 0 -1.0135 TD [(of)-336(CS)]TJ 8.4651 4.0483 TD [(Nanosheets)-3112.2(Mouse)-335(pre-OB)-3066.7(The)-333.5(covalent)]TJ 17.7478 -1.0135 TD [(incorporation)-338.2(of)-330.2(GO)]TJ T* [(into)-332.6(a)-336.2(chitosan)]TJ 0 -1.0077 TD [(network)-331.6(favorably)]TJ 0 -1.0135 TD [(modulated)-335.2(the)]TJ T* [(biological)-335.4(response)]TJ 0 -1.0077 TD [(of)-330.2(osteoblasts,)-339.1(such)]TJ 0 -1.0135 TD [(that)-333.7(cell)-334.9(attachment,)]TJ T* [(proliferation,)-336(and)]TJ T* [(formation)-334.1(of)]TJ 0 -1.0077 TD [(extracellular)-336.2(matrix)]TJ 0 -1.0135 TD [(are)-333.6(signicantly)]TJ T* (enhanced.)Tj 9.6801 12.1448 TD [(The)-333.5(signicant)-334.9(enhancement)]TJ .9099 -1.0135 TD [(of)-336(biological)-335.4(function)-331.9(is)]TJ T* [(related)-339(to)-330.4(a)-336.2(combination)-331.6(of)]TJ 0 -1.0077 TD [(a)-336.2(number)-330.7(of)-336(physico-)]TJ 0 -1.0135 TD [(chemical)-336.6(factors,)-335.1(including)]TJ T* [(a)-336.2(large)-335.7(surface)-332.8(area,)]TJ 0 -1.0077 TD [(nanoscale)-336.1(roughness,)-335.6(the)]TJ 0 -1.0135 TD [(presence)-254.3(of)-243.8(pendant)-251.3(groups,)]TJ T* [(a)-336.2(hydrophilic)-335.1(nature,)-334.3(and)-332.4(a)]TJ T* [(high)-274.8(water)-278.9(retention)-276.7(ability.)]TJ 12.1102 9.11 TD (Depan)Tj /F4 1 Tf 2.9484 0 TD [(et)-331.6(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 126.822 688.9888 Tm (8)Tj 0 9.845 -9.845 -0 260.7307 56.5795 Tm [(GO-modied)-336.3(CS)]TJ .9098 -1.0077 TD (scaffold)Tj 8.4651 1.0077 TD [(The)-333.5(carboxyl)-338.7(groups)]TJ .9099 -1.0077 TD [(of)-336(GO)-331.9(are)]TJ 0 -1.0135 TD (covalently)Tj T* [(attached)-341.2(with)-333.4(the)]TJ 0 -1.0077 TD [(amine)-336.9(group)-333.2(of)]TJ 0 -1.0135 TD (CS.)Tj 8.4651 5.056 TD [(Nanosheets)-3112.2(Mouse)-335(pre-OB)-3066.7(Biological)-336.4(functions)-332.7(of)]TJ 17.7478 -1.0077 TD [(the)-332.6(pre-OB)-337.2(including)]TJ 0 -1.0135 TD [(cell)-334.9(attachment,)]TJ T* [(proliferation,)-336(growth)]TJ 0 -1.0077 TD [(and)-332.4(mineralization,)]TJ 0 -1.0135 TD [(are)-333.6(signicantly)]TJ T* [(enhanced)-335.1(in)-336.2(the)]TJ T* [(presence)-334.9(of)-336(GO,)]TJ 0 -1.0077 TD [(compared)-335.1(with)]TJ 0 -1.0135 TD [(unmodied)-333.7(chitosan.)]TJ 9.6801 9.1043 TD [(The)-333.5(difference)-337.2(of)-336(cell)]TJ .9099 -1.0077 TD [(behavior)-332.9(is)-336(related)-339(to)-330.4(the)]TJ 0 -1.0135 TD [(degree)-337.7(and)-332.4(topography)-333.7(of)]TJ T* [(protein)-336.7(adsorption)-333.7(on)-330.2(the)]TJ 0 -1.0077 TD [(scaffolds.)-336.9(BSA)-332.9(is)-336(widely)]TJ 0 -1.0135 TD [(spread)-336.3(on)-330.2(CS-GO)-335.6(as)-337(small)]TJ T* [(globules,)-335.1(whereas)-339.3(the)]TJ T* [(globules)-337.5(are)-333.6(large)-335.7(and)]TJ 0 -1.0077 TD [(randomly)-332.9(distributed)-335.1(on)]TJ 0 -1.0135 TD [(pure)-333.4(CS.)-334.4(This)-333.4(subtle)-335.5(but)]TJ T* [(important)-334.2(difference)-337.2(in)-336.2(the)]TJ T* [(adsorption)-333.7(of)-336(protein)-330.9(is)]TJ 0 -1.0077 TD [(responsible)-335.7(for)-337(the)]TJ 0 -1.0135 TD [(observed)-338.3(differences)-338.1(in)]TJ T* [(cellular)-334.4(interactions.)]TJ 12.1102 14.166 TD [(Depan)-336.3(and)-332.4(Misra)]TJ 0 7.3837 -6.5625 -0 256.3086 708.888 Tm (9)Tj 0 9.845 -9.845 -0 410.1164 56.5795 Tm [(rGO-CS)-336.6(substrata)-2159.2(Hummers)-333.6(method;)]TJ 10.2848 -1.0135 TD (hydrazine)Tj T* (treatment;)Tj T* (spin-coating)Tj 8.4651 3.0405 TD [(Nanosheets;)-337.7(lm)-879.4(hMSCs)-6127.8(G-incorporated)-335.3(CS)]TJ 17.7478 -1.0135 TD [(substrate)-333.7(promotes)]TJ T* [(adhesion)-332.7(and)]TJ T* [(differentiation)-336(of)]TJ 0 -1.0077 TD (hMSCs.)Tj 9.6801 4.0483 TD [(rGO-CS)-336.6(substrata)-333.7(with)]TJ .9099 -1.0135 TD [(asymmetrical)-312.9(nanotopology)]TJ T* [(and)-332.4(its)-337.2(secondary)-334.7(effects)]TJ T* [(such)-333.2(as)-337(stiffness)-332.4(and)]TJ 0 -1.0077 TD [(roughness)-332.2(provided)-337.5(a)]TJ 0 -1.0135 TD [(suitable)-333.1(environment)-337.2(for)]TJ T* [(adhesion)-332.7(and)-338.1(proliferation)]TJ T* [(of)-336(hMSCs)-334.7(as)-331.2(well)-334.5(as)]TJ 0 -1.0077 TD [(enhanced)-335.1(cell-substrata)]TJ 0 -1.0135 TD [(interactions)-338.4(and)-332.4(cell-cell)]TJ T* (contacts.)Tj 12.1102 10.1235 TD (Kim)Tj /F4 1 Tf 2.1134 0 TD [(et)-331.6(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 405.7511 680.7683 Tm (10)Tj 0 9.845 -9.845 -0 530.7023 713.3668 Tm (\()Tj /F4 1 Tf .334 0 TD (continued)Tj /F3 1 Tf 3.9619 0 TD (\))Tj /F5 1 Tf 8.9663 0 0 8.9663 299.6786 34.2425 Tm (482)Tj ET endstream endobj 106 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 108 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 109 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 107 0 obj <>stream 0 0 0 1 k /GS1 gs 412.157 56.636 .28348 702.312 re f 177.619 56.636 .22678 702.312 re f 204.094 56.636 .28346 702.312 re f BT /F7 1 Tf 0 9.845 -9.845 -0 172.1196 359.4897 Tm 0 Tc 0 Tw (Table)Tj /F3 1 Tf 3.0002 0 TD [(1.)-499.6(\()]TJ /F7 1 Tf 1.5836 0 TD (Continued)Tj /F3 1 Tf 4.8948 0 TD (\))Tj /F4 1 Tf -40.2407 -1.6182 TD (Graphene)Tj 0 -1.0135 TD (types)Tj 11.1773 1.0135 TD (Preparation)Tj .7832 -1.0135 TD (methods)Tj 7.8662 1.0135 TD (Application)Tj 1.0711 -1.0135 TD [(modes)-5108.8(Cell)-334.7(types)-5817.7(Outcomes)]TJ 29.6507 1.0135 TD (Possible)Tj -.7429 -1.0135 TD [(mechanisms)-8570.9(Reference)]TJ /F3 1 Tf -49.8057 -1.9061 TD [(3D)-331(GFs)-6170.8(Growing)-337(graphene)]TJ 10.2848 -1.0135 TD [(on)-336(3D)-331(Nickel)]TJ T* (scaffolds)Tj 8.4651 2.027 TD [(Film)-5827.2(hMSCs)-6127.7(3D)-331(GFs)-337.4(can)-333.5(maintain)]TJ 17.7478 -1.0135 TD [(hMSCs)-334.7(viability)-333.4(and)]TJ T* [(promote)-331.9(osteogenic)]TJ T* (differentiation)Tj 0 -1.0077 TD [(without)-330.8(the)-338.3(need)-334.5(for)]TJ 0 -1.0135 TD [(extrinsic)-334.1(biochemical)]TJ T* (manipulation.)Tj 9.6801 6.0753 TD [(The)-333.6(mechanism)-337.2(driving)]TJ .9098 -1.0135 TD [(spontaneous)-335.5(differentiation)]TJ T* [(remains)-332.9(unclear,)-336.5(but)-337.1(is)]TJ T* [(suspected)-334.7(to)-336.2(be)-331.4(an)-337.2(intrinsic)]TJ 0 -1.0077 TD [(cellular)-334.4(response)-338.2(to)-336.2(the)]TJ 0 -1.0135 TD [(stress)-335(derived)-337.7(from)-333.4(the)]TJ T* [(interaction)-337.6(with)-333.4(a)-336.2(high)]TJ 0 -1.0077 TD [(stiffness)-338.2(material.)]TJ 12.1102 7.083 TD (Crowder)Tj /F4 1 Tf 3.8294 0 TD [(et)-337.3(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 212.4283 697.7762 Tm (11)Tj 0 9.845 -9.845 -0 296.5038 56.6362 Tm [(GO-ac)-6711.9(Hummers)-334.5(method;)]TJ 10.2848 -1.0135 TD [(self-assemblies)-343(on)]TJ T* (water)Tj 8.4651 2.027 TD [(Film)-5827.2(hMSCs)-6127.7(hMSCs)-334.7(show)]TJ 17.7478 -1.0135 TD (spontaneous)Tj T* (osteogenic)Tj 0 -1.0077 TD [(differentiation)-336(on)]TJ 0 -1.0135 TD [(rough)-333.2(GO-ac)-337.2(lm)]TJ T* [(without)-330.8(the)-338.3(use)-332.2(of)]TJ T* [(any)-332.4(chemical)]TJ 0 -1.0077 TD [(inducers.)-336.1(The)-333.5(extent)]TJ 0 -1.0135 TD [(of)-330.2(mineralization)]TJ T* [(increases)-335.9(with)]TJ 0 -1.0077 TD [(increasing)-336.1(roughness)]TJ 0 -1.0135 TD [(of)-330.2(the)-338.3(GO-ac)-337.2(lm.)]TJ 9.6801 11.1313 TD [(The)-333.6(rough)-333.2(topology)-336.5(of)-330.2(the)]TJ .9098 -1.0135 TD [(cross-linked)-336.7(lm)-332.4(creates)]TJ T* [(increased)-336.1(cytoskeletal)]TJ 0 -1.0077 TD [(tension)-336.5(to)-330.4(grow)-333(and)]TJ 0 -1.0135 TD [(differentiate.)-338.3(The)-333.5(rough)]TJ T* [(surface)-338.5(topology)-330.7(provides)]TJ T* [(more)-334.5(anchoring)-333.9(points)-334.4(for)]TJ 0 -1.0077 TD [(the)-332.6(adhesion)-338.5(and)]TJ 0 -1.0135 TD [(proliferation)-338.4(of)-330.2(hMSCs.)]TJ 12.1102 8.0965 TD (Tang)Tj /F4 1 Tf 2.3956 0 TD [(et)-331.6(al.)]TJ /F3 1 Tf 0 7.3837 -6.5625 -0 292.1385 683.603 Tm (12)Tj 0 8.7511 -8.7511 -0 424.233 64.5732 Tm [(G,)-340.6(graphene;)-333.7(GO,)-341.7(graph)6.1(ene)-342.2(oxide;)-335(rGO,)-339.1(reduced)-337.3(graphene)-336.1(oxide;)-335(OB,osteoblasts;)-339.8(BSA,)-334.1(bovine)-336.3(serum)-339.7(albumin;)-335.5(HA,)-335.3(hydroxyapatite;)-335.9(CS,)-339.5(chitosan;)-336.3(BMP-2,)]TJ 64.071 0 TD [(bone)-333.4(morphogenetic)-338.3(protein-2;)-332.7(CVD,)]TJ -64.978 -1.0236 TD [(chemical)-327.3(vapor)-324.3(deposition;)-325.1(FRGO,)-328.7(few-layer)-326.6(rGO)-330(lms;)-324.3(GO-ac,)-332.7(acrylated)-329.2(GO;)-323.7(hASCs,)-330.2(human)-323.3(adipose-derived)-330.1(stem)-328.1(cells;)-326.8(hMSCs,)-325.1(human)-329.8(mesenchymal)-330.9(ste)5.2(m)-326.8(c)]TJ 65.723 0 TD [(ells;)-333.3(hFOB,)-326.4(huma)5.9(n)-329.2(fetal)-329.4(OB;)-323.9(MSC,)]TJ -65.723 -1.0236 TD -.0001 Tc [(mesenchymal)-337.4(stem)-334.7(cells;)-333.4(3D,)-333.1(three-dimensional;)-336.4(3D)-330.4(GFs,)-336.6(3D)-330.4(graphene)-336.2(foams.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 297.4109 34.2425 Tm 0 Tc (483)Tj ET endstream endobj 110 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 113 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 114 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 111 0 obj <>stream /GS1 gs BT /F3 1 Tf 9.843 0 0 9.843 62.022 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(the)-367.5(surface)-368(charge)-372.9(of)-365(graphene)-369.4(have)-363.8(a)-365.1(large)-370.8(impact)-367.5(on)-365.1(the)]TJ 0 -1.1174 TD .012 Tc [(bi)5(ol)5(og)5.1(ical)-265.7(and)-259.8(t)-.7(ox)5.1(icol)5(og)5.1(ical)-265.7(r)5.2(e)-1.8(s)5.3(pon)5.1(se)-261(to)-265.6(r)5.2(e)-1.8(d)-259.8(b)-.6(l)5(ood)-259.8(cell)5(s.)-262.1(At)]TJ 0 -1.1116 TD .0131 Tc [(th)6.2(e)-426.9(s)6.4(ma)5.1(ll)6.1(es)6.4(t)-425.9(s).7(i)6.1(z)-.7(e)5.1(,)-422.3(GO)-420.8(sh)6.2(ow)5.4(ed)-420(th)6.2(e)-426.9(g)6.2(re)5.1(at)6.1(est)-420.1(h).5(e)5.1(m)5(oly)6.2(t).4(i)6.1(c)-426.9(a)5.1(c)-.7(-)]TJ T* .0117 Tc [(ti)4.7(vi)4.7(ty,)-435.2(w)-1.8(h)4.8(e)-2.1(r)4.9(e)-2.1(as)-438.5(agg)4.8(r)-.9(egated)-438.7(graph)4.8(en)4.8(e)-439.8(s)-.7(heet)4.7(s)-438.5(e)-2.1(x)4.8(h)-.9(i)4.7(b)-.9(it)4.7(ed)-438.6(t)4.7(h)-.9(e)]TJ T* .0125 Tc [(lo)5.6(west)-420.7(h)5.6(e)-1.3(mol)5.5(y)-.1(t)5.5(i)-.2(c)-421.7(a)4.5(ct)5.5(iv)5.6(ity)5.6(.)-417.1(T)-1.3(h)5.6(e)-1.3(i)5.5(r)-420.5(st)5.5(udy)-414.8(al)5.5(so)-420.6(d)5.6(e)-1.3(mon)5.6(s).1(tr)5.7(at)5.5(ed)]TJ 0 -1.1174 TD .012 Tc [(th)5.1(at)-547.9(compact)5(e)-1.8(d)-542(graph)5.1(en)5.1(e)-548.9(s)-.4(h)5.1(e)-1.8(ets)-547.6(a)4(re)-543.2(mo)5.1(re)-548.9(d)5.1(a)-1.8(mag)5.1(i)-.7(n)5.1(g)-547.8(to)]TJ 0 -1.1116 TD .0111 Tc [(hu)4.2(man)-306.8(s)-1.3(k)4.2(i)-1.6(n)-301()-1.3(br)4.3(ob)4.2(lasts)-306.6(t)4.1(han)-306.8(t)-1.6(h)4.2(e)-307.9(less)-306.6(d)4.2(e)-2.7(n)4.2(s)-1.3(ely)-306.8(p)4.2(acked)-306.8(G)-2.4(O.)]TJ 7.3823 0 0 6.5614 293.6125 663.7605 Tm .0145 Tc (60)Tj 9.843 0 0 9.843 62.022 648.4534 Tm .0118 Tc [(As)-432.6(fo)4.9(r)-432.8(t)-.9(he)-434(mechani)4.8(s)-.6(m,)-435.1(Zh)4.9(an)4.9(g)]TJ /F4 1 Tf 13.2934 0 TD .0132 Tc [(et)-431.5(al)6.2(.)]TJ /F3 1 Tf 2.684 0 TD .0118 Tc [(repo)4.9(rted)-432.8(th)4.9(at)-432.9(CVD-)]TJ -15.9774 -1.1174 TD [(gr)5.1(own)-605.5(g)-.7(r)5.1(a)-1.9(p)5(h)-.7(ene)-600.9(i)-.8(n)5(c)-1.9(reas)5.2(ed)-599.7(the)-600.9(a)-1.9(cti)4.9(v)-.7(ati)4.9(o)-.7(n)-605.5(o)5(f)-605.4(c)3.9(as)5.2(pas)5.2(e)-606.6(3)]TJ 0 -1.1116 TD .0115 Tc [(\(apo)4.6(pt)4.5(osi)4.5(s)-381.1(mar)4.7(k)-1.1(er\),)-377.8(r)4.7(e)-2.3(l)4.5(e)-2.3(ase)-382.4(o)]TJ 12.2336 0 TD [(f)-381.1(l)4.6(actate)-376.6(dehyd)4.7(ro)4.7(genase,)-377.7(a)3.6(nd)]TJ -12.2336 -1.1116 TD [(generatio)4.5(n)-548.4(o)4.5(f)-548.4(r)-1.2(eactiv)4.5(e)-549.5(o)4.5(xyg)]TJ 12.1472 0 TD .0073 Tc [(e)-6.5(n)-546.7(s)-5.1(p)-5.3(ec)-6.5(ie)-6.5(s)-552.3(\().5(R)-6.3(O)-.4(S)-5.2(\))-552.5(in)-552.5(n)-5.3(e)-.7(u)-5.3(r).5(a)-6.5(l)]TJ -12.1472 -1.1174 TD .0121 Tc [(ph)5.2(eo)5.2(ch)5.2(romo)5.2(c)-1.7(yt)5.1(oma-)5.3(deri)5.1(ved)-363.4(P)-.4(C12)-363.4(c)-1.7(ells)5.4(.)]TJ 7.3823 0 0 6.5614 226.4314 608.9951 Tm .0145 Tc (64)Tj 9.843 0 0 9.843 237.6566 604.5731 Tm .0138 Tc [(Li)6.8(ao)]TJ /F4 1 Tf 2.2578 0 TD .0089 Tc [(et)-372.5(al.)]TJ /F3 1 Tf 2.5458 0 TD .0131 Tc [(al)6.1(so)]TJ -22.6472 -1.1116 TD .0117 Tc [(repo)4.8(rted)-432.9(t)4.7(h)-.9(at)-433(aggr)4.9(eg)4.8(at)4.7(ed)-432.9(g)4.8(r)-.9(aph)4.8(e)-2.1(n)4.8(e)-434.1(sh)4.8(eets)-432.7(i)4.7(n)-.9(d)4.8(u)-.9(ced)-427.1(a)-434.1(hi)4.7(gh)]TJ T* [(level)-335.2(o)-1(f)-329.3(R)-2(OS)-334.9(in)-335.1(h)4.7(u)-1(man)-329.3(s)-.8(k)4.7(i)-1.1(n)-335.1()4.9(bro)4.7(bl)4.6(as)4.9(ts.)]TJ 7.3823 0 0 6.5614 225.9779 587.0549 Tm .0145 Tc (60)Tj 9.843 0 0 9.843 236.8629 582.6896 Tm .0133 Tc [(Ho)6.4(we)5.3(ve)5.3(r,)-330(wh)6.4(en)]TJ -17.7629 -1.1116 TD .0131 Tc [(ca)5.1(nc)5.1(er)-258.7(ce)5.1(ll)-258.8(lin)6.2(es)-258.5(we)5.1(re)-259.9(use)5.1(d).5(,)-261(d)6.2(ec)5.1(rea)5.1(s).7(e)5.1(s)-264.3(i)6.1(n)-264.5(c)5.1(e)-.7(ll)-258.8(vi)6.1(ab)6.2(il)6.1(ity)-258.7(we)5.1(re)]TJ 0 -1.1174 TD [(lo)6.2(we)5.1(r)-333.5(i)6.1(n)-333.6(m)5(os)6.4(t)-333.7(c)5.1(as)6.4(es.)]TJ 7.3823 0 0 6.5614 146.1543 565.1148 Tm .0137 Tc (59,65,66)Tj 9.843 0 0 9.843 72 549.8077 Tm .0111 Tc [(There)-371.3(a)-2.7(re)-371.3(a)-377.1(f)4.3(e)-2.7(w)]TJ /F4 1 Tf 7.1363 0 TD .0134 Tc [(in)-367.8(vi)6.4(vo)]TJ /F3 1 Tf 3.2715 0 TD .0119 Tc [(s)5.2(t)-.8(u)5(d)-.7(i)4.9(e)-1.9(s)-374.9(w)4.2(it)4.9(h)-375.1(r)-.7(egard)-369.3(t)-.8(o)-369.3(t)-.8(he)-370.5(bi)4.9(o-)]TJ -11.4215 -1.1116 TD .0131 Tc [(co)6.2(mp)6.2(at)6.1(ib)6.2(il)6.1(ity)-523.6(of)-523.6(gra)5.1(ph)6.2(en)6.2(e)-530.6(a)5.1(nd)-529.4(i)6.1(t).4(s)-523.5(d).5(er)6.3(iv)6.2(at)6.1(iv)6.2(es.)]TJ 7.3823 0 0 6.5614 258.8031 543.2313 Tm .0138 Tc (57,58)Tj 9.843 0 0 9.843 281.1401 538.866 Tm .0114 Tc (Sahu)Tj /F4 1 Tf -22.2613 -1.1174 TD .0138 Tc [(et)-373.3(a)6.9(l)1.1(.)]TJ /F3 1 Tf 2.5688 0 TD .0112 Tc [(have)-377(d)4.3(e)-2.6(v)4.3(e)-2.6(lo)4.3(ped)-375.8(a)-382.7(s)4.5(i)-1.5(mple)-377(met)4.2(h)-1.4(o)4.3(d)-381.6(t)4.2(o)-381.6(p)4.3(r)-1.4(epare)-377(a)-377(t)-1.5(her-)]TJ -2.5688 -1.1116 TD .0124 Tc [(mosens)5.7(iti)5.4(ve)-375.8(h)5.5(y)-.2(d)5.5(rog)5.5(el)-374.7(s)5.7(y)-.2(st)5.4(em)-375.8(b)5.5(a)-1.4(s)5.7(e)-1.4(d)-374.6(o)5.5(n)-380.4(n)5.5(an)5.5(o-)5.6(sized)-374.6(G)4.7(O)-375.5(b)-.2(y)]TJ T* .0073 Tc [(a)-6.5(d).4(d)-5.3(i).3(n)-5.3(g)-385.5(a)-386.6(s)-5.1(ma)-6.5(ll)-385.6(a)-6.5(m)-.8(o)-5.3(u)-5.3(n).4(t)-385.6(o)-5.3(f)-385.4(P)-5.2(lu)-5.3(ro)-5.3(ni)-5.4(c)-386.6(b)-5.3(lo)-5.3(ck)-391.2(co)-5.3(po)-5.3(ly)-5.3(me)-6.5(r)-385.4(a)-6.5(s)-385.3(a)]TJ 0 -1.1174 TD .0121 Tc [(ph)5.2(ys)5.4(ical)-288.6(cr)5.3(oss)5.4(l)-.6(i)5.1(n)-.5(k)5.2(e)-1.7(r,)-285.1(wi)5.1(tho)5.2(u)-.5(t)-288.6(a)4.1(ny)-288.5(chemi)5.1(cal)-288.6(mod)5.2(i)-.6()5.4(c)-1.7(atio)5.2(n)-288.5(o)-.5(f)]TJ 0 -1.1116 TD .0099 Tc [(G)-3.6(O)2.2(.)-270(I)3.1(t)-267.8(w)-3.6(as)-267.5(re)-3.9(ported)-267.7(that)-267.8(the)-268.8(g)-2.7(el)-267.8(forma)-3.9(t)2.9(ion)-267.7(w)2.2(a)-3.9(s)-267.5(long)-267.7(lasting)]TJ T* .0129 Tc [(an)6(d)-431.7(s)6.2(ta)4.9(bl)5.9(e.)-428.3(Whe)4.9(n)-431.7(i)5.9(n).3(j)5.9(e)-.9(c)4.9(t).2(ed)-425.9(su)6(bc)4.9(ut)5.9(an)6(eo)6(usl)5.9(y)-431.7(i)5.9(n).3(t)5.9(o)-431.7(m)4.8(i).2(c)4.9(e)-.9(,)-428.3(t)5.9(he)]TJ 0 -1.1174 TD .0118 Tc [(hi)4.8(st)4.8(olo)4.9(g)-.8(i)4.8(c)-2(al)-352.3(i)4.8(n)-.8(v)4.9(e)-2(s)5.1(tig)4.9(at)4.8(io)4.9(n)-352.2(r)5(ev)4.9(ealed)-352.2(t)4.8(hat)-352.3(t)4.8(hese)-347.6(GO-P)5.1(lur)5(o)-.8(n)4.9(i)-.9(c)]TJ 0 -1.1116 TD .0124 Tc [(hy)5.5(dr)5.6(ogels)-397.4(d)5.5(i)-.3(d)-397.6(n)5.5(ot)-397.8(s)5.7(how)-392.7(any)-391.9(s)0(ev)5.5(er)5.6(e)-398.8(c)-1.4(h)5.5(r)-.2(o)5.5(n)-.2(ic)-393(in)5.7(a)-1.4(mmato)5.5(r)-.2(y)]TJ T* [(resp)5.6(ons)5.8(e)-479.3(a)4.5(nd)-478.2(mig)5.6(h)-.1(t)-472.5(b)-.1(e)-473.6(b)-.1(io)5.6(co)5.6(mp)5.6(at)5.5(ib)5.6(le)-479.3(f)5.7(o)-.1(r)-472.4(fut)5.5(ur)5.7(e)]TJ /F4 1 Tf 21.3051 0 TD .0134 Tc [(in)-471.5(vi)6.4(vo)]TJ /F3 1 Tf -21.3051 -1.1116 TD .0131 Tc [(ap)6.2(pl)6.1(ic)5.1(at)6.1(ion)6.2(s).7(.)]TJ 7.3823 0 0 6.5614 113.5559 433.644 Tm .0145 Tc (67)Tj 9.843 0 0 9.843 124.611 429.2786 Tm .0137 Tc [(Du)6.8(ch)]TJ /F4 1 Tf 2.5573 0 TD .0132 Tc [(et)-345.1(al.)]TJ /F3 1 Tf 2.517 0 TD .0122 Tc [(d)5.3(i)-.5(rect)5.2(ly)-346(ad)5.3(mi)5.2(nis)5.5(t)-.5(ered)-351.8(so)5.3(lu)5.3(tio)5.3(ns)]TJ -11.433 -1.1174 TD [(of)-386.3(aggr)5.4(eg)5.3(at)5.2(ed)-386.3(gr)5.4(ap)5.3(hene,)-382.9(P)-.3(lu)5.3(ro)5.3(ni)5.2(c)-393.2(d)5.3(is)5.5(per)5.4(s)-.2(ed)-392.1(g)5.3(r)-.4(aph)5.3(e)-1.6(n)5.3(e)-393.2(and)]TJ 0 -1.1116 TD [(GO)-393(i)5.1(n)-.5(t)5.1(o)-392.2(th)5.2(e)-393.3(l)-.6(un)5.2(gs)-392(o)5.2(f)-392.1(mi)5.1(ce)-393.3(and)-392.2(o)5.2(bserv)5.2(e)-1.7(d)-392.2(t)5.1(hat)-398.1(G)4.4(O)-393(c)-1.7(aus)5.4(e)-1.7(d)]TJ T* .0119 Tc [(severe)-382(p)5(e)-1.9(r)5.1(s)-.5(is)5.2(tent)-381(l)4.9(ung)-375.1(in)5.2(a)-1.9(mmati)4.9(o)-.7(n)5(.)-383.2(I)5.1(n)-380.9(co)5(nt)4.9(ras)5.2(t)-.8(,)-377.4(t)-.8(h)5(i)-.8(s)-380.7(t)-.8(o)5(x)-.7(-)]TJ 0 -1.1174 TD [(icit)4.8(y)-346.4(w)-1.7(as)-346.2(si)4.8(gn)4.9(ican)4.9(t)-.9(l)4.8(y)-346.4(redu)4.9(ced)-346.4(i)-.9(n)-340.6(t)-.9(he)-341.8(case)-347.6(o)4.9(f)-346.4(pr)5(ist)4.8(i)-.9(n)4.9(e)-347.6(gr)5(a-)]TJ 0 -1.1116 TD .0124 Tc [(ph)5.5(en)5.5(e)-663.7(a)4.4(fter)-662.5(l)5.4(i)-.3(qu)5.5(id)-656.8(ph)5.5(ase)-658(e)-1.4(x)5.5(fol)5.4(iati)5.4(on)5.5(,)-664.9(a)4.4(nd)-656.8(was)-656.6(f)-.2(u)5.5(r)-.2(th)5.5(er)]TJ T* .012 Tc [(mini)5(mi)5(zed)-461.4(w)-1.5(h)5.1(e)-1.8(n)-455.6(t)-.7(h)5.1(e)-462.6(un)5.1(ox)5.1(idi)5(z)-1.8(ed)-461.4(gr)5.2(ap)5.1(hene)-462.6(was)-455.4(w)-1.5(el)5(l)-461.5(d)5.1(is-)]TJ 0 -1.1174 TD [(pers)5.3(ed)-340.4(with)-334.7(the)-335.8(b)-.6(lo)5.1(ck)-340.4(cop)5.1(o)-.6(l)5(y)-.6(mer)-340.4(P)5.3(lur)5.2(o)-.6(n)5.1(i)-.7(c.)-342.8(It)-334.8(als)5.3(o)-340.4(demo)5.1(n-)]TJ 0 -1.1116 TD [(st)5(rated)-352(t)-.7(h)5.1(a)-1.8(t)-357.8(t)5(he)-358.9(cov)5.1(a)-1.8(l)5(e)-1.8(n)5.1(t)-357.8(ox)5.1(id)5.1(ati)5(o)-.6(n)-352(o)-.6(f)-357.7(g)5.1(rap)5.1(h)-.6(ene)-353.1(i)-.7(s)-357.5(a)-358.9(maj)5(o)-.6(r)]TJ T* .0124 Tc [(co)5.5(nt)5.4(ri)5.4(but)5.4(or)-253.6(t)5.4(o)-253.6(it)5.4(s)-253.4(p)-.2(u)5.5(l)-.3(mon)5.5(a)-1.4(r)5.6(y)-253.6(to)5.5(xi)5.4(cit)5.4(y)-253.6(and)-253.6(s)5.7(ugg)5.5(es)5.7(ted)-253.6(t)-.3(h)5.5(a)-1.4(t)-253.8(t)5.4(he)]TJ T* [(di)5.4(sp)5.5(ers)5.7(i)-.3(o)5.5(n)-357.3(of)-351.5(pr)5.6(ist)5.4(i)-.3(n)5.5(e)-358.5(gr)5.6(ap)5.5(hene)-358.5(i)5.4(n)-357.3(t)5.4(h)-.2(e)-352.7(P)-.1(lu)5.5(ro)5.5(nic)-352.7(p)-.2(r)5.6(o)-.2(v)5.5(i)-.3(des)-357.1(a)]TJ 0 -1.1174 TD .0113 Tc [(path)4.4(way)-496.6(f)-1.3(o)4.4(r)-496.6(th)4.4(e)-497.8(s)-1.1(afe)-492.1(h)-1.3(andl)4.3(in)4.4(g)-496.6(a)-2.5(n)4.4(d)-496.6(p)4.4(o)-1.3(tent)4.3(ial)-496.8(b)-1.3(i)4.3(o)-1.3(med)4.4(i)-1.4(cal)]TJ 0 -1.1116 TD .0132 Tc [(ap)6.3(pl)6.2(ic)5.2(at)6.2(ion)-396.8(o)6.3(f)-396.8(2).6(D)-397.7(c)5.2(arb)6.3(o).6(n)-396.8(n)6.3(an)6.3(om)5.1(at)6.2(eri)6.2(a)-.6(l)6.2(s).8(.)]TJ 7.3823 0 0 6.5614 230.2299 302.1165 Tm .0145 Tc (68)Tj 9.843 0 0 9.843 241.7952 297.7511 Tm .0087 Tc [(As)-401.1(for)]TJ /F4 1 Tf 3.1218 0 TD .0138 Tc [(i)6.8(n)-396.2(vi)6.8(vo)]TJ /F3 1 Tf -21.3858 -1.1116 TD .0118 Tc [(st)4.8(ud)4.9(ies)-363.5(o)-.8(n)-363.7(t)-.9(h)4.9(e)-370.6(b)4.9(i)-.9(ocompati)4.8(bi)4.8(lit)4.8(y)-369.4(i)4.8(n)-369.4(o)4.9(ther)-369.4(l)4.8(i)-.9(v)4.9(i)-.9(ng)-363.7(or)5(gani)4.8(sms)5.1(,)]TJ 0 -1.1174 TD .0126 Tc [(Go)5.7(ll)5.6(av)5.7(ell)5.6(i)-397.6(an)5.7(d)-397.4(L)-1.2(i)5.6(n)0(g)-397.4(s).2(h)5.7(o)0(wed)-397.4(t)5.6(hat)-397.6(m)4.5(ul)5.6(ti)5.6(-fu)5.7(ncti)5.6(on)-397.4(g)5.7(r)0(ap)5.7(hene)]TJ 0 -1.1116 TD 0 Tc [(\(c)19.7(oa)19.7(te)13.8(d)-266(w)0(i)19.8(t)0(h)-261.5(p)0(o)20.8(l)0(y)20.7(a)0(c)18.5(r)0(y)20.9(l)0(i)14.8(c)-267.2(ac)18.5(id)-261.5(an)19.7(d)-266()0(u)15.2(o)0(r)20.9(e)0(s)19.9(c)0(e)18.5(i)0(n)-261.5(o)0(-)20.9(m)0(e)18.4(t)0(h)20.7(a)0(c)18.5(r)0(y)20.9(l)0(a)13.8(t)0(e)19.5(\))]TJ T* [(was)-437.1(biocompatible)-434.3(with)-431.8(zebrash)-438.1(and)-430.7(did)-435.4(not)-429.7(induce)-435.3(any)]TJ 0 -1.1174 TD [(signicant)-543.3(abnormalities.)]TJ 7.3823 0 0 6.5614 164.7496 247.3511 Tm (69)Tj 9.843 0 0 9.843 177.4488 242.929 Tm (Yan)Tj /F4 1 Tf 2.206 0 TD [(et)-539.1(al.)]TJ /F3 1 Tf 2.8395 0 TD [(found)-535.4(that)-541.5(an)-539(in-)]TJ -16.7723 -1.1116 TD [(travitreal)-349(injection)-346.8(of)-342(GO)-349.5(into)-344.5(rabbits)-344(eyes)-346.4(did)-343.3(not)-343.3(lead)-346.7(to)]TJ T* [(gross)-702(changes)-702.2(in)-699.3(the)-701.5(eyeballs)-704.6(appearance,)-701(intraocular)]TJ 0 -1.1174 TD [(pressure,)-613.1(electroretinogram,)-617.1(or)-612.7(on)-607(histological)-615(examina-)]TJ 0 -1.1116 TD (tion.)Tj 7.3823 0 0 6.5614 79.8803 203.4708 Tm (70)Tj 9.843 0 0 9.843 91.3889 199.1054 Tm [(Among)-416.6(the)]TJ /F4 1 Tf 5.057 0 TD [(in)-417(vivo)]TJ /F3 1 Tf 3.2946 0 TD [(studies,)-415.4(only)-419.2(one)-419.2(study)-414.4(has)-419(re-)]TJ -11.3351 -1.1116 TD [(ported)-370.7(possible)-366.9(long-term)-369.6(toxicology)-363.9(of)-365(graphene)-369.4(in)-370.9(living)]TJ T* [(systems.)-335.6(It)-330.6(is)-330.4(reported)-339.5(that)-328.4(PEGylated)-337(nanographene)-340.4(sheets)]TJ 0 -1.1174 TD [(did)-452.7(not)-452.7(cause)-458.1(appreciable)-461.7(toxicity)-454(to)-457.3(treated)-454.9(mice)-457.3(over)-454.8(a)]TJ 0 -1.1116 TD [(period)-439.8(of)-439.9(3)-444.6(months,)-437.4(as)-440.9(evidenced)-446.7(by)-439.9(blood)-437.6(biochemistry,)]TJ T* [(hematological)-660.1(analysis,)-659.5(and)-655.3(histological)-661.1(examinations.)]TJ 7.3823 0 0 6.5614 293.7259 148.7055 Tm (71)Tj 9.843 0 0 9.843 62.022 133.3417 Tm (The)Tj /F4 1 Tf 1.9007 0 TD [(in)-336.4(vivo)]TJ /F3 1 Tf 3.1333 0 TD [(effect)-338.5(of)-342(graphene)-340.6(and)-338.5(its)-337.4(derivatives)-338.3(might)-341.1(be)]TJ -5.034 -1.1116 TD [(related)-742.9(to)-733.8(their)-738.4(method)-734.9(of)-739.4(synthesis,)-734.2(physicochemical)]TJ T* [(properties,)-408.4(concentration,)-408.7(time)-404.5(of)-405.3(exposure,)-406(administration)]TJ 0 -1.1174 TD [(route,)-407.6(and)-401.9(choice)-407.6(of)-405.3(animals)-408.7(used.)-400.5(Most)-408.4(studies)-406.2(report)-405.3(no)]TJ 0 -1.1116 TD [(occurrence)-604.3(of)-601.2(adult)-600.2(animal)-597.9(death.)]TJ 7.3823 0 0 6.5614 207.8362 93.8834 Tm (67,68,70,71)Tj 9.843 0 0 9.843 248.8251 89.5181 Tm [(Most)-604.3(of)-595.4(the)]TJ -18.9782 -1.1116 TD [(available)-285.7(literature)-291.4(considers)-282.7(graphene)-288.7(and)-280.9(its)-285.6(derivatives)-286.5(to)]TJ 0 -1.1174 TD [(be)-423.8(hemocompatible.)]TJ 7.3823 0 0 6.5614 143.8866 72 Tm [(71,7)-8.6(2)]TJ 9.843 0 0 9.843 164.6929 67.5779 Tm [(However,)-424.1(several)-425.8(report)-7.8(s)-421.4(showed)]TJ -10.4308 -1.1116 TD [(an)-343.2(inammato)-9(ry)-342(reaction.)]TJ 7.3823 0 0 6.5614 165.7133 61.0016 Tm (67,68)Tj 9.843 0 0 9.843 185.7259 56.6362 Tm [(In)-347.7(summary,)-348.6(the)-344.4(literature)-349(is)]TJ 12.9363 67.9184 TD [(still)-512.7(limited)-511.7(and)-511.3(not)-510.3(sufcient)-519(to)-509.2(reach)-510.1(any)-511.3(conclusions.)]TJ 0 -1.1174 TD [(Further)-337.1(investigations)-340.6(are)-333.9(needed)-338.4(for)-331.5(conrmation.)]TJ 1.0137 -1.1116 TD [(It)-445.8(should)-438.5(be)-446.9(mentioned)-440(that)-443.6(most)-443.3(of)-445.7(the)-442.3(available)-446.9(data)]TJ -1.0137 -1.1116 TD [(with)-322.3(regard)-319.9(to)-319.1(the)-315.6(toxicity)-321.5(and)-315.5(biocompatbility)-326.1(of)-319(graphene)]TJ T* [(and)-453.7(its)-458.4(derivatives)-453.5(were)-456.8(obtained)-454.9(from)-454.8(studies)-452.2(on)-451.5(its)-452.6(po-)]TJ 0 -1.1174 TD [(tential)-373.4(use)-367.1(as)-366(a)-370.9(vehicle)-368.6(in)-370.9(drug)-367.2(delivery.)]TJ 7.3823 0 0 6.5614 478.1479 674.7021 Tm (57,58,67,71,73)Tj 9.843 0 0 9.843 526.11 670.3369 Tm [(In)-370.8(this)]TJ -21.645 -1.1116 TD [(case,)-287.6(graphene)-283(and)-280.9(its)-279.8(derivatives)-280.7(are)-282.1(normally)-282.1(systemically)]TJ T* (administered,)Tj 7.3823 0 0 6.5614 366.633 652.8187 Tm (67,71)Tj 9.843 0 0 9.843 386.7589 648.4534 Tm [(or)-359.3(directly)-362.8(administered)-363.7(to)-359.4(organs)-358.9(of)-353.5(an-)]TJ -7.4876 -1.1174 TD [(imals)-8(.)]TJ 7.3823 0 0 6.5614 336.9826 641.877 Tm (68,70)Tj 9.843 0 0 9.843 358.8094 637.455 Tm [(Thus,)-527.2(their)-531(biological)-532.2(reactions)-531.8(may)-529.8(be)-527.5(more)]TJ -4.6481 -1.1116 TD [(obvious)-405.1(and)-407.6(direct.)-404.3(By)-400.7(contrast,)-406.3(when)-403.9(they)-403.1(are)-408.8(applied)-402(as)]TJ T* [(scaffold)-540.9(materials)-533.2(in)-532.2(bone)-535.5(tissue)-537.5(engineering,)-531.9(G)-537.6(and)-528.6(its)]TJ 0 -1.1174 TD [(derivatives)-309.5(will)-310.9(be)-302.9(more)-306.3(locally)-304.2(sequestered)]TJ /F4 1 Tf 18.2237 0 TD [(in)-307.6(situ)]TJ /F3 1 Tf 2.5343 0 TD [(,)-302.9(and)-309.7(the)]TJ -20.758 -1.1116 TD [(inammati)-9.2(on)-342(or)-347.8(toxic)-346.7(reaction)-346.6(may)-345.5(be)-343.2(quite)-346.7(different)-352.2(from)]TJ T* [(systemic)-306(administration.)-310.8(However,)-303.2(little)-307.9(is)-301.6(known)-300.1(about)-306.3(the)]TJ T* [(inammati)-9.2(on)-388.1(or)-388.1(toxic)-387.1(reaction)-392.7(of)-388.1(graphene)-392.4(and)-384.6(its)-389.3(deriva-)]TJ 0 -1.1174 TD [(tives)-294.7(when)-294.4(they)-299.4(are)-293.6(used)-293.4(as)-291.2(scaffolds)-299.9(in)-290.3(constructing)-297.9(tissue-)]TJ 0 -1.1116 TD [(engineered)-275(bones,)-263.3(because)]TJ /F4 1 Tf 10.9665 0 TD [(in)-261.5(vivo)]TJ /F3 1 Tf 2.9835 0 TD [(bone)-264.8(regenerative)-272.7(models)]TJ -13.95 -1.1116 TD [(of)-336.2(graphene)-334.8(or)-336.2(its)-331.7(derivatives)-338.3(have)-335(not)-337.5(been)-335(available.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 313.0582 516.9258 Tm [(The)-338.2(Effects)-333.7(of)-330.2(Graphene)-337.4(on)-333.8(the)-328.3(Surface)-335.8(Modication)]TJ 0 -1.2203 TD [(of)-336.6(Implant)-334.9(or)-335.1(Scaffold)-335.6(Materials)]TJ /F3 1 Tf 9.843 0 0 9.843 323.0361 489.5432 Tm [(Graphene,)-408.2(as)-400.6(a)-399.7(2D,)-403.9(single-atom-thick)-404(nanomaterial,)-408.8(can)]TJ -1.0137 -1.1174 TD [(be)-383.5(coated)-378.8(on)-376.6(implants)-380(or)-376.5(scaffold)-379.6(materials.)-386.9(The)-374.3(graphene)]TJ 0 -1.1116 TD [(coat)-427.3(will)-420.4(enhance)-421.3(biocompatibility,)-423(mechanical,)-430.7(and)-419.2(other)]TJ T* [(properties.)-587(Graphene)-583.4(has)-586(a)-578.2(great)-583.9(potential)-583(as)-584.9(a)-578.2(surface)]TJ T* [(modicatio)-9(n)-329.4(material)-336.4(for)-337.3(implants)-333.9(and)-332.8(scaffolds.)]TJ /F10 1 Tf 8.9663 0 0 8.9663 313.0582 423.7794 Tm [(Graphene)-335.2(coatings)-333.4(for)-338.9(enhanced)-327.6(hemo-)]TJ 0 -1.2203 TD [(and)-335.7(biocompatibility)-335.3(of)-336.7(nitinol)-336.5(stents)]TJ /F3 1 Tf 9.843 0 0 9.843 323.0361 396.3968 Tm [(The)-449.2(novel)-450.3(material)-457.4(nitinol)-446(\(NiTi\))-452.4(is)-451.4(often)-450.3(used)-448.9(in)-451.6(bio-)]TJ -1.0137 -1.1174 TD [(medical)-404.4(implant)-396.4(manufacturing)-399.4(due)-396.1(to)-394(its)-400.8(superior)-395.7(proper-)]TJ 0 -1.1116 TD (ties.)Tj 7.3823 0 0 6.5614 329.2723 378.8219 Tm [(74,7)-8.6(5)]TJ 9.843 0 0 9.843 348.4345 374.4566 Tm [(However,)-262.9(its)-256.8(metal)-257(nature)-256.7(results)-262.1(in)-255.8(metal)-257(leaching,)]TJ -3.5941 -1.1116 TD [(lack)-254.5(of)-244.1(cell)-248.9(adhesion,)-250.7(and)-246.4(proliferatio)-10.2(n)-243(and)-252.1(thrombosis)-248.2(when)]TJ 0 -1.1174 TD [(in)-359.4(contact)-357(with)-351.1(owing)-358.8(blood,)-354.7(which)-353.3(limits)-359.5(its)-354.7(application.)]TJ 0 -1.1116 TD [(An)-337.1(ideal)-336.4(surface)-333.5(coating)-338.6(is)-336.2(expected)-336.1(to)-330.6(have)-335(high)-332.8(adhesion)]TJ T* [(strength,)-526.1(be)-521.7(chemically)-529.9(inert,)-522.9(and)-522.8(show)-523.5(hemo-)-526.2(and)-522.8(bio-)]TJ T* [(compatibil)-9.3(ity.)-611.8(Previously,)-620.3(numerous)-621.5(materials,)-623(including)]TJ 0 -1.1174 TD [(diamond-like)-385.8(carbon)-383.3(\(DLC\),)-380.6(SiC,)-382.1(TiN,)-377.6(and)-378.8(many)-381.2(polymer)]TJ 0 -1.1116 TD [(materials,)-525.1(have)-513.6(been)-519.3(tested,)-519.3(but)-516.1(found)-518.1(wanting.)]TJ 7.3823 0 0 6.5614 514.9983 302.1165 Tm (7678)Tj 9.843 0 0 9.843 538.5259 297.7511 Tm (For)Tj -22.9064 -1.1116 TD [(exam)-8(ple,)-330.6(DLC)-334.7(coatings)-339.5(show)-333.4(reduced)-333.7(wear,)-339.3(corrosion,)-336.9(and)]TJ 0 -1.1174 TD [(debris)-347.5(formation.)-338.5(DLC)-346.2(coatings)-339.5(also)-339.6(reduced)-345.2(thrombogeni-)]TJ 0 -1.1116 TD [(city)-386(by)-382.3(minimizing)-383.8(platelet)-387.2(adhesion)-385.5(and)-384.6(activation.)-387.1(How-)]TJ T* [(ever,)-407.6(some)-398.3(contradictory)-409.8(results)-400.4(were)-405(reported,)-406.3(suggesting)]TJ 0 -1.1174 TD [(that)-391.7(no)-388.1(signicant)-387.8(improvement)-391.5(could)-386.9(be)-389.3(observed.)-388.7(In)-388.1(ad-)]TJ 0 -1.1116 TD [(dition,)-471.2(instability)-468.9(of)-468.7(the)-465.4(DLC)-467.2(coating)-471.1(caused)-470.7(by)-463(its)-469.9(high)]TJ T* [(level)-353.7(of)-347.7(residual)-351(stress)-352.9(and)-350(poor)-344.2(adhesion)-356.7(in)-347.9(aqueous)-349.7(envi-)]TJ 0 -1.1174 TD [(ronments)-241.5(should)-231.2(be)-233.7(carefully)-238.2(consid)-7.7(ered.)]TJ 7.3823 0 0 6.5614 474.9731 214.4692 Tm (76)Tj 9.843 0 0 9.843 484.6676 210.0472 Tm (Podila)Tj /F4 1 Tf 2.7992 0 TD [(et)-233.9(al.)]TJ /F3 1 Tf 2.229 0 TD (used)Tj -22.4629 -1.1116 TD [(graphene-coated)-259.7(NiTi)-254.4(\(Gr-NiTi\))-254.9(as)-250.8(a)-255.7(scaffold)-252.9(and)-252.1(found)-253.1(that)]TJ T* [(graphene)-340.6(met)-334.1(all)-338.8(the)-332.9(earlier)-339.7(criteria.)-338.6(Gr-NiTi)-339.2(supported)-333.5(ex-)]TJ T* [(celle)-9.3(nt)-336.4(smooth)-347.6(muscle)-344.2(and)-344.3(endothelial)-344.4(cell)-346.8(growth,)-339.3(leading)]TJ 0 -1.1174 TD [(to)-290.3(better)-285.6(cell)-289.2(proliferation.)-291.2(They)-289(also)-287.7(showed)-284.9(that)-288(the)-286.8(serum)]TJ 0 -1.1116 TD [(albumin)-332.9(adsorption)-323.2(on)-330.5(Gr-NiTi)-327.6(was)-327.7(higher)-324.7(than)-328.2(brinogen,)]TJ T* [(an)-573.6(impor)-6.8(tant)-570.3(and)-574.7(well-known)-578.6(criterion)-571.3(for)-573.5(promoting)-575.8(a)]TJ 0 -1.1174 TD [(lower)-387.8(thrombosis)-380.7(rate.)-384.6(In)-382.3(addition,)-382.4(spectroscopic)-387.4(measure-)]TJ 0 -1.1116 TD [(ments)-428.3(conrmed)-426.9(the)-425.1(lack)-427.3(of)-422.6(charge)-430.5(transfer)-425.7(between)-432.7(gra-)]TJ T* [(phene)-549.3(and)-545.9(brinogen,)-544.3(suggesting)-547.7(that)-547.2(graphene)-547.9(coatings)]TJ 0 -1.1174 TD [(inhibited)-270.8(platelet)-272(activation)-268.4(on)-267.1(the)-269.5(surface)-270.1(of)-267.1(the)-269.5(implants.)]TJ 7.3823 0 0 6.5614 544.8187 104.8819 Tm (79)Tj 9.843 0 0 9.843 313.0582 89.5181 Tm [(These)-296.8(hemo-)-290.1(and)-286.7(biocompatible)-296(properties,)-287.5(along)-294.8(with)-287.8(their)]TJ 0 -1.1116 TD [(high)-465.3(strength,)-468.5(chemical)-470(inertness,)-470.5(and)-465.2(durability,)-465.4(indicate)]TJ 0 -1.1174 TD [(that)-437.8(graphene)-438.5(is)-434.1(an)-435.3(ideal)-440.1(coating)-436.5(for)-435.2(biomedical)-436.6(implants)]TJ 0 -1.1116 TD [(and)-338.5(devices.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (484)Tj 49.6032 0 TD [(GU)-334.7(ET)-338.7(AL.)]TJ ET endstream endobj 115 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 117 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 118 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 116 0 obj <>stream /GS1 gs BT /F10 1 Tf 8.9663 0 0 8.9663 59.7543 725.7825 Tm 0 0 0 1 k 0 Tc 0 Tw [(Graphene)-335.2(coatings)-333.4(for)-332.5(improving)-337.4(CNTs)]TJ 0 -1.2203 TD [(resistance)-335(to)-336.7(fatigue)]TJ /F3 1 Tf 9.843 0 0 9.843 69.7323 698.3998 Tm [(CNTs)-652.4(are)-650.7(another)-655.2(kind)-649.6(of)-647.3(carbon)-654(nanomaterial)-658.8(that)]TJ -1.0137 -1.1174 TD [(combine)-368.5(elasticity,)-364(mechanical)-363.9(resilience,)-370.6(and)-361.6(low)-361.4(density,)]TJ 0 -1.1116 TD [(and)-695.6(they)-691.1(have)-692.1(been)-692.1(exploited)-692.3(as)-688.6(scaffold)-696.4(materials.)]TJ 7.3823 0 0 6.5614 291.4582 680.825 Tm (80)Tj 9.843 0 0 9.843 59.7543 665.5179 Tm [(However,)-464.4(all)-454(CNT-based)-464.4(materials)-464.1(explored)-454.7(to)-457.3(date)-461.9(have)]TJ 0 -1.1174 TD [(undergone)-484.5(structural)-491.5(collapse)-484.7(or)-480.2(signicant)-485.7(plastic)-488.3(defor-)]TJ 0 -1.1116 TD [(mation,)-508(with)-500.9(a)-503.4(reduction)-502(in)-503.4(compressive)-506.1(strength,)-503(which)]TJ T* [(limits)-941.2(their)-934.2(applications.)]TJ 7.3823 0 0 6.5614 169.1149 637.0014 Tm (8183)Tj 9.843 0 0 9.843 196.8377 632.636 Tm (Kim)Tj /F4 1 Tf 2.7128 0 TD [(et)-936.6(al.)]TJ /F3 1 Tf 3.6344 0 TD (fabricated)Tj -20.2742 -1.1116 TD [(graphene-coated)-513.2(CNTs)-502.6(and)-499.8(found)-500.8(that)-506.9(they)-501(exhibited)-502.2(no)]TJ 0 -1.1174 TD [(change)-528.5(in)-526.5(mechanical)-530.9(properties)-531.7(after)-526.3(more)-525.1(than)-524.1(1)]TJ /F8 1 Tf 22.1979 0 TD ()Tj /F3 1 Tf .72 0 TD (10)Tj 7.3823 0 0 6.5614 295.1999 615.0613 Tm (6)Tj 9.843 0 0 9.843 59.7543 599.7542 Tm [(compressive)-650.1(cycles,)-647(and)-643.8(their)-646.2(original)-649.7(shape)-647(recovered)]TJ 0 -1.1116 TD [(quickly)-239.5(after)-244(compression)-240(release.)-246.1(Moreover,)-240(the)-235(coating)-240.7(did)]TJ 0 -1.1174 TD [(not)-458.4(affect)-459.4(the)-459.6(structural)-457(integrity)-460.8(of)-457.2(the)-453.8(nanotubes)-461.4(or)-451.4(the)]TJ 0 -1.1116 TD [(compressibility)-371.6(and)-361.6(porosity)-365.9(of)-365(the)-361.7(nanotube)-362.6(network.)-370.4(The)]TJ T* [(coating)-436.5(also)-437.5(increased)-434.9(Youngs)-434.6(modulus)-435.1(and)-436.4(energy)-435.1(stor-)]TJ 0 -1.1174 TD (age.)Tj 7.3823 0 0 6.5614 75.9685 549.3542 Tm (84)Tj 9.843 0 0 9.843 89.348 544.9321 Tm [(The)-616.2(application)-609.4(of)-612.7(graphene)-611.3(coating)-615.1(to)-607.1(improve)]TJ -3.0066 -1.1116 TD [(CNTs)-457.6(properties)-451.1(will)-454.9(make)-451.5(these)-451.3(materials)-458.3(attractive)-453.9(for)]TJ T* [(articial)-330.5(muscles)-327.8(and)-321.2(scaffolds)-328.7(for)-320(bone)-322.3(tissue)-324.4(engineering)-10.1(.)]TJ /F10 1 Tf 8.9663 0 0 8.9663 59.7543 501.1085 Tm [(Reinforcement)-340.1(effects)-328.3(of)-336.7(graphene)-330.2(materials)]TJ 0 -1.2203 TD [(on)-337.6(polymer)-329.6(polyprophlenefumarate)]TJ /F3 1 Tf 9.843 0 0 9.843 69.7323 473.7259 Tm [(Po)21(l)16.1(y)0(p)20.8(r)0(o)26.6(p)0(h)20.8(l)0(e)25.3(n)0(e)19.7(f)0(u)26.6(m)0(a)18.4(r)16.2(at)19.5(e)-226.9(\()16.2(PP)21.2(F\))21(,)-222.3(a)0(n)-210.7(i)0(n)20.7(j)16.1(ec)18.5(ta)25.3(bl)20.7(e,)-213(cr)25.5(os)21(s-)21.1(l)16.1(i)0(n)20.7(k)0(a)25.4(b)0(l)20.7(e)15(,)]TJ -1.0137 -1.1116 TD [(and)-459.5(biodegradable)-462.7(polymer,)-462.9(has)-459.3(been)-461.7(widely)-458.2(investigated)]TJ 0 -1.1174 TD [(for)-389.1(applications)-397.2(in)-388.2(bone)-391.5(tissue)-393.5(engineering)-390.2(as)-389.1(the)-390.5(polymer)]TJ 0 -1.1116 TD [(matrix.)-415.8(A)-410.9(major)-411.2(motivation)-417.1(behind)-411.1(these)-410.9(studies)-411.9(is)-411.1(to)-411.3(en-)]TJ T* [(hance)-734.7(the)-730.3(mechanical)-732.5(properties)-733.3(of)-727.9(the)-730.3(biodegradable)]TJ 0 -1.1174 TD [(polymer)-430.7(for)-423.7(improved)-426(structural)-428.2(integrity)-432(when)-426.9(implanted)]TJ 0 -1.1116 TD [(under)-432.9(load-bearing)-437.4(conditions.)]TJ 7.3823 0 0 6.5614 184.1952 412.3275 Tm (85)Tj 9.843 0 0 9.843 195.8173 407.9621 Tm (Lalwani)Tj /F4 1 Tf 3.7265 0 TD [(et)-429.7(al.)]TJ /F3 1 Tf 2.6207 0 TD (reinforced)Tj -20.1705 -1.1116 TD [(PPF)-509.7(using)-506.5(various)-504.1(2D)-509.9(nanostructures:)-509.5(single-)-510(and)-505.6(multi-)]TJ 0 -1.1174 TD [(walled)-436.3(GO)-435.9(nanoribbons,)-431.3(and)-436.4(GO)-430.2(nanoplatelets.)-437.4(Compres-)]TJ 0 -1.1116 TD [(sion)-303.8(and)-304(exural)-309.5(testing)-302.8(showed)-308(signicant)-307.1(enhancement)-307.3(in)]TJ T* [(the)-402(mechanical)-404.2(properties)-405(of)-393.8(the)-402(2D-reinforced)-404.6(PPF)-400.2(nano-)]TJ T* [(composites,)-536.3(which)-531.8(were)-537.5(better)-533.3(when)-530.6(compared)-537.6(with)-529.7(1D)]TJ 0 -1.1174 TD [(nanostructures)-450.7(\(single-)-442(or)-445.7(multi-walled)-444.5(CNTs\).)-449.6(The)-443.4(result)]TJ 0 -1.1116 TD [(also)-397.2(indicated)-393.9(that)-391.7(the)-390.5(extent)-395.1(of)-393.8(mechanical)-392.7(reinforcement)]TJ T* [(was)-535(closely)-534.2(dependent)-531.9(on)-532.1(the)-534.5(nanostructure)-536.2(morphology)]TJ 0 -1.1174 TD [(and)-661.1(followed)-667.7(the)-655.4(trend)-663.4(of)-658.8(nanoplatelets)]TJ /F8 1 Tf 17.9069 0 TD (>)Tj /F3 1 Tf .72 0 TD (nanoribbons)Tj /F8 1 Tf 5.1146 0 TD (>)Tj /F3 1 Tf -23.7415 -1.1116 TD [(nanotubes.)-390(The)-391.6(study)-385.6(demonstrated)-392.4(that)-386(harnessing)-393.2(the)-384.7(re-)]TJ T* [(inforcing)-512.4(potential)-508.1(of)-509(2D)-509.9(nanostructures)-514.1(could)-507.9(lead)-507.9(to)-509.2(a)]TJ 0 -1.1174 TD [(whole)-301.4(new)-304.8(class)-301.3(of)-295.9(ultrastrong,)-304.8(lightweight)-302.8(biomaterials)-300.5(for)]TJ 0 -1.1116 TD [(tissue)-335.9(engineering)-338.4(applications.)]TJ 7.3823 0 0 6.5614 185.7259 269.8582 Tm (86)Tj /F5 1 Tf 8.9663 0 0 8.9663 59.7543 242.8724 Tm [(The)-338.2(Effects)-333.7(of)-336.6(Graphene)-331.1(on)-333.8(the)-334.6(Adhesion,)]TJ 0 -1.2203 TD [(Proliferation,)-340.6(and)-331.9(Differentiation)-337.3(of)-336.6(MSCs)]TJ /F3 1 Tf 9.843 0 0 9.843 69.7323 215.4897 Tm [(As)-342.7(a)-342.1(possible)-343.9(surface)-345(modication)-344.2(material)-342.2(in)-342.1(bone)-339.6(sub-)]TJ -1.0137 -1.1116 TD [(stitutes,)-514.6(the)-505.7(effects)-512.2(of)-509(graphene)-513.4(on)-503.3(MSCs)-512.8(or)-509(osteoblasts)]TJ 0 -1.1174 TD [(\(osteogenic)-9.9(ally)-253.5(differentiated)-256.6(MSCs\))-260.5(have)-254.4(been)-254.4(investigated)]TJ 0 -1.1116 TD [(\(Table)-338.5(1\).)]TJ /F10 1 Tf 8.9663 0 0 8.9663 59.7543 160.6676 Tm [(The)-337(adhesion)-332.8(of)-336.7(MSCs)-330.7(on)-331.3(graphene)]TJ /F3 1 Tf 9.843 0 0 9.843 69.7323 144.2267 Tm [(Adhesion)-304.5(is)-301.6(a)-301.8(crucial)-299.4(prerequisite)-310.6(to)-296.1(many)-306.3(cell)-300.7(functions,)]TJ -1.0137 -1.1116 TD [(such)-425.8(as)-429.4(proliferation,)-423.7(synthesis)-431.2(of)-422.6(proteins,)-428.1(and)-424.9(formation)]TJ T* [(of)-503.3(mineral)-501.1(deposits.)-502.9(Kalbacova)]TJ /F4 1 Tf 13.7311 0 TD [(et)-498.8(al.)]TJ /F3 1 Tf 2.7589 0 TD [(reported)-506.5(that)-501.2(bone)]TJ -16.49 -1.1116 TD [(marrow-derived)-458.8(MSCs)-449.5(\(BMMSCs\))-455.8(cultured)-449.1(on)-451.5(SiO)]TJ 7.3823 0 0 6.5614 273.8267 109.7575 Tm (2)Tj 9.843 0 0 9.843 281.9338 111.4016 Tm (sub-)Tj -22.5723 -1.1174 TD [(strates)-459.1(formed)-458.2(focal)-457.2(adhesions)-455.5(\(FAs\))-455.2(that)-455.1(were)-462.6(large)-451.4(and)]TJ 0 -1.1116 TD [(homogenous)-7.5(ly)-284.6(distributed)-295.8(on)-290.2(the)-292.6(cell)-289.2(periphery,)-292.2(resulting)-293.5(in)]TJ T* [(a)-359.4(state)-359.2(of)-353.5(quiescence.)-365.8(By)-354.6(contrast,)-360.2(the)-355.9(FAs)-360.9(in)-353.7(contact)-362.8(with)]TJ 0 -1.1174 TD [(CVD)-397.7(grown)-392.2(graphene)-398.2(lms)-397.1(are)-391.5(smaller,)-394.9(weaker,)-400.3(and)-396.1(con-)]TJ 0 -1.1116 TD [(centrated)-377.7(on)-365.1(the)-367.5(protruding)-374.1(ends)-368.2(of)-365(the)-373.2(cells,)-368.4(which)-370.5(corre-)]TJ 25.5097 67.9242 TD [(sponds)-288.4(to)-290.3(an)-285.6(active)-292.6(state)-295.9(of)-284.4(the)-292.6(cells.)]TJ 7.3823 0 0 6.5614 457.7385 729.5242 Tm (51)Tj 9.843 0 0 9.843 467.9999 725.1588 Tm [(However,)-291.7(Kim)]TJ /F4 1 Tf 6.2781 0 TD [(et)-285.7(al.)]TJ /F3 1 Tf -22.244 -1.1174 TD [(found)-356.8(that)-357.2(adipose-derived)-361(stem)-358.1(cells)-353.5(\(ASCs\),)-362.9(with)-356.9(similar)]TJ 0 -1.1116 TD [(characteristics)-616.8(to)-612.9(BMMSCs,)-618.3(showed)-613.2(increased)-619.2(adhesion)]TJ T* [(when)-386.6(grown)-386.5(on)-382.3(GO)-384.1(lms,)-389(indicated)-388.2(by)-382.3(a)-382.4(large)-388.1(number)-389.1(of)]TJ T* [(FAs)-458.8(and)-459.5(a)-463(higher)-457.1(correlation)-465.2(between)-467.2(the)-459.6(orientations)-465.1(of)]TJ 0 -1.1174 TD [(actin)-503.4(laments)-507.6(and)-505.6(vinculin)-499.9(bands)-507.6(compared)-503.1(with)-506.6(ASCs)]TJ 0 -1.1116 TD [(grown)-472.9(on)-468.7(glass)-478.7(substrates.)]TJ 7.3823 0 0 6.5614 420.7747 663.7605 Tm (6)Tj 9.843 0 0 9.843 429.1086 659.3951 Tm [(In)-468.7(addition,)-474.6(Some)]TJ /F4 1 Tf 8.0693 0 TD [(et)-475.8(al.)]TJ /F3 1 Tf 2.7071 0 TD (dis-)Tj -22.7912 -1.1116 TD [(covered)-483.5(that)-478.1(ASCs)-478.3(attached)-486(at)-481.6(higher)-480.2(levels)-481.3(to)-480.4(graphene)]TJ 0 -1.1174 TD [(derivative-poly)-515.8(\(L-lysine\))-514.4(\(PLL\))-514.5(composite-coate)-12.2(d)-507.9(cover-)]TJ 0 -1.1116 TD [(slips)-523.7(compared)-531.9(with)-523.9(coverslips)-525.8(coated)-528.6(with)-529.7(only)-522.9(GO)-528.1(or)]TJ T* (PLL.)Tj 7.3823 0 0 6.5614 330.8031 619.9368 Tm (87)Tj 9.843 0 0 9.843 342.0849 615.5715 Tm [(In)-388.1(another)-390.3(study)-391.3(by)-388.1(Kim)-391.4(and)-390.4(his)-394.9(colleagues,)-393.6(rGO-)]TJ -3.1736 -1.1174 TD [(chitosan)-587.2(substrata)-593.8(were)-589.3(fabricated)-591.8(after)-589.6(spin)-591.8(coating)-592(of)]TJ 0 -1.1116 TD [(rGO-chitosan)-495.3(composites)-498.3(on)-491.8(bare)-496.3(glass.)-493.7(They)-490.6(found)-495(that)]TJ T* [(rGO-chitosan)-374.4(substrata,)-372.6(regardless)-377(of)-365(the)-373.2(incorporated)-374(gra-)]TJ T* [(phene)-468.6(concentration,)-472(provided)-465.1(a)-468.8(suitable)-472.1(environment)-470.9(for)]TJ 0 -1.1174 TD -.0273 Tc [(hM)-6.3(SC)-259.8(ad)-5.4(he)-6.5(si)-5.5(on)-5.4(:)-258.9(h).4(MS)-5.2(Cs)-258.6(o)-5.4(n)-253(t)-5.5(h).4(e)-259.9(r)-5.3(GO)-6.2(-ch)-5.4(i).3(t)-5.5(o).4(s)-5.2(a)-.8(n)-258.8(s)-5.2(ub)-5.4(st)-5.5(ra)-6.5(ta)-259.9(s)-5.2(h).4(o)-5.4(w)-.5(ed)]TJ 0 -1.1116 TD 0 Tc [(a)-359.4(large)-359.3(number)-360.3(of)-359.3(FAs)-360.9(and)-361.6(enhanced)-359(expression)-358.6(of)-359.3(the)-361.7(in-)]TJ T* (tegrin)Tj /F9 1 Tf 2.7128 0 TD (b)Tj /F3 1 Tf 7.3823 0 0 6.5614 342.992 537.2219 Tm (1)Tj 9.843 0 0 9.843 346.6771 538.866 Tm (.)Tj 7.3823 0 0 6.5614 349.1149 543.2313 Tm (10)Tj 9.843 0 0 9.843 360.2267 538.866 Tm [(Other)-376.3(studies)-371.6(have)-381.1(reported)-368.3(that)-380.2(osteoblast)9.7(s)-381(o)0(r)]TJ -5.0167 -1.1174 TD [(preosteobl)9.7(asts,)-596.2(when)-588.2(cultured)-593.1(on)-589.7(chitosan-GO)-592.2(scaffolds,)]TJ 0 -1.1116 TD [(Nylon)-346.3(6,6-GO)-350.5(hybrid,)-350(and)-350(few-layer)-348.4(reduced)-351(graphene)-346.3(ox-)]TJ T* [(ide)-332.9(lms)-328(\(FRGO\),)-329.4(showed)-331(better)-331.7(cell)-329.5(adhesion.)]TJ 7.3823 0 0 6.5614 501.562 509.329 Tm (79,53)Tj 9.843 0 0 9.843 320.8251 494.9857 Tm [(Therefore,)-305.9(there)-307.4(is)-301.6(still)-305.3(some)-306.1(controversy)-308.1(in)-307.6(terms)-307.3(of)-301.7(cell)]TJ -1.0137 -1.1116 TD [(adhesion)-327.9(morphology)-323.4(when)-329(MSCs)-328.5(are)-328.1(in)-324.9(contact)-328.2(with)-322.3(G)-330.3(o)0(r)]TJ T* [(GO.)-445.1(The)-443.4(inconsistency)-449.8(may)-443.4(be)-441.1(accounted)-446.7(for)-446.7(by)-445.7(the)-442.3(dif-)]TJ 0 -1.1174 TD [(ference)-530.7(in)-526.5(cell)-531.1(types,)-528.4(the)-528.7(graphene)-530.6(derivatives,)-531.8(the)-528.7(sub-)]TJ 0 -1.1116 TD [(strates,)-335.8(and)-332.8(the)-332.9(manufactur)-10(ing)-331.7(methods)-332.6(of)-336.2(G)-330.3(o)0(r)-336.2(GO.)]TJ /F10 1 Tf 8.9663 0 0 8.9663 310.8472 423.7794 Tm [(The)-330.6(proliferation)-338.6(of)-330.4(MSCs)-337(on)-331.3(graphene)]TJ /F3 1 Tf 9.843 0 0 9.843 320.8251 407.3385 Tm [(After)-491.4(incubation)-497.5(for)-492.8(48)-169.2(h,)-494.1(Kalbacova)]TJ /F4 1 Tf 16.1905 0 TD [(et)-498.8(al.)]TJ /F3 1 Tf 2.7474 0 TD [(found)-495(that)]TJ -19.9516 -1.1116 TD [(BMMSCs)-269.3(homogenously)-274.7(covered)-270.4(the)-269.5(CVD)-271(grown)-271.3(graphene)]TJ 0 -1.1174 TD [(lm)-298.2(in)-296.1(a)-301.8(conuent)-299.1(layer,)-299.3(but)-297.2(formed)-302.7(separate)-301.3(islands)-302.5(on)-295.9(the)]TJ 0 -1.1116 TD (SiO)Tj 7.3823 0 0 6.5614 326.0975 372.8125 Tm (2)Tj 9.843 0 0 9.843 332.1637 374.4566 Tm [(substrate.)-245.9(Cell)-248.8(counting)-240.6(conrmed)-248.3(that)-242(more)-242.9(cells)-244(were)]TJ -2.1656 -1.1116 TD [(present)-332.5(on)-336.3(the)-332.9(CVD-grown)-336.1(graphene)-340.6(lm)-332.8(than)-334(on)-330.5(the)-338.7(SiO)]TJ 7.3823 0 0 6.5614 546.2361 361.8708 Tm (2)Tj 9.843 0 0 9.843 310.8472 352.5164 Tm (substrate.)Tj 7.3823 0 0 6.5614 348.3778 356.9385 Tm (51)Tj 9.843 0 0 9.843 358.4125 352.5164 Tm [(Likewise,)-275.9(Lee)]TJ /F4 1 Tf 5.9843 0 TD [(et)-274.2(al.)]TJ /F3 1 Tf 2.3039 0 TD [(reported)-276.1(a)-273(higher)-272.8(density)-273.9(of)]TJ -13.1206 -1.1116 TD [(cells)-342(on)-336.3(CVD-grown)-341.8(graphene)-340.6(and)-338.5(GO)-343.8(substrates)-341.3(than)-339.8(that)]TJ T* [(on)-463(a)-463(polydimethylsilxane)-469.7(\(PDMS\))-468.8(substrate.)]TJ 7.3823 0 0 6.5614 494.8156 334.9983 Tm (5)Tj 9.843 0 0 9.843 503.0928 330.633 Tm (Meanwhile,)Tj -19.5312 -1.1116 TD (Nayak)Tj /F4 1 Tf 3.1851 0 TD [(et)-573.7(al.)]TJ /F3 1 Tf 2.9029 0 TD [(studied)-573.4(the)-574.8(inuence)-576.7(of)-566.6(graphene)-576.7(on)-572.4(cell)]TJ -6.088 -1.1174 TD [(growth)-554.8(using)-552.6(four)-557.3(substrates)-554.4(with)-552.7(variable)-559.7(stiffness)-557.9(and)]TJ 0 -1.1116 TD [(surface)-368(roughness,)-371.2(and)-367.3(discovered)-371.5(that,)-372.1(independent)-367.2(of)-370.8(the)]TJ T* [(substrate)-271.3(\(PDMS,)-275.3(polyethylene)-276.3([PET],)-270.3(glass)-271.4(slide,)-275.1(or)-267.1(silicon)]TJ 0 -1.1174 TD [(wafer\),)-381.8(there)-376.5(was)-379.5(no)-376.6(signicant)-382(difference)-384.3(in)-376.7(cell)-381.4(viability)]TJ 0 -1.1116 TD [(between)-334.7(graphene-coated)-340.4(and)-338.5(uncoated)-335(substrates.)]TJ 7.3823 0 0 6.5614 513.4676 269.2346 Tm (4)Tj 9.843 0 0 9.843 320.8251 253.9275 Tm (Tang)Tj /F4 1 Tf 2.5861 0 TD [(et)-521.9(al.)]TJ /F3 1 Tf 2.805 0 TD [(explored)-529.6(cross-linked)-528(GO)-522.3(lms)-529.5(as)-521.5(a)-526.4(bio-)]TJ -6.4048 -1.1174 TD [(compatible)-292.6(scaffold)-287.5(for)-291.2(MSCs)-288.2(and)-292.4(found)-287.7(that)-288(GO)-291.9(lms)-287.6(also)]TJ 0 -1.1116 TD [(facilitated)-265(the)-258(growth)-255.2(of)-261.4(BMMSCs.)]TJ 7.3823 0 0 6.5614 451.1054 236.3527 Tm (12)Tj 9.843 0 0 9.843 461.0266 231.9873 Tm [(For)-262.3(ASCs,)-257.1(Some)]TJ /F4 1 Tf 7.0153 0 TD [(et)-256.9(al.)]TJ /F3 1 Tf -22.2728 -1.1116 TD [(reported)-604.5(that)-599.1(a)-601.3(graphene)-605.5(derivative-PLL)-603.2(composite)-606.8(had)]TJ 0 -1.1174 TD [(more)-340.8(than)-339.8(double)-342(the)-338.7(ability)-343.5(to)-342.1(proliferate)-344.2(ASCs)-340(compared)]TJ 0 -1.1116 TD [(with)-356.9(PLL)-362.6(alone,)-362.7(indicating)-359.4(that)-357.2(these)-364.9(materials)-360.4(are)-362.7(not)-360.5(cy-)]TJ T* [(totoxic)-406.7(for)-406.4(the)-402(cells.)]TJ 7.3823 0 0 6.5614 394.4692 192.5291 Tm (87)Tj 9.843 0 0 9.843 405.8645 188.1637 Tm [(In)-405.3(addition,)-405.5(the)-407.8(GO)-407.1(lm)-401.9(and)-407.6(rGO-)]TJ -9.6533 -1.1116 TD [(chitosan)-281.9(substrata)-282.8(\(5%\))-276.1(proved)-278.5(to)-278.8(be)-279.8(a)-278.7(suitable)-282(environment)]TJ 0 -1.1174 TD [(for)-297(the)-298.3(time-dependent)-303.9(viability)-299.7(of)-295.9(ASCs)-299.7(and)-298.2(BMMSCs.)]TJ 7.3823 0 0 6.5614 536.9951 170.5889 Tm (6,10)Tj 9.843 0 0 9.843 320.8251 155.2818 Tm [(In)-710.6(addition,)-710.7(the)-713(proliferation)-714(of)-710.6(osteoblasts)-716.9(or)-710.6(pre-)]TJ -1.0137 -1.1116 TD [(osteoblasts)-480.8(on)-480.3(graphene-related)-485.5(materials,)-484.8(including)-478(rGO,)]TJ 0 -1.1174 TD [(GO)19.1(/g)20.7(ra)19.7(ph)20.8(en)13.9(e-)19.7(hy)20.8(dr)20.9(ox)20.8(ya)13.9(pa)19.7(ti)20.6(te)19.6(,)-435.4(c)0(h)19.7(i)0(t)14.8(o)0(s)21(a)0(n)19.7(-)0(g)20.9(r)0(a)19.7(p)0(h)15.1(e)0(n)19.7(e)-434.2(ox)20.8(id)14.9(e)-434.2(\()0(C)19.8(S)0(-)]TJ 0 -1.1116 TD [(GO)19.1(\),)-315.5(an)19.7(d)-323.6(N)0(y)20(l)0(o)20.7(n)-323.6(6,)18.5(6-)20.9(GO)19.1(,)-320.2(w)0(a)13(s)-323.4(en)19.7(ha)19.7(nc)19.7(ed)19.7(.)]TJ 7.3823 0 0 6.5614 470.2109 126.7653 Tm [(7)16.2()0(9)24.7(,)0(5)20.4(3)16.2(,5)20.4(4)]TJ 9.843 0 0 9.843 320.8251 111.4582 Tm [(However,)-320.5(Kim)]TJ /F4 1 Tf 6.3357 0 TD [(et)-320.3(al.)]TJ /F3 1 Tf 2.4018 0 TD [(evaluated)-325.9(the)-321.4(cytotoxicity)-321.5(of)-319(GO)-326.5(in)]TJ -9.7512 -1.1174 TD [(ASCs)-593.4(and)-597.7(found)-593(that)-593.3(a)-595.5(moderate)-595.4(concentration)-601.1(of)-595.4(GO)]TJ 0 -1.1116 TD (\()Tj /F8 1 Tf .3974 0 TD (<)Tj /F3 1 Tf .72 0 TD [(0.1)-166.9(mg/mL\))-384.8(resulted)-385.6(in)-382.5(good)-384.5(ASCs)-386.1(viability,)-389.5(but)-383.6(a)-382.4(high)]TJ -1.1174 -1.1116 TD [(concentration)-635.6(of)-635.7(GO)-631.7(showed)-636.3(some)-640.2(cytotoxicity)-632.5(toward)]TJ 0 -1.1174 TD (ASCs.)Tj 7.3823 0 0 6.5614 336.1889 72 Tm (6)Tj 9.843 0 0 9.843 343.0487 67.5779 Tm [(Similarly,)-332.8(Wang)]TJ /F4 1 Tf 7.0441 0 TD [(et)-326(al.)]TJ /F3 1 Tf 2.4133 0 TD [(demonstrated)-329(that)-328.4(GO)-326.5(could)]TJ -12.7289 -1.1116 TD [(induce)-285.5(signicant)-284.1(cytotoxicity)-286.9(of)-284.4(human)-290.1(broblast)-281.7(cells)-290.1(at)-285.7(a)]TJ /F5 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(GRAPHENES)-338.3(POTENTIALS)-339(IN)-335.1(DEVELOPING)-335(NEW)-337.3(IMPLANT)-336.1(OR)-334.7(SCAFFOLD)-336.2(MATERIALS)-10282.8(485)]TJ ET endstream endobj 119 0 obj <>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/XObject<>/Font<>>>/Thumb 123 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 124 0 obj <>/ProcSet[/PDF/Text/ImageC]/XObject<>/Font<>>> endobj 120 0 obj <>stream /GS1 gs BT /F3 1 Tf 9.843 0 0 9.843 62.022 412.781 Tm 0 0 0 1 k 0 Tc 0 Tw [(concentration)-474.4(above)-474.4(50)-163.5(mg/L.)]TJ 7.3823 0 0 6.5614 184.0818 417.1464 Tm (88)Tj 9.843 0 0 9.843 196.1007 412.781 Tm [(In)-468.7(another)-470.9(study)-472(by)-468.7(Kim)]TJ /F4 1 Tf -13.6217 -1.1174 TD [(et)-418.2(al.,)]TJ /F3 1 Tf 2.8395 0 TD [(the)-413.5(proliferation)-420.2(rate)-415.8(of)-416.9(hMSCs)-416(decreased)-418.7(with)-414.5(the)]TJ -2.8395 -1.1116 TD [(incorporation)-581.4(of)-572.4(higher)-572.3(amounts)-580.3(of)-572.4(rGO)-575.2(into)-574.9(the)-574.8(rGO-)]TJ T* [(chitosan)-264.6(substrata.)]TJ 7.3823 0 0 6.5614 135.0425 384.2645 Tm (10)Tj 9.843 0 0 9.843 144.9637 379.8991 Tm [(On)-262.3(the)-258(other)-260.2(hand,)-262.4(G)-255.4(and)-263.6(GO)-257.4(exhibited)]TJ -8.4264 -1.1116 TD (negligible)Tj /F4 1 Tf 4.4695 0 TD [(in)-451.6(vitro)]TJ /F3 1 Tf 3.5768 0 TD [(toxicity)-448.2(to)-451.6(BMMSCs,)-451.3(ASCs,)-452.9(or)-451.4(osteo-)]TJ -8.0463 -1.1174 TD [(blasts)-416.6(when)-409.6(they)-414.6(were)-416.5(used)-414.3(as)-412.1(coating)-413.5(materials,)-415.6(as)-412.1(men-)]TJ 0 -1.1116 TD [(tioned)-296(earlier.)-291.3(Thus,)-296.8(further)-291.1(systemic)-294.5(studies)-296.7(are)-293.6(required)-293.4(to)]TJ T* [(wholly)-491.6(understand)-497.1(the)-488.4(potential)-496.6(biological)-491.9(effects)-494.9(and)-494(to)]TJ 0 -1.1174 TD [(address)-424.3(concerns)-426.8(over)-420.2(health)-423.9(hazards)-425.7(before)-423.6(any)-419.2(practical)]TJ 0 -1.1116 TD (application.)Tj /F10 1 Tf 8.9663 0 0 8.9663 62.022 292.1952 Tm [(The)-337(differentiation)-335.3(of)-330.4(MSCs)-337(into)-331.8(osteogenic)-335.9(lineages)]TJ 0 -1.2203 TD [(on)-331.3(graphene)]TJ /F3 1 Tf 9.843 0 0 9.843 72 264.8125 Tm [(A)-313(study)-310.7(by)-313.2(Kim)]TJ /F4 1 Tf 6.9116 0 TD [(et)-314.5(al.)]TJ /F3 1 Tf 2.3845 0 TD [(showed)-313.7(that)-316.9(GO/graphene-CaCO)]TJ 7.3823 0 0 6.5614 295.5968 263.1685 Tm (3,)Tj 9.843 0 0 9.843 62.022 253.8708 Tm [(hybrid)-444.4(materials)-446.8(exhibited)-450.4(remarkably)-447.8(enhanced)-445.4(hydroxy-)]TJ 0 -1.1116 TD [(apatite)-328.4(formation)-329.3(when)-329(incubated)-324.7(in)-330.6(a)-324.8(simulated)-330.4(body)-321.2(uid)]TJ 0 -1.1174 TD [(solution)-579.2(compared)-578(with)-575.7(bare)-576.9(GO)-579.9(and)-574.7(graphene)-576.7(lms.)]TJ 7.3823 0 0 6.5614 293.7259 236.296 Tm (52)Tj 9.843 0 0 9.843 62.022 220.9889 Tm [(Later,)-444.5(other)-438.7(studies)-440.7(indicated)-440(that)-443.6(the)-436.6(formation)-444.5(of)-439.9(extra-)]TJ 0 -1.1116 TD [(cellular)-421.6(matrix)-418.2(of)-416.9(osteoblasts)-423.2(or)-411.1(preosteobla)-9.9(sts)-417.7(on)-411.1(CS-GO)]TJ 0 -1.1174 TD [(and)-332.8(FRGO)-335.3(was)-339.2(signicantly)-338.3(enhanced.)]TJ 7.3823 0 0 6.5614 219.4015 203.4141 Tm (79)Tj 9.843 0 0 9.843 72 188.107 Tm [(In)-336.2(addition,)-336.3(positive)-338.5(results)-337(for)-337.3(the)-338.7(osteogenic)-337.1(differenti-)]TJ -1.0137 -1.1116 TD [(ation)-266.1(of)-261.4(MSCs)-265.2(on)-261.4(graphene)-265.7(have)-265.9(been)-260.2(obtained.)]TJ 7.3823 0 0 6.5614 252.4535 181.5307 Tm [(46,)-8.6(12)]TJ 9.843 0 0 9.843 275.4141 177.1653 Tm (Nayak)Tj /F4 1 Tf -21.6795 -1.1174 TD [(et)-539.1(al.)]TJ /F3 1 Tf 2.8395 0 TD [(cultured)-541.3(BMMSCs)-540(in)-538(osteogenic)-544.5(medium)-540.3(without)]TJ -2.8395 -1.1116 TD [(bone)-299.3(morphogenetic)-307.3(protein-2)-305(\(BMP-2\),)-300.8(which)-301.4(did)-302.9(not)-297.2(lead)]TJ T* [(to)-324.9(osteogenic)-331.4(differentiation)-331.6(over)-328.1(the)-321.4(whole)-330.2(duration)-327(of)-324.7(the)]TJ T* [(experiment)-252.1(\(15)-250.9(days\).)-246(Howev)-8.4(er,)-248.7(once)-248.6(the)-246.5(substrates)-254.9(\(PDMS,)]TJ 0 -1.1174 TD [(PET,)-291.2(glass)-288.6(slide,)-286.6(and)-286.7(silicon)-291.3(wafer\))-291.9(were)-289.8(coated)-286.7(with)-287.8(CVD-)]TJ 0 -1.1116 TD [(grown)-380.7(graphene,)-384.3(BMMSCs)-378.8(successfully)-385(differentiated)-383.4(into)]TJ T* [(osteoblasts,)-472.7(which)-468.4(was)-471.7(conrmed)-473(by)-468.7(quantitative)-472.4(alizarin)]TJ 0 -1.1174 TD [(red)-430.6(staining.)-434.1(Interestingly,)-435(both)-430.8(BMP-2-treated)-434.5(and)-430.7(CVD-)]TJ 0 -1.1116 TD [(grown)-403.8(graphene-coated)-403.7(substrates)-404.6(induced)-401.8(cell)-404.4(differentia-)]TJ T* [(tion)-373.3(at)-377.9(the)-373.2(same)-376.4(rate,)-378.9(suggesting)-374.9(that)-374.4(graphene)-375.1(might)-375.6(be)-377.7(a)]TJ 0 -1.1174 TD [(driving)-267.1(force)-272.7(of)-267.1(bone)-264.8(cell)-271.9(formation.)]TJ 7.3823 0 0 6.5614 207.1558 61.0016 Tm (4)Tj 9.843 0 0 9.843 213.4488 56.5795 Tm [(In)-267.1(another)-269.3(study,)-268.1(after)]TJ 10.1198 36.1882 TD [(12)-365.1(days)-368.2(of)-359.3(osteogenic)-371.7(induction,)-360.5(there)-370.8(was)-362.2(a)-365.1(sevenfold)-363.5(in-)]TJ 0 -1.1174 TD [(crease)-327.8(in)-319.1(the)-315.6(extent)-326(of)-319(mineralization)-321.4(in)-319.1(BMMSCs)-321.2(cultured)]TJ 0 -1.1116 TD [(on)-347.8(CVD-grown)-353.3(graphene)-352.1(compared)-353.3(with)-351.1(those)-346.4(on)-347.8(PDMS.)]TJ 7.3823 0 0 6.5614 548.5038 395.2062 Tm (5)Tj 9.843 0 0 9.843 313.0582 379.8991 Tm (Tang)Tj /F4 1 Tf 2.4191 0 TD [(et)-360.6(al.)]TJ /F3 1 Tf 2.4709 0 TD [(reported)-362.5(spontaneous)-359.8(osteogenic)-360.2(differentiation)]TJ -4.89 -1.1116 TD [(of)-313.2(MSCs)-311.3(on)-313.2(a)-307.5(cross-linked)-314.9(GO)-315(lm,)-313.2(without)-308.5(the)-315.6(use)-309.5(of)-313.2(any)]TJ 0 -1.1174 TD [(chem)-8(ical)-237.4(inducers.)-239.1(Furthermore,)-237.9(the)-235(extent)-239.6(of)-238.3(mineralization)]TJ 0 -1.1116 TD [(increased)-314(with)-305(an)-308.6(increase)-307.1(in)-307.6(the)-304.1(roughness)-310.2(of)-301.7(the)-309.9(GO)-303.4(lm.)]TJ T* [(Thus,)-285.3(the)-281.1(GO)-286.2(lm)-281(may)-282.2(represent)-284(a)-284.5(chemical-free)-287.6(method)-279.8(of)]TJ 0 -1.1174 TD [(inducing)-499.8(osteoblastic)-506.4(differentiation.)]TJ 7.3823 0 0 6.5614 463.181 329.4991 Tm (12)Tj 9.843 0 0 9.843 475.4266 325.0771 Tm [(The)-501(enhanced)-503(dif-)]TJ -16.4958 -1.1116 TD [(ferentiatio)-10.3(n)-559.8(o)0(f)-566.6(ASCs,)-562.3(including)-570.2(osteogenesis)-569.3(and)-563.2(adipo-)]TJ T* [(genesis,)-433.7(on)-428.4(GO)-430.2(lm)-425(has)-430.5(also)-431.7(been)-427.2(reported.)]TJ 7.3823 0 0 6.5614 496.9699 307.559 Tm (6)Tj 9.843 0 0 9.843 504.9069 303.1936 Tm [(In)-428.4(addition,)]TJ -19.4908 -1.1174 TD [(Aliza)-9(rin)-389.3(Red)-391.4(S)-392.6(staining)-390.3(and)-396.1(western)-390.9(blot)-396.3(analysis)-391.2(by)-393.9(Kim)]TJ /F4 1 Tf 0 -1.1116 TD [(et)-285.7(al.)]TJ /F3 1 Tf 2.3269 0 TD [(showed)-279.2(up-regulation)-287.7(of)-278.6(the)-286.8(osteogenic)-285.3(differentiation)]TJ -2.3269 -1.1116 TD [(of)-313.2(hMSCs)-312.4(in)-307.6(the)-309.9(rGO-chitosan)-316.8(substrata)-311.6(compared)-318.8(with)-310.8(the)]TJ T* [(chitos)-7.8(an)-268.3(substrata)-271.3(and)-269.4(tissue)-266.8(culture)-275.2(polystyrene,)-271.3(in)-267.3(both)-269.5(the)]TJ 0 -1.1174 TD [(proliferativ)-10.2(e)-244.2(and)-246.4(osteogenic)-250.7(induction)-247.6(media.)]TJ 7.3823 0 0 6.5614 492.1511 252.7369 Tm (10)Tj 9.843 0 0 9.843 501.9589 248.3716 Tm [(These)-250.7(recent)]TJ -19.1913 -1.1116 TD [(invest)-7.8(igations)-614.9(indicate)-623.2(an)-619.6(active)-620.9(or)-618.5(potential)-623.3(pro-osteo-)]TJ T* [(differentiation)-343.1(capability)-337.6(of)-330.5(G)-336(o)0(r)-330.5(GO.)]TJ /F10 1 Tf 8.9663 0 0 8.9663 313.0582 204.548 Tm [(Cell)-336.3(behavior)-336.8(of)-330.4(MSCs)-337(on)-331.3(3D)-336(graphene)]TJ /F3 1 Tf 9.843 0 0 9.843 323.0361 188.107 Tm [(All)-424.9(the)-425(reports)-429.2(mentioned)-422.7(earlier)-431.8(investigated)-426(stem)-427.2(cell)]TJ -1.0137 -1.1116 TD [(behav)-7.8(ior)-366.3(on)-370.8(2D)-371.7(graphene)-375.1(sheets.)-375(Crowder)]TJ /F4 1 Tf 17.8321 0 TD [(et)-372.1(al.)]TJ /F3 1 Tf 2.5055 0 TD (employed)Tj -20.3375 -1.1174 TD [(3D)-584.8(graphene)-588.2(foams)-583.6(\(3D)-585.9(GFs\))-586.6(as)-584.9(culture)-586.2(substrates)-583.2(for)]TJ 0 -1.1116 TD [(BMMSCs)-263.6(for)-256.7(the)-252.3(rst)-257.6(time.)-258.2(GFs)-257.2(were)-261(fabricated)-257.8(by)-255.6(growing)]TJ T* [(graphene)-415.5(on)-405.4(3D)-406.2(nickel)-412.4(scaffolds,)-412.8(and)-407.6(the)-407.8(nickel)-406.6(was)-414.1(sub-)]TJ T* [(sequently)-432.8(removed)-431.7(by)-422.7(FeCl)]TJ 7.3823 0 0 6.5614 427.1243 131.6976 Tm (3)Tj 9.843 0 0 9.843 435.0046 133.3417 Tm [(etching.)-428.4(GFs)-430(were)-428(shown)-426.6(to)]TJ -12.3891 -1.1174 TD [(maintain)-496.6(BMMSCs)-499.7(viability)-489.8(and)-494(to)-491.9(stimulate)-497.6(changes)-494.8(in)]TJ 0 -1.1116 TD [(morphology.)-378.6(When)-382.2(cultured)-374.2(on)-376.6(GFs)-378.2(for)-377.6(7)-375.5(days,)-377.4(BMMSCs)]TJ T* [(exhibited)-387(spindle-shaped,)-379.3(elongated)-382.3(morphology)-381(with)-379.9(thin,)]TJ 0 -1.1174 TD [(aligned)-355.9(nuclei)-349(and)-350(strongly)-354.4(expressed)-352.8(both)-350.1(osteocalcin)-356.8(and)]TJ 0 -1.1116 TD [(osteop)-7.7(ontin,)-395.1(indicating)-394(spontaneous)-400.1(osteogenic)-400.5(differentia-)]TJ T* [(tion)-269.6(of)-267.1(BMMSCs)-263.6(without)-268.2(the)-269.5(need)-265.9(for)-268.2(extrinsic)-265.8(biochemical)]TJ 0 -1.1174 TD [(manipulati)-9.3(on.)]TJ 7.3823 0 0 6.5614 367.7668 61.0016 Tm (11)Tj ET q 1 i 191.622 732.019 m 552.189 732.019 l 552.189 460.063 l 191.622 460.063 l W n q 360.926 0 0 271.956 191.622 460.063 cm /Im1 Do Q Q BT /F6 1 Tf 9.845 0 0 9.845 62.022 649.6439 Tm [(FIG.)-302.2(1.)]TJ /F3 1 Tf 4.0828 0 TD [(Schematic)-308.6(diagram)]TJ -4.0828 -1.0135 TD [(depicting)-334.3(the)-338.3(possible)-331.6(mech-)]TJ T* [(anisms)-336.3(of)-336(the)-332.6(biological)]TJ T* [(effects)-338.7(of)-330.2(graphenes)-340.5(on)]TJ 0 -1.0077 TD [(mesenchymal)-340.4(stem)-334.5(cells)-335.7(or)]TJ 0 -1.0135 TD [(osteoblastic)-338.2(cells)]TJ /F4 1 Tf 7.25 0 TD [(in)-336.2(vitro)]TJ /F3 1 Tf 3.0117 0 TD (.)Tj -10.2617 -1.0135 TD [(?)-272.8(Means)-272.8(inconclusive)-274.9(results.)]TJ 0 -1.0077 TD [(Arrow,)-338.2(promotion;)-334.1(bar,)-330(inhi-)]TJ 0 -1.0135 TD [(bition.)-332.3(G,)-333.4(graphene;)-340.8(Dex,)]TJ T* (dexamethasone;)Tj /F9 1 Tf 6.8008 0 TD (b)Tj /F3 1 Tf .5528 0 TD (-GP,)Tj /F9 1 Tf -7.3537 -1.0135 TD (b)Tj /F3 1 Tf .5528 0 TD [(-glycerophosphate.)-336(Color)]TJ -.5528 -1.0077 TD [(images)-337.7(available)-336.6(online)-335.7(at)]TJ 0 -1.0135 TD (www.liebertpub.com/teb)Tj /F5 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (486)Tj 49.6032 0 TD [(GU)-334.7(ET)-338.7(AL.)]TJ ET endstream endobj 121 0 obj <>stream Adobed       7  s!1AQa"q2B#R3b$r%C4Scs5D'6Tdt& EFVU(eufv7GWgw8HXhx)9IYiy*:JZjzm!1AQa"q2#BRbr3$4CS%cs5DT &6E'dtU7()󄔤euFVfvGWgw8HXhx9IYiy*:JZjz?$*99mIdc)SLGs 9O|7?I37f?ӏ|پ??ӏ|پqO34%vo 8gxݛw?N?^7f?ӏ|پ??Ӄ>K[}'pgxݛ듎-=Q>Hvd9/ȃ0v?$f]vlUٱWf]vlUٱWf]v#=*O? 79 N1X`s.Qw!VNt ^oEVsYG#G7}]j?_,>k7m .D?`'}]luR^ՆOǚn]YF G&0č䥿d ?B';vXZI0xc|Iw//fB?2bJ?o7r' Yx"BR??V+0!3#"ٱWf]vlUٱWf]vlUOs},H+GlP$RIdcǵmؗ7?Y>!voVoiL|1ܾ!voVoi L|1ܾ!voVoi L|1ܾ!voVoiL|1ܾ!voVoiL|1ܾ!voVoi L|1ܾ!voVoi L|1ܾ!voVoi L|1ܾ!voVoiL|1ܾ!voVoi L|1ܾ!voVoi L|1ܾ!vZ\Sq7NR(Qv+פ%>v^NCyUoy]VREӥq?$K! 6zO T|kαr}jKtk =,V}wͧ_2ZUm#pK=HBjv^"Z~|@vLO\ƙռ'[zo5(^G4'QIFj)P{ t,+m{GP4+q-4X5 2k={(f2,0%X%JicHM/^Tni+,qK[iyf1 FeP?Bp5i7+NZ"3-dfPʜ.EkǶ@@UJgy鼷mq@fXZX~ ES|ߜZՎZ|{glwWR V٣nیa"4W^M\׭.EH.ld ,w,걲ԬzFkMkLl/M*P vta6?V6%{WG.5 ~}GMl5Q෷.B`w-iviL:4m5{{K֬+꒴кO VuF F),KZt-S.y%\ıL iL4W]#2}ثb͊6*ثb͊6*F p9}voNb<`svy/n*!$٤Gq[LjXԜrv)Sݚ۳WjknS5N6PUe=Ab+kk!*?gČrJ<,rvQw*!sj6>s/pv;6͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثbZPkcdZ` f*Q9tq,x S,ScJܱvjJƕٹcJܱvSqqFһ˞?﷫/d%QڌRǥ1觡UXr!`cb͊6*ثbzbȬRĎlqG=κs{=?97m,j:t]qgx"Ƙe ww{ai}^2ጅ #0UZ}]"/| r;K&P*ҏơ"8n%uiկO)b+,YLfF+sMwZTk+C;c(x|+Sq2>+..k닋[woAM" "l_-<)]JmcXиU\LĒĴ( ;Vv\JGFf$GɤdR0mMVŵWY#WuU`Ѹ$I~\yMX~J=бH.[tCqWi?JD~3B =7EsLl-Itti[2ڈeUw^sG7d7Rk\~n b7E=+ Q%zr]٩Mq$*[~Wy뙶ӄ%ߒO4*⌇FR4~mM[^[Zir*J0$S,4iߊTAtV[ʚFE%Y\^j(;ޒ8TNM@i~bFM{ j>ZZ@:jFi3)k,=%c?T[qYpk,*;"WxdG#o0}GsH9aVUHn 3:*Hk_Hӣ8[E7aeM=0z|4V6]*Iu%=K!b.\I?|7Z _>_g~ZJZ@PBĹ5ߕk]1׉*Z h5Q!n v4U@ԥ)?~JKJAroPpc1z4F+μ{dG#&y{qfGq EQcR3p{MMCohkRi-,xHdv%n I|4u>愹w|0]^ F,35=kZoCI}u<1p.mrީ^] nrR ׉25#zBi|.cwdezbd2*h07iW"5x 5^FPegS.q$W?~o c#GrC#) =Nie+QKbexFHAM)"$Zweeeq;IkFes#A]݉]yGengB6%zPҿ~F=9\?~֎|2Baޝ P*IS3m K_Baf9͊6*ثb͊6*sz6sSُ?ÛTt"#fzܭefPk٫WWf6\m]ڻ5qvjjTu*2;]Ym:rۺutW{}ّ9I}(IP:ªáop .͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثbHv]/-Rܔuo|_ ]K5 {Wc 8ĄkqœDa|?-$~]vƲ*VH꼑ըwyⵆ@<=Wv_ҵkWm̮7qtdj2;~_y[u=JW{Y"{ikiʰUHgIy#-j^Z86c0IhNc}kosq ެ" jlzW?ք7[Gp*G P16 'E{Z}j?͇;EKmYSGÛ⏩olk t}inV%Ң*KI؄`S*|rG6!hhweNThk˗ё?T]Mu0bЮt98fkVU*hO\?/k7ݶ)e_a4Q^Bo.\ՠ%uiuKkdhKk<|h06Mhi:EŌz62i_^I3_mcP>h(Nѵ}&x THeHX2!,$Q h,Z<- k:Nw}kkޏ"`QF̽;aĒǫ$zFcimuX]t&:|%61?_zcm.uKxUgKY̬ܝ#›ȰLM5&- բTOQ!H:;/-{I[}uqlWq5!>0<6WFo/M%i"\[[ `ȫ#G.=0&ͩY6rάmnѧH#h,oL f27) k}.qE&u(g% 9P[.F{__0km1=1dFn ~A>$xO@ba~$MMВTw1K]=g sG~<%:qeϽa> ښIFsG`q۳sǍmE4,y^[֚TEoˀy%b@Cy8pǎb=:o`ӒGm(!-éTi!!O6,A<)?Z%${[upK r+u(qm?YFqoJҬuk ̷F %*ﴕ4P>d"eKAd\g 5˭ kIkj;M~Gbio\'T^kjDMzs ;WQN(۳K FOK[^6dm؎ˋlǶ5c]-;_(!T}?A͖fd/~㳰.jS~]& n}23F_ic/vHcut;76@@mRytF1ssi>؜hDQ6;\m.\m]\m\m.ˮ6\m]ڻ5qvjj٫WWf6̱ccYb%YV2.8I:ªá6 ې .͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ኻ / [s̜xsɒf]vlUٱWf]vlUٱWf]vlUٱWemnͫPnMX'CeY1f9v?n"4P9=@Z*{og-ͯ1\̾`4rE*05beݿiz`i41V$Hs?`y:}L#;Nyb.6|,ʧ٫۳Wf۳rmٹbܱ[vnX7,Vݛ+n[vjܱ[vjܱ[vjv n9vܓ'~^W#Neqkms6ْE 9DIrGy^u;JQ*Dhf^^dNr;Xl ݒlvlUɦ+qQ Z )խrM^af/oE|2(voY+f/oE|2(voﹿY+f/oE|2(voﹿY+f/oE|2(va[WtG |2(v GI:ۆlxb͊6*ثbvj ٨<1Avj h+PxcA] WfƂ54٨0WeWf]vlULUTA]ψA_! Q5cL@v k9MįtxF:uFlr۱Zvvjjܱf6ݚ۳rݚڻ5qvnX۳WnX۳rݛ6٫*,mJ݂ۗ/62q╍͎͊6*ثb͊6*ثb͊6*ثb͊6*ثb/ՆȾ,vQ#Lg.nH'Wo=NgNaWf劻7,UٹbvnXr]*ܱWf劻7,UٹbvnXr]*+CهPF4:6%e :s_8sψ[NE Wf®}RSBvH(v s'vqsPvD<竍RtM*MZW- I=kL5KJ-2I6q,1&DW| ~ji}I'%RhVoEՠ 5-n?.M2{g-5t衶f& ͵)Zgm䋛K}vK]=upn1> Z)|Fͥ5\#g ȱqZVH0~iږ4@VbP@]\ H_i%!KJV9cd@>]YŬڽƞIxCXHM;Z)lOD6Rw+$v@^FPҥլLQc.,@ Cޟyg$ZDv d4PkZ'4(Sam*AqpQc_+Iచ(ˏ"+ t\FA vxl9rO2'Bl떣H3}X^s=o>.MwlY:/苟҂/NJ}o|jN,1h?4k j/ N|<~FQom<$RN_K4y VcCv#LvlUٱWf]vy/Û\N1VIYCOf0#԰*7io,+c*דE}^Zku#Pא돉.EY^Ek ܐHż$2cq1YC$:E$rQRzv.ENT%/$u,ƀbniڎx67qӣ/ a9$6$UgH)`?O,,>u?HKJ`h;6vcL#$"SQZvjS<605ıE$"nDPy*N:U洂_{(zf[x*N`RK 㳙-iHS|u֖7,w98Wsė;(([}3Pyml[s=6E 5+6WG x6KCHȥ$SFFGbiGԙF.μ?3/4V=?ruS9_xvh:hk+[pY9?e?y 6iKb6nִ9uF{lďFѕQ qٶ13%ʺm`eT$8Ak+;|_)M%iW;Ds,We@d|: YN.]y;hdӭo|c<2/l95!*O>e?}ݦi|2m.mӼhʚǮ4YI0Շ i& wV󆟫Gz'T*Z㣖ONc (߾F!4j-[Is2sm2B҇uAE8  旗4)Wp[|Zq8Oܓ o.ޙ=^E5['Mj̒Z |"BYbRiɥj6g.uql묐].L:]RQQ5F*>ruhnqCuz)3YHiKGUX`!0hwg}kynҤ?GCQ yc8Dv8$xl;^7`RUpjn^f6͊6*إٱChDgeoN'6`S\jF*vucXv>:y(={*ءٱWf]vlU؍cln?'yb%["\ØdDȊ`6Kb͊6*ثb͊6*ثb͊6*ثb͊1]C1I'~8V l:$7#.\i]һ5qvjJ]7q{y5t]_Q1:E)$Ϸ/TC1 $1_MLtcnoWIO(Ѳ_MАt8A(2$mwx<; {{Y Q0B+@Nُ$@ei ͽ$yJ4 >e6f:$Wʔ9B\hvoQᝤ+8lu}T..[g;# s֗v7) :YFy_u]$-Mskuuoodr])oX~R7WSA0bU4ٌveGQ:Mh]Ⱥ&y,"'?mk}IgOJ\j9n)?lE?XUk- ͻf6?y_]8Y!o5MY{kkbM${1"`tQ:_ƿ&ii {msuo4џmayHEpUןt #Kx`./-.[(G^[ +->)⾗F |CmLlw06ob +7mĬ鈜JTn< {;Y%mb(j죓.ew` npNլu+(lf_NUBTB) I^^鷲D`XEFTxW YjG9lC7nsvlUٱWf]wK$٩ך8ĹW.aci:mB{Q 䣐ax:v{Ac)[yGSUaZ'>h[O4vqO$v64R8PxvA2Jz-%ܰ%++ sq5}7N4J^^. =QAH3S4ݹ:}jR) FʢxxĒI=O\S5e~ ,Q,pmNI^<v!i~C]>_gf`4 w~Yٿu?48C]>_!Vv]CjI94e]Ҵoh>(V\W5u68\]CI, u`gnO,n<8~j_NS:Os!ܴk';W^')Q&\Vݚ5q[vjfԍ;=Y_gSܡgaX.}_\١xF8 35i޹43FE_Y#r"&^]hkSK=[. KUaeq C,c!;tv]WQޕGq$] #)^4v)Y p 2-,(dgOo}csB d#Pۊ2!7e{uա k*饓 ߧu0K&H񃸞䞝RIKZCS#Lp ,>lMhr-<~s9]WiJ㔇+6Ilr bwgP$TIk5q[vUq[vjmucq[v ўl 0c?͊ xonvlUٱWf]vlUٱWf]vlUٱWcUV Q[ٱW`}BSăF|iIvFU_}ٴX9;/4vnX۳rƖݛ4ܱf-(xl< i޶_%̶W`=7 sV;Σj(vcwOՋk5.[P5kkJ4=:qڣ4lnL XvF|ib+=E%%ȍN@j6:# j4#wrF G$U9š(Q8̷w,vnX۳rƖݛ4ܱf-5A؍AvH}M6ُ_L)3YTv8;dvE<584\$3g'뵻H; _|p?-j>cѠIW[A*E A?r&+g(ߓ(^^MRﴛg)e-$jr)mA{gk(/a6Wztw~Z*M"mƻecOѳʮ9-!kC_[8]̟8Oo.͡!d!>JXI1`9[ów6eGȭ[ɓ-5CqowZEƴ:l'ےFa_E̳:Sm4:˱(I"f^qqit/F}RYT064Q e5a䃘=vn7OmZ 2{veB)8+=:`-/Q沾+'PqLwy2zu{cG#{W?O mF(,AYhڅi*ޭ9/]sgKGPNoF~ Bm[Pj6O5='S׮ot!ӶP*߂)́n փ=_| $$>Q%ךxsr%"'5ٱWf]vlUO__fL{L݁淍ݛdcHW!9cFK%n 4ɀm/uşBҟT@>PqAQc^G B*PߵV'vC?εׅkLt݌tO+8}@oVJ ň_Ywb ӵoNɋ/'٘1+xqGܻ65ڻ5qvjj٫mrJ)E`~'o _?i:n-@f@wV982HJpuڞŇ!5?hhq'טO/wK]V,rx-?tKwK]V,rx-?tKwK]V,rx-?tKwK]V,rx-?tKwK]V,rx-?tKwK]V,rx-?tKwK]V,rx-?tKwK]V,rx-?tKwK]V,rx-?tKwK]V,rx-?tKwK]2Nԯb4B)OaN#Gݚ٫*늻5qWf*]ڏtHjoef_h<Ůx`? $>է`]H[q"^;40",)؝;Ǖm^9+H/4OxVtxb&",ܮ~~Ϙ2 ot{o@؇'!tŗ kKNU]\UU]\U٫5qWakGH٭a)nvlUTmu(SJ*22yea.!1ED|Qz$̯ϸ8yvo;Rc{˳/" {˳/"ϸ/c]q(O/c]q~}#wȤ{˳/"ϸ'._$C!^cE?}?p_G$666Vo|w$Ԝ”nd "(;ٱWf]vlURӚ+9ҡX]N9E^LbN[3_?~X7g?ڿ='Yk??j\7g#Osߢuc?{~ֿ?ڿ='Zk??j\7kGڿ=#Yc?{~|m#OcH kpq 0 $:+[K&L xքA6^U5|8Uӱ]._ת5eRiQ>8wœ];|Uٷ]qlO"BE}CpaVj:= 7V #!pf 11߫xaZ^eW٫٪qvmW`iΛ<G΄~|[Ot%IWdROFePm0ܼI8ZLxGrG;7}'Xk1ߡcEƇrG;7}'Xk1ߡcEDŽw/{~ܼI8ZLhw/{~ߡcEDŽw/{C__^dcXկӢNe**ܩLv>icCG4 Dquvh>Lt$$t\vv-8WW+C٘ӼuNuN[aǽ0dkmi۳rƖݛ4ܱf-ծj[gH fvO,#<[Mm:PnVq$џg!3 s۰~kWN%]ۤ=/eĸM"F ;Gi]C{'c%dOi]'dѢ+;$ fi`mJ[M:+wDTW D"H& ]Zkqg%)qEGI@HHW` ۳GlA n冑n[vnX۳rƖݛ4y|Oo^s.OaTث5耪(+Uk@NNE;~gRߤ5 W4? f!qBٿHjO/]S? f!?s\|1vo? f4? }PsN?~~!|bQq >SZ]-exǮU(i,vlUٱWf]vlUٱWf]b\UٱWf*]vlUٱWf]vcvzGINh!}sjjM?dK=s~$*`K||5cB~=;f˗`V3+Ҿ$lH;xHgqX; GEM3A/=$((zST}p#YK~4 8IuwB}Z T}bC$n'Gwv)wtiy=I&GNc}rB|s)"\n` >-/BZ' eO v]hyJUk得Ny EaŁA؎/8ef`#W %5Ie׎ޢ1PTHEr2I.bRH$^ Y׾| "sܜu9,rup KQ&I7&,w3d*{2:yQ:;$VrJR4ٴsۂx @4`0I'4zs×ԏ:7RS#)ƴ3_%flqӳok5q;5qv6IDh W+t2b1i~צaSGy9xE@`ٱWf]vlUٱWf]vlUٱWf]vlUٱWf]]E[K?0F!bؘ;\*Wvjȧ`Cg-14 x*t'.lSG#2j7|r۫;E^POCi$M'S^2x6lONe?/;Gd6c)o^}jS4#rE#+^<@ mgာc¾qvKimfk@JC EG$M?[˿7 Sg[WE#n đfcˬ#dFƟw{jvnQ#(P.y2ܸ55 SvMXMuk6XE ۵W&>Uwm#U-.o-oO)k+7&xTQ˟?e\:o9kƛZͨi~nL{C<2β,~j9qSI:={Mqyu14ݭF\@Wd år3o9MIԍ%z34ZUB>;KདྷY<v :Euhv*W$:?s8oK01ܗf]vq &nݘNTGio]|eٹ>4׌79/ӏ..o4Kx˳sr8^2ܿN>4׌79/ӏ..o4Kx˳sr8^2ܿN>4׌79/ӏ..o4Kx˳sr8^2b3Kx˰UTn_mNq m|,QT S),"7A 4rN9qZqH?k,>nuR PF@~5;3'ip l78VB2;;6*ث*iI|.dTV,cWb{F_lHe,(ym02< q>X.n&[X#_|e$$ryHQ#:qG5eX7|NrIª{݊MisAo[iO)2W$qĀ+)aVÓXӠNi_խ[z<5pק X4 ;*vAb:0ϏF(;gv63];d]@br|1=AKc(upM)Π^&qPRҴ-[0W{^mgIfW>$1;b1yѴUC BM!gi@^lKP䣎"se1 Eԗ"˭2c)xvupT**k9{^*ث2[XPrkW{y"P: Yxb͊6*ثb͊6*ثb͊6*ثb͊6*m g~p<8d]˩ٹcIvnX64:.cwsykH۱`EGm"2;Gd[K˖! ,ל21"-c]X3/P]&y]*&̞Wdy ރ|=S; {*_*v[;ײSuS@`\:2W-vk*yn {[K}@R]Z֥óT12}'mNɞUӣLw1ۚ^%_$3\WbO.ndEG#._Z#6֪6ʞ]]21llc @j' n3>/T[><.m+K 2\Wȴ˛z98c`v+g[)VDp `ޤ-D9a Hqm?aev*KrƕٹcHvnXһon%qEO$bv@= ,iA(Xfَbs_F6;/:=uTkK\Lfd$Ŷn-!6OH$'m/ՕɹSg5~řs+8 _jagy ;U5 iuV\XaQ.<`~YDiإ@@$D7(J  Z5o+3IU(HH8 Ylu+=Z$TmM֢cȼl N0TҼǨX]ir;ͮr.lD$~e"04^IM+F-4X;sP*:*8F03vgmcTՠ'$y/Q4=0G,dI,`xŜmjmE IȠo5jdKYg7r 5(S)eE+T@t}6 uZ 8Qd׵hz e6DZ擫_ͪ2Mioy+(F{sy?V6am%Ӣ€I44r+ #|y|OqrCLqJxГb :.& \79OLO_O<(U׵[nb0CO/S-b 21 2DJ;s0)$mw"W=~Sn$ey "sEOlOM4Cvihmy1*rȞ6, MG;gԌP.Cq8Dj[t6-4/aL8r۟ XFB a`yMƵ$}Eg-2;X% ֧rTXvv.[_.7).ϼn)+ثbK$٭8y"|ӭo0i .T$pא@{1dQy*]'AԖh-~[tFhZMęGLCGү{gC*^U$IƔvc G.wJRZ@dNwh-*f@fB^R"ҵ9.V6kw@F%WV2Y\iKf[@EMhpΞS,632Q7+ -|wsukk]sbiy Bi ۦ,<ƌ5sHJ/C|zeR>_Fuc -H1Μ~ڕs_jYv*$^l+]϶tϘM{KV Y')$U%~\gXB򪅂vdvN HU]O,شЯ9#.vߜ>Yo5hvvwVZ{{ȣ%h,EE|a M2H+|¾X֯m!M< V}5i< "}bffqz&OJ6va1n(y R*]&5+ċJf>OlMjS3) j[m;g pp˹ CP\Z[M^Gq]B T O#Z[&6bx:r_+MSHtgKetc QFv>8kc2E{~.H<4zDenԸ"l,G=G[8w=ohӏQw5(59kx9?4df4P:'?Fs͌CSZ͌hv38\^'f<+B\a"qMx5Wd';}VZn }y%Gv]PĭUP3ڝ U}"k0YEej--g"F/@ cf7c_G5Hm|k}5hܽSXTKPPgO[(ntQ݃5Й XW y)i{o)yb-Bk涼t5M8<ƢgH=J'1F`}3CWvIk˝CEu[(H&*+#z/D`7I8+R垗mw{%Ɩmu+]?ZM#HV(G"pm&4]q^IxldW 6qO7N;Dqz/OM )[a,RP^[oG!K%Q}[M-n%Sc D\LbCVU`md9oʓ;;$;ҵ "{x"xTZqe/R+,ˬkjW0ZKa \Y gtѐ < \@{y'(h?^xyKMԥQ4IƒJ'N+V6 82m7ens:m@p戾&1N6]B]j帙ck %#t򁤅IwFOY $fcms Er;b䢊znAiibaY7*In#UXƭ|)o9i%Vooçz^rC#C,-*(lp23c#Z%ƥu}N9]nwY JQK->'F,ŌB!݇V[GnPIܱ'|@:9b6N͊6*ثb͊6*ثb͊6*ثb͊6*ثbM sBHJqEvA-Z9?eq2ÆTerַf*]WvlUٱWf*]Wvj\U٫5qWf*tQMq_h$Z$]7ؿ#7v/r"]wZ'Iot(.b$ޞ6qGj`{O!ivliv$<+0Y>nEҪs*@$ڐHx?eJVMb_-c!eSʻWv-UR̾`I}-F4+JSSV#=*ZWK6i!շ,T`y?6  gKpx< jveJNL9sqY8޼s UY/9y-J]N-^5 G5șú/Ec]0HI hTG 1"(UKX>^{yYb31bORN+-_?#j]lyka1Ӯ*|Bx;.rZOL-kރ5z$rM4y r!ٱWf]hK+ 9Sj;K RQYJ~j8'\j.N~<)ٿIǃ'q]ݛ>x'V~ߏvoV_V~'ߏ>.J~>voV_S~ߏ>.J~>h7+/}Of%eOcϸ JI'Jhth[fyŕXP΋CPR?3]vlU؍ݤWP<2|Ad' AXBzַ*;8>9NTy89l]ڻ5qvjj٫WWf6\m]ڻ5qvjj٫JڊN۰f{X$ӑ3i1~' @;_p39vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWafpQnᩉC^͗`+ӟvD***2Ă,:>8QnͿ+nS۳T>865N+nS۳TbrI@ܒv,=&=.kHA&.S`ߛ}9oo^۸|oq'1c|קyIYh#B+G [{o)gO$ eR'*$Ðl*N{`NR InpO$7`o/o;7{_E+f/kȶe|Pߥ_ K"cC~I[L|2(vo/o鏆W^%m1ٿK$->_;7{_E+f/kȶe|Pߥ_ K"cC{{.ɨJAVA(͔d'bNLU\}ثqO7qO7qO7qO7v*G݊7Qb?}ثpOv*b]vlUF XXn g(> v6 (q:~6*8: 3񺳒6 9pBQSp8d&״5kiYxssPb<8$,_+)Qʊ]qiTy8.2;6*ثb͊6*ثb͊6*ثbK,q!y*[v tfuN!w=yh=R'; |FK]uT=B-WCvgr2C>Ϝb$d]5Qk}E#jlJ>1/NQ~A/NQӿPkWnثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb]{Bn@[e; }d4b7dSGCхOVAW vj\R\U٫7,i]Wfm٫];7!P7,NJ%@sDe4Nؗ<[f }R rJTAYٚ('㽏"w>gCյ;I"`9Ɍԁ;]qMQ>faoз`죠W|=y'γW9uvX-uo++ y8NP*B=T;Q@D^^ň(%Z6hx'9) am'izKj:}Y\ul4.$Ce$g3j`oTEEvXT&jF_Xqsʥvvo[f[vo[f[vo[f[vo[f[vo[fDžmٽlxVݛDžmإr82b;svSCӓp15TCwO3$"Kz~ßNZcK>'xJ㸷O3{׈(4xĭ% w4]lHeuvDfX)A!EiSN?>)+Vf?>$fd8vn- .A2MoreDphhw,Nc70 ʇCũҽkffBc+ 1lb͊6*܅i]Waf=LENb5pr8z~?\\b]mM=$K'l˶֟'sxpc2? 6N).ukfOO҃9 v~08ckUg[O,z_D @Z#v;29xXbvfvds^ΩiA@TlؽBNe$ph*GCٌ$('*efA(|C>S(wet!nu۲qvjj٪q5q;5q5qvjm]im~{tQCQ CvN}9Kw?Y裋~rs1svLok1+'-~OyUO!*GFjG\OQȺ챛NQ׿݉_-4ߢ}J33"B;}iK8rP^oNA߽.nb͊6*ثb͊6*ثb͊6*ثb͊6*ثyJL]v :,lv 5^,WaՃ AKFm@˲um+MrmUN(XWRiHC{X-t:x8,gf#17dBON?N077o;.n. @F.ivjU٪qWf]vjU٪qWf]vjUإ+8̮6fîSx>Y,.`i~nqcu-ҤK RD~̇LwXѵcr-C,FP!`j=iEVY~hy̚OguS-(M>897<+YZϩY_i\,Z!KE5fBٻJA /ocyg\"ܱ>m{ȿ2$&OO2IϢl}RJ8-}^b5Xy~= cb3ܛA*z` z}οH^./5; VA+ňL^\'=I?_3E/uFi㺷ZnnLHCz}$6G]Rw6:>ky{ mq/n%XdJEso殱#kw|jF+DM_Zn1R_tke Z_y١"de>Oڌ6f]gNM_V31yT|D@[|ۧc=3b9``#+u;z@Xh=LtDg&XX)cJ]P<W~X~6yx$T"RxI1 $Q7|'~bX$tqHcWO'mJe#Fwt mXTR[u`RDKӴer-GɶʵG|׻ae'ljOѐ⟝Wzk{]2bT5YOHTf3!ʟ64'ހ;/)ZTMip5G3MTq!F#+FmSF6*11w D~JXտFֲ[]y}"R/Ā Gq~jVV:EV1oz?Y6*W :FbVZm NեAi7xUg^C5ZqHc`N~]Zjӵh#H8$:Jؐ; n'旤>`9|mw#ZHQь"o??_yGi%ƛ5QMc ^,ƨ|X7gv4x$)yAuk; ,HumZ͡gFgD^ V++V;FMn/ehA  cEu`Jb3,|Kog *s^RNqeee:ͤjq&è { $[W6 7qJ{˿(q|j. 0c/I몺.زdykc kV/|=A4 (rmkT>W/:LԬ W[*ңmȷ^ܕ.O%S[M@S-ּ35[,j– ;za\? Z3qne;5F* jv;˘ *ͨLj\ȈhͩLj\"_~dstI/%;+0(@ݏlI}/oD13?>D_)~Qbp~_]ǻ?Iv韖<^7•M>=|?aἇNE~Kc~P@Pv,J،,`A(`1P~N͊1]~]fi6sAX9A&='6рr@Sl'f]vlUGuLD7я׶k Lwcwhvl51C&.`J,7O~sg~itCu.Ҟ:I~>dZz'e͊6*ثb͊6*ثb͊6*ثb͊9%\}wdGh=An_`:}~84ˋ~Ϩy;/hR7'vLK!`~ӟom o'gMyvlUɡh9PM^XnI<5[$ܲ'=Ua QƟקoDwRꓻOT T $h<dE{q۠Q>o5ŽŦ<3Z[;vV6zT;=$K M/גq ;'ЗWK\}cTè\3+Zö2/'RRmtx5KIx0!Ao#yMfӡnMjy]F+rI8A)_HzdQ@ ޘ7^򶛩z ޱf1#z( 1G2HGz08d`n$,Ŗ=2MX'F1Ю涤j*ݒŃԙ:m4c(ѕ$Pb=ܺ3w4;jz7t~,f)m &h$e2־?2xQ"I 0":SA>1hRc*ۓ׉FY̒H总aAkR(Ă}͞q2dh[lrF1&D 5/mܘe8| _s ۸`j^N?oa\*|6iϿOqk G!G]4krvSVU$,~ab)9%߇1I)}7ON6v;Q\c Nc"2m͊6*ثb͊6*ثb͊^70G0-C~%P-^VҿB[heu5#ip˜Gtn S?+k<'jW|0/-7cۋOGܜpdzpGcoL[F\t6jɆCy66*ثb͊6*ثb1yrY)82>ҟ㘺=D8f>=CcCCzs-ڗƓ[܊+؃}LbϾ3Oɢş|/O.3$$du5F"BB'cvlUٱWf]vlUٱWf]vlUٱWf& vr͛[&׼t}%-꣱;'SGcvg}8#>Ϝ VSV#n/uWj_vHnIsnZN,7;ɬ蹡rvlUٱWf]v)O2rQB23Ec,>:KIvo#Y~P{'ɇa{?ڼ#ؠKy|40v/4e֛6] 5Q?[fd?7b<_iyVV 6p M̐3Y0jrN$wei`2X<GVQ?(i~l)J5XP@u[W2s/rY'SʚpY&(ڴd[*/fQt~YAC3IyPq74zqC3ygT>myXj Z(ݞ]H_*߮Gc %PU<];HŦ{9F-Ԓ""iej{tp|Qѵ+.M{2Ė+][!js^*zu؏Oe(_4o-su6kmgDנF1j#8,Q2,yT̫kPh~`b+LD٘/_<U=6^[v>[Izz]nb;`;ϟ7>[V-2i2M1;B~޵%z@."ZM.*I}ͬVm,",G?6 :5*iM-׸!bGvQ a'FEF Vk1C 4KP|dPw*BKy~\hnYCp$VCC}9Ǩ>BV,zϐ61kT?݌9?6X4 D\>J vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]+GP_+kqfkzcZ}ɩ5~_7I<?YvKsrݛvlUٱWf]vlUٱWf]vlUXѬu[FJTq#2>eĴj4MiwFw ߏ|W~92|eӞG;{>|2`<]+ktK v9J&^X䈔M_&ثb͊6*ثb͊6*&2?4KS0nb`cn?E;#q浞QD˸u8x!;$olyJk+[܎[Sջ淶;g&?͘0;'yovlUٱWf]vlUٱWf]vSt˒9_S~tԯbOVel(:bŃO(DD]e)_B̹N͊6*ثb͊ ]z8 t!U ƹnbNOSSEQ'aIR;~~ƞ-|o"ߥs+yf-'4_Ȼ7i?> E_c+yeYc்]|o"ߥds+yf+'4_Ȼ7i?> EٿJ, 1W.VOf?i7voҲ1L|񼋰EsN%$A5N,1'`7aNo8]F"q* ]WIdGq'p*,*O5v'v(p`lvlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vBngPy~g@.͊6*ثb͊6*ثb͊6*ث=i}lQ,(Fpחg XUߕ֋3|hOOx7|/gkOnϙ=xO1':Ve%ͤ7[sC4l=S ⁰6*ثb͊6*ث\`~ekeՏ/ɞRcuXn>ʏړ\{/1oYGpy|ݓMZg>~s׊*kv]nKL{ov"nnɖj۝vlUٱWf]vlUٱWf]vSt˒8g'_m/?S;6r.cb͊6*ثb͊!_6tЌ*-Z4뮅_1G6ݍڳfER*mV/O3{?22q>Ўד\w?*.w^ZLT-{w(?i:jz=zs=\Hd?vuBnmYI"de<(Fc( #n\̊iezWjw8;7}^ ޡƗ;7qixz^ ީƗ;0(qN4AٽS/voT¼AإVĸ? 4},Xvfثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ϵ?4O?J?6΁]vlUٱWf]vlUٱWf]vlUٱWf]g⌍ "( EmSʷĽۚ3hi&siC~6yF&~6 Q~YyY[iosqC;Qa5̷1ٱWf]vlUNTURN*ta2M|:qb=_ۯgݗAZa_\!Ļ:O$Yدu J(vie.rqad5͊6*ثb͊6*ثb͊6*ǦF\ƿ#?5Ǐ=>vi.ꟽssvlUٱWf]vlUٱWg(hPyJhޠwthm7`va |6Iq';$^uVxéhؒ:WpwulN72KsXѼɤ˥{iFݙuV9d1Qc8 .[&yɚƓqx~TMg?veU잣:mh鵘AF]|8"ښ{f_Z[jcwo#U#d>i'`韕jZUփneFCTKib!gW7<-NHԉZ#wrxdxm喛=5Ɇo.^ʜLkwh@HX֣G<^IgI:i k2"Y=@8@һFD5ȼ'x㷽WDWy%FIzFnc#m:t5im{Kmg%E-rH]'8NOH1B8X[{}MdI̱^܈Dzn1mm:}zkX,f2:X4&R1ůWCW_D-k۫VcWQOO7=ξAu}Z-m2;Ƅ2n╢I%-`1ˏ-yro=h>w$n%NA,Ä$O|28|,-$,.y|R!};DV*⤼r~,2GUTբcX/tD)%:lNX.l~[OZe YL Dw~PiRz^..na׵ 4XlQX+ĵvyd 6'al7=TP$u%dpm+>X5V= y\iCf)顐WG?/@m]'ҵ jIICJqPdD '|-k^e֦nmCG`шdPD TdjIO͟8] Mu>+d!K2AJYۚS"+?b W[JLy][C"m(0 k`w2Obثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ϵ?4O?J?6΁]vlUٱWf]vlUٱWf]vlUٱWf]vSaU=F*WүQw۩;٠lm.yofm>_'a42= M%7g?tvhed92p?X a;6*ثb͊6*ثb͊6*ثbzde]g3S_?xa/b~ݝ91ٱWf]vlUٱWf]vb0S htZdtG=eײ5 G>K89qˎ<;|ǥE}K[daF)،z\|ARōą1567ϊ?\i":J GL$Df3<Ll<ůsYXj765ż3G5`\о\?VYG!|^>tؒi6e_Ld^|^T'||07MmJOMm ˏ !Zbio)$Wdj$5bA2 |T;Oz-ϫ4R-#/aM`='DJLpQƫ 2t<׮<37h{oXWRmA ]#4c9<m>^ޥZ]fh #')U:{ N{fXfxJHQu9QҬ3 /4(""c]a_1iuk ZA)o|7~g< Ӏ:ΊP\*d|-S ڲo"D-9]=bOk4]#$;T;d(}eAMr\ b|#яW3?⿑xvoϘ04cwó|Gøg3/8~#>1`h+f ?F?q_ϼ;7g_?q1;F}ٿ>b|#яW3?⿑xvw[t3+QUAI Tbu^&Ópny$jWa(iH幠NW<ۏ.#ʼBQ]ׄ򣼻7K΅>!GGyvoҗ^\|BٿJ]xG q Twf)u7+Q]ׄGyvoҗ^\|Bʎߥ.#ٿJ]xG q Twf)u7+Q]ׄGyvXnఌ_a\\,ˡ+0Ə_҇?[d(Sd:vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]UOb" I7W1f{29}9";KTv9av좞̭Iд.( N:=_7n| )voSA|SY1پw-OG4cO{}fZh ˽پw-OG4cO{ j|,݃Ɵԍda!}(ߎ|Neo~Ƥ4b}F[Rhg4TEfb{n\ʵ643 (*hIo.yA kO(KyHXKJ=N@ǛV<$~J| D[M7Bbbw(+Kol.D%7W4JxYEKSQ~ώ Y Rwvޚa- +nw1P6kh:%! %PTￎH44E"Ht&i-%n& kN`M)Up*zWy-E@#$h Er#lCCN9_\Ai6,p<*r!*j8Ey@;-G˚h5c%R[cvwA!uiG$k|,2+T)lwRԨj(0q@JǠ?ˁf}[/DfNuRa +b͊6*ثb͊6*ثb͊6*ثw>0Ə_҇?[d(Sd:vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]v5+CK^RH߀c. njqJLe N)^yKmXFWlC†d gf?-mͿoć|{:}Nk99yOXYelvycP9T7ߜ&͏/7#g{Km/t۱إٱWf]vlUٱWf]vlUٱWf]vlUٱWe7L+~Fkz|=S\=/?{g";6*ثb͊6*ثb͊6*ثskMƜbN;Q؏z}|v/kKE9m!}>WWd?T+0̺2K 4jP|dZ|^#ͿkL1aJxЗd5YAO-%F 󗕵,$teE~)?ۯL wH|+K2 -VX]Lm Eb\ta3鴋ZG .Jk7H%ГToiZakN`u-lRnuXfM.8iA ދ+YnoI [D|?kwSypˬ%fi.i/'J{Z}f` XsZUj;S_]XE=튴d'g/xwJl)z+K{4땴eKiNFrݼq?n)%}F([m"ڸjv֭kZDc=ѭm` -E.rr4dOP6i&zύݐ>han#hv4^{0 |9V<2a2!|kwI,蛷hG"b>uǗ^K'nʺP N9teĜ2JT|/ u35HK9YLT&.EzO'kq~6֗B%4R((#y+A 71im.mמ4)YWSrڛqer^iYIEB93 UޱuMy|[3j륥ݲVUH`>V~YXx򅮠1i:}}YLB8ONN rR3jdwyf"BE0ALsGoqe-4ŏK:Um4xcM6=#Tha޴UYI^hg:mm^Zei{u_Y/ii$Q/eJUIrݣ.3ٓykU FK˫ ="WI{ĖGw S\ߊmiVZ,QstY?CoOqو)-e|תy`}Ӯ!OA+@w3kC.XT| o7i$ 1XB#UiO5Z͊6*ثb͊6*ثb͊6*ثw>aG/iCƔ kл6*ثb͊6*ثb͊6*ثb͊6*ثb¿2Fޑ6\ {XG^~"7aM&MFAş&3t+NMvjhe?.v{jK|K9NӬt(ll`K{Ku 1*3ɒS.x(;^-}eH}UxpL~WxpƩKp7éˡՈ2tX59t3oO M#qTu5|!!cp^`2vlUٱWf]vlUٱWf]vlUٱWf]vSt˒8g'_m/?S;.r.cb͊6*ثb͊6*ثb͊6*Amk\Mtʜxj2~8:d̾FSVE綒Rܽy%W6 |ٶ5ח|:\k\aJzūfZmkEY"];Elۜͨ\!T^,@O2MW#4QKpts#U;S62ۛa3^}\ ȭ*ƒ[o (R8P׮c`euw.4RJ&Ydxfw-_Rg~ZyO)" sPಆ+m}8ʱ";q"8O0}e^%I;MHR3I14@` 8HKmnZ8+]I yؤ"8ڠ2QER4yX 廾P[h[, (݀jx-k~4JސǪ^z ՂKF-107 <͢EU24Q e=t U>8.|ŦeK!c)J|r#I:w]O#j֫|ZjQKK_P'Ս9.M~ a~Cmcgq F UL|NiǟmnG~S.֭+omAJi+YU[&=d3Q淺H±'pPxY'&X -,NOlmͥ+˛ajLդJ{thB"xQ׆A]8#BtmKI[en#Eդ< |?t$:E}/E+k?4sEs$r~!,kf"bH40hyQյ%T/D1%rD9a?-k.ɪ [tZ2oDt^lYF/Lac Viv8B&, ']HRI~{RAhqSms#ѬiIk3ǧSKϢ@wpcѵ[TGSsrur@O*UmͱɐI?_GҴ9=:Z"6EUfbWY;TEf&QN`[4讘~ ϰe$ПpsE.Gs#_ePvo_ceh;7~/1Zߋlf_6Vuj6x1J(xlx "&$HQw~YZ~񍕠JM>Bܤ3Jp \"d18tmywjgaŚ&d$xci,UJ ֞8x#כhFtXt$t_ce4d̺tHDrPL DwY6ރ=hfRf7Jxy݇Mv>t 'i=t8-$[ xȉ'Iu=UAb9GiL7OXcJߣe4;OXcKn7OXcJߣe4ߣe4ߣe4ߣte4;OXcKn;OXcKn7OXavaiqm><``aWf]KUh6jȒ'g q$'l錽Qa#V&ιwTlk[`5 2 TȊwva'# nIh%V 2w.ٱWf]vlUٱWf]vlUWm jኻ7bGzQ(*ޔ>ኻ7bGzQ(*ޔ>ኻ7bG~*v*u2=G_\Qa2؏?F͹}=fO}cߦd|/qOwڿ=fO}cߦd|/qOwڿ=fO}cߦd|/qOwڿ=fO}cߦd|/qOwڿ=fO}cߦd|/qOwڿ=fO}cߦd|/qOwڿ=]gCEUPc1ve ;ێ*)]7QPO:Bb>1nxg~-NCi; qէ";$ߗzo,J 57kFOc}zW]C_LvL2Nثb͊6*ثb͊6*\y:o3G$4S 5r ǘoBpfл$@Pfڻ/vlUٱWf]vlUٱWf]vlUٱWf]?/mzIa5#ԕP~vWdT]ߗutz6!T[f[t{:~}w=93?vvUE Q@sUٱWf]vlUٱWce9chP⌤T|F$ EdWëhd֕|wUɦQ~94OG}Oc[z| 9!}GP:jcqw; 5vlUٱWf]vlUٱWf]vlUdFG pA؂1ߢ W5cSR Oь`nSjㄿz.hŀ@:ҷvlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWd^R/nGZߨfIzv2bn-cNd^ qχZ(uKU72A6zi^.])X6sepgkh6){$ƥJL0 s \ۇ "æTzޟ&>j6%¼)IjQlu].ťAIn˧\\qib ΣT8^ρ8/z%vo_%vyF.k{SU{e LaNMN5Z6$\ŮiZZu2Z\1HPV">+ljxx^ljx8c\xs^E$Ҥo0]Oh;f^?:&R rvPX*1Wg >k&ɪ %fCA_C|02q]G{/jbx]bzovN#ͺ"jGE& 'O|9ca[sy>eٱWf]vlUٱWf]om!dʿ mFSOB~Ni>,hiZW!? />&/!b|$OB-vQCGvlUٱWf]vlUٱWf]̿#zh-Kb~&=9M vGcdOoN8RZsgݐ_]ՇNnLJ4{cJ]~ףN,9vvpȀ;6vlUٱWf]vlUٱWf]E]0NחKKnJ\k{2q<3:vd/O1vy_͖~1:N?VeiGP(rqs;;}91 j3dvlUٱWf]vlUى6jqSԕ#R Mb^`Uri^] 6|)=,)z+G+$9N dUxb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثbf(]NxLPnS.M@[ykRuXߡ~ }{e >^qJ/޴3yI<[}|":ټ!QF\_K~ [DRKbgYuH{* iAI&0sr t)K:`khk+Jfss/Xs\OPfMSYѵMJ[O-ڝ>s\Z]һCSF7Q#kviי(-*aAx ,^AÙ/-ň[#GƆhp[l[JC)g!3XVM9-lm6WHdKoD .~Qb\{~YAwjw_\]G;2 72}( U7|ehwҺѿMZi56zj44ެMh!zǚmtmNtWN땸39Ai:B(E2M~K'ʗ:Ų4ZeZNȭ¢,QG!K4kv}gWӵ2ޫ.m9Ŀq>$ |?k!Ky!5Ht,:R&4VT@0+E]VH/5mauw %hIy; aɌ>j:տit%r;N.~㤆Z[MZKߥKr.;69L~1F?kUQQvU53,j޽[9my]GEq}sjr/)N*QO-˗\D> 'o|Ϲ,-/camy\^IfCk+g~L/#-dǤ&ݵs%цVϪ4,ʟ(0a:.-ߔW]f]:[;{'O wYYW^[;H[Ikaj(t q$(%R eO?QW_Ȇ_%i`MP+ڂ}a-⸑*nW;rͨI7wwZis"1n E,/N bvXbxzՠ$}SOӡkYKnibOPYV:7T./k%hkV>ge.#N~$_7~cZ־y֠}/KtS)bP=GgN}osoΝ6:GtZ_]lԕVmD@Ln :7gɂgpɬhXƹ]vQ`:z+Wb@sD_[cEwa5yGhz*>㕜ttsݯ{jezg) [9r.;+8$caAH_&8cCxT n:uyӉ${Ipf銧P?ZL6O-G=;DZG*JKs?rc >MGO~mPvpSP̿n2 > 7G\\XvlUͧ tޢC0Fw}POLvWf[‰D#en<ézQݣi4 7c3+g.#X`HkͨeSkU.30\4Ь, >ʍ}p0p?w07=g*UٱWf]vlUٱWf]vlUٱWf !'4~2x#zٿ^j;CH?生ᕜ1|~>VO~H8پx|ǫh5ػ6*ثb͊6*ثbona^4|I48c#J(:`W_&"}~Z\|]$_&-f5h7I Eپ}-_M>Z.jkqvoO_돀}~Z\|]$_&-f5hXjr5C*A,&*=rFYF|e9Ԛz- A'nWv:4/YۆK+Ρqjn+CcMs Mt_4k"̺]%4`+#*ᗒ4+[X h$08*P:9/vq( ..繝̓M#wv5,w$Y4M\xpY>v_MkS\x'Ƽ!_Y>'lx8voR;7[Ƽ!_Y>'n;/MqGvQ?2qHvODu-D囬B_9daw|3 c-amtjW~.m .*Y9ӮWS .wd-jg,pwNvyw-dL%Jѣ<|+J9EvᾞoX8D(Xt{M%k!.124㽱uqLk$d-uڼbiQ Sown>x% 9CWLno7z[GU{7?ӷS, @r:"(UQz()CWf卫rٹm]ٹcj܆6civjQN x_~Ê(Fku8:kEz:2_?<9GWzpylXsiymu b;rQ u1lPyrk<}D[Dk9xF{*ߝ:L#y:t~^-uK̷37 ߻1 I>:l ^6] #Sm'VI* +CgE;Wf]vlUٱWf]vlUٱWf]vlUMvsOv>ى(<NŲ(vlUٱWf]vQeM1WawZcH7WdC[5, O7 ʤQv|I4h^^5~,Ѷsj>qͽ9վ-Ϛtzzu坕ڨZyU~7*/'߶gqWvŌHsř]H:לtM.Q k Brn+bH^% #Υ{<6jJU`'̚^E=(OUIn$ Q[Cz&_5I@ 9JP9|1A--M s1@K we GՒnksb)].6nnබrO41m֌^ime]NֳOp(UUw:ub'#ӂ63TPu8ղnI|ë[i< qɍܱ"$~1*OGcӯ=LE &.!d F]E!M>9Z(cʱ]ҴwFK2_,4tP}^s{ZR[y$*;RVڌV mC3@|?-󙿜]_Fq?ofh\-9ٿlch_fqvof'󙿜]_Fp~[Bs74?ch_fqvof'l . ?/#d-9ٿlch_fqvof'󙿜]_Fp~[Bs74??п|>Rad[r̦;~D% e!FFkCbaMg}\μf@XpɳYc P:aKLHK4Kݶ vn?j5<è{x :ǨNAvo/_#{Y+ pGq uTWR>L͉^q$GJZi%e1; ɖ\S=75͸AV/!,{q`]EK1@MOrO'r}cO7(N?Z͊6*ثb͊6*ثWe͊6*ث>XJ㻍ÁE8̆;;ae_JEZ:{2# y891@j0ɺ.y^yǩTP χh#Œw kqD#v1葨A3 d܍bb͊6*ثb͊6*ثb͊6*ثbn,nYITu Av. C,8$l69v 0>+m!7fn ̄ 8 vKq(ُ'3cCReu/>o&_>Zj)imkXr\[kXTY?vJ+~=(18N6/;yV"ss=pn%o%LH`X>U|Kg=51O UXnZVW-q`9v \+E1WV{b 8im= y?xKj:o5k+k_j:\NźG *QV~YdK]49m mILfO '忛j+(c(4m[UV6S$1(+M\,xK57ږ-4Rኋ`k%fWp0Y8MobdnYOki1dGH^EP$V> _6KX떩GynnG0*FXLi@G-ySaYkw\j&Yq7@%#5OPyn0Gʀn58MyMwq&#HЅb$:֋/=jC$#AyK(SGsi@')C? ]^ſi5ߥ[|Q?ӏ<—s~oqGRvo~-N>(_ ]^ſikKٿK8|)w;-uk"wrX#(_ ]j c[Wf]vlUٱWf]vD?04?4&qu1$g8͊6*ثb͊6*ثm5{s+YŴ\orG~{f;Mf+N\V;5qZvji٫ӳWf+N\V;5qZvj\V;5qZvjkJIPA[B6 0JE qqZ[ieeViP?:ơz,29ҷu};Mԯn#ӭu۫ZW זAYA1$Z?JCGg`u{>R[R6f!2' {6GM.~lP$HDj;ޭ~Viaئ{ yp2*"Kp"F("i 3] 'PNG2V+*N2Uh~tQҦmnQ8ZPCˈ&uQB\S 2:}S^L~8mgM/@Imݤ{t2Bz'[Yy/[Q[wƓ0ةYFXa)MÔtj]GP',Gմn=kZiUk/^2o~u +K N &wNѺ'>ĝ4!]k 9. 6}VNV7fr-%_ߔmtG0Kp-1wBT)VnN F1?2m e8Y&#x]KRe):]IByNTwn^n{/}8zoKuivZNail!݉?m3YܥvGܷgv)_34ӟ iqqO.)o1ZvjVfi٪1ZvjVfi٪1ZvjVvjVfi٪1ZvjVfi٪1ZvjVt#it;'mG~33c{dև|=Fb͊6*ثb͊6*ثb͊6*vF5i}]5Dj?ːsfO ;2v!/Wf劻7,Uٹb_|Uٹ{vjvnXr]r]*ܱWf劻7,U٫Ju{t\лQzrXSV8}\-y];hC.W 2ҟ>y=ŀqO<Ǚ90#]$~jʺiq˨,I {ӗltwhU>zP'0Ɋr6i ?Ew&??SWL?/'d/2y~b$[K1+D5q㚹,s(6@vq'~kVm幵YQ60YXn=fNne@NȒ&^_,v6zsX]uxA*0bz 58Oy,/Y+xil$tGOSTeƓTOq-톋k=3<h"̭ʜ wڇ&i-E]YEgs}±0ߢRgiuLxZw.v$Vג[XLq`fx 3z`8?4Ιs.۫A9hJbUA'z`hDp&KX\8o%F,U@T_|07mJGӬ]^#:x!&6H%bx @VZuus 1iU'2}8Ď( \!@b~;-k㒔$XI(M{mꈃى"-xiQ䲿Si9hRcG }jN&Ҵl 7IgnJ  w'"g +i#1jЯ-T>\LqskƳֺUť2n#\<q⣺!-.4=2 "Hu[_P}EZOA⛚]ſt7K)^MkA=Eb/ՊOE䱵Kgϣr]26}c>/atΣi]HTdjUjҢ1cKB8R@u ;o4+CfǹX[ް^'i~bwV4)tIcYiTv'ȸz<姚] P^YMFK`o*\[H}Ȥz:WtKf}3*Վ ľ <6yĐ~n L Qf'DW,7 vyAhL#8Ui_5y Pk@UO'Ԁ:ro ்Ptդy堑/럗ZڪX-,FhJc q?*_z)*|..Q2P}]O7/!Z_]kiy !0~~QȽQjCɻ.}kW#ykQ{9F{p[vS]8O{kKHu2<%mC䜹xԋ~K79mG3Jmr}?Uxt94ہ07 f)'#|yZb@gKN5?Y0XPT& rv:|r7CօnT Y@PVr`J#Ap9&%^L%.[fG{/>ef]vlUٱWeqqWe]^cxl QKtD{uP1T-O) /Zoj**x`;`㫊i٫ӳri٫ӳWfӳWf+N\V;5qZvjiٹbi٫ӳWf+Nf+N\VVg?M~ ^wx@f:vb͊6*ثb͊6*ثb͊6*l T7$`*eC;}y5эm37b5F*TbQ5F*צ*7>~K2!G\]; ~Gɖ\_HmYvuNN{IIY#]*i&$$$kbc۰ug4teD;<+juO,I2*CbEE?Yq~8!Cc;$F(zeK Dc3yfu8SyOî^Ms">²2 HnQz\ymFy<2߸>+BCߗN/Cu D!uE6E]NHxR̭j -"WHE,;\#3FEXcc {qm%) !dZ3EA N;M}J]?OԒXL14~ơeqq7y/.n`[F3HP'Z{SoǖlxMBIT?0Ïgu=u%y.,nDޘ\NYk6nNQSQ2[8^hG%ux4"}V;xrжݱ^ANsYX$ӆ.bo5cB8P+\/)h`tNy P[Әy'$VJXIw΁jeDN)ge! kpL曥[\6ڜzF@P:ӾDiG ciTu턷:d;lfyxK=0Uג4kRQy:"/=~j>G %m2 :80[Z3+r/2JIoko,^3}lq @J4^~QwˋA"?֑1A,vvVΊ=>a4L*r,(P?-tiོimlY c!PSPiC]`8D^%xv]LV_rhzYUze*ExTl<6ŭY6p۪}UC]a c9rMhS:G`;xb!#FU=vK{3\H@ ;jֳꐪLrLS/UQQ̘W!W"{˟;77`{+dEB=wfW"!;_~?y_lٿsȯGN9?Wݏ#W['pvop+n+;C~xw%yA\vIl,-mxƞ;ORODPu̻d6*ثb͊6*ث3 ]^8z<ܨ~J; $h_z?5scjڻ66͍cjڻ66͍cjڻ66͍cjڻ66͍cjڻ66͍cjUe*ªŒsHCTD~+mDxfB_ Jثb͊6*ثb͊6*ثb:@hV ~9nN#&#wd^5  }evuqWf*WvjU٪1WcdѲBFG=ݜtY56zzW DnJq;7z;$vd5u;x2Ǘ3Yٸ@Lz%/!_'a-㰻Ҟ)yR"cʟf,L2$gt'JwdROW?fƌl|8ȸ٫]Wvj\U٫1;j|!m!&g˪ƹ /\݆yBv57Z]~Ұ0d0vFOj+͇h]ݕ#kH4#wf]ȑ5wf]ȑ5wf]ȑ5we?HR? Ws$x)+?B+?B+?B\^?Gwvo\^?Gwvo\^?G?HR? CiV;K$5cl:fllab͊6*ثb͊6*ثb͊6*ثb͊6*ثe8,]Bc)X~*s9;cܹdx׾VUmscjڻ/Wfj%w,ɩ\G hdEaI#.ogg1n^q^v{^ILѠbneL-m,\1O[}MʖP^]i:F|g|}]Ƃ*Na֧1Me[vnG[vnX۳r8۳r8۳r8۳r8۲AcI3fY&gwac1vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlU؍6z?eU=2 .N-RGqg'f1o\|QS'e~}K?>(+'e}K?>(+'e~}K?>(+'f1o\|QW>Nb/|ſ_qGq_;/ſ_ v h@(v? >f :nw+x!M;@XSv\"ܝ&5$UPơ g}ܛKyPH0) Cx;fFpHG[qv7 ثbzbCFy7f9}E4\h_rʖqZvnGfqZvnGd'kA<>i**ΜJ܊֙FQ{= OhUuv;Pn'7VH3cᒔ Z"Fџ=8ATEK?z<·XX$aʭb}P19IHee1s݈I֥uhYZ53SI\"|hC>8[_>_O|݆cԡZ.=Ehz⼿v' 2YCga,%(ۗ>$o/z^\J Q(42lH]~7aD&>hkijm5JgTS]6l\e{ 5XcǐaJ4syT/g,-ny=EVea-tٲxx1'2JF&"˛t] a;Ji ;#HH$AÓD9b=\܀ b]ܟ2^|%~m! 7Y"ԮO.̅R9 iU@+SY#ꃫ_X+Iv#M͡]K+sLA"?OA,|ӭQm71p[wo:m̻y _#iٹmi\Zv_#ӰonU%'2Ǜ|~^2Kx8n嗛sOϣ(Z~(9*lrx1ϋl_OaŰߛrMŮX4N"[fF&J㏳MA \"/>ʃIԧ;E9Z89#fE={&q2ۃ5ʁ۰y T=4yOT[-Cj Ikh9(v-|zÊc KѴ/P!3idysKaihfGx$Fֹd940-R7K}摥ٹUfyDRp Oy~]F;8 G. S^٪)R%h<ӡ4{[!ۋ!Q=9-^.\9 "Q16V.}NDȹn (Y~!\!h~qߤ趼XE&i @j/fߕ7446:/lsso7n}V ?m?k,.֬\[-0r++W|ZK0MwskvK2%vTwko0RCk/.ik9#c"OvS$^yvlj&E/0΁/ԸZa!S 0e՗Zbk˲_gE8tW%*CJ:)u vFސ +$m7?@JiF$:5ngZf[Z22 qCȑN$S9yͨ_iW+ ƘG4qT$\?'@߮?eno` hI"ep#Fn?r8atԠvyZy `hm?G>%WWyyk7v1d\YҵeiǢ.F&*]"Ajw]L\ZBJxhiVē$fwԏ Oh,L>ybRNJV`I; dWlVhQ-=Y4R(ܒуJe>9tTd-+sTcjڻ"y|zl*Fc0BEwS*ː6ci1u<7an0LƋQ/DB! дʒ:YLb7#M92a$/݉QyL-qnfJ9)thƟLKqP4?2wXKiMOV58/mltɣ!eBkD\WDG;'gC'ev)5k`P孾k<{dFKpuƵIy Ǵ8c(dž]!_sSk=9䷼IPV6%Cنhr(f2>\}J ,RO `z,2=;kgr\TIl#})ANx&!]; yhErIx>H3{|PU3v26.\UDѯfYEq2$/"ٯNy@Tdb+gǧdžPsFҴO3hh61y2;5 OU}/g3 dvנTN?V?'hǂɝ{y*-RɴyZ=y/ J>m4pN8ˌDŽӱ[|C'f;Mӣi]}{OԐwו[⑶;d< ywwUzqD@(>qiJj>m/5̦Ph#Թz0oPʶtIh1I J Mv?.+>yGM DYR1B|dd0D,z FmNmN͹JePHa@e~fwz%dTanm$%/"!S6h1iٯ!o9Ӷ'%3y̳I{$|Q<8{-kCa[vә=YkI=Xc*/zA]0|طB^^\!8ޛ9ޜi6A.^Q/o_SIRi) 29\G4g>5 [yVQݩL9l]ѓՍVC'|\9SA_/j=Bl#q$5+K.qb| !7t]5!2;]rӕB>PzB:K)kS49oI$*WwV(0[#suL՘ՎNJ9jC,o6^z Kvk6*ثQJ‘Unܕ#nA{, zݻ]iXQe|@P*>hԼhHte.͊6*ثb/hՔ3jӢ֊H|&vjr1{CYd/`?i5L<}˛zlnjU٪1WdT>O{pAI17f MHh2N.ٽ.¯5\6@єL-a%!X_{2q}VL}0u+= 7LO!8Zܻdk$CyMyVu^F_3yFU%EhԿ'Rv W I-+㳲=AyuWZYk< 4Dj(T"%pi┾@w/MAn+ۙIcTDw'.\Rd"1@'oͿҭf, aMȆVA#XHd0woj/z,Z@]2GYd15Q&%ۅxSrlp@[;h'hWpo P=f5^w*L'#IofeQ@& JƀLc[7W߹n۷枧3MiL!ԴCƢqޞj1[!@-k#$R(VӕLhfpLM6|4:IȉNXǪǫnryo&:MXju/f*p J(-j'fb)_7S!y^4gAzZ(<g2#Mdcy5[vJyvT*rm.1rEFL~YI=ϻvBkHRϨT)Ze?󞌐{BwXG2V"XU٪1Wf]QNwCiS;|>C6*ثb͊6*ثb͊6*ثbȷLw?&_6:y2>܎WfqvnGWf+rƕٹi]ƕٹi]4Wf+rƕٹi]ƕٹi]ƕٹ)Zz>l>F]#߹ <~m/f`ᬪ(ov}.|Xϼt>N$MC4/VGA g4EU;ndB@AOѣյ5縇@hԤH"V4֚4!UIvf(8sagޝ:$I෸ӧUO/X)4aJ$˳/`Eǀw/. X k1%]yCܼr.ꪊ@UQ@`IWf]vlUٱWf]vC|3༅\<0Q]W?һW9V]mS ;b쭼>x Pxb.6; b.@;6à1M;6&SAS]b.˭:}د 鿏|i.]t1O (vx]_ mnA6)͊]Tw]_(@SGIȣ]. \cDCCnn2ثb͊6*ثb͊6*ثb͊,ἲoB+{(LaAg>42ImqŻp\{07 (%up٫5qWf*]Wvj\U٫5qWf*]WvjƱ!rp/gN&-=Ҵ#~j\|Za \7Dnُ,;au' T0+zQm5R6*ثAM<krqO vo_뇎=.f?5ǽxe_{׆]/kpǽxe_8 _s}~\x޼2vZZ1>xzb$;6*ثb͊6*ثbX%ꊵ ?M)eYN/q4i|ZvUqWf*i٫Ӳ늻*;5qWf+N\V\V\V\V\U٫ӳWf+N\V\U؜? HnBvrx sO<]˔oSnsCqDFcE ;(mp[]vlUٱWf]vlUٱWf]vlUٱWf]5:B9\ezR?^w~p?aȪHXTLv]qCWvj\U٫5qWf*]Wvj\U٫5qWf.Uݛһ$~VHِd}8Nڽ ~3IvK?/+.i*xlŎ1 (=y˷?Vnh[цh:*I]&lq%A `G7a5v.͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊ uk7~?Ř*f6S9h v<Avu;=;O/Gigq%+8Գ FdӬ.BOORT)$`*|I/yXXi&mDE\-F&WpK)mƚ0yyzEUqXz ni(4h@]!UW`ЭG!5 "/6FقDy32z[Cvh,RğE?@ }~)Xp3ÆNٱWf]vlUٱWf]$'2:e="b},a e ;:S٪qvji] 5NvjU٪qvji]Wfƕ٪qvji]YnI+˚hEDz:;~Ypzcu[d{xg"taPU?<A1vycroGMGԯ[#pf;;'FO/?W-$}z1=&H H<_wJ_j$r?õs=&ójWY̗ 4L#lrc Nv5n@49|U4Yi ȶˏ5f'ҒA(p$>otjr_^&K]x$$#@a2  RaòF\vG[A_ai6;;;^49mV KIa1 O~';\xonMmG(̽9غ`ad8͊6*ثbjlUGLzg.t_6ish%e5)# Ew%?cG],} rq^Tv[]8BV'M4듲^٩.C\*ywLaԷPnc0،vohI;pbJu-JmmHV_ 8eXq91MFls^FԤNxP|az}PX~,|,6_Pvw] 7hڂ/)V VsO{:fi2G+,bm/ood[t1Fplacq&[n\jzZ; A=N[ iz]]_7 {t'jARA[yEI-M%OlAM)JdZח[k9"Xݻ=;uHUJaJ]j҆ uKHn&#hy=1)x&(]beRR?PNl6¸ԭ ;xRè#voUB |1Wf[һ7ԭ HE:_DĻ[&K]<뚏u*4nbf #ԃըxld#2<ɇ~$?~e7z$k(X8ڐC|lzYcGkOW6![n:Ͱcn7vN-ZYm5 y8F^%kFaS|A2@;9|ZFYʸ͊1^Pm\ |t}3'K˧9AhEvy Էi ›lM{7yNzcղyL?3-/u/#v6Vus7&`m9nW~cMmmbIUo"Lo5h>imu HSdh-,U*Ѹp5L@s 8Wu*i3jq}LbBSHM^6Br$;Ho,=x '%oZ$i@yփ/|(.k+]?[y\M 19$pՒa&y>S.nl RT6 ^k ˢ_Oi滟/CZƐl%(8kU7Bʚ];R4k;A>Inm,擞@@5zaɮJt,iZז:{<4 ~rPT8#H̼٘Oeއmy}F_.}L+8P۳J =FqjΕmiھk>x/,bo%zGXhø5XƷgo;p[WՑUhcbL;k廉q\F!5AO Eޤt.[k1j >Ѳz,m]in\C/P116yN <ڥϩɧ#z"Ds HG bpIѵKwRi:v^y_UvF;`" H;tbOuw˺o`Ե5Xm"Xa2NU#Y8kR cگ]tuocťkv&yh庵#6FHqҴpl+̚Og4k=.z['C֕7RPf:$һ(׎dXz.90/{]͞,4LdPM!S#5}gIZMT=%d5hvC|5d'B(~Ly!w].2nOWaWB~bFtAv91\HD6Wӆhznh ݜȚeym4>k=CM({PnYZEJ̣$fuDH7M5C͐ڎoj^iHe;{y$ehĈUH2jI/8V=({Eǎa;.Ʉ3P(l_I>n'd3{b͊6*ث\UOt}:y簳[2ܼQ4ے v]FL DPivG+S[]r0"Q)˞?5:cp>d?Qcuu۵fS1hb?c{FoZ"L}/pҧp 7lYIFT/glGY oyN[o%fKk6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊ /-hڋsVH?٭-ş&?D- ./dA;YWp3r(Ia\M$Gdx߯2Gi=$>G2$;>Z8pou3P~_+7oSݦW =Z']m`-#H~Uy !ˈgk|]cE76lO=ŷa}OnvfEk!>0J+3yԺ[qDe%;wMǃӒ"7x\0Z\t1>ɟQ#4^AFUޞ=bt'U?'}~ccDwdFdS30  ԭ?mV1gZHTn1o6܋}B%Sݗ$Ni{O%|{\њƷf]vCZ-N nő#l}GUvg6< f< Nx'f< Ni)VVwǁ4$A1;U% 1TE -*\\\Iqs+q)-,1wf=K1'{մA2,VbqYY\%͜[\G&k̤coc-V^@ TkۉnG tI*IG"WFHҊ;]ee4 cmGooo TDQ@`ǁy縚I瑥V/,K33f;N6-o-.-eU:єqZn;Y#)bYhAD@`< Jlʼnf$5$' <6K#*TW9ނNL:g#5E4e's&(b,fiKrcyNq??);7 [giXk%)8Ky|q??);7 [giXk+OmOco/??%y|NO!'ecA,Ǩ;$6on"AEQϾe6]aCb͊6*ثb͊*hTh`dhơA}mK,3̜Grs_R$x`8ˊ>${R_`˫?yn'&\}xPlt'~gaA=D#Ìzq]g%&ӆ)4 Í6t|ė6^h]\iuգ&jv/~}!Ǘsk2K` F9nnnX-4ܰӳr֝ ZvnXmiٹckN;7,miٹaf֝6ܰӳrkNƼJs8rwoUNN248Y4O%>_򛫥ʴh,eg=C~W96lrU.nlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]4on/a;}buP@LJQ$Cvq5ןqZLeRM5eIvv,{GNtOae-܈1y;YvY:2:%b DEQ,/(?]CGJV?q:DŽGhۏ-ly;yb=NUǦ0ڀ탵;⏍Ovǟgk'gJ46*BK4G~,; 1i[crYor8ٿ~Z1'Տr8 ,cOq^fkXV?. 9?3x]crXg'7/_?O7/_?Op7/_?O7/_?Op7/_?O7/_?Ovo_5c(vVFcaV5n=I&r@`]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]b6˾Vޯr"_Fȕ򼹣\Y> Q{9g/?ih9y{ɌzdP~'0o.nuW?׹~Q?aM&c,rґ fb)G3'ǚW:pkYygD{8Я' JV:" 5hɬ;]s^4tvT8(ݙI=|bs&5\}4uq~E'v3h~Yz+qx]Bx(" *"C>yN,N6b͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثbZΑauB[[)"GQ,SGbH6:^):EܜC9_x7:ӍV!ȏ\GNRBQtҹejrEiʲa7t;6*ثb͊6*ثb͊6*ثb͊6*ثbƴ($y-Mc$S׈s .~c_cw>Y/Hɼo&|竓k2Vvon@<8{dK i>?vuT4UTPQt3^Ev*ثb͊6* j/`I?傓`ȵB_I*;[]UGrIi/6Xa݆c_it#׏JTfMwe_]k l ʌêz,cXhF+_l $bٹ`;7,Uً*vchE/`8  j}9t0\a)>~Z%[DQ~@ܽOWC<^zmB[Ze# Nepk&mfhaߎ? RXk7S:c8Hǟ1.ɾ'GAPwbhi%#1R $.X<.w .iG#±'%tL@rޘ%Mk[M~R),m$$ V i,vG }o%mySWv]`.V4Fۮ"|u/).t̪*P7>+|5&FF&kS d9Z}vaui6+]^A v(C׏]_kwikTFiA',ݗ{33+*ɾሠam oy7{R'U6*>׆ 蜊zBis[Ozm [6M~}Me_O^PyLuX۩gMRlGN4o3qcscjw6ɩK K SƵQ+Locl?^"tep8#Vn?|}g,/DL&.AA#C^C>Wn>Q7<`-ta0SJGw6 qy>LkvlUٱWf]vlUٱWf]vb*yi2yXWF< a [4?Cq2`naG.w{z$9_6;N-Zl6qW|_OOo/eaG#7 iqOif=km-hHo$?jr([-9j˜mJWaim5E@}&Wkiwferej (T"dg!G~SAyg&|"jvq,"$d*?~pKCOeIjtS7)Nj hIET6O ?vlUٱWf]vS2$OL >ۯ+QѾy{;Iyu)<*??}̗"8"@js[m; ӳs֝6fӲ}|Wq,_HNMF ɌDц_O9hzw; `uld'Ďn2HvlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlU6[[V{iHV0hv@l,4q6ai(M#~ތnE<ݐgZާ?[K}>45m,=- .A %g/tM3$[I#vnᔱu*T=Nin}6K4ZŽiFRS8|rZ)֫+[xHoMu"[L(Q~a R@k/"^ZyŤryi$쫳%:#O#ʙ1Z?VWwux9Fzd<ݩQƿvG::k:G},\^PҋEBB)id}Yn&>8bEELw2&yfR5+톚ߔ|߫IjZiM6kh(E?W8m\NyUy\:jBh;K{cI$mRזMgɓ]^W EyXDvӬF$u r]rbT~{gyM_X!u=[OI2[[z$hL/RYApR3t}?Ky=-"Ix(n$r0( +ޘ`K}+}+UyeEedJVV F鏂vtz$zjT6-coۘmZ9kjٗWS˺N6z ߫"%½Բ7("~KYlqE&G4-WeInOJ3K @k\_}eRl֭dg+ՊdXnLTf]vlUٱWf]vlUٱWf]vlUٱWe;RĀ'aLU<[mM`"os^#,1)}Y̓K6)]}SCˣkNC W< -Y]0< |,=/N(5 P(3E~*ثb͊6*ثb͊7!㊻7%r_7%r_7%r_7%r_7!㊻6*ثCi?ZA]C0=bc'fh_qzc3kO)Cd:?/֭aw@O㙐Ayn < N3b͊6* y}،u?ِYdvv]MrՕ1GsR%c"ep6SWM;5qSWZvjkN_|mi٫ӳWE;5}f)fVdnhtak@Kb5DE=C[/bc1˜wf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWcd$B)28į6a\*}#Zj+Qro_=ܘ4y;UսմW6,LHSUeaPGg($(b<ĒjpV)2- ny#({v~/ߙtó~~/ߍߤߋAl;7+[J~4ó~~/ߍߤߋAl;7+[:Ӧ[%o_ aٿI[ƂvoV~h-a!TKSku~Rxa*kvN3Pf]vlUٱWf]vlUٱWf]vlUٱWg4C~whEvxkɽ-:|92J?cGMU<(TEF`={6~1*!vjgO,t-d-u͊6*ثb͊6*ثb[TEJՠc#c䕚rbu=k^،z-Gsi%DdXJ4+w#kiRxx7Y$JZkjm% ErdFx}<L{CJKAg9FbNB/WHl RF#vLS( È"/kZ=ԉ,xh r|2Wm4>G=ǨYŎC6 Y}ӏiI{L<<Xe:b2wJ>̷vbh+)X0劻j7i"+#m2 vGW̒7)7يef˴Eer2vnC$ ;?.7/ Nx-{r2N\Rƃ+iKTk'R0TRX $$× zS3?4uȲ~da՞[L6q:ͿH~ߏSs%$qD\ܼ@QNrK'<_TmNn}_Ci꞉Ƶ r|N :\tX$) nN,`pSDz Ab#"8Z?s_-z-k~2\\'H4=;>o[0MW@ eLx%~^n1%H M:7i1iwz}ݭ0MĀ4@e OqW*#&6M{sh[IgFT0"MDz9{ڭ@H^cab7[cėf$C"QNm+R,Eƭs>%]~㓰/q]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]~fiW 7W_/꧃ ?o"Dag Cʾa>a~*Nr)R2u_Q7lia5"$8Q\wf*PG]E*ޔ_ȿp]ҋ;7/1WfE*ޔ_ȿp]ҋzQ"voJ/_bޔ_ȿp]ҋzQ"voJ/_bb͊6*ثb͊,M#} *u,Öڙen8@ĞX!@HOA`s)0GsDRƕeO<BO)Ũ90p40K48ff4 nI9qKH^7P#eaPA #2A#99J0!B=T3̯5G?\ƻ49D@KH8PN̠_bGK*I;KHDYNʌ``nXGTh匕xe`hApF: ?e>op~9Դ{{[ĆkRF5YbbD:}Am,1`(; खHhu#ř 8A#B|;ŬsRCɄ[8䘻6*ث~cޱOFʭΧ7&(Yq&r"*#bD+.P2dX5Kn"BA[s_ i]?WO#vI%Ɵ*+ZJnQLd2:gg_/Ε{Ih^Ȑ_K+*UN팓^{reXK{ZFcsi1u>"?|iW# cJW#kqڅ+ a pvu.|5nt>Zhd8SJ@ь042G23ӛz//ZkmRGne]W!nPS%ɦKWKN^gXU4K/ӆ1#)&d-[M$r+քןGXww\i_Iah#\!+qx^D]˭?2t+MGke[_"EO ]m=0v/2^^EDiX )=8Ï!l`:'`2 'nZUʂrF[mvCkERIZ6kVy>*J+9AZGͦ~SzS5%Վ|*JLgRI?4oRԵ׮]Ԏ8pWSɗr:dnS!OVi-HV)n˗TE&rcO. OuP\ễ.Aܷ^<vn<ͷ(?.5&ajmO,Gյe5~ TWmN J_[5+#HI`+s+!vBTWl~WZhڊ$wh`9\GY2X?Nw5=[;U"ey)Ρnw$4NGRp‡aɿ%{HC)p؏,ӳr֝ E;#ud *8$pYfS!G,ÄD}n1q cUoʑ'jn :~v_#àYj+]R9 Ze\&)jpx ?\?ї{uR JejQU嗙zKDiDeFʏ@$E\ZQ=_L O>m9oƏkן6պӊݖE@ r0Gam0Ko^'̒W ~WVfZ% FV)U@ \hjzc1?ͥ``aN˒鉯qmAemGOz!^+P|;QFI;\x#/zOEGS:rS>J-|{c{ڵiyvӎ1BYD!e[mK$e p es iLWHId  N<\uMZw-;:W,ssNZvQcUGCnFwT?G gcK2!'&ٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUHv#K)bnb*7=DɷN'fIk;]ӿw{l%( ve[ ?_r㣷'dT[D3K5bX~_?K fXiٿH_E돀cfXiپ_?>ZvoE돀cfXiپ_?>ZvoE돀Xik_)dI)8lA{i9H}4bٱWf]vlUٱWbq"r3YCda%?V`x]o<˫yVP[+9;1E0;1D~O@kAGsֿ'^Mǚo/m, :l z~#I ]8%iM?.yu"X:%ϖRC}+=ͩ.N1ڧk,~_Kݯ`g]ʗ6c*av|:󖹦M^i4qm2Oꕾd` Jl2 ȉ ~T򖍩i֟T-^s:eqnJ!tԃiuwg\5%!Qjqf_NJ.|v*֚]~]TWSV^}i9zC* |ɣi:/4KRKëCuNAoʞ]-uCOgqrBZep^E)u|6r^j^NK%H JeDjT;a F;e(XGwgyW2"FQo^y6zX&tMR"a$>^"QᇿiӼa|KcwtuALeEmet *&209[fy .As?P&$աYyTEk8s%YJ1ЍtO2}˰~Zثb͊!wvw5ĩK!Y"(wfb|qP'VtC8RUjNu(u;Ummtװy#X+sGNjsڧ g 6DWz_EmnҪ:d˒f)*V%uWFhsE`I z ̢:i:e<"v*PUlTuɪg%)w0V*,?ByaQڏK峒+IIV71!gNӼI# \K]W"@F09!+WzbYya4Kn.< [V Rnpt Myk\/2R(~*@,:uYiTRi)UErq&H>1œ '2}鏜s]cEsG=ȉdUT)9?TWRUF[2XĎ91)IW_v|hw!SY~g,%燙IuHM2D HhHۛ]>9%\;:xga/o̝hw/ss--M>m3/v̫4Txx AӲckNgB⻓1vF1<ךE6ow4G \qS \hT w&5 ;TWY *V?!bt q|y|)bx@'eHScivnXӳr֝[3/Lytw{. b͊6*ثb͊6*ثb͊6*ثb͊6*ث]{;ڇ50+ v_Wغj1nG=_c2]-6ޞ5KB}+$~ n3_I,8?oQyw,#IgdOR{ĵWs@2PbM'W;ml(co.[周M@TJj{#yp՞(~ԃVr[TIg_0LgY!RE7 WgZf2O92AcF]ҧ"d-m7,M;M[Z#OQ 7dIu?0hP) @P1W4XΛln/YYUO) z4ZyCX-5(#aUv MH [)xv%^E4dRU1;o6n[mV{HG=whxMqA[,+K* "裓2Z&|EH1 ߑR<1mpU/KA~_C ץp%k0 ıY^1MI XPѾ|iDM-"6^cPf'eHhz)\4O1菪%u c("d3Jӯ.-ғkCM]Q.oOZSԧQb7[o D+BZ)Z21Pb`Zq^Ӽ˨hVPMM*dՠe%I{ 6j\`互('ɰE-Pus)A0-Y)e3Q#ܻ'!j.K\/.r9ї#"y"B뚋OmsxKܥI)7HbSe~@*H=F$nln Bdf%\!*+eIK LJ2j⺷C$r.ZQ\ILDO%9 #^0~ }_|m2y(lK^a\ثb͊8掇k6"#{=VٴٜGPJK]QmL v(оL_Ӵ]n[,J2Ik,DUHm;@ߚ&+d]BMn@Xix9Y)%GirgKW)^mL37-+qUʻXMG%^]졽!sUDUePu2 ?5\O;MBk([( XA׵Km]y5'Ai?H(v+MX iy⿱`fFL־Y}"D97TIV~fϖZŅZUr3[H5A-42b~uZ[/\3nSY0˿: i ijK"I&"ny9זPŁޟBKnWOE1qdѳH˅W"?Kzd@WдcO,X&PҘ$PxSb\&'_>.VTnӬm5iz#}So n,#mVO㼻>umM_Om`bVC!n #pa0Gc+ϫ( b ZK֡{ˇ\I4m#"u|6vD|> ViAZA i^'\[$Pяf9"Md!媿&jPwŸ/qu'nu!QO\ГnOTĞ /fA(XwŢzRViwQNe8g, 'ԨN$ 1\?|u45['q ]I)s!G/+~[[F40OaE-sѾ;U!*0K $$|t_)MIn 59lX PWyC0*EC d.X]O3o4OںdBT!V4c'ҟ\f[Vzq򾡫yZFش%\E-Q=0d'+^nҴ$ysU[ŞY{kb%{HsJ9E+zΥ4WZwcw!_WYlB WaEiZKtZ1=L^@2'kO!=r9![ Mz}{7[ś8# ~a~MX7Z RZDpIu5^z ?5izs%{\Z]M8ZYc\ Lo2jZ{. uK-Z%y&[ȢD)dj2?y~g.TOCc HyC78vRH@ƥE{ky^U-*MBmrfYEz~(f <<dZ)1HwӦK|@nZ$t|HXutC:; v,?W1͉Uh+3i n㙑F}<}G ;y~KkYsM>. ]vlUٱWf]v "=~+an'vs9|;y[-5/0">AӾea2=n1#wZȾh_+oL1L~fJȽͥeܚ^{w{s"@me&TCɘ+-Yv.1'o 1o<[]կ-u =)5;XFEfu*̭EcR|Ծe,nuHM];j]ʎ)JӅ5?fu_CFYNƯ|Rv/ΡkʺjGE)ZXW'Gۦdǜ/F >{iswlC@:H5NG!>6fC #o$Zߩqao}bom ''ɑm5h?e;S 8ˆkeb%Y]w,av9"~lBOyhZ]֖SkwՄ<$)bx'>/o3-R[/3kI8X.>&cr  0#)<6()N|זP*^c^\udǗ`ͩ$Lvwֶ .|^$y #*{t`u 8?'c_(Iueaw$>a 2BXF놓ry,jl{@rZ5k z?’iJI5}e/]ynP8%Jw֕M/˶:lM޻^JKa%j9?k-5r|h]D,Z|q5vHSgLd=j>/!|[iZKFb.HW (mSsc9.C#~u&.;}n^* GKbG1rM‹G^'c(ylE>9v{U,vlUٱWf] r_OFS>CKz/ ~a4Kb^Kk$J\~GxNJTOÉyc׾c׬K.LJRE1b;7-V JRC^\4DŽys% ^[FP1Neǒ\Me+Q- $(~|xOw4 2zHC!Yil oky׍Dy oNc/^\p>h/NWT ޡ#plmК5r|5Wæ*Mq7|BOM2Ztڵ{nuϔua{ ګ61kEBեw **0+%HPȄ2 9Y-qa&)cbF+B;1ަvJ6fArI"WZ+KBE+&3ܫB6#: 0r ,78ݑI_P)OPHNt{x;ýijvk_O(Xڣ)?ʕ켶n$ޙ_P(G@z'p:v_`pw-ARH5;l5Ο73@[5oNF-r_v+Eo|7Zmf-b]6cc;8JAHbVrϧ22ީ0zRKm<8 >o^pK1Ot?a 7| <̪#O,07D~ܑౙ1%8\H#e$ӜQG'$4Jc_ LVڃZ=ImGːFGNIb͊1]][m^PHXϊ};fUޏ vNc9.ļ.>i75M&ˇ")^jۚln 3qXLl_gP;9K'F]E/NZH^Yz J9q\:phI=c)2Kɧ[[='VP}6a2L?z/N򭬞UiM->RmI$e ߮+'<]WZMy2Jʥ-^l;ړ"IC閚UwPYiΞ.&b/6KDޣ/KbtoᵞZTr$ BGx`4k?baJzNtb:BD3]6.@N>9+6{yGJoJjT1#j6A)99\&O0?05-wzc 4FE0޸{ꜯcٽS v:  j~#J <-~A deгpn͊6*ثͶ^X-2-k3 f#$48sՍ叓-oak{ĜQ#v<16?c^87bfM^~b߯4ڜQ^NnynޝZvnX-iٹaf卭;7M]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vq:k~[<.t`Y?r%cP'Fkڙc1{_d{#aXz'a栖%l5>+7oB;wr69v.Y~О!߯yЁeYWf]vlUٱW`-OI"w0U0d'HQ%q4]_:(QiZG"eaA; ͏1rk5819VhṵO$G,1UBB_Ltq䀕3E8D7;d ?ӗ~SsQo.N?ܿ9ݛ ?ӏ1/nf?14L}ٿO 8Sr(vo.N?ܿ9ݛ ?ӏ1/nf?14>Q; "N|ynIfbdJҠӭ8)ye=Yʹ "(: e3e7&ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb9[3hhZ|֓#2hV>l92oM.ӆN2/SO&h>]Oo/,]rݽ)$IUq9Ne׌>?m?3IokYtAd8he~Q/1Db9d?_k:l^-ٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vQU`A*jQV-6&;vgf&m biDZEOJ'n51JûéǓ~WNkNZvn~ӳs֝֝6f獭;+-Y좂X%dh0r4=<]%6 X~z>u+[(6шoR|INg lLIؾI͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثTcjKٹ/6|qvQM6vr/<麗44O7ièԵH-л6KQ=i(./g:z˥!\ ?go::o Y|ٹ/6|qvnK㍫r_m]̼N vq'wF< ~`Nx 3}#{~ZPo:ƝhmŅVIJL~ ]uy #FQ<ܗ%m|qf8ڻ/ 6*ثb͊6*ثb͊6*ثb͊6*ث[Xbq 17`"Q{lLG_aom~zVOJ+2#@qrv FM?p dCCw 'i*IӬR$d~lw9̍ny&.͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb"Hec Wa\Lyn c2\fuQopvP 'c1vYqiG#pv5ȵ%kYKYE?N\y]a/Qn.xVbI?w([xwɫ} /nQI"ʽH^BSJq^Ik5pZ۲$%i>w(2roZG_ =W}2PYFQo<4V RS `cݲcaZ(=6y)'e)d"I R+^aa4;בgG%P:/pk 2[u2Guu %993\7'Hzca蚆56(36dࣦ5S,G#~{OZyoB}+Jcwz~.Q mƆNyE##yKљaY!RAu(AQăSlVH 7XIF`CA/|h`L^K"ߴܫHBR9ÄAz/twB=؄!q5Œ-1|{aol4Kq N9LXo͎Tzn_ 7n&W#꩷h+^G /|?|G->c;Klb2I`l3S Le~a1yCN+S,躰XヽmyF^U5GZmo[H1kSޏVXMvFV֊+0ȝE0>mL^^&(a{⮌%jpMv#j:{succ4o 'Nq~rƻu&cz(e$wo7hZyO5K+{Kl/"\!A3EzNϝWzڼzzMŽ;ƙY%FA4~ /ö1cLu?4)áN}=^{K:;Y,l X#hbsY!Q^;>Wm /hlֶOa#nhF/Z au+y%FNrg<ڪ]]Mo:[Ao۟I`wd*I~a~/?Hjm>n_t- [:V`۲" - ͺlw=Zi/qc2[БL|_T<7n[A֭'ҵԑLa=X>єobyb/'F &u<`ͫJ#dEQL~0.kԽmT]FI%t=ShV1Dy&d>eK]fwWFmf11N?H9/5j%zm;{;9=R{kSc RUx=2So&#ngVuqywɦ M,%c?!_w}>U:z$%v-X}Kq6I"! Yż$ {l e--hJ95:׶×\?K 'wO?t]-IpmoksǦH$י#c!躅 ytHުd|gK{ ԥuKw7J>J zL~\󚦮iZw\-Ѽy[p>HL&q۹-醭o'2hh{mtO@/TK/h~f'ѺOЬ%UmM\dfN #߇y̺f尾֚v)opiaFX֕:~Hԓ5ܓyI31;6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*'#>E1] ='o|`I؋[[Kmnc1\@6] OȌS˅K ֑*K਎1)Ay|k1Xm0>>FJZֿQˢM[$qy3YKH[ _yQkmoO iy+j٬?UQF)j#fQ_4`&=W'IKeo,,mVEazPs'|ny%ԴFR} her$N ˋj c@K<(X$>n|}J崭OLҢׯ5." ote66u(MpnyY4h\[Cfbʢ`9 a\ ~y0doK|_'G-1KojX_$hXO*ԮZzP苨ח[q,mB'.#E䱖-pؔJ_:ecaKn`Yn2@{Ҹ<ҺFޘ_ dQǟ>GKMřǐJwAGGڥHqR.MǗ@*jN0_,iZM՝o[E \ILLaIo%߿oZy}'V>kյ{[_ҏi-<(ӈ]Cݯt{Kkx//(-+bhfIY9;I)o^_6'ǵ kBjn,=>Q#\4 3B+E`Eڝ)|k6io/4oQ]{Sr<:T0GaG 7FO/$bm zaxky{KӞ x+G) Z|0ע6PŷL4i#eѪLd$mYN2nz痼gŠ=ZI< ,W3Yxi@z'=?ڇա4=OiYN Ot1 0kҍtu7OqO|_fw޾G.*_YZ ''ṷoid6nٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf]vlUٱWf41WdF^v R;ebI^&P{Ҧ0ra#d<:Lc@=??_ﵷz_q}WORq:l?Wzٿ:7_lQOORq}ާ)vo΍W[ާ)voΏW[ާ)v_cG}\N~oS%_q}ޫ)v_gG}\-jS%ٿ?_lWzvoƍW-joS. |O?zٿ7_lWzql?QOؗe4'zٿ:7_|?BoUK"YܭC,՚^2FjRq͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ثb͊6*ث endstream endobj 125 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 128 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 129 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 127 0 obj <>stream /GS1 gs BT /F5 1 Tf 8.9663 0 0 8.9663 59.7543 725.7825 Tm 0 0 0 1 k 0 Tc 0 Tw [(Mechanism)-337.8(of)-336.6(Graphenes)-332.8(Positive)-335.8(Effects)-333.7(on)-333.8(the)]TJ 0 -1.2203 TD [(Proliferation)-337.1(and)-338.2(Osteogenic)-334.2(Differentiation)-337.3(of)-336.6(MSCs)]TJ /F3 1 Tf 9.843 0 0 9.843 69.7323 698.3998 Tm -.017 Tc [(The)-462.8(a)-2(b)4.9(i)4.8(li)4.8(t)4.8(y)-467.3(of)-461.6(gr)5(aph)4.9(e)3.8(ne)-462.8(to)-461.6(pr)5(o)4.9(m)-2(o)4.9(t)4.8(e)-468.5(t)4.8(he)-462.8(pr)5(o)4.9(l)-.9(i)4.8(f)-.8(er)5(at)4.8(i)4.8(o)-.8(n)-461.6(a)-2(n)4.9(d)]TJ -1.0137 -1.1174 TD -.0198 Tc [(osteogenic)-471.3(differentia)-4.8(tion)-470.2(o)2.1(f)-470.1(B)1.1(M)-4.5(M)1.2(SC)-4.6(s)-470(a)1(nd)-470.1(A)-4.5(S)2.3(Cs)-470(has)-470(b)2.1(e)-4.8(e)1(n)]TJ 0 -1.1116 TD -.0214 Tc [(d)-5.2(e)-.6(mo)-5.2(nst)-5.3(r).6(at)-5.3(ed)-425.7(\()-5.2(F).7(ig)-5.2(.)-422.2(1)-5.2(\).)-422.2(I)-5.2(t)-425.8(has)-431.2(b).5(ee)-6.4(n)-419.9(r)-5.2(ep)-5.2(ort)-5.3(e)-.6(d)-425.7(t).4(h)-5.2(a)-.6(t)-425.8(t).4(o)-5.2(pog)-5.2(rap)-5.2(hy,)]TJ T* -.0201 Tc [(c)-5.1(h)1.8(em)-5.1(istry,)-363.3(and)-366.8(physical)-366.9(properti)]TJ 12.6944 0 TD -.0214 Tc [(es)-362.1(o)-5.2(f)-362.3(b)-5.2(i).4(oma)-6.4(t).4(er)-5.2(ia)-6.4(ls)-362.1(a)-6.4(r).6(e)-369.2(c)-.6(ri)-5.3(tic)-6.4(al)]TJ -12.6944 -1.1174 TD -.0198 Tc [(para)-4.8(meters)-614(for)-614.1(d)2.1(irecting)-608.4(c)-4.8(ell)-614.3(f)2.2(a)-4.8(t)2(es.)]TJ 7.3823 0 0 6.5614 203.1306 658.9415 Tm -.0239 Tc (81)Tj 9.843 0 0 9.843 216.17 654.5195 Tm -.0204 Tc [(In)-614.7(re)-5.4(cent)-609.1(y)-4.2(ears,)-611.3(the)]TJ -15.891 -1.1116 TD -.0195 Tc [(m)-4.5(echanism)-252.2(h)2.4(as)-250.8(been)-251(explore)-4.5(d)-245.2(from)]TJ 13.9558 0 TD -.02 Tc [(different)-251.6(a).8(spe)-5(c).8(ts)-251.3(\(Table)-252.6(1\).)]TJ /F10 1 Tf 8.9663 0 0 8.9663 59.7543 621.6943 Tm 0 Tc [(Adhesion)-339(mechanism)]TJ /F3 1 Tf 9.843 0 0 9.843 69.7323 605.2534 Tm [(FAs)-441.6(are)-449.1(large)-445.7(protein)-441.1(complexes)-446.6(that)-443.6(indicate)-444.7(the)-448.1(con-)]TJ -1.0137 -1.1174 TD [(nections)-506.5(between)-507.5(cells)-509(and)-499.8(the)-505.7(extracellular)-510.2(matrix.)-502.2(FAs)]TJ 0 -1.1116 TD [(play)-334(a)-336.3(key)-332.8(role)-334(in)-330.6(the)-332.9(mediation)-336.4(of)-330.5(adhesion)-339.4(and)-332.8(migration)]TJ T* [(of)-503.3(cells.)]TJ 7.3823 0 0 6.5614 93.5433 576.7368 Tm (89)Tj 9.843 0 0 9.843 105.8456 572.3715 Tm [(Several)-506.5(studies)-504.1(have)-502.1(suggested)-501.6(that)-506.9(nanoscale)]TJ -4.6826 -1.1174 TD [(structures)-433.6(of)-434.1(substrates)-433.4(may)-426.2(regulate)-433(FAs.)-433.5(Kim)]TJ /F4 1 Tf 20.3433 0 TD [(et)-429.7(al.)]TJ /F3 1 Tf 2.6149 0 TD (hy-)Tj -22.9582 -1.1116 TD [(pothesized)-371.7(that)-362.9(the)-361.7(unique)-365(nanotopography)-369.2(of)-359.3(the)-367.5(GO)-366.8(lm)]TJ T* [(would)-334.8(inuence)-340.6(the)-332.9(formation)-335(of)-336.2(FAs.)]TJ 7.3823 0 0 6.5614 215.0362 543.855 Tm (6)Tj /F10 1 Tf 8.9663 0 0 8.9663 59.7543 517.5494 Tm [(Cell)-336.3(morphology)-336.6(mechanism)]TJ /F3 1 Tf 9.843 0 0 9.843 69.7323 501.1085 Tm [(Micromorphology)-820.6(regulates)-819.8(multiple)-823.8(biological)-814.5(pro-)]TJ -1.0137 -1.1116 TD [(cesses,)-444.9(including)-443.4(adhesion,)]TJ 7.3823 0 0 6.5614 170.3621 494.5322 Tm (90)Tj 9.843 0 0 9.843 182.0976 490.1668 Tm (proliferation,)Tj 7.3823 0 0 6.5614 233.9716 494.5322 Tm (91)Tj 9.843 0 0 9.843 245.707 490.1668 Tm [(and)-442.2(differen-)]TJ -18.8918 -1.1116 TD (tiation.)Tj 7.3823 0 0 6.5614 87.5905 483.5905 Tm (92)Tj 9.843 0 0 9.843 98.1354 479.2251 Tm [(Moreover,)-332.2(studies)-325.5(suggest)-325.4(that)-328.4(cell)-329.5(shape)-324.4(is)-324.7(a)-330.6(key)]TJ -3.8993 -1.1174 TD [(regulator)-300.4(in)-290.3(MSCs)-295(commitment)-299.7(to)-290.3(osteoblasts.)]TJ 7.3823 0 0 6.5614 248.8251 472.592 Tm (93)Tj 9.843 0 0 9.843 259.0865 468.2267 Tm (BMMSCs)Tj -20.2511 -1.1116 TD [(cultured)-483.7(on)-480.3(graphene)-484.6(exhibited)-484.9(a)-480.3(spindle)-481.2(shape)-485.7(with)-477.8(no-)]TJ T* [(ticeable)-457.3(lopodia)-459.3(extensions)-456.7(and)-453.7(cellular)-456.2(protrusions.)]TJ 7.3823 0 0 6.5614 280.403 450.7085 Tm (4,5,51)Tj 9.843 0 0 9.843 59.7543 435.3448 Tm [(Thus,)-504.2(the)-499.9(elongated)-503.2(MSC)-500.4(morphology)-501.9(on)-497.5(graphene)-507.6(may)]TJ T* [(permit)-337.5(higher)-336.2(rates)-336(of)-330.5(proliferation.)]TJ /F10 1 Tf 8.9663 0 0 8.9663 59.7543 401.7826 Tm [(Mechanical)-339.2(mechanism)]TJ /F3 1 Tf 9.843 0 0 9.843 69.7323 385.3416 Tm [(CVD)-334.4(graphene)-334.8(consists)-332.2(of)-330.5(many)-329.3(ripples)-331.4(and)-332.8(wrinkles)-333.4(on)]TJ -1.0137 -1.1116 TD [(the)-321.4(micrometer)-328.2(scale,)-323.4(caused)-320.9(by)-324.7(the)-321.4(difference)-321(between)-323.2(the)]TJ T* [(thermal)-570.2(expansion)-565.1(coefcients)-563.8(of)-566.6(Copper)-561.7(and)-563.2(graphene.)]TJ 0 -1.1174 TD [(rGO)-367.9(also)-368.4(showed)-365.6(wrinkles)-368(in)-365.2(the)-361.7(atomic)-367.5(force)-370.6(microscopy)]TJ 0 -1.1116 TD [(image)-245.3(because)-242.6(of)-238.3(the)-235(spin-coating)-246.1(process.)]TJ 7.3823 0 0 6.5614 228.0755 345.8834 Tm (54)Tj 9.843 0 0 9.843 237.8267 341.518 Tm (Some)Tj /F4 1 Tf 2.517 0 TD [(et)-239.6(al.)]TJ /F3 1 Tf 2.2348 0 TD (and)Tj -22.843 -1.1116 TD [(Misra)-381.9(and)-373.1(Chaud)-7.7(hari)-374.3(assumed)-379.5(that)-380.2(the)-373.2(higher)-382.3(surface)-379.6(area)]TJ 0 -1.1174 TD [(might)-271.9(be)-274.1(the)-275.3(cause)-273.7(of)-272.9(higher)-272.8(adhesion)-276(and)-269.4(proliferation.)]TJ 7.3823 0 0 6.5614 282.2172 323.9999 Tm [(53,8)-8.6(7)]TJ 9.843 0 0 9.843 59.7543 308.6361 Tm (Nayak)Tj /F4 1 Tf 2.8568 0 TD [(et)-245.4(al.)]TJ /F3 1 Tf 2.2463 0 TD [(thought)-238.4(that)-247.7(the)-240.7(ripples)-245.1(and)-240.6(wrinkles)-247(might)-243.1(play)]TJ -5.1031 -1.1116 TD [(a)-278.7(role)-270.6(in)-273(protein)-279.8(adsorption,)-274.8(cell)-271.9(adhesion,)-279.5(proliferation,)-273.9(and)]TJ 0 -1.1174 TD (differentiation.)Tj 7.3823 0 0 6.5614 118.8283 291.118 Tm (4)Tj 9.843 0 0 9.843 69.7323 275.7543 Tm [(Recent)-523.9(studies)-521.4(suggest)-521.2(that)-518.4(nanostructured)-525.8(and)-517.1(micro-)]TJ -1.0137 -1.1116 TD [(rough)-466.2(topographies)-464.8(might)-467.8(also)-460.5(mediate)-467.7(osteogenic)-469.6(differ-)]TJ T* (entiation.)Tj 7.3823 0 0 6.5614 96.8882 258.2361 Tm [(94,9)-8.6(5)]TJ 9.843 0 0 9.843 116.9008 253.8708 Tm [(The)-345.5(study)-339.5(by)-347.8(Tang)-340.8(a)]TJ /F4 1 Tf 8.9506 0 TD [(et)-343.3(al.)]TJ /F3 1 Tf 2.4479 0 TD [(proposed)-343.8(that)-339.9(the)]TJ -17.2042 -1.1174 TD [(rough)-546.9(topology)-544.7(of)-549.3(the)-546(cross-linked)-551(GO)-545.4(lm)-545.9(created)-548.1(in-)]TJ 0 -1.1116 TD [(creased)-311.6(cytoskeletal)-311.9(tension)-308.4(for)-308.5(hMSCs)-306.6(to)-307.6(grow,)-302.4(which)-307.2(had)]TJ T* [(been)-329.3(shown)-328.7(to)-330.6(guide)-323.6(differentiation)-337.3(into)-327.2(osteoblasts.)]TJ 7.3823 0 0 6.5614 270.7086 225.3543 Tm (12)Tj 9.843 0 0 9.843 281.3668 220.9889 Tm (Kim)Tj /F4 1 Tf -22.5147 -1.1174 TD [(et)-498.8(al.)]TJ /F3 1 Tf 2.7531 0 TD [(hypothesized)-494.8(that)-501.2(the)-494.2(unique)-497.5(characteristics)-501.6(of)-491.7(the)]TJ -2.7531 -1.1116 TD [(nanoscale)-521.4(topographical)-513.5(\(asymmetrical)-522.7(nanotopology\))-511.1(as-)]TJ T* [(pect)-306.4(of)-301.7(graphene)-306(and)-304(its)-302.9(secondary)-306.9(effects,)-302.5(such)-304.9(as)-302.7(stiffness)]TJ 0 -1.1174 TD [(and)-315.5(roughness)-315.9(within)-313.1(substrata,)-315(might)-312.3(play)-316.7(a)-313.3(crucial)-316.7(role)-310.9(in)]TJ 0 -1.1116 TD [(the)-338.7(enhancement)-336.1(of)-336.2(hMSC)-334.5(differentiation.)]TJ 7.3823 0 0 6.5614 230.1165 170.5323 Tm (10)Tj 9.843 0 0 9.843 69.7323 155.2252 Tm [(Misra)-324.3(and)-321.2(Chaudhari)-324.4(reported)-328(that)-322.6(the)-321.4(addition)-321.4(of)-324.7(GO)-320.7(to)]TJ -1.0137 -1.1174 TD [(Nylon)-513.4(6,6)-512.5(led)-511.4(to)-509.2(a)-509.1(small)-514.8(decrease)-515.5(in)-509.2(the)-511.4(contact)-512.6(angle,)]TJ 0 -1.1116 TD [(making)-377.8(the)-379(hybrid)-375.3(polymer)-378.8(relatively)-383.6(more)-375.4(hydrophilic.)-379.9(A)]TJ T* [(hydrophilic)-416.8(surface)-414.1(is)-416.8(expected)-411(to)-417(inuence)-415.5(cell)-410.2(assembly)]TJ T* [(and)-390.4(conformation)-385.6(of)-388.1(cytoskeletal)-386.8(protein,)-392.7(such)-385.5(that)-386(hydro-)]TJ 0 -1.1174 TD [(philicity)-340(favors)-335.8(cell)-335.3(attachment)-334.1(and)-338.5(proliferation.)]TJ 7.3823 0 0 6.5614 257.7826 104.7685 Tm (53)Tj 9.843 0 0 9.843 69.7323 89.4614 Tm (Engler)Tj /F4 1 Tf 3.0699 0 TD [(et)-395.2(al.)]TJ /F3 1 Tf 2.5458 0 TD [(found)-391.4(that)-397.5(stiff)-391.4(substrates)-398.9(promoted)-397.2(osteo-)]TJ -6.6294 -1.1116 TD [(genic)-347.8(differentiation.)]TJ 7.3823 0 0 6.5614 143.6598 82.885 Tm (96)Tj 9.843 0 0 9.843 154.4314 78.5197 Tm [(Howev)-8.4(er,)-340.8(the)-350.2(elasticity)-349(of)-342(graphene)]TJ -9.6187 -1.1174 TD [(and)-240.6(PDMS)-242(are)-241.7(in)-238.5(the)-235(same)-243.9(order)-237(of)-238.3(magnitude)-244.1(\()]TJ /F9 1 Tf 19.128 0 TD (*)Tj /F3 1 Tf .9964 0 TD [(37)-170.3(MPa\);)]TJ -20.1244 -1.1116 TD [(therefore,)-500.7(the)-494.2(differences)-500.4(in)-491.9(cell)-496.6(differentiation)-498.6(were)-497.1(un-)]TJ 25.5097 67.9242 TD [(likely)-371(to)-365.2(be)-372(caused)-372.8(by)-370.8(differences)-373.7(in)-370.9(substrate)-369.2(stiffness.)-377(In)]TJ 0 -1.1174 TD -.016 Tc [(addition,)-405.3(graphene)-409.9(is)-402.8(very)-408.8(thin;)-403.1(t).1(her)-16(e)9.5(fore,)-405.3(t).1(he)-404.2(subs)-16(t)10.7(r).2(ate)-404.2(s).4(up-)]TJ 0 -1.1116 TD [(porting)-241.6(graph)-15.9(e)9.5(n).3(e)-242.8(h).3(as)-241.4(a)-242.8(dominant)-241.8(i).2(nuence)-248.5(o).3(n)-241.6(overall)-241.8(stiff)-15.9(n)10.7(ess.)]TJ T* -.0153 Tc [(Hence,)-312.5(Nayak)]TJ /F4 1 Tf 5.8749 0 TD -.0156 Tc [(et)-316.3(al.)]TJ /F3 1 Tf 2.3096 0 TD -.0152 Tc [(and)-315.8(Lee)]TJ /F4 1 Tf 3.4904 0 TD 0 Tc [(e)15(t)-295(al)26.5(.)]TJ /F3 1 Tf 2.3096 0 TD -.0158 Tc [(speculated)-310.6(t)-15.8(h)10.7(a)-.8(t)-310.8(s).6(tiff)-15.8(n)10.8(ess)-310.4(i).3(s)]TJ -13.9846 -1.1116 TD -.0159 Tc [(not)-333.9(a)-334.9(d).3(ifferentiating)-333.8(f).3(actor)-15.9(.)]TJ 7.3823 0 0 6.5614 415.729 685.7006 Tm -.0179 Tc (4,5)Tj /F10 1 Tf 8.9663 0 0 8.9663 310.8472 659.3951 Tm 0 Tc [(Biochemical)-336(and)-329.4(molecular)-337.4(mechanisms)]TJ /F3 1 Tf 9.843 0 0 9.843 320.8251 642.9542 Tm (Lee)Tj /F4 1 Tf 1.8661 0 TD [(et)-360.6(al.)]TJ /F3 1 Tf 2.4767 0 TD [(tested)-360.3(the)-361.7(adsorption)-357.8(capacity)-365.1(of)-359.3(the)-361.7(substrate)]TJ -5.3565 -1.1116 TD [(and)-534.4(found)-535.4(that)-535.7(graphene)-536.4(adsorbed)-535(approximately)-537.8(8%)-538.9(of)]TJ 0 -1.1174 TD [(serum)-353.2(proteins,)-353.3(compared)-359.1(with)]TJ /F8 1 Tf 13.2416 0 TD (<)Tj /F3 1 Tf .72 0 TD [(1%)-354.6(adsorption)-352(on)-353.5(PDMS)]TJ -13.9615 -1.1116 TD [(on)-238.3(day)-234.9(1.)-240.7(Serum)-238.1(contains)-241.6(many)-242.9(extracellular)-245.2(matrix)-239.6(globular)]TJ T* [(proteins)-298(and)-298.2(glycoproteins,)-302.5(such)-299.1(as)-296.9(bronectin,)-299.1(which)-301.4(plays)]TJ 0 -1.1174 TD [(a)-463(major)-463(role)-466.4(in)-463.1(facilitating)-472.5(cell)-462(adhesion.)-469.5(Lee)]TJ /F4 1 Tf 19.9862 0 TD [(et)-464.3(al.)]TJ /F3 1 Tf 2.6898 0 TD (also)Tj -22.676 -1.1116 TD [(found)-443.2(that)-449.3(graphene)-444.3(had)-448(a)-445.8(higher)-445.6(adsorption)-450(capacity)-451.5(for)]TJ T* [(dexamethasone)-741.3(and)]TJ /F9 1 Tf 9.1119 0 TD (b)Tj /F3 1 Tf .5529 0 TD [(-glycerophosphate)-743.4(compared)-745(with)]TJ -9.6648 -1.1116 TD [(PDMS)-339.9(after)-336.2(1)-340.9(day)-338.5(of)-336.2(incubation.)-339.7(This)-339.6(may)-339.8(be)-337.4(attributed)-342.1(to)]TJ /F9 1 Tf 0 -1.1174 TD (p)Tj /F3 1 Tf .5529 0 TD (-)Tj /F9 1 Tf .3341 0 TD (p)Tj /F3 1 Tf .8064 0 TD [(stacking)-258.9(between)-259.9(the)-258(aromatic)-261.4(rings)-258.8(in)-255.8(the)-258(biomolecules)]TJ -1.6934 -1.1116 TD [(and)-240.6(the)-240.7(graphene)-242.7(basal)-243.9(plane.)]TJ 7.3823 0 0 6.5614 427.0676 537.7322 Tm (5)Tj 9.843 0 0 9.843 433.1337 533.3668 Tm [(Dexamethasone)-246.8(is)-238.3(a)-244.2(synthetic)]TJ -12.4237 -1.1116 TD [(glucocorticoid)-560.8(that)-553(alters)-556.1(the)-557.5(expression)-560.2(levels)-556.2(of)-555.1(many)]TJ 0 -1.1174 TD [(proteins)-309.5(and)-315.5(enzymes)-311.7(which)-312.9(are)-316.6(required)-310.7(during)-312(osteogenic)]TJ 0 -1.1116 TD [(differentiation.)-375.3(However,)-372.3(dexamethasone)-372.7(should)-369.4(act)-368.6(syner-)]TJ T* [(gistically)-393.9(with)]TJ /F9 1 Tf 6.2493 0 TD (b)Tj /F3 1 Tf .5529 0 TD [(-glycerophosphate)-397.8(to)-388.2(synthesize)-394.5(new)-391.2(min-)]TJ -6.8022 -1.1174 TD [(eralized)-336.2(bone)-339.6(matrix.)-335.2(Insulin)-336(is)-336.2(the)-332.9(main)-335.2(mediator)-340.9(for)-331.5(fatty)]TJ 0 -1.1116 TD [(acid)-340.9(synthesis.)-348.3(Graphene)-347.2(also)-345.3(shows)-340.1(high)-344.3(adsorption)-346.3(of)-342(in-)]TJ T* [(sulin,)-469.8(which)-474.2(is)-474.4(a)-474.6(key)-471(regulator)-473.2(for)-475.5(the)-471.1(synthesis)-477.3(of)-468.7(fatty)]TJ T* [(acids;)-320(however,)-319.6(insulin)-318.9(on)-313.2(graphene)-323.3(was)-316.2(denatured)-318.8(through)]TJ 0 -1.1174 TD [(graphenes)-630.5(strong)]TJ /F9 1 Tf 8.15 0 TD (p)Tj /F3 1 Tf .5529 0 TD (-)Tj /F9 1 Tf .3283 0 TD (p)Tj /F3 1 Tf 1.1807 0 TD [(interaction.)-630.1(Thus,)-630.9(graphene)-628.6(sup-)]TJ -10.212 -1.1116 TD [(pressed)-458.9(adipogenic)-458.3(differentiation)-464.1(of)-457.2(BMMSCs.)]TJ 7.3823 0 0 6.5614 508.762 428.1448 Tm (5)Tj 9.843 0 0 9.843 516.9258 423.7794 Tm [(In)-457.2(addi-)]TJ -20.9365 -1.1116 TD [(tion,)-255.8(it)-255.9(has)-263.5(been)-254.4(reported)-264.6(that)-259.3(there)-255.6(is)-261.3(an)-256.8(inverse)-257.6(relationship)]TJ 0 -1.1174 TD [(between)-386.6(osteogenesis)-390.8(and)-378.8(adipogenesi)-9.9(s)-381(i)0(n)-382.5(MSC)-385.2(differenti-)]TJ 0 -1.1116 TD (ation.)Tj 7.3823 0 0 6.5614 333.0708 395.2629 Tm (97)Tj 9.843 0 0 9.843 320.8251 379.9558 Tm (Depan)Tj /F4 1 Tf 3.0123 0 TD [(et)-395.1(al.)]TJ /F3 1 Tf 2.5516 0 TD [(also)-402.9(tested)-400.7(the)-396.3(adsorption)-403.9(capacity)-399.6(of)-399.6(sub-)]TJ -6.5776 -1.1174 TD [(strates)-269.1(and)-263.7(found)-264.7(that,)-262.7(in)-267.3(the)-263.8(case)-266.9(of)-267.1(pure)-264.7(CS,)-265.7(the)-263.8(adsorption)]TJ 0 -1.1116 TD [(of)-445.7(bovine)-445.6(serum)-451.2(albumin)-448.1(was)-448.6(random)-446.7(and)-448(large)-451.4(globular)]TJ T* [(aggregates)-660.7(were)-658.4(observed.)-659.4(By)-654.1(contrast,)-659.7(in)-658.9(the)-655.4(CS-GO)]TJ 0 -1.1174 TD [(scaffolds,)-516.4(the)-517.2(globules)-516.9(were)-514.4(small)-520.6(and)-517.1(uniformly)-512.4(spread)]TJ 0 -1.1116 TD [(over)-489.4(the)-494.2(surface)-494.8(of)-491.7(the)-488.4(scaffold.)-498.3(GO)-487.8(possess)-497.7(carboxylic,)]TJ T* [(hydroxyl,)-427.1(and)-424.9(epoxide)-424.9(groups,)-430.3(which)-428.1(render)-423.6(the)-430.8(scaffolds)]TJ T* [(hydrophilic.)-518.2(These)-515.7(hydrophilic)-520.5(functional)-520.6(groups)-519(interact)]TJ 0 -1.1174 TD [(with)-443.3(the)-448.1(functional)-445.7(groups)-444.1(of)-445.7(protein)-441.1(molecules)-452.4(via)-442.3(elec-)]TJ 0 -1.1116 TD [(trostatic)-335.1(and)-332.8(van)-338.5(der)-332.7(Waals)-338.3(forces)-337(to)-330.6(induce)-337.4(the)-332.9(adsorption)]TJ T* [(of)-486(protein)-487.2(molecules.)-484.7(Thus,)-486.9(the)-488.4(signicant)-485.7(differences)-494.7(in)]TJ 0 -1.1174 TD [(protein)-441.1(adsorp)-7.5(tion)-442.4(can)-443.4(be)-446.9(attributed)-445.8(to)-440.1(an)-446.9(increase)-445.3(in)-445.8(the)]TJ 0 -1.1116 TD [(hydrophilicity)-334(of)-336.2(the)-338.7(hybrid)-335(scaffolds)-334.5(induced)-338.5(by)-336.3(the)-332.9(intro-)]TJ T* [(duction)-331.7(of)-336.2(hydrophilic)-336.2(GO.)]TJ 7.3823 0 0 6.5614 420.6613 241.8519 Tm (9)Tj 9.843 0 0 9.843 320.8251 226.4881 Tm [(As)-308.1(for)-308.5(FRGO,)-310(Shi)]TJ /F4 1 Tf 7.741 0 TD [(et)-308.8(al.)]TJ /F3 1 Tf 2.373 0 TD [(reported)-310.7(that)-311.1(the)-309.9(surface)-310.4(oxygen)]TJ -11.1278 -1.1116 TD [(content)-338.6(of)-336.2(FRGO)-341.1(has)-338.3(a)-342.1(strong)-340.6(inuence)-340.6(on)-336.3(protein)-337.4(adsorp-)]TJ T* [(tion.)-324.9(Quantitative)-329.3(measurements)-331.1(indicated)-324.8(that)-328.4(the)-327.1(amounts)]TJ 0 -1.1174 TD [(of)-595.4(adsorbed)-598.4(fetal)-601.3(bovine)-595.4(serum)-600.9(on)-595.5(moderately)-603.5(reduced)]TJ 0 -1.1116 TD [(FRGO)-485.1(was)-489(signicantly)-488(higher)-485.9(than)-483.7(that)-489.6(on)-486(nonreduced,)]TJ T* [(highly)-335.2(reduced)-333.7(FRGO)-335.3(and)-332.8(the)-338.7(control)-331.6(glass)-334.7(slides.)]TJ 7.3823 0 0 6.5614 515.3951 176.0881 Tm (7)Tj 9.843 0 0 9.843 320.8251 160.7811 Tm [(The)-247.6(mechanism)-251.9(driving)-249.8(the)-246.5(spontaneous)-250.3(differentiation)-256.7(of)]TJ -1.0137 -1.1174 TD [(MSCs)-386.1(toward)-388.9(the)-390.5(osteoblastic)-391.2(lineage)-385.8(on)-388.1(3D)-389(GFs)-389.7(remains)]TJ 0 -1.1116 TD [(unclear.)-423.7(It)-428.5(is)-422.6(suspected)-427.8(that)-426.3(the)-419.3(intrin)-7(sic)-424.9(properties)-422.3(of)-428.4(3D)]TJ T* [(GFs)-510.7(resulted)-512.3(in)-509.2(increased)-515.6(cytoskeletal)-519.3(tension)-510(and,)-509(thus,)]TJ 0 -1.1174 TD [(guided)-462.9(the)-465.4(cell)-467.8(behavior.)]TJ 7.3823 0 0 6.5614 414.8786 121.3228 Tm (11)Tj 9.843 0 0 9.843 426.8408 116.9008 Tm [(However,)-464.4(detailed)-467.7(studies)-469.5(are)]TJ -11.7844 -1.1116 TD [(required)-333.7(to)-336.4(fully)-334(understand)-335.8(the)-332.9(mechanism.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 310.8472 84.0189 Tm [(Conclusions)-335.9(and)-331.9(Prospects)]TJ /F3 1 Tf 9.843 0 0 9.843 320.8251 67.5779 Tm [(The)-403.1(unique)-399.6(properties)-405(of)-405.3(graphene)-403.9(make)-405.4(it)-399.9(a)-405.4(promising)]TJ -1.0137 -1.1116 TD [(material)-273.1(for)-273.9(various)-273.7(elds.)-274.8(Here,)-276(we)-274.9(reviewed)-272.5(recent)-275.1(studies)]TJ /F5 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(GRAPHENES)-338.3(POTENTIALS)-339(IN)-335.1(DEVELOPING)-335(NEW)-337.3(IMPLANT)-336.1(OR)-334.7(SCAFFOLD)-336.2(MATERIALS)-10282.8(487)]TJ ET endstream endobj 130 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 132 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 133 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 131 0 obj <>stream /GS1 gs BT /F3 1 Tf 9.843 0 0 9.843 62.022 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(with)-339.6(regard)-342.9(to)-336.4(graphenes)-342.6(effects)-345.1(on)-336.3(the)-338.7(adhesion,)-342.8(prolifer-)]TJ 0 -1.1174 TD [(ation,)-574.8(and)-568.9(differentiation)-573.5(of)-572.4(MSCs,)-573.9(and)-568.9(its)-573.6(potential)-571.4(to)]TJ 0 -1.1116 TD [(promote)-263.6(osteodifferentiation,)-266.8(which)-261.1(point)-265(to)-255.8(its)-262.6(future)-261.3(use)-263.5(in)]TJ T* [(surface)-419.9(modication)-419.1(of)-416.9(implants)-420.3(or)-416.9(scaffold)-419.9(materials.)-421.4(To)]TJ T* [(date,)-378.9(studies)-371.6(on)-376.6(graphenes)-377.1(contribution)-377.7(to)-370.9(bone)-374.2(tissue)-376.3(en-)]TJ 0 -1.1174 TD [(gineering)-346.5(are)-345.4(still)-339.9(quite)-346.7(new,)-342.8(and)-344.3(knowledge)-347.3(on)-342(the)-344.4(effects)]TJ 0 -1.1116 TD [(of)-347.7(graphene)-346.3(is)-347.7(limited.)-348.1(Within)-349.1(the)-344.4(limitation)-354(of)-342(the)-350.2(present)]TJ T* [(investigation,)-389.2(we)-384.4(believe)-385.8(that)-386(graphene)-386.7(may)-385.8(have)-386.9(a)-388.2(prom-)]TJ 0 -1.1174 TD [(ising)-264.8(future,)-264.7(and)-263.7(further)-268.1(research)-272.4(will)-264.9(realize)-266(its)-262.5(potential.)-269.6(In)]TJ 0 -1.1116 TD [(spite)-312(of)-307.4(the)-309.9(signicant)-312.9(progress)-309(mentioned)-313.2(earlier,)-314.3(there)-307.4(are)]TJ T* [(still)-478.1(some)-473.1(important)-479.2(challenges.)-479.9(First,)-475.3(the)-476.9(potential)-473.5(long-)]TJ 0 -1.1174 TD [(term)-358.2(toxicity)-356.1(and)-355.8(the)-355.9(nonbiodegradable)-362.3(nature)-360.4(of)-353.5(graphene)]TJ 0 -1.1116 TD [(should)-260(be)-256.8(further)-256.6(invest)-7.8(igated.)-254.5(Second,)-259.9(our)-256.7(unders)-7.5(tanding)-256.8(of)]TJ T* [(graphene-cell)-417.8(interactions)-420.2(and)-413.4(its)-412.3(internal)-420.4(mechanisms)-414.1(are)]TJ T* [(incomplete,)-624.3(and)-620.8(many)-617.3(hypotheses)-623.6(remain)-620.8(to)-618.6(be)-619.6(tested.)]TJ 0 -1.1174 TD [(Third,)-396.1(a)-393.9(comparison)-394.6(of)-393.8(the)-396.3(osteogenic)-394.7(effects)-397(of)-393.8(graphene)]TJ 0 -1.1116 TD [(with)-351.1(those)-352.2(of)-347.7(current)-349.9(successful)-353.8(implants)-351.2(or)-347.7(scaffold)-356.6(mate-)]TJ T* [(rials)-352.3(should)-346.4(be)-354.7(performed)-347.4(before)-354.5(we)-349.8(can)-351.2(conclude)-352.3(whether)]TJ 0 -1.1174 TD [(graphene)-427(is)-422.6(a)-422.7(promising)-425.9(nano-material)-429.5(for)-417.9(promoting)-426.1(sur-)]TJ 0 -1.1116 TD [(face)-359.2(modication)-361.5(of)-353.5(implants)-357(or)-353.5(scaffold)-362.3(materials.)-358.1(Lastly,)]TJ T* [(the)-258(exact)-256.8(effects)-258.7(of)-249.8(graphene)-259.9(on)-255.6(cells,)-253.2(tissues,)-259.6(or)-255.6(organs,)-252.9(and)]TJ 0 -1.1174 TD [(their)-323.7(metabolic)-326(pathway)]TJ /F4 1 Tf 10.1774 0 TD [(in)-324.9(vivo)]TJ /F3 1 Tf 3.1045 0 TD [(remain)-327(unclear)-322.3(and)-327(require)]TJ -13.2819 -1.1116 TD [(further)-337.2(studies.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 463.1243 Tm (Acknowledgments)Tj /F3 1 Tf 9.843 0 0 9.843 72 446.6833 Tm [(This)-287.8(study)-287.7(was)-293.1(supported)-287.5(by)-290.2(grants)-289.9(from)-287.8(the)-286.8(Program)-292.1(for)]TJ -1.0137 -1.1116 TD [(New)-288.4(Century)-292.2(Excellent)-291.5(Talents)-287.8(in)-290.3(University)-289.7(from)-287.8(Ministry)]TJ 0 -1.1174 TD [(of)-451.4(Education)-451.4(of)-451.4(China)-451.3(\(NCET-11-0026\))-451.6(and)-448(Peking)-451.2(Uni-)]TJ 0 -1.1116 TD [(versity)-337.2(985)-331.6(Program.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 392.3716 Tm [(Disclosure)-336.7(Statement)]TJ /F3 1 Tf 9.843 0 0 9.843 72 375.9306 Tm [(The)-334(authors)-337.1(indicated)-336.3(no)-330.5(potential)-341.1(conicts)-333.6(of)-336.2(interest.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 354.0471 Tm (References)Tj /F3 1 Tf 9.2951 0 0 9.2951 66.6708 337.9464 Tm [(1.)-500.4(Rose,)-271(F.R.,)-264.4(and)-273(Oreffo,)-269.9(R.O.)-269.1(Bone)-265.7(tissue)-270.5(engineering:)-271.1(hope)]TJ 1.2503 -1.1223 TD [(vs)-334.9(hype.)-334.2(Biochem)-336.5(Biophys)-333.7(Res)-331.8(Commun)]TJ /F6 1 Tf 17.2669 0 TD (292)Tj /F3 1 Tf 1.5004 0 TD [(,)-335.5(1)0(,)-335.7(2002.)]TJ -20.0177 -1.1284 TD [(2.)-500.4(Dominici,)-236.6(M.,)-237.4(Le)-232.1(Blanc,)-239.1(K.,)-233.6(Mueller,)-241.7(I.,)-234.4(Slaper-Cortenbach,)]TJ 1.2503 -1.1223 TD [(I.,)-295.4(Marini,)-298.3(F.,)-295.9(Krause,)-299(D.,)-294.6(Deans,)-302.7(R.,)-291.7(Keating,)-302.7(A.,)-294.6(Prockop,)]TJ 0 -1.1284 TD [(D.,)-459.3(and)-468.2(Horwitz,)-461(E.)-465.6(Minimal)-459.8(criteria)-468(for)-462.5(dening)-465(multi-)]TJ 0 -1.1223 TD [(potent)-461.4(mesenchymal)-461.4(stromal)-462.5(cells.)-464.6(The)-457.9(International)-462.1(So-)]TJ 0 -1.1284 TD [(ciety)-331.2(for)-328.3(Cellular)-332.1(Therapy)-336.9(position)-327.9(statement.)-334.2(Cytotherapy)]TJ /F6 1 Tf 0 -1.1223 TD (8,)Tj /F3 1 Tf 1.0857 0 TD [(315,)-329.9(2006.)]TJ -2.336 -1.1284 TD [(3.)-500.4(Treiser,)-496.4(M.D.,)-495.4(Yang,)-494.4(E.H.,)-498(Gordonov,)-493.1(S.,)-491.1(Cohen,)-497.7(D.M.,)]TJ 1.2503 -1.1223 TD [(Androulakis,)-398.1(I.P.,)-390(Kohn,)-398.7(J.,)-395.8(Chen,)-393.9(C.S.,)-392.4(and)-395(Moghe,)-394.6(P.V.)]TJ 0 -1.1284 TD [(Cytoskeleton-based)-401.2(forecasting)-401.1(of)-393(stem)-399.3(cell)-398.2(lineage)-396.7(fates.)]TJ 0 -1.1223 TD [(Proc)-333.3(Natl)-334.6(Acad)-339.9(Sci)-330.2(U)-337.2(S)-332.4(A)]TJ /F6 1 Tf 11.2775 0 TD (107,)Tj /F3 1 Tf 2.0859 0 TD [(610,)-336(2010.)]TJ -14.6138 -1.1284 TD [(4.)-500.4(Nayak,)-358.4(T.R.,)-354.8(Andersen,)-354.2(H.,)-355.6(Makam,)-355.7(V.S.,)-352.6(Khaw,)-355.7(C.,)-352.7(Bae,)]TJ 1.2503 -1.1223 TD [(S.,)-381.3(Xu,)-386.2(X.,)-380(Ee,)-384.6(P.L.,)-383.4(Ahn,)-386.3(J.H.,)-385.5(Hong,)-380.4(B.H.,)-385(Pastorin,)-386.8(G.,)]TJ 0 -1.1284 TD [(and)-334(Ozyilmaz,)-337.1(B.)-334.4(Graphene)-340.9(for)-334.4(controlled)-339.8(and)-334(accelerated)]TJ 0 -1.1223 TD [(osteogenic)-591.5(differentiation)-598.3(of)-594.2(human)-590(mesenchymal)-595.5(stem)]TJ 0 -1.1284 TD [(cells.)-336.5(ACS)-332.9(Nano)]TJ /F6 1 Tf 7.1971 0 TD (5,)Tj /F3 1 Tf 1.0857 0 TD [(4670,)-330(2011.)]TJ -9.5331 -1.1223 TD [(5.)-500.4(Lee,)-279.2(W.C.,)-284.1(Lim,)-282(C.H.,)-281.3(Shi,)-277.3(H.,)-282.4(Tang,)-281.2(L.A.,)-278.4(Wang,)-283.7(Y.,)-282.4(Lim,)]TJ 1.2503 -1.1284 TD [(C.T.,)-385.3(and)-376.7(Loh,)-386.7(K.P.)-383.1(Origin)-381.8(of)-380.8(enhanced)-383.9(stem)-381(cell)-386(growth)]TJ 0 -1.1223 TD [(and)-364.5(differentiation)-372.6(on)-366.2(graphene)-369.9(and)-364.5(graphene)-369.9(oxide.)-364.3(ACS)]TJ 0 -1.1284 TD (Nano)Tj /F6 1 Tf 2.5007 0 TD (5,)Tj /F3 1 Tf 1.0796 0 TD [(7334,)-336.1(2011.)]TJ -4.8306 -1.1223 TD [(6.)-500.4(Kim,)-489(J.,)-487.3(Choi,)-492.8(K.S.,)-486.8(Kim,)-489(Y.,)-489.8(Lim,)-489.3(K.T.,)-485.8(Seonwoo,)-491.6(H.,)]TJ 1.2503 -1.1284 TD [(Park,)-345.5(Y.,)-343.4(Kim,)-342.6(D.H.,)-339.1(Choung,)-347.3(P.H.,)-340.4(Cho,)-340.8(C.S.,)-343.6(Kim,)-342.6(S.Y.,)]TJ 0 -1.1223 TD [(Choung,)-426.6(Y.H.,)-430.6(and)-431.6(Chung,)-426.4(J.H.)-428.1(Bioactive)-431.7(effects)-431.6(of)-429.5(gra-)]TJ 0 -1.1284 TD [(phene)-680.1(oxide)-681.4(cell)-678.8(culture)-681.5(substratum)-675.5(on)-683.4(structure)-677.1(and)]TJ 0 -1.1223 TD [(function)-445.7(of)-447.9(human)-443.6(adipose-derived)-448.6(stem)-448.1(cells.)-446.3(J)-444.5(Biomed)]TJ 0 -1.1284 TD [(Mater)-333.4(Res)-337.9(A)]TJ /F6 1 Tf 5.6113 0 TD (101,)Tj /F3 1 Tf 2.0859 0 TD [(3520,)-336.1(2013.)]TJ 18.0598 70.9158 TD [(7.)-500.4(Shi,)-271.2(X.T.,)-272.3(Chang,)-266(H.X.,)-272(Chen,)-271.9(S.,)-271.5(Lai,)-268.3(C.,)-267.3(Khademhosseini,)]TJ 1.2503 -1.1223 TD [(A.,)-239.7(and)-236.4(Wu,)-236.5(H.K.)-241.5(Regulating)-238.6(cellular)-240(behavior)-237(on)-238.2(few-layer)]TJ 0 -1.1284 TD [(reduced)-406.3(graphene)-406.5(oxide)-400.8(lms)-404.1(with)-403.6(well-controlled)-408.5(reduc-)]TJ 0 -1.1223 TD [(tion)-334.9(states.)-335.8(Adv)-337.5(Funct)-330.5(Mater)]TJ /F6 1 Tf 12.107 0 TD (22,)Tj /F3 1 Tf 1.5797 0 TD [(751,)-336(2012.)]TJ -14.937 -1.1283 TD [(8.)-500.4(Depan,)-401.1(D.,)-392.2(Girase,)-402.1(B.,)-395.4(Shah,)-398.1(J.S.,)-392.9(and)-395(Misra,)-401.6(R.D.)-397.1(Struc-)]TJ 1.2503 -1.1223 TD [(ture-process-property)-573.7(relationship)-564.3(of)-557.6(the)-565.2(polar)-561.7(graphene)]TJ 0 -1.1284 TD [(oxide-mediated)-324(cellular)-319.3(response)-321.2(and)-315.7(stimulated)-323.4(growth)-315.3(of)]TJ 0 -1.1223 TD [(osteoblasts)-597.3(on)-591.9(hybrid)-588.1(chitosan)-599.2(network)-594.1(structure)-591.8(nano-)]TJ 0 -1.1284 TD [(composite)-336.6(scaffolds.)-341.4(Acta)-333.3(Biomater)]TJ /F6 1 Tf 14.9614 0 TD (7,)Tj /F3 1 Tf 1.0796 0 TD [(3432,)-336.1(2011.)]TJ -17.2913 -1.1223 TD [(9.)-500.4(Depan,)-358.4(D.,)-355.6(and)-352.3(Misra,)-358.9(R.D.)-354.5(The)-354.2(interplay)-358(between)-356.2(nanos-)]TJ 1.2503 -1.1284 TD [(tructured)-641.4(carbon-grafted)-643.6(chitosan)-641.9(scaffolds)-646.3(and)-639(protein)]TJ 0 -1.1223 TD [(adsorption)-237.7(on)-238.2(the)-235.8(cellular)-233.9(response)-241.9(of)-234.4(osteoblasts:)-237(structure-)]TJ 0 -1.1284 TD [(function)-604.3(property)-607.2(relationship.)-601(Acta)-607.7(Biomater)]TJ /F6 1 Tf 20.3775 0 TD (9,)Tj /F3 1 Tf 1.3479 0 TD (6084,)Tj -21.7255 -1.1284 TD (2013.)Tj -1.7505 -1.1223 TD [(10.)-500.5(Kim,)-239(J.,)-237.3(Kim,)-239(Y.R.,)-232.5(Kim,)-239(Y.,)-239.7(Lim,)-233.2(K.T.,)-241.8(Seonwoo,)-235.4(H.,)-233.6(Park,)]TJ 1.7505 -1.1284 TD (S.,)Tj /F4 1 Tf 1.415 0 TD [(et)-357.7(al.)]TJ /F3 1 Tf 2.4763 0 TD [(Graphene-incorporated)-361.3(chitosan)-361.3(substrata)-362.9(for)-358.8(ad-)]TJ -3.8913 -1.1223 TD [(hesion)-534.2(and)-529.2(differentiation)-537.3(of)-533.2(human)-529(mesenchymal)-534.6(stem)]TJ 0 -1.1284 TD [(cells.)-336.5(J)-334.7(Mater)-339.5(Chem)-332.4(B)]TJ /F6 1 Tf 9.6063 0 TD (1,)Tj /F3 1 Tf 1.0857 0 TD [(933,)-329.9(2013.)]TJ -12.4424 -1.1223 TD [(11.)-500.5(Crowder,)-235.9(S.W.,)-239.5(Prasai,)-232.7(D.,)-233.6(Rath,)-234.7(R.,)-236.8(Balikov,)-234.6(D.A.,)-235.4(Bae,)-233.3(H.,)]TJ 1.7505 -1.1284 TD [(Bolotin,)-388.4(K.I.,)-382.6(and)-382.8(Sung,)-381.7(H.J.)-385.4(Three-dimensional)-388.8(graphene)]TJ 0 -1.1223 TD [(foams)-445.1(promote)-439.6(osteogenic)-439(differentiation)-445.8(of)-435.7(human)-443.6(mes-)]TJ 0 -1.1284 TD [(enchymal)-336(stem)-338.3(cells.)-336.5(Nanoscale)]TJ /F6 1 Tf 13.4061 0 TD (5,)Tj /F3 1 Tf 1.0857 0 TD [(4171,)-330(2013.)]TJ -16.2423 -1.1223 TD [(12.)-500.5(Tang,)-323.9(L.A.,)-327.2(Lee,)-321.9(W.C.,)-326.8(Shi,)-320(H.,)-325.1(Wong,)-322.2(E.Y.,)-327.2(Sadovoy,)-319.3(A.,)]TJ 1.7505 -1.1284 TD [(Gorelik,)-416.7(S.,)-411.8(Hobley,)-414.8(J.,)-408.1(Lim,)-416.1(C.T.,)-409.7(and)-413.3(Loh,)-411.1(K.P.)-413.6(Highly)]TJ 0 -1.1223 TD [(wrinkled)-374.1(cross-linked)-371.7(graphene)-369.9(oxide)-364.2(membranes)-374.4(for)-364.9(bio-)]TJ 0 -1.1284 TD [(logical)-245.6(and)-242.5(charge-storage)-248.1(applications.)-243(Small)]TJ /F6 1 Tf 18.743 0 TD (8,)Tj /F3 1 Tf .9942 0 TD [(423,)-238.4(2012.)]TJ -21.4876 -1.1223 TD [(13.)-500.5(Novoselov,)-457.1(K.S.,)-456.3(Geim,)-456.8(A.K.,)-455(Morozov,)-458.2(S.V.,)-456.3(Jiang,)-454.9(D.,)]TJ 1.7505 -1.1284 TD [(Zhang,)-494.8(Y.,)-489.8(Dubonos,)-489.7(S.V.,)-486.8(Grigorieva,)-490.7(I.V.,)-492.3(and)-492.6(Firsov,)]TJ 0 -1.1223 TD [(A.A.)-412.2(Electric)-412.7(eld)-403.6(effect)-414(in)-408.4(atomically)-407.8(thin)-408.1(carbon)-408.1(lms.)]TJ 0 -1.1284 TD (Science)Tj /F6 1 Tf 3.4583 0 TD (306,)Tj /F3 1 Tf 2.0859 0 TD [(666,)-329.9(2004.)]TJ -7.2947 -1.1223 TD [(14.)-500.5(Wei,)-374.4(W.,)-370.6(and)-370.6(Qu,)-367.9(X.)-367.7(Extraordinary)-377.9(physical)-367.4(properties)-372.3(of)]TJ 1.7505 -1.1284 TD [(functionalized)-342.1(graphene.)-333.3(Small)]TJ /F6 1 Tf 13.0219 0 TD (8,)Tj /F3 1 Tf 1.0857 0 TD [(2138,)-330(2012.)]TJ -15.858 -1.1223 TD [(15.)-500.5(Yang,)-341.9(M.,)-341.1(Yao,)-341.8(J.,)-341(and)-340.1(Duan,)-341.9(Y.)-343.3(Graphene)-340.9(and)-346.2(its)-339.9(deriva-)]TJ 1.7505 -1.1284 TD [(tives)-338.4(for)-334.4(cell)-337.2(biotechnology.)-331.9(Analyst)]TJ /F6 1 Tf 15.2908 0 TD (138)Tj /F3 1 Tf 1.5004 0 TD [(,)-335.5(72,)-335.8(2013.)]TJ -18.5417 -1.1223 TD [(16.)-500.5(Lee,)-242.6(C.,)-242.9(Wei,)-240.3(X.,)-239.7(Kysar,)-239.8(J.W.,)-241.8(and)-242.5(Hone,)-238.2(J.)-237.2(Measurement)-243.8(of)]TJ 1.7505 -1.1284 TD [(the)-443.2(elastic)-438(properties)-445.5(and)-437.7(intrinsic)-443.8(strength)-438.7(of)-435.6(monolayer)]TJ 0 -1.1223 TD [(graphene.)-339.4(Science)]TJ /F6 1 Tf 7.7216 0 TD (321)Tj /F3 1 Tf 1.5004 0 TD [(,)-329.4(385,)-336(2008.)]TJ -10.9725 -1.1284 TD [(17.)-500.5(Novoselov,)-377.8(K.S.,)-370.9(Falko,)-369.6(V.I.,)-376.5(Colombo,)-370.8(L.,)-374.2(Gellert,)-371.5(P.R.,)]TJ 1.7505 -1.1223 TD [(Schwab,)-556.7(M.G.,)-556.4(and)-553.6(Kim,)-556.1(K.)-556.8(A)-556.7(roadmap)-554.2(for)-554(graphene.)]TJ 0 -1.1284 TD (Nature)Tj /F6 1 Tf 3.0618 0 TD (490,)Tj /F3 1 Tf 9.2951 0 0 9.2951 377.1779 317.1967 Tm [(192,)-336(2012.)]TJ -6.8982 -1.1223 TD [(18.)-500.5(Mayorov,)-336.2(A.S.,)-334.3(Gorbachev,)-335.1(R.V.,)-336.2(Morozov,)-330.1(S.V.,)-334.3(Britnell,)]TJ 1.7505 -1.1284 TD [(L.,)-599.9(Jalil,)-600.1(R.,)-602.8(and)-596.3(Ponomarenko,)-600.4(L.A.)-601.6(Micrometer-scale)]TJ 0 -1.1223 TD [(ballistic)-420.7(transport)-410.7(in)-414.5(encapsulated)-417.2(graphene)-418.7(at)-412.6(room)-417.2(tem-)]TJ 0 -1.1284 TD [(perature.)-341.2(Nano)-335.7(Lett)]TJ /F6 1 Tf 8.3377 0 TD (11,)Tj /F3 1 Tf 1.5797 0 TD [(2396,)-336.1(2011.)]TJ -11.6678 -1.1223 TD [(19.)-500.5(Morozov,)-415.5(S.V.,)-419.7(Novoselov,)-414.4(K.S.,)-413.6(Katsnelson,)-417.2(M.I.,)-416.8(Sche-)]TJ 1.7505 -1.1284 TD [(din,)-347.6(F.,)-344.7(Elias,)-346.4(D.C.,)-342.3(and)-346.2(Jaszczak,)-349.9(J.A.)-348.8(Giant)-346.9(intrinsic)-346.2(car-)]TJ T* [(rier)-393.1(mobilities)-385.7(in)-390.1(graphene)-388.2(and)-388.9(its)-388.7(bilayer.)-388.8(Phys)-386.8(Rev)-393.7(Lett)]TJ /F6 1 Tf 0 -1.1223 TD (100,)Tj /F3 1 Tf 2.0859 0 TD [(016602,)-330.3(2008.)]TJ -3.8364 -1.1284 TD [(20.)-500.5(Balandin,)-507.3(A.A.)-503.7(Thermal)-500.6(properties)-506.5(of)-496.6(graphene)-504(and)-504.8(na-)]TJ 1.7505 -1.1223 TD [(nostructured)-336(carbon)-341(materials.)-336.5(Nat)-335(Mater)]TJ /F6 1 Tf 17.1876 0 TD (10,)Tj /F3 1 Tf 1.5858 0 TD [(569,)-329.9(2011.)]TJ -20.5239 -1.1284 TD [(21.)-500.5(Nair,)-368(R.R.,)-369.9(Blake,)-367.2(P.,)-363(Grigorenko,)-371.2(A.N.,)-363.5(Novoselov,)-371.7(K.S.,)]TJ 1.7505 -1.1223 TD [(Booth,)-310(T.J.,)-300.4(and)-309.6(Stauber,)-306.9(T.)-301(Fine)-306(structure)-305.1(constant)-306.4(denes)]TJ 0 -1.1284 TD [(visual)-332.4(transparency)-338.9(of)-332(graphene.)-333.3(Science)]TJ /F6 1 Tf 17.0657 0 TD (320,)Tj /F3 1 Tf 2.0798 0 TD [(1308,)-330(2008.)]TJ -20.896 -1.1223 TD [(22.)-500.5(Bunch,)-424.5(J.S.,)-423.4(Verbridge,)-430.2(S.S.,)-421.1(Alden,)-420.8(J.S.,)-423.4(van)-425.5(der)-421.7(Zande,)]TJ 1.7505 -1.1284 TD [(A.M.,)-623.5(Parpia,)-623.9(J.M.,)-621(and)-620.7(Craighead,)-624.4(H.G.)-625.7(Impermeable)]TJ 0 -1.1223 TD [(atomic)-538.3(membranes)-539(from)-535.4(graphene)-540.6(sheets.)-537.6(Nano)-537(Lett)]TJ /F6 1 Tf 23.2259 0 TD (8,)Tj /F3 1 Tf -23.2259 -1.1284 TD [(2458,)-336.1(2008.)]TJ -1.7505 -1.1223 TD [(23.)-500.5(Novoselov,)-566.8(K.S.,)-560(Jiang,)-558.6(Z.,)-563.3(Zhang,)-561.9(Y.,)-563(Morozov,)-561.9(S.V.,)]TJ 1.7505 -1.1284 TD [(Stormer,)-499.8(H.L.,)-498(Zeitler,)-499.9(U.,)-495.9(Maan,)-502.4(J.C.,)-492.3(Boebinger,)-504.3(G.S.,)]TJ 0 -1.1223 TD [(Kim,)-318.2(P.,)-314.2(and)-315.7(Geim,)-316.5(A.K.)-314.7(Room-temperature)-321.7(quantum)-321.4(Hall)]TJ 0 -1.1284 TD [(effect)-340.8(in)-329.1(graphene.)-339.4(Science)]TJ /F6 1 Tf 11.4605 0 TD (315,)Tj /F3 1 Tf 2.0859 0 TD [(1379,)-330(2007.)]TJ -15.2969 -1.1223 TD [(24.)-500.5(Wang,)-308.1(Y.,)-300.7(Huang,)-305.5(Y.,)-300.7(Song,)-308.5(Y.,)-300.7(Zhang,)-305.8(X.,)-300.7(Ma,)-302.7(Y.,)-306.8(Liang,)]TJ 1.7505 -1.1284 TD [(J.,)-591(and)-590.2(Chen,)-595.2(Y.)-587.3(Room-temperature)-596.1(ferromagnetism)-592(of)]TJ 0 -1.1223 TD [(graphene.)-339.4(Nano)-335.7(Lett)]TJ /F6 1 Tf 8.7219 0 TD (9,)Tj /F3 1 Tf 1.0796 0 TD [(220,)-336(2009.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (488)Tj 49.6032 0 TD [(GU)-334.7(ET)-338.7(AL.)]TJ ET endstream endobj 134 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 136 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 137 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 135 0 obj <>stream /GS1 gs BT /F3 1 Tf 9.2951 0 0 9.2951 59.7543 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(25.)-500.5(Yan,)-427.1(L.,)-423(Zheng,)-427.7(Y.B.,)-421.6(Zhao,)-427.6(F.,)-424(Li,)-422.5(S.,)-424(Gao,)-427.1(X.,)-422.7(Xu,)-428.9(B.,)]TJ 1.7505 -1.1223 TD [(Weiss,)-244.9(P.S.,)-238.1(and)-242.5(Zhao,)-238.5(Y.)-239.7(Chemistry)-241.9(and)-242.5(physics)-240.7(of)-234.4(a)-242.2(single)]TJ 0 -1.1284 TD [(atomic)-251.7(layer:)-248.3(strategies)-256.9(and)-248.6(challenges)-248(for)-249(functionalization)]TJ 0 -1.1223 TD [(of)-325.9(graphene)-327.2(and)-327.9(graphene-based)-331.8(materials.)-330.4(Chem)-326.3(Soc)-324.7(Rev)]TJ /F6 1 Tf 0 -1.1283 TD (41,)Tj /F3 1 Tf 1.5858 0 TD [(97,)-329.7(2012.)]TJ -3.3363 -1.1223 TD [(26.)-500.5(Salas,)-340(E.C.,)-336.5(Sun,)-338.9(Z.,)-337.6(Luttge,)-335.3(A.,)-337.3(and)-340.1(Tour,)-334.2(J.M.)-340.4(Reduction)]TJ 1.7505 -1.1284 TD [(of)-393(graphene)-400.4(oxide)-388.6(via)-394.4(bacterial)-396.9(respiration.)-396.4(ACS)-393.9(Nano)]TJ /F6 1 Tf 23.2259 0 TD (4,)Tj /F3 1 Tf -23.2259 -1.1223 TD [(4852,)-336.1(2010.)]TJ -1.7505 -1.1284 TD [(27.)-500.5(Park,)-491.9(S.,)-491.1(Mohanty,)-498(N.,)-489.8(Suk,)-491.3(J.W.,)-491.9(Nagaraja,)-497.1(A.,)-489.8(An,)-496(J.,)]TJ 1.7505 -1.1223 TD [(Piner,)-381.7(R.D.,)-385(Cai,)-381(W.,)-382.8(Dreyer,)-387.6(D.R.,)-385(Berry,)-380.4(V.,)-380(and)-382.8(Ruoff,)]TJ 0 -1.1284 TD [(R.S.)-404.6(Biocompatible,)-407(robust)-398.2(free-standing)-409.8(paper)-401.8(composed)]TJ 0 -1.1223 TD [(of)-466.1(a)-461.8(TWEEN/graphene)-467.2(composite.)-464.8(Adv)-465.6(Mater)]TJ /F6 1 Tf 20.0116 0 TD (22,)Tj /F3 1 Tf 1.7139 0 TD (1736,)Tj -21.7255 -1.1284 TD (2010.)Tj -1.7505 -1.1284 TD [(28.)-500.5(Liu,)-349.5(S.,)-344.7(Zeng,)-348.3(T.H.,)-345.5(Hofmann,)-344.2(M.,)-347.2(Burcombe,)-351.8(E.,)-343.7(Wei,)-350(J.,)]TJ 1.7505 -1.1223 TD [(Jiang,)-357.3(R.,)-358.8(Kong,)-356(J.,)-359.3(and)-352.3(Chen,)-357.3(Y.)-361.6(Antibacterial)-361.3(activity)-354.9(of)]TJ 0 -1.1284 TD [(graphite,)-651.2(graphite)-651.2(oxide,)-644.9(graphene)-650.4(oxide,)-651(and)-645.1(reduced)]TJ 0 -1.1223 TD [(graphene)-260.1(oxide:)-254(membrane)-259.2(and)-260.8(oxidative)-258.1(stress.)-254.3(ACS)-259.8(Nano)]TJ /F6 1 Tf 0 -1.1284 TD (5,)Tj /F3 1 Tf 1.0857 0 TD [(6971,)-330(2011.)]TJ -2.8361 -1.1223 TD .0192 Tc [(2)19.2(9)19.2(.)-481.3(Chang,)-420(Y.,)-420(Y)-.8(ang,)-420(S.T.,)-420(L)-1.1(iu,)-420(J)1.6(.)-5.3(H)-.8(.,)-420(Dong)-5.3(,)-413.9(E)-1.1(.,)-420(Wan)-5.3(g).8(,)-420(Y)-.8(.,)]TJ 1.7505 -1.1284 TD .3965 Tc [(C)373.3(a)373.9(o)378.1(,)0(A)376.5(.)378.1(,L)376.2(i)372.5(u)378.1(,Y)376.5(.)372(,)0(a)380(n)372(dW)379.8(a)373.9(n)378.1(g)372(,)0(H)376.5(.)]TJ /F4 1 Tf 14.1319 0 TD .0197 Tc [(In)-376.9(vitr)-3.9(o)]TJ /F3 1 Tf 3.6229 0 TD .0204 Tc [(toxicity)-376.2(evalu-)]TJ -17.7549 -1.1223 TD .019 Tc [(ati)-5(o).6(n)-280(o).6(f)-276.2(g)-5.5(raph)-5.5(en)-5.5(e)-278.1(oxi)-5(de)-278.1(on)-280(A54)-5.5(9)-273.9(cells)-4.6(.)-279.9(T)-1.3(oxicol)-279.4(L)-1.3(ett)]TJ /F6 1 Tf 22.1646 0 TD .0184 Tc [(20)-6.1(0,)]TJ /F3 1 Tf -22.1646 -1.1284 TD [(2)-6.1(01,)-335.4(201)-6.1(1.)]TJ -1.7505 -1.1223 TD 0 Tc [(30.)-500.5(Dean,)-297.3(C.R.,)-290.6(Young,)-295.1(A.F.,)-291.6(Meric,)-296.9(I.,)-289.3(Lee,)-297.5(C.,)-291.7(Wang,)-295.9(L.,)-294.9(and)]TJ 1.7505 -1.1284 TD [(Sorgenfrei,)-598.7(S.)-588.6(Boron)-593.4(nitride)-591.3(substrates)-593.9(for)-596.7(high-quality)]TJ 0 -1.1223 TD [(graphene)-339.4(electronics.)-335.4(Nat)-335(Nanotechnol)]TJ /F6 1 Tf 16.1874 0 TD (5,)Tj /F3 1 Tf 1.0857 0 TD [(722,)-329.9(2010.)]TJ -19.0235 -1.1284 TD [(31.)-500.5(Zhang,)-421.6(Y.,)-416.6(Zhang,)-421.6(L.,)-416.9(and)-419.4(Zhou,)-417.3(C.)-413.6(Review)-423.7(of)-417.4(chemical)]TJ 1.7505 -1.1223 TD [(vapor)-300(deposition)-301.9(of)-301.5(graphene)-302.8(and)-303.5(related)-301.5(applications.)-304(Acc)]TJ 0 -1.1284 TD [(Chem)-338.5(Res)]TJ /F6 1 Tf 4.5622 0 TD (46,)Tj /F3 1 Tf 1.5858 0 TD [(2329,)-330(2013.)]TJ -7.8985 -1.1223 TD [(32.)-500.5(Berger,)-311.5(C.,)-303.9(Song,)-308.5(Z.,)-301(Li,)-306.6(X.,)-306.8(Wu,)-309.7(X.,)-306.8(Brown,)-302.2(N.,)-306.8(Naud,)-311.4(C.,)]TJ 1.7505 -1.1284 TD [(Mayou,)-455.6(D.,)-459.3(Li,)-453(T.,)-459.6(Hass,)-456(J.,)-456.8(Marchenkov,)-454.9(A.N.,)-461.1(Conrad,)]TJ 0 -1.1223 TD [(E.H.,)-241.8(First,)-247.9(P.N.,)-242.9(and)-242.5(de)-242.4(Heer,)-244.7(W.A.)-238.1(Electronic)-248.3(connement)]TJ 0 -1.1284 TD [(and)-242.5(coherence)-238.1(in)-237.6(patterned)-240.8(epitaxial)-243.4(graphene.)-241.9(Science)]TJ /F6 1 Tf 22.2256 0 TD (312,)Tj /F3 1 Tf -22.2256 -1.1223 TD [(1191,)-336.1(2006.)]TJ -1.7505 -1.1284 TD [(33.)-500.5(Stankovich,)-536.2(S.,)-527.7(Dikin,)-531.9(D.A.,)-534.3(Dommett,)-529.4(G.H.,)-534.3(Kohlhaas,)]TJ 1.7505 -1.1223 TD [(K.M.,)-263.6(Zimney,)-268.3(E.J.,)-263.8(Stach,)-261.6(E.A.,)-266.2(Piner,)-259.7(R.D.,)-263(Nguyen,)-269(S.T.,)]TJ 0 -1.1284 TD [(and)-730.4(Ruoff,)-736(R.S.)-727.8(Graphene-based)-735.9(composite)-733.1(materials.)]TJ 0 -1.1223 TD (Nature)Tj /F6 1 Tf 3.0618 0 TD (442,)Tj /F3 1 Tf 2.0859 0 TD [(282,)-329.9(2006.)]TJ -6.8982 -1.1284 TD [(34.)-500.5(Li,)-239.5(X.,)-239.7(Cai,)-240.7(W.,)-242.5(An,)-239.8(J.,)-237.3(Kim,)-245.1(S.,)-235(Nah,)-244.2(J.,)-237.3(Yang,)-244.3(D.,)-239.7(Piner,)-241.4(R.,)]TJ 1.7505 -1.1223 TD [(Velamakanni,)-396.7(A.,)-392.2(Jung,)-390.1(I.,)-393(Tutuc,)-396.7(E.,)-392.5(Banerjee,)-390.5(S.K.,)-395.3(Co-)]TJ 0 -1.1284 TD [(lombo,)-420.6(L.,)-416.9(and)-413.3(Ruoff,)-418.9(R.S.)-416.8(Large-area)-421.7(synthesis)-416.5(of)-417.4(high-)]TJ 0 -1.1223 TD [(quality)-247.5(and)-242.5(uniform)-242.5(graphene)-247.9(lms)-245.6(on)-238.2(copper)-249.5(foils.)-245.1(Science)]TJ /F6 1 Tf 0 -1.1284 TD (324,)Tj /F3 1 Tf 2.0859 0 TD [(1312,)-330(2009.)]TJ -3.8364 -1.1223 TD [(35.)-500.5(Bae,)-404.1(S.,)-399.6(Kim,)-397.5(H.,)-404.4(Lee,)-401.2(Y.,)-398.3(Xu,)-398.4(X.,)-398.3(Park,)-400.4(J.S.,)-405.1(Zheng,)-397.2(Y.,)]TJ 1.7505 -1.1284 TD [(Balakrishnan,)-306.2(J.,)-298.3(Lei,)-298.8(T.,)-301(Kim,)-293.8(H.R.,)-299.6(Song,)-302.4(Y.I.,)-297.2(Kim,)-299.9(Y.J.,)]TJ 0 -1.1223 TD [(Kim,)-360.9(K.S.,)-358.7(Ozyilmaz,)-361.5(B.,)-358.8(Ahn,)-355.8(J.H.,)-355(Hong,)-362.1(B.H.,)-354.5(and)-358.4(Iiji-)]TJ 0 -1.1284 TD [(ma,)-260.3(S.)-253.2(Roll-to-roll)-254.6(production)-256.9(of)-258.8(30-inch)-250.9(graphene)-260.1(lms)-257.7(for)]TJ T* [(transparent)-340.1(electrodes.)-335.8(Nat)-335(Nanotechnol)]TJ /F6 1 Tf 16.6875 0 TD (5,)Tj /F3 1 Tf 1.0857 0 TD [(574,)-329.9(2010.)]TJ -19.5237 -1.1223 TD [(36.)-500.5(Reina,)-300.1(A.,)-294.6(Jia,)-296(X.,)-294.6(Ho,)-300.8(J.,)-292.2(Nezich,)-301.2(D.,)-294.6(Son,)-296.2(H.,)-294.6(Bulovic,)-295.6(V.,)]TJ 1.7505 -1.1284 TD [(Dresselhaus,)-582.2(M.S.,)-576(and)-578(Kong,)-581.7(J.)-572.7(Large)-580.6(area,)-582.8(few-layer)]TJ 0 -1.1223 TD [(graphene)-430.9(lms)-422.4(on)-427.2(arbitrary)-430.3(substrates)-429.2(by)-421.1(chemical)-431.2(vapor)]TJ 0 -1.1284 TD [(deposition.)-338.6(Nano)-335.7(Lett)]TJ /F6 1 Tf 9.222 0 TD (9,)Tj /F3 1 Tf 1.0796 0 TD [(30,)-335.8(2009.)]TJ -12.0521 -1.1223 TD [(37.)-500.5(Singh,)-247.1(V.,)-251.9(Joung,)-243.9(D.,)-251.9(Zhai,)-250.1(L.,)-246.1(Das,)-249.4(S.,)-247.2(Khondaker,)-251.6(S.I.,)-249.7(and)]TJ 1.7505 -1.1284 TD [(Seal,)-279.7(S.)-271.5(Graphene)-279.9(based)-276.6(materials:)-275(past,)-277.9(present)-278.7(and)-273(future.)]TJ 0 -1.1223 TD [(Prog)-335.1(Mater)-333.4(Sci)]TJ /F6 1 Tf 6.5628 0 TD (56,)Tj /F3 1 Tf 1.5858 0 TD [(1178,)-330(2011.)]TJ -9.8991 -1.1284 TD [(38.)-500.5(Hummers,)-550.3(W.S.,)-544.5(Jr.,)-544.7(and)-541.4(Offeman,)-552(R.E.)-543.8(Preparation)-545.1(of)]TJ 1.7505 -1.1223 TD [(graphitic)-339.7(oxide.)-333.8(J)-334.7(A)0(m)-330.8(Chem)-338.5(Soc)]TJ /F6 1 Tf 13.8331 0 TD (80,)Tj /F3 1 Tf 1.5858 0 TD [(1339,)-330(1958.)]TJ -17.1693 -1.1284 TD [(39.)-500.5(Yamaguchi,)-350(H.,)-349.5(Eda,)-342.1(G.,)-349.5(Mattevi,)-348.6(C.,)-346.6(Kim,)-348.7(H.,)-343.4(and)-346.2(Chho-)]TJ 1.7505 -1.1223 TD [(walla,)-400(M.)-395.9(Highly)-397.7(uniform)-395(300)-165.1(mm)-395.9(wafer-scale)-401.8(deposition)]TJ 0 -1.1284 TD [(of)-521(single)-521.5(and)-517(multilayered)-520.2(chemically)-522.4(derived)-523.5(graphene)]TJ 0 -1.1223 TD [(thin)-334.9(lms.)-337.1(ACS)-332.9(Nano)]TJ /F6 1 Tf 9.2525 0 TD (4,)Tj /F3 1 Tf 1.0796 0 TD [(524,)-336(2010.)]TJ -12.0826 -1.1284 TD [(40.)-500.5(Becerril,)-272.2(H.A.,)-272(Mao,)-266.2(J.,)-273.9(Liu,)-264.1(Z.,)-270.5(Stoltenberg,)-269.7(R.M.,)-272.9(Bao,)-265.7(Z.,)]TJ 1.7505 -1.1223 TD [(and)-553.6(Chen,)-558.6(Y.)-550.7(Evaluation)-559(of)-551.5(solution-processed)-558.3(reduced)]TJ 0 -1.1284 TD [(graphene)-296.7(oxide)-291(lms)-288.2(as)-290.3(transparent)-291.3(conductors.)-297.5(ACS)-290.3(Nano)]TJ /F6 1 Tf 0 -1.1223 TD (2,)Tj /F3 1 Tf 1.0857 0 TD [(463,)-329.9(2008.)]TJ 24.1774 70.8975 TD [(41.)-500.5(Kim,)-428(J.,)-426.3(Cote,)-423.8(L.J.,)-428.5(Kim,)-428(F.,)-430.1(Yuan,)-427.3(W.,)-425.5(Shull,)-429.5(K.R.,)-427.7(and)]TJ 1.7505 -1.1223 TD [(Huang,)-299.4(J.)-298.2(Graphene)-298.2(oxide)-303.2(sheets)-299.7(at)-296.7(interfaces.)-307.6(J)-298.1(A)0(m)-300.3(Chem)]TJ 0 -1.1284 TD (Soc)Tj /F6 1 Tf 1.8298 0 TD (132,)Tj /F3 1 Tf 2.0859 0 TD [(8180,)-330(2010.)]TJ -5.6662 -1.1223 TD [(42.)-500.5(Cote,)-387.2(L.J.,)-385.8(Kim,)-385.3(F.,)-381.3(and)-388.9(Huang,)-384.7(J.)-383.6(Langmuir-Blodgett)-391.5(as-)]TJ 1.7505 -1.1283 TD [(sembly)-436.2(of)-429.6(graphite)-437.7(oxide)-437.4(single)-430(layers.)-437.2(J)-432.3(A)0(m)-434.5(Chem)-436.1(Soc)]TJ /F6 1 Tf 0 -1.1223 TD (131,)Tj /F3 1 Tf 2.0798 0 TD [(1043,)-336.1(2009.)]TJ -3.8303 -1.1284 TD [(43.)-500.5(Dikin,)-544.1(D.A.,)-546.5(Stankovich,)-548.4(S.,)-546(Zimney,)-548.9(E.J.,)-544.3(Piner,)-546.4(R.D.,)]TJ 1.7505 -1.1223 TD [(Dommett,)-303.7(G.H.,)-302.5(Evmenenko,)-310.1(G.,)-300.7(Nguyen,)-305.6(S.T.,)-304.2(and)-303.5(Ruoff,)]TJ 9.2951 0 0 9.2951 327.118 641.4802 Tm [(R.S.)-502.2(Preparation)-508.5(and)-498.7(characterization)-509.9(of)-508.8(graphene)-504(oxide)]TJ T* [(paper.)-334.8(Nature)]TJ /F6 1 Tf 5.8736 0 TD (448,)Tj /F3 1 Tf 2.0798 0 TD [(457,)-336(2007.)]TJ -9.7039 -1.1284 TD [(44.)-500.5(Chen,)-345.1(C.M.,)-346.1(Yang,)-354.1(Q.H.,)-345.2(Yang,)-348(Y.G.,)-351.3(Lv,)-343.8(W.,)-346.2(Wen,)-350.6(Y.F.,)]TJ 1.7505 -1.1223 TD [(Hou,)-361.9(P.X.,)-364.8(Wang,)-369.1(M.Z.,)-361.5(and)-364.5(Cheng,)-363.5(H.M.)-367.2(Self-assembled)]TJ 0 -1.1284 TD [(free-standing)-556.2(graphite)-553.6(oxide)-553.3(membrane.)-552.1(Adv)-550.9(Mater)]TJ /F6 1 Tf 22.7197 0 TD (21,)Tj /F3 1 Tf -22.7197 -1.1284 TD [(3007,)-330(2009.)]TJ -1.7505 -1.1223 TD [(45.)-500.5(Azevedo,)-423.9(J.,)-426.3(Costa-Coquelard,)-429.6(C.,)-425.9(Jegou,)-431.1(P.,)-424(Yu,)-422.8(T.,)-429.1(and)]TJ 1.7505 -1.1284 TD [(Benattar,)-471.2(J.J.)-474.4(Highly)-470.9(ordered)-477.6(monolayer,)-474.7(multilayer,)-473.1(and)]TJ 0 -1.1223 TD [(hybrid)-521.1(lms)-532.2(of)-521(graphene)-528.4(oxide)-528.9(obtained)-526.9(by)-524.8(the)-528.6(bubble)]TJ 0 -1.1284 TD [(deposition)-332.4(method.)-333.5(J)-334.7(Phys)-332(Chem)-338.5(C)]TJ /F6 1 Tf 14.8211 0 TD (115,)Tj /F3 1 Tf 2.0798 0 TD [(14678,)-336.3(2011.)]TJ -18.6515 -1.1223 TD [(46.)-500.5(Shih,)-802(C.J.,)-803.4(Lin,)-800.8(S.,)-802.2(Sharma,)-800.9(R.,)-804.1(Strano,)-802.7(M.S.,)-801.7(and)]TJ 1.7505 -1.1284 TD [(Blankschtein,)-242.3(D.)-239.7(Understanding)-250(the)-241.9(pH-dependent)-243.4(behavior)]TJ 0 -1.1223 TD [(of)-478.3(graphene)-485.7(oxide)-480.1(aqueous)-478.2(solutions:)-485.3(a)-480.1(comparative)-482.7(ex-)]TJ 0 -1.1284 TD [(perimental)-740.1(and)-742.6(molecular)-746.6(dynamics)-745.7(simulation)-740(study.)]TJ 0 -1.1223 TD (Langmuir)Tj /F6 1 Tf 4.2878 0 TD (28,)Tj /F3 1 Tf 1.5858 0 TD [(235,)-329.9(2012.)]TJ -7.624 -1.1284 TD [(47.)-500.5(Park,)-357.7(S.,)-356.9(An,)-361.8(J.,)-359.3(Jung,)-353.5(I.,)-362.5(Piner,)-357.3(R.D.,)-360.6(An,)-355.7(S.J.,)-362.4(and)-358.4(Li,)-355.4(X.)]TJ 1.7505 -1.1223 TD [(Colloidal)-313(suspensions)-318.9(of)-313.7(highly)-316.9(reduced)-320.9(graphene)-315(oxide)-315.4(in)]TJ 0 -1.1284 TD [(a)-236.1(wide)-237.6(variety)-242.4(of)-234.4(organic)-242.9(solvents.)-234.3(Nano)-244.2(Lett)]TJ /F6 1 Tf 18.2489 0 TD (9,)Tj /F3 1 Tf .9881 0 TD [(1593,)-232.4(2009.)]TJ -20.9875 -1.1223 TD -.0187 Tc [(4)-18.7(8)-18.7(.)-519.2(Bagri,)-250.5(A.,)-250.5(M).2(attevi)6.1(,)-250.5(C).8(.,)-250.5(Acik)5.6(,)-250.5(M).2(.,)-250.5(Ch)5.6(ab)5.6(al,)-250.5(Y)-2.1(.J)6.4(.,)-250.5(Chho)5.6(walla,)-250.5(M).2(.)5.6(,)]TJ 1.7505 -1.1284 TD [(and)-275(S)2.7(h)5.6(e)-4.7(n)5.6(oy,)-274.9(V.B.)-274.9(Stru)5.6(ctural)-280.5(ev)5.6(oluti)6.1(o)-.5(n)-275(durin)5.6(g)-275(t)0(he)-273.1(redu)5.6(ct)6.1(ion)-275(o)-.5(f)]TJ 0 -1.1223 TD -.0209 Tc [(chemic)-6.9(ally)-338.2(de)-6.9(rive)-6.9(d)-332.1(g)-2.7(raphene)-336.3(oxide.)-338.1(N)1.8(at)-337.6(Chem)]TJ /F6 1 Tf 18.6637 0 TD -.0182 Tc (2,)Tj /F3 1 Tf 1.043 0 TD [(581)6.1(,)-335.4(2)6.1(010.)]TJ -21.4571 -1.1284 TD 0 Tc [(49.)-500.5(Salavagione,)-410.6(H.J.,)-416(Martinez,)-410.7(G.,)-416.6(and)-407.2(Ellis,)-414.8(G.)-410.4(Recent)-414.2(ad-)]TJ 1.7505 -1.1223 TD [(vances)-640.8(in)-634(the)-638.4(covalent)-640.9(modication)-645.1(of)-636.9(graphene)-638.2(with)]TJ 0 -1.1284 TD [(polymers.)-335.2(Macromol)-333.4(Rapid)-338.5(Commun)]TJ /F6 1 Tf 15.614 0 TD (32,)Tj /F3 1 Tf 1.5797 0 TD [(1771,)-336.1(2011.)]TJ -18.9442 -1.1223 TD [(50.)-500.5(Menard-Moyon,)-312.3(C.,)-316.1(Kostarelos,)-315.9(K.,)-306.8(Prato,)-314.6(M.,)-316.7(and)-309.6(Bianco,)]TJ 1.7505 -1.1284 TD [(A.)-343.3(Functionalized)-348.8(carbon)-341(nanotubes)-349.8(for)-340.5(probing)-344.3(and)-346.2(mod-)]TJ 0 -1.1223 TD [(ulating)-332.9(molecular)-337.9(functions.)-335.2(Chem)-332.4(Biol)]TJ /F6 1 Tf 16.5777 0 TD (17,)Tj /F3 1 Tf 1.5858 0 TD [(107,)-336(2010.)]TJ -19.914 -1.1284 TD [(51.)-500.5(Kalbacova,)-421.8(M.,)-420.4(Broz,)-420.6(A.,)-416.6(Kong,)-417(J.,)-420.2(and)-419.4(Kalbac,)-423.2(M.)-420.3(Gra-)]TJ 1.7505 -1.1223 TD [(phene)-375.1(substrates)-380.4(promote)-378.6(adherence)-378.4(of)-380.8(human)-376.6(osteoblasts)]TJ 0 -1.1284 TD [(and)-334(mesenchymal)-333.3(stromal)-340.5(cells.)-336.5(Carbon)]TJ /F6 1 Tf 16.6875 0 TD (48,)Tj /F3 1 Tf 1.5797 0 TD [(4323,)-336.1(2010.)]TJ -20.0177 -1.1223 TD [(52.)-500.5(Kim,)-421.9(S.,)-417.9(Ku,)-422.8(S.H.,)-419.7(Lim,)-422.2(S.Y.,)-419.7(Kim,)-421.9(J.H.,)-422(and)-419.4(Park,)-424.8(C.B.)]TJ 1.7505 -1.1284 TD [(Graphene-biomineral)-701.1(hybrid)-691.8(materials.)-702.5(Adv)-697.3(Mater)]TJ /F6 1 Tf 22.7197 0 TD (23,)Tj /F3 1 Tf -22.7197 -1.1223 TD [(2009,)-330(2011.)]TJ -1.7505 -1.1284 TD [(53.)-500.5(Misra,)-297.9(R.D.,)-293.5(and)-297.4(Chaudhari,)-296.9(P.M.)-295.4(Cellular)-301.6(interactions)-300.2(and)]TJ 1.7505 -1.1223 TD [(stimulated)-280.7(biological)-282(functions)-280.3(mediated)-280.6(by)-274.7(nanostructured)]TJ 0 -1.1284 TD [(carbon)-554.4(for)-547.9(tissue)-557.2(reconstruction)-553.4(and)-553.6(tracheal)-555.9(tubes)-552.4(and)]TJ 0 -1.1223 TD [(sutures.)-334.6(J)-334.7(Biomed)-332.1(Mater)-339.5(Res)-331.8(A)]TJ /F6 1 Tf 13.2597 0 TD (101,)Tj /F3 1 Tf 2.0798 0 TD [(528,)-336(2013.)]TJ -17.0901 -1.1284 TD [(54.)-500.5(Agarwal,)-307.2(S.,)-302(Zhou,)-307.5(X.,)-306.8(Ye,)-305(F.,)-302.1(He,)-305(Q.,)-306.8(Chen,)-308.5(G.C.,)-305.7(Soo,)-302.3(J.,)]TJ 1.7505 -1.1284 TD [(Boey,)-235.3(F.,)-241.1(Zhang,)-238.7(H.,)-233.6(and)-236.4(Chen,)-241.4(P.)-234.9(Interfacing)-245.7(live)-235.4(cells)-238.9(with)]TJ 0 -1.1223 TD [(nanocarbon)-333.6(substrates.)-337.8(Langmuir)]TJ /F6 1 Tf 13.8331 0 TD (26,)Tj /F3 1 Tf 1.5797 0 TD [(2244,)-336.1(2010.)]TJ -17.1632 -1.1284 TD [(55.)-500.5(Feng,)-410.3(L.,)-410.8(and)-407.2(Liu,)-410.5(Z.)-410.8(Graphene)-414.1(in)-408.4(biomedicine:)-414.2(opportu-)]TJ 1.7505 -1.1223 TD [(nities)-331.8(and)-334(challenges.)-339.6(Nanomedicine)-335.7(\(Lond\))]TJ /F6 1 Tf 18.4136 0 TD (6,)Tj /F3 1 Tf 1.0857 0 TD [(317,)-329.9(2011.)]TJ -21.2497 -1.1284 TD [(56.)-500.5(Chung,)-371.5(C.,)-377.1(Kim,)-379.2(Y.K.,)-375.7(Shin,)-375(D.,)-380(Ryoo,)-371.4(S.R.,)-380.2(Hong,)-374.3(B.H.,)]TJ 1.7505 -1.1223 TD [(and)-462.1(Min,)-456.6(D.H.)-467.1(Biomedical)-461.9(applications)-462.5(of)-466.1(graphene)-461.3(and)]TJ 0 -1.1284 TD [(graphene)-333.3(oxide.)-333.8(Acc)-339.8(Chem)-332.4(Res)]TJ /F6 1 Tf 13.3329 0 TD (46,)Tj /F3 1 Tf 1.5797 0 TD [(2211,)-336.1(2013.)]TJ -16.6631 -1.1223 TD [(57.)-500.5(Pinto,)-484.4(A.M.,)-483.2(Goncalves,)-483.8(I.C.,)-483.3(and)-486.5(Magalhaes,)-485.7(F.D.)-486.7(Gra-)]TJ 1.7505 -1.1284 TD [(phene-based)-306.5(materials)-312.1(biocompatibility:)-310.8(a)-303.2(review.)-311.5(Colloids)]TJ 0 -1.1223 TD [(surf)-333.7(B)-334.3(Biointerfaces)]TJ /F6 1 Tf 8.5694 0 TD (111C,)Tj /F3 1 Tf 2.8056 0 TD [(188,)-329.9(2013.)]TJ -13.1255 -1.1284 TD [(58.)-500.5(Jastrzebska,)-377.4(A.M.,)-373.4(Kurtycz,)-378.8(P.,)-375.2(and)-376.7(Olszyna,)-375.6(A.R.)-378.8(Recent)]TJ 1.7505 -1.1223 TD [(advances)-419.7(in)-414.5(graphene)-418.7(family)-420.6(materials)-415.8(toxicity)-417.8(investiga-)]TJ 0 -1.1284 TD [(tions.)-334.2(J)-328.6(Nanopart)-342.3(Res)]TJ /F6 1 Tf 9.1427 0 TD (14,)Tj /F3 1 Tf 1.5858 0 TD [(1320,)-330(2012.)]TJ -12.479 -1.1223 TD [(59.)-500.5(Cai,)-399.3(X.,)-404.4(Tan,)-403.1(S.,)-399.6(Yu,)-404.5(A.,)-404.4(Zhang,)-397.3(J.,)-402(Liu,)-404.4(J.,)-402(and)-401.1(Mai,)-405.9(W.)]TJ 1.7505 -1.1284 TD [(Sodium)-740.8(1-naphthalen)-753.5(esulfonate-functionalized)-749.3(reduced)]TJ 0 -1.1223 TD [(graphene)-449.2(oxide)-449.6(stabilizes)-449.1(silver)-450.6(nanoparticles)-451.5(with)-446.3(lower)]TJ 0 -1.1284 TD [(cytotoxicity)-623.3(and)-626.8(long-term)-624.6(antibacterial)-632.3(activity.)-623.4(Chem)]TJ 0 -1.1223 TD [(Asian)-334.4(J)]TJ /F6 1 Tf 3.3851 0 TD (7,)Tj /F3 1 Tf 1.0796 0 TD [(1664,)-336.1(2012.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(GRAPHENES)-338.3(POTENTIALS)-339(IN)-335.1(DEVELOPING)-335(NEW)-337.3(IMPLANT)-336.1(OR)-334.7(SCAFFOLD)-336.2(MATERIALS)-10282.8(489)]TJ ET endstream endobj 138 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 140 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 141 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 139 0 obj <>stream /GS1 gs BT /F3 1 Tf 9.2951 0 0 9.2951 62.022 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(60.)-500.5(Liao,)-408.7(K.H.,)-412.3(Lin,)-410.5(Y.S.,)-407.5(Macosko,)-410.4(C.W.,)-406.1(and)-413.3(Haynes,)-412.6(C.L.)]TJ 1.7505 -1.1223 TD [(Cytotoxicity)-514.1(of)-508.8(graphene)-516.2(oxide)-510.6(and)-517(graphene)-510.1(in)-512(human)]TJ 0 -1.1284 TD [(erythrocytes)-419.5(and)-419.4(skin)-420(broblasts.)-416.7(ACS)-424.4(Appl)-416.3(Mater)-418.8(Inter-)]TJ 0 -1.1223 TD (faces)Tj /F6 1 Tf 2.397 0 TD (3,)Tj /F3 1 Tf 1.0796 0 TD [(2607,)-336.1(2011.)]TJ -5.227 -1.1283 TD [(61.)-500.5(Sasidharan,)-463.2(A.,)-459.3(Panchakarla,)-466.5(L.S.,)-456.6(Chandran,)-462(P.,)-460.6(Menon,)]TJ 1.7505 -1.1223 TD [(D.,)-392.2(Nair,)-398.5(S.,)-393.5(and)-395(Rao,)-393.7(C.N.)-397.1(Differential)-398.8(nano-bio)-397.5(interac-)]TJ 0 -1.1284 TD [(tions)-382.9(and)-382.8(toxicity)-387.3(effects)-388.9(of)-380.8(pristine)-389.3(versus)-383.8(functionalized)]TJ 0 -1.1223 TD [(graphene.)-333.3(Nanoscale)]TJ /F6 1 Tf 8.7707 0 TD (3,)Tj /F3 1 Tf 1.0857 0 TD [(2461,)-330(2011.)]TJ -11.6068 -1.1284 TD [(62.)-500.5(Hong,)-642.7(B.J.,)-638.7(Compton,)-639.2(O.C.,)-641.2(An,)-642.4(Z.,)-642.6(Eryazici,)-645.1(I.,)-636.9(and)]TJ 1.7505 -1.1223 TD [(Nguyen,)-311.7(S.T.)-310.2(Successful)-315.8(stabilization)-315.1(of)-307.6(graphene)-315(oxide)-315.4(in)]TJ 0 -1.1284 TD [(electrolyte)-402.7(solutions:)-406(enhancement)-399.8(of)-405.2(biofunctionalization)]TJ 0 -1.1223 TD [(and)-334(cellular)-337.6(uptake.)-332(ACS)-339(Nano)]TJ /F6 1 Tf 13.1682 0 TD (6,)Tj /F3 1 Tf 1.0796 0 TD [(63,)-335.8(2012.)]TJ -15.9983 -1.1284 TD [(63.)-500.5(Chng,)-359.2(E.L.,)-351.9(and)-358.4(Pumera,)-361.8(M.)-353.2(The)-360.3(toxicity)-356.8(of)-356.4(graphene)-357.7(ox-)]TJ 1.7505 -1.1284 TD [(ides:)-246.9(dependence)-248.2(on)-244.3(the)-248(oxidative)-245.9(methods)-247.3(used.)-247.9(Chemistry)]TJ /F6 1 Tf 0 -1.1223 TD (19,)Tj /F3 1 Tf 1.5858 0 TD [(8227,)-330(2013.)]TJ -3.3363 -1.1284 TD .0232 Tc [(6)23.2(4)23.2(.)-477.3(Zh)4.8(an)4.8(g)4.8(,)-403.8(Y.)4.8(,)-403.8(A)3.2(l)5.3(i)-.8(,)-397.7(S)1.9(.F)8(.,)-397.7(De)6.7(rv)4.8(is)5.7(hi)5.3(,)-403.8(E)2.9(.)4.8(,)-403.8(Xu)4.8(,)-403.8(Y)3.2(.,)-403.8(Li)5.3(,)-403.8(Z)2.9(.)4.8(,)-403.8(Ca)6.7(s-)]TJ 1.7505 -1.1223 TD .0194 Tc [(ciano,)-480.8(D)-6.7(.)1(,)-480.8(a)-3.2(nd)-480.9(Biris)-4.2(,)-480.8(A.S.)-480.8(Cyto)-5.1(toxi)-4.6(ci)-4.6(ty)-480.9(effect)-4.6(s)-480(o)1(f)-483.2(g)1(ra-)]TJ 0 -1.1284 TD .0192 Tc [(ph)-5.3(ene)-802.4(a)2.7(nd)-798.2(s)-4.4(i)1.3(ngl)-4.8(e-w)-6.9(a)2.7(l)-4.8(l)-791.6(carbon)-798.2(nanot)-4.8(ubes)-797.3(i)1.3(n)-798.2(n).8(eural)]TJ 0 -1.1223 TD .0198 Tc [(ph)-4.7(aeochrom)-4.3(ocyto)-4.7(m)1.8(a-d)-4.7(e)3.3(ri)-4.2(ved)-437.8(P)-1.5(C12)-437.8(cell)-4.2(s)2.3(.)-437.7(A)-.2(CS)-434.6(Nano)]TJ /F6 1 Tf 23.2015 0 TD .0245 Tc (4,)Tj /F3 1 Tf -23.2015 -1.1284 TD .0184 Tc [(31)-6.1(81,)-335.4(201)-6.1(0.)]TJ -1.7505 -1.1223 TD 0 Tc [(65.)-500.5(Peng,)-422.5(C.,)-425.9(Hu,)-416.7(W.,)-425.5(Zhou,)-423.4(Y.,)-422.7(Fan,)-422.4(C.,)-419.8(and)-425.5(Huang,)-421.3(Q.)-422.6(In-)]TJ 1.7505 -1.1284 TD [(tracellular)-740.5(imaging)-741.7(with)-732.9(a)-742.4(graphene-based)-740.4(uorescent)]TJ 0 -1.1223 TD [(probe.)-336.7(Small)]TJ /F6 1 Tf 5.5442 0 TD (6,)Tj /F3 1 Tf 1.0796 0 TD [(1686,)-336.1(2010.)]TJ -8.3742 -1.1284 TD [(66.)-500.5(Wen,)-326.2(H.,)-325.1(Dong,)-325.5(C.,)-328.3(Dong,)-325.5(H.,)-325.1(Shen,)-324.9(A.,)-331.2(Xia,)-322.9(W.,)-327.9(and)-327.9(Cai,)]TJ 1.7505 -1.1223 TD [(X.)-410.4(Engineered)-420.3(redox-responsive)-416(PEG)-409.3(detachment)-419.3(mecha-)]TJ 0 -1.1284 TD [(nism)-450(in)-445(PEGylated)-454.1(nano-graphene)-450.3(oxide)-443.5(for)-450.3(intracellular)]TJ 0 -1.1223 TD [(drug)-332.3(delivery.)-340.2(Small)]TJ /F6 1 Tf 8.7158 0 TD (8,)Tj /F3 1 Tf 1.0857 0 TD [(760,)-336(2012.)]TJ -11.552 -1.1284 TD [(67.)-500.5(Sahu,)-404.2(A.,)-404.4(Choi,)-401.3(W.I.,)-409.7(and)-401.1(Tae,)-407.3(G.)-404.3(A)-404.3(stimuli-sensitive)-408.6(in-)]TJ 1.7505 -1.1223 TD [(jectable)-388.3(graphene)-394.3(oxide)-382.5(composite)-391.5(hydrogel.)-385.3(Chem)-393.4(Com-)]TJ 0 -1.1284 TD (mun)Tj /F6 1 Tf 2.1164 0 TD (48,)Tj /F3 1 Tf 1.5797 0 TD [(5820,)-336.1(2012.)]TJ -5.4466 -1.1223 TD [(68.)-500.5(Duch,)-439.5(M.C.,)-431.5(Budinger,)-438.9(G.R.,)-439.9(Liang,)-433.3(Y.T.,)-437(Soberanes,)-439.2(S.,)]TJ 1.7505 -1.1284 TD [(Urich,)-459.7(D.,)-453.2(and)-462.1(Chiarella,)-458.5(S.E.)-456.6(Minimizing)-459.6(oxidation)-455.1(and)]TJ 0 -1.1223 TD [(stable)-391.5(nanoscale)-394.8(dispersion)-395.4(improves)-390.1(the)-394.4(biocompatibility)]TJ 0 -1.1284 TD [(of)-332(graphene)-339.4(in)-335.2(the)-333.4(lung.)-329.4(Nano)-335.7(Lett)]TJ /F6 1 Tf 14.6748 0 TD (11,)Tj /F3 1 Tf 1.5858 0 TD [(5201,)-330(2011.)]TJ -18.011 -1.1223 TD [(69.)-500.5(Gollavelli,)-270.9(G.,)-264.1(and)-266.9(Ling,)-264.2(Y.C.)-269.1(Multi-functional)-273.5(graphene)-266.2(as)]TJ 1.7505 -1.1284 TD (an)Tj /F4 1 Tf 1.4211 0 TD [(in)-469.3(vitro)]TJ /F3 1 Tf 3.6168 0 TD (and)Tj /F4 1 Tf 1.9152 0 TD [(in)-475.4(vivo)]TJ /F3 1 Tf 3.4034 0 TD [(imaging)-467.2(probe.)-477(Biomaterials)]TJ /F6 1 Tf 12.3692 0 TD (33,)Tj /F3 1 Tf -22.7257 -1.1223 TD [(2532,)-336.1(2012.)]TJ -1.7505 -1.1284 TD [(70.)-500.5(Yan,)-323.5(L.,)-319.3(Wang,)-320.3(Y.,)-319(Xu,)-319.1(X.,)-319(Zeng,)-323.9(C.,)-316.1(Hou,)-319.3(J.,)-322.7(and)-315.7(Lin,)-325.1(M.)]TJ 1.7505 -1.1223 TD [(Can)-332.7(graphene)-327.2(oxide)-333.7(cause)-329.6(damage)-330.2(to)-329.1(eyesight?)-335.2(Chem)-332.4(Res)]TJ 0 -1.1284 TD (Toxicol)Tj /F6 1 Tf 3.4583 0 TD (25,)Tj /F3 1 Tf 1.5858 0 TD [(1265,)-330(2012.)]TJ -6.7945 -1.1223 TD [(71.)-500.5(Yang,)-244.3(K.,)-239.7(Wan,)-240.8(J.,)-237.3(Zhang,)-244.8(S.,)-241.1(Zhang,)-238.7(Y.,)-239.7(Lee,)-242.6(S.T.,)-243.2(and)-242.5(Liu,)]TJ 1.7505 -1.1284 TD (Z.)Tj /F4 1 Tf 1.1467 0 TD [(In)-283.2(vivo)]TJ /F3 1 Tf 3.0801 0 TD [(pharmacokinetics,)-291.1(long-term)-283(biodistribution,)-286.9(and)]TJ -4.2268 -1.1223 TD [(toxicology)-376(of)-374.7(PEGylated)-374.8(graphene)-376(in)-371.8(mice.)-374(ACS)-375.6(Nano)]TJ /F6 1 Tf 23.2259 0 TD (5,)Tj /F3 1 Tf -23.2259 -1.1284 TD [(516,)-336(2011.)]TJ -1.7505 -1.1223 TD [(72.)-500.5(Sasidharan,)-768.1(A.,)-758.2(Panchakarla,)-765.4(L.S.,)-767.7(Sadanandan,)-765.4(A.R.,)]TJ 1.7505 -1.1284 TD [(Ashokan,)-676.9(A.,)-672.8(Chandran,)-681.6(P.,)-674.1(and)-675.6(Girish,)-679.8(C.M.)-675.4(Hemo-)]TJ T* [(compatibility)-579.8(and)-578(macrophage)-581.3(response)-583.5(of)-575.9(pristine)-578.4(and)]TJ 0 -1.1223 TD [(functionalized)-336(graphene.)-339.4(Small)]TJ /F6 1 Tf 13.0219 0 TD (8,)Tj /F3 1 Tf 1.0796 0 TD [(1251,)-336.1(2012.)]TJ -15.8519 -1.1284 TD [(73.)-500.5(Nahain,)-394.6(A.A.,)-387.9(Lee,)-395.1(J.E.,)-385.8(Jeong,)-394.5(J.H.,)-391.6(and)-388.9(Park,)-388.2(S.Y.)-389.2(Pho-)]TJ 1.7505 -1.1223 TD [(toresponsive)-436.5(uorescent)-438.7(reduced)-436.8(graphene)-436.9(oxide)-431.3(by)-433.3(spir-)]TJ 0 -1.1284 TD [(opyran)-275.8(conjugated)-275.2(hyaluronic)-273.3(Acid)-274.2(for)]TJ /F4 1 Tf 15.9556 0 TD [(in)-274.2(vivo)]TJ /F3 1 Tf 3.0069 0 TD [(imaging)-272(and)]TJ -18.9625 -1.1223 TD [(target)-333.7(delivery.)-340.2(Biomacromolecules)]TJ /F6 1 Tf 14.8638 0 TD (14,)Tj /F3 1 Tf 1.5858 0 TD [(4082,)-330(2013.)]TJ -18.2001 -1.1284 TD [(74.)-500.5(Shah,)-544.5(A.K.,)-540.4(Sinha,)-544.1(R.K.,)-543.6(Hickok,)-549(N.J.,)-537.9(and)-547.5(Tuan,)-543.5(R.S.)]TJ 1.7505 -1.1223 TD [(High-resolution)-546.2(morphometric)-543.4(analysis)-543.4(of)-539.3(human)-541.2(osteo-)]TJ 0 -1.1284 TD [(blastic)-427.7(cell)-428.7(adhesion)-429(on)-427.2(clinically)-432(relevant)-429.7(orthopedic)-425.8(al-)]TJ 0 -1.1223 TD [(loys.)-334.7(Bone)]TJ /F6 1 Tf 4.6964 0 TD (24,)Tj /F3 1 Tf 1.5858 0 TD [(499,)-329.9(1999.)]TJ -8.0327 -1.1284 TD [(75.)-500.5(Wu,)-315.8(S.,)-320.3(Liu,)-312.9(X.,)-319(Wu,)-315.8(G.,)-319(Yeung,)-317.6(K.W.,)-317.5(Zheng,)-318(D.,)-312.9(Chung,)]TJ 1.7505 -1.1223 TD [(C.Y.,)-433.8(Xu,)-435(Z.S.,)-432.2(and)-431.6(Chu,)-432.2(P.K.)-431.9(Wear)-436.5(mechanism)-438.5(and)-431.6(tri-)]TJ 0 -1.1284 TD [(bological)-337.4(characteristics)-345.1(of)-338.1(porous)-331.7(NiTi)-338.4(shape)-337.6(memory)-335.9(al-)]TJ 0 -1.1223 TD [(loy)-390.2(for)-395.4(bone)-395.1(scaffold.)-391(J)-395.7(Biomed)-393.1(Mater)-394.4(Res)-392.8(A)]TJ /F6 1 Tf 19.5785 0 TD (101,)Tj /F3 1 Tf 2.1469 0 TD (2586,)Tj -21.7255 -1.1284 TD (2013.)Tj -1.7505 -1.1223 TD [(76.)-500.5(Roy,)-371.2(R.K.,)-366.7(and)-370.6(Lee,)-370.7(K.R.)-366.7(Biomedical)-370.5(applications)-371(of)-368.6(dia-)]TJ 1.7505 -1.1284 TD [(mond-like)-329.5(carbon)-328.8(coatings:)-330.4(a)-321.5(review.)-329.8(J)-328.6(Biomed)-326(Mater)-333.4(Res)]TJ 0 -1.1223 TD [(B)-334.3(Appl)-330.9(Biomater)]TJ /F6 1 Tf 7.4045 0 TD (83,)Tj /F3 1 Tf 1.5858 0 TD [(72,)-329.7(2007.)]TJ 9.2951 0 0 9.2951 313.0582 725.1588 Tm [(77.)-500.5(Huang,)-518.9(N.,)-514.2(Yang,)-518.8(P.,)-515.5(Leng,)-513(Y.X.,)-516(Chen,)-515.9(J.Y.,)-513.5(Sun,)-515.7(H.,)]TJ 1.7505 -1.1223 TD [(Wang,)-381.3(J.,)-377.6(Wang,)-381.3(G.J.,)-379.4(Ding,)-379.8(P.D.,)-377(Xi,)-379.5(T.F.,)-377.3(and)-376.7(Leng,)-378.8(Y.)]TJ 0 -1.1284 TD [(Hemocompatibility)-482(of)-472.2(titanium)-472.3(oxide)-474(lms.)-471.3(Biomaterials)]TJ /F6 1 Tf 0 -1.1223 TD (24,)Tj /F3 1 Tf 1.5858 0 TD [(2177,)-336.1(2003.)]TJ -3.3363 -1.1283 TD [(78.)-500.5(Gutensohn,)-255.8(K.,)-251.9(Beythien,)-257.3(C.,)-249(Bau,)-253.5(J.,)-255.6(Fenner,)-252.4(T.,)-252.2(Grewe,)-258.7(P.,)]TJ 1.7505 -1.1223 TD [(Koester,)-384(R.,)-377.1(Padmanaban,)-380.7(K.,)-373.9(and)-382.8(Kuehnl,)-378.2(P.)]TJ /F4 1 Tf 19.2126 0 TD [(In)-374.7(vitro)]TJ /F3 1 Tf 3.4827 0 TD (an-)Tj -22.6953 -1.1284 TD [(alyses)-360.7(of)-356.4(diamond-like)-358(carbon)-359.3(coated)-360.6(stents.)-362.1(Reduction)-354.9(of)]TJ 0 -1.1223 TD [(metal)-318.6(ion)-317(release,)-317.6(platelet)-322.5(activation,)-316.8(and)-315.7(thrombogenicity.)]TJ 0 -1.1284 TD [(Thromb)-334(Res)]TJ /F6 1 Tf 5.3978 0 TD (99,)Tj /F3 1 Tf 1.5858 0 TD [(577,)-329.9(2000.)]TJ -8.7341 -1.1223 TD [(79.)-500.5(Podila,)-433.8(R.,)-432(Moore,)-427.4(T.,)-435.2(Alexis,)-431.6(F.,)-430.1(and)-431.6(Rao,)-430.3(A.)-428.7(Graphene)]TJ 1.7505 -1.1284 TD [(coatings)-312.5(for)-303.9(biomedical)-310.8(implants.)-313.5(J)-304.2(Vis)-311.6(Exp)-307.3(e50276,)-304(2013.)]TJ -1.7505 -1.1223 TD [(80.)-500.5(Edwards,)-632.3(S.L.,)-627.4(Werkmeister,)-636.8(J.A.,)-629.4(and)-626.8(Ramshaw,)-630.6(J.A.)]TJ 1.7505 -1.1284 TD [(Carbon)-390.3(nanotubes)-380.3(in)-384(scaffolds)-390.2(for)-383.2(tissue)-386.4(engineering.)-387.5(Ex-)]TJ T* [(pert)-335.9(Rev)-338.8(Med)-333.3(Devices)]TJ /F6 1 Tf 9.5758 0 TD (6,)Tj /F3 1 Tf 1.0796 0 TD [(499,)-336(2009.)]TJ -12.4058 -1.1223 TD [(81.)-500.5(Zanello,)-425(L.P.,)-413.9(Zhao,)-421.5(B.,)-413.7(Hu,)-422.8(H.,)-416.6(and)-419.4(Haddon,)-415.4(R.C.)-418.7(Bone)]TJ 1.7505 -1.1284 TD [(cell)-398.2(proliferation)-399.2(on)-396.7(carbon)-395.9(nanotubes.)-398.7(Nano)-396.7(Lett)]TJ /F6 1 Tf 21.079 0 TD (6,)Tj /F3 1 Tf 1.1467 0 TD (562,)Tj -22.2256 -1.1223 TD (2006.)Tj -1.7505 -1.1284 TD [(82.)-500.5(Abarrategi,)-775.5(A.,)-764.3(Gutierrez,)-769.3(M.C.,)-767(Moreno-Vicente,)-773.5(C.,)]TJ 1.7505 -1.1223 TD [(Hortiguela,)-317.1(M.J.,)-316(Ramos,)-313.4(V.,)-319(Lopez-Lacomba,)-315.3(J.L.,)-318.7(Ferrer,)]TJ 0 -1.1284 TD [(M.L.,)-385.9(and)-376.7(Del,)-383.9(M.F.)-380.7(Multiwall)-381.6(carbon)-383.7(nanotube)-381.1(scaffolds)]TJ 0 -1.1223 TD [(for)-303.9(tissue)-301(engineering)-302.1(purposes.)-304.9(Biomaterials)]TJ /F6 1 Tf 18.6271 0 TD (29,)Tj /F3 1 Tf 1.5492 0 TD [(94,)-299.2(2008.)]TJ -21.9268 -1.1284 TD [(83.)-500.5(Firkowska,)-395.2(I.,)-393(Olek,)-396.2(M.,)-389.9(Pazos-Perez,)-398.2(N.,)-392.2(Rojas-Chapana,)]TJ 1.7505 -1.1223 TD [(J.,)-280(and)-279.1(Giersig,)-281.6(M.)-273.9(Highly)-281.9(ordered)-282.4(MWNT-based)-280.7(matrixes:)]TJ 0 -1.1284 TD [(topography)-562.4(at)-558.9(the)-559.1(nanoscale)-565.6(conceived)-560.4(for)-560.1(tissue)-563.3(engi-)]TJ 0 -1.1223 TD [(neering.)-340.6(Langmuir)]TJ /F6 1 Tf 7.8863 0 TD (22,)Tj /F3 1 Tf 1.5858 0 TD [(5427,)-330(2006.)]TJ -11.2226 -1.1284 TD [(84.)-500.5(Kim,)-550(K.H.,)-540.4(Oh,)-544.8(Y.,)-544.7(and)-547.5(Islam,)-542.2(M.F.)-545.4(Graphene)-548.3(coating)]TJ 1.7505 -1.1223 TD [(makes)-361.6(carbon)-353.2(nanotube)-356.7(aerogels)-362.3(superelastic)-359(and)-358.4(resistant)]TJ 0 -1.1284 TD [(to)-335.2(fatigue.)-333.9(Nat)-335(Nanotechnol)]TJ /F6 1 Tf 11.7288 0 TD (7,)Tj /F3 1 Tf 1.0857 0 TD [(562,)-336(2012.)]TJ -14.565 -1.1223 TD [(85.)-500.5(Yaszemski,)-336.1(M.J.,)-328.2(Payne,)-329.3(R.G.,)-330.1(Hayes,)-333.2(W.C.,)-326.8(Langer,)-330.7(R.S.,)]TJ 1.7505 -1.1284 TD [(Aufdemorte,)-381.1(T.B.,)-373.1(and)-370.6(Mikos,)-376.8(A.G.)-375.6(The)-372.5(ingrowth)-376(of)-374.7(new)]TJ 0 -1.1223 TD [(bone)-261(tissue)-258.3(and)-260.8(initial)-258.5(mechanical)-258.8(properties)-262.5(of)-258.8(a)-260.5(degrading)]TJ 0 -1.1284 TD [(polymeric)-339.8(composite)-336.6(scaffold.)-336.1(Tissue)-334(Eng)]TJ /F6 1 Tf 17.5719 0 TD (1,)Tj /F3 1 Tf 1.0857 0 TD [(41,)-335.8(1995.)]TJ -20.408 -1.1223 TD [(86.)-500.5(Lalwani,)-396.1(G.,)-392.2(Henslee,)-392(A.M.,)-391.7(Farshid,)-393.3(B.,)-389.3(Lin,)-392.2(L.,)-386.4(Kasper,)]TJ 1.7505 -1.1284 TD [(F.K.,)-834.5(Qin,)-837.1(Y.X.,)-839.3(Mikos,)-834.2(A.G.,)-833.2(and)-834.1(Sitharaman,)-841.2(B.)]TJ 0 -1.1223 TD [(Two-dimensional)-653.8(nanostructure-reinforced)-662.2(biodegradable)]TJ 0 -1.1284 TD [(polymeric)-614.3(nanocomposites)-621.2(for)-608.9(bone)-614.7(tissue)-612.1(engineering.)]TJ 0 -1.1223 TD (Biomacromolecules)Tj /F6 1 Tf 8.3682 0 TD (14,)Tj /F3 1 Tf 1.5797 0 TD [(900,)-336(2013.)]TJ -11.6983 -1.1284 TD [(87.)-500.5(Some,)-330.6(S.,)-326.4(Ho,)-331.3(S.M.,)-325.9(Dua,)-329.6(P.,)-326.4(Hwang,)-331.4(E.,)-331.5(Shin,)-326.2(Y.H.,)-326.9(Yoo,)]TJ 1.7505 -1.1223 TD [(H.,)-404.4(Kang,)-402.9(J.S.,)-405.1(Lee,)-401.2(D.K.,)-406.2(and)-401.1(Lee,)-401.2(H.)-404.3(Dual)-402.2(functions)-402.2(of)]TJ 0 -1.1284 TD [(highly)-493.8(potent)-491.9(graphene)-491.8(derivative-poly-L-lysine)-502.9(compos-)]TJ 0 -1.1223 TD [(ites)-295.5(to)-286.4(inhibit)-291.5(bacteria)-293.6(and)-291.3(support)-294.6(human)-291.2(cells.)-293.8(ACS)-290.3(Nano)]TJ /F6 1 Tf 0 -1.1284 TD (6,)Tj /F3 1 Tf 1.0857 0 TD [(7151,)-336.1(2012.)]TJ -2.8361 -1.1223 TD [(88.)-500.5(Wang,)-338.6(K.,)-337.3(Ruan,)-339(J.,)-341(Song,)-332.9(H.,)-337.3(Zhang,)-342.4(J.,)-334.9(Wo,)-334.1(Y.,)-337.3(Guo,)-337.5(S.,)]TJ 1.7505 -1.1284 TD [(and)-590.2(Cui,)-590.2(D.)-587.3(Bioccompatibility)-588.8(of)-588.1(graphene)-589.4(oxide.)-590(Na-)]TJ 0 -1.1223 TD [(noscale)-341.5(Res)-331.8(Lett)]TJ /F6 1 Tf 7.1361 0 TD (6,)Tj /F3 1 Tf 1.0857 0 TD [(8,)-329.6(2011.)]TJ -9.9723 -1.1284 TD [(89.)-500.5(Humphries,)-788.3(J.D.,)-788(Wang,)-783.8(P.,)-783.9(Streuli,)-783.4(C.,)-785.8(Geiger,)-787.3(B.,)]TJ 1.7505 -1.1284 TD [(Humphries,)-343.1(M.J.,)-340.4(and)-346.2(Ballestrem,)-341.5(C.)-340.5(Vinculin)-346.8(controls)-341.1(fo-)]TJ 0 -1.1223 TD [(cal)-288.8(adhesion)-288.7(formation)-283(by)-286.9(direct)-284.9(interactions)-294.1(with)-281.6(talin)-289.9(and)]TJ 0 -1.1284 TD [(actin.)-337.4(J)-334.7(Cell)-337.8(Biol)]TJ /F6 1 Tf 7.3374 0 TD (179,)Tj /F3 1 Tf 2.0798 0 TD [(1043,)-336.1(2007.)]TJ -11.1677 -1.1223 TD [(90.)-500.5(Hamilton,)-486.7(D.W.,)-482.2(and)-480.4(Brunette,)-485.2(D.M.)-483.1(The)-482.3(effect)-487.2(of)-478.3(sub-)]TJ 1.7505 -1.1284 TD [(stratum)-297.8(topography)-288(on)-293(osteoblast)-293(adhesion)-294.8(mediated)-292.8(signal)]TJ 0 -1.1223 TD [(transduction)-442.9(and)-431.6(phosphorylation.)-439.2(Biomaterials)]TJ /F6 1 Tf 20.0421 0 TD (28,)Tj /F3 1 Tf 1.6834 0 TD (1806,)Tj -21.7255 -1.1284 TD (2007.)Tj -1.7505 -1.1223 TD [(91.)-500.5(Chen,)-278(C.S.,)-276.6(Mrksich,)-273.8(M.,)-274(Huang,)-275(S.,)-277.6(Whitesides,)-279.2(G.M.,)-275.8(and)]TJ 1.7505 -1.1284 TD [(Ingber,)-345.3(D.E.)-339.4(Geometric)-345.6(control)-341.9(of)-344.2(cell)-343.3(life)-341.4(and)-340.1(death.)-344.1(Sci-)]TJ 0 -1.1223 TD (ence)Tj /F6 1 Tf 2.1774 0 TD (276,)Tj /F3 1 Tf 2.0859 0 TD [(1425,)-330(1997.)]TJ -6.0138 -1.1284 TD [(92.)-500.5(Roskelley,)-482.2(C.D.,)-470.4(Desprez,)-480.3(P.Y.,)-474.6(and)-474.3(Bissell,)-476.2(M.J.)-474.5(Extra-)]TJ 1.7505 -1.1223 TD [(cellular)-252.2(matrix-dependent)-253.4(tissue-specic)-251.5(gene)-253(expression)-247.7(in)]TJ 0 -1.1284 TD [(mammary)-419.1(epithelial)-413.8(cells)-415.7(requires)-421.4(both)-408.7(physical)-416.2(and)-413.3(bio-)]TJ 0 -1.1223 TD [(chemical)-260.4(signal)-253.1(transduction.)-260(Proc)-254(Natl)-255.3(Acad)-254.5(Sci)-257(U)-257.9(S)-253.1(A)]TJ /F6 1 Tf 22.7257 0 TD (91,)Tj /F3 1 Tf -22.7257 -1.1284 TD [(12378,)-336.3(1994.)]TJ -1.7505 -1.1223 TD -.0188 Tc [(9)-18.8(3)-18.8(.)-519.3(McBeath)5.5(,)-262.8(R.,)-256.7(P)2.6(irone,)-262.8(D)3.9(.M.)5.5(,)-262.8(Nel)6(s).2(on,)-256.7(C.M.,)-256.7(B).7(hadriraju,)-256.7(K.,)-256.7(a)1.3(nd)]TJ 1.7505 -1.1284 TD [(Chen,)-348.3(C).6(.S.)-348.3(C).6(ell)-341.7(s).1(hape,)-348.3(c)1.2(yto)5.4(s).1(keletal)-347.8(t)-.2(ensi)5.9(on,)-348.3(and)-342.3(R).6(hoA)-343.9(regu)5.4(-)]TJ 0 -1.1223 TD [(late)-334.1(stem)-329.5(cell)-329.3(lin)5.6(eag)5.6(e)-334.1(commit)6.1(m)-.1(ent.)-329.8(Dev)-329.9(C).8(ell)]TJ /F6 1 Tf 17.9927 0 TD -.0243 Tc (6,)Tj /F3 1 Tf 1.043 0 TD -.0182 Tc [(48)6.1(3,)-329.3(200)6.1(4.)]TJ /F5 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm 0 Tc (490)Tj 49.6032 0 TD [(GU)-334.7(ET)-338.7(AL.)]TJ ET endstream endobj 142 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 144 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 145 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 143 0 obj <>stream /GS1 gs BT /F3 1 Tf 9.2951 0 0 9.2951 59.7543 725.1588 Tm 0 0 0 1 k 0 Tc 0 Tw [(94.)-500.5(Dalby,)-420.8(M.J.,)-419.7(Gadegaard,)-418.6(N.,)-422.7(Tare,)-415.8(R.,)-419.8(Andar,)-417.6(A.,)-422.7(Riehle,)]TJ 1.7505 -1.1223 TD [(M.O.,)-654(Herzyk,)-653.7(P.,)-649.7(Wilkinson,)-655.8(C.D.,)-653.4(and)-651.2(Oreffo,)-654.1(R.O.)]TJ 0 -1.1284 TD [(The)-549.4(control)-549.2(of)-545.4(human)-547.3(mesenchymal)-552.8(cell)-544.6(differentiation)]TJ 0 -1.1223 TD [(using)-609.2(nanoscale)-614.4(symmetry)-615.3(and)-608.5(disorder.)-612.4(Nat)-609.5(Mater)]TJ /F6 1 Tf 23.2259 0 TD (6,)Tj /F3 1 Tf -23.2259 -1.1283 TD [(997,)-336(2007.)]TJ -1.7505 -1.1223 TD [(95.)-500.5(Oh,)-435(S.,)-436.2(Brammer,)-438.9(K.S.,)-438(Li,)-434.7(Y.S.,)-431.9(Teng,)-439.8(D.,)-434.9(Engler,)-435.7(A.J.,)]TJ 1.7505 -1.1284 TD [(Chien,)-503.3(S.,)-497.2(and)-504.8(Jin,)-499.2(S.)-497.1(Stem)-500.7(cell)-501.9(fate)-504.8(dictated)-500(solely)-503.2(by)]TJ 0 -1.1223 TD [(altered)-246.6(nanotube)-246.9(dimension.)-247.1(Proc)-241.8(Natl)-249.2(Acad)-242.3(Sci)-244.8(U)-245.7(S)-240.9(A)]TJ /F6 1 Tf 22.2256 0 TD (106,)Tj /F3 1 Tf -22.2256 -1.1284 TD [(2130,)-336.1(2009.)]TJ -1.7505 -1.1223 TD [(96.)-500.5(Engler,)-478.4(A.J.,)-476.9(Sen,)-477.3(S.,)-472.8(Sweeney,)-475.6(H.L.,)-479.7(and)-474.3(Discher,)-475.5(D.E.)]TJ 1.7505 -1.1284 TD [(Matrix)-243.4(elasticity)-242.1(directs)-241.5(stem)-240.8(cell)-239.6(lineage)-244.3(specication.)-244.6(Cell)]TJ /F6 1 Tf 0 -1.1223 TD (126,)Tj /F3 1 Tf 2.0859 0 TD [(677,)-329.9(2006.)]TJ -3.8364 -1.1284 TD [(97.)-500.5(Kawai,)-591.2(M.,)-591.2(and)-584.1(Rosen,)-588.3(C.J.)-589.9(PPARgamma:)-593.9(a)-583.8(circadian)]TJ 1.7505 -1.1284 TD [(transcription)-402.1(factor)-403.7(in)-396.2(adipogenesis)-401.8(and)-401.1(osteogenesis.)-407.1(Nat)]TJ 0 -1.1223 TD [(Rev)-338.8(Endocrinol)]TJ /F6 1 Tf 6.7397 0 TD (6,)Tj /F3 1 Tf 1.0857 0 TD [(629,)-329.9(2010.)]TJ 9.843 0 0 9.843 438.803 725.1588 Tm [(Address)-331.9(correspondence)-343.5(to:)]TJ /F4 1 Tf -.4205 -1.1174 TD [(Yongsheng)-339(Zhou,)-330.2(DDS,)-336.8(PhD)]TJ -.5817 -1.1116 TD [(Department)-337.7(of)-336.4(Prosthodontics)]TJ -2.5112 -1.1116 TD [(School)-336.2(and)-331.6(Hospital)-338.2(of)-330.6(Stomatology)]TJ 7.4991 -1.1116 TD [(Peking)-338.6(University)]TJ -5.9383 -1.1174 TD [(22)-336.3(Zhongguancun)-336.8(South)-333.9(Avenue)]TJ 6.5661 -1.1116 TD [(Haidian)-331.4(District)]TJ .4377 -1.1116 TD [(Beijing)-333(100081)]TJ 1.7279 -1.1174 TD [(P.R.)-334(China)]TJ -10.114 -1.8719 TD (E-mail:)Tj /F3 1 Tf 3.3925 0 TD [(kqzhouysh@hsc)-9.2(.pku.edu.cn)]TJ /F4 1 Tf -.2707 -1.9237 TD [(Received:)-339.6(October)-339.2(13,)-333.9(2013)]TJ .4493 -1.1116 TD [(Accepted:)-338.4(January)-338.1(9,)-332.8(2014)]TJ -7.3436 -1.1116 TD [(Online)-337.2(Publication)-337.5(Date:)-335.9(February)-334.5(26,)-333.9(2014)]TJ /F5 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(GRAPHENES)-338.3(POTENTIALS)-339(IN)-335.1(DEVELOPING)-335(NEW)-337.3(IMPLANT)-336.1(OR)-334.7(SCAFFOLD)-336.2(MATERIALS)-10282.8(491)]TJ ET endstream endobj 146 0 obj [/Indexed/DeviceRGB 255 147 0 R] endobj 147 0 obj <>stream 8;X]O>EqN@%''O_@%e@?J;%+8(9e>X=MR6S?i^YgA3=].HDXF.R$lIL@"pJ+EP(%0 b]6ajmNZn*!='OQZeQ^Y*,=]?C.B+\Ulg9dhD*"iC[;*=3`oP1[!S^)?1)IZ4dup` E1r!/,*0[*9.aFIR2&b-C#soRZ7Dl%MLY\.?d>Mn 6%Q2oYfNRF$$+ON<+]RUJmC0InDZ4OTs0S!saG>GGKUlQ*Q?45:CI&4J'_2j$XKrcYp0n+Xl_nU*O( l[$6Nn+Z_Nq0]s7hs]`XX1nZ8&94a\~> endstream endobj 85 0 obj <> endobj 149 0 obj <>stream h,U˫%G3śݸ%YDV.Dqp&w{W*~sĐb,BDA] qL~GS,^w왛g7nܸ_}?ӓ|sO?3׾K7gΞ=ًg/aX/߼~COnSNu;xMF37UyQМf<(Nt5Ps1oxݰw}m WXm_(T"YCEѧy^fEPdbWuvrCdhvuuXtiQhCХ>ʱ\}ӳ-QMG= :ñ5Z/vB[lYLw5\"ep삗-ѥ.LiN|0JK|]bH6kc *sA8iC'Elxf1I]}6ͥEIv-~S?&۠C۷ǣ܋t_of$0K' e];}ﭝinq{ڃ{s#IYZUd)*YٔX*щ]m]޻YwANU*LMpzw?60 * Nۈ ,dH}y_/ <;6{ ~FoEGJTf/I'C>C)L0=-Aw0rjDc"l+[jjLg=EG@a&d3=Uz|)zҗmnR0$8S"a (zshDш "HA5,QV.;:D"I*2ֈiRXR:AePD-2Qbm͵0‹A xUv5Pb܎q;ѥ؍ٴE]F,/HMJi2JaOg&ui,ܻOE-z6 '?}Mr2QѨ582+T'OQ8gCtL$ :r*F4M,p><6NfkX% 0RX&y"t N:  d|}׻-vQcQR@ȕuU75Qj0`Pu#y>O?zIHRԼl B9$>qKa6|Vfkߡo~"+bw'd̫i* ܳ͠z݁'5(tw.=KIzIkX$EJVph0κ5C@͉ h'03vt+=_݇XlVlO}t?Rf;WVZ,t `̷xw}7zhrf5} 0SԔQRL kLT-]юWh#HNt_v.jrj endstream endobj 148 0 obj <> endobj 150 0 obj <> endobj 112 0 obj <> endobj 151 0 obj <>stream hބU PTW C `t p-@c7MD Qf%lfD jR1ۦ5L2U{syW%89*교Ȱ0@}ZԤ@mBU@ a{JD0B۶}& *UiM1b[;F;aD/:wb_ h9ŐhJ5&]A?N LHF0kMƭ3 iX6ެiSL:!QgZ5І'S,m .IѤgͩx)`s ?$jA'Cт0N%8%!Iv 0$8 #I^CPvxaCǥYduYSE)Fve|"C ɘ8;p)bt:D~߁L;נ[1G`_וq`R0)2py2NosG>EG3` JڞV/0)NdfǫNFsƛT|Bs4 fDC L=vO-.#vUUڍ踖FȰ.|[}S]2JVv5%䰜qZV]&MXe.Ek۶T0kZrw6Dpl9U?Q|a@-SZнKaSC]M{I~eSp/@MH& ɜ^_Cm^GV¼D%.Ot8%_85m"5wŢy9tּs_UOv)}m0Ce5`yh򸸶>+W'͎0Zm\o96X a;ޓY;w4Pp,Yhd?4'H1I >ów}S\/ IJrsv%|+, 8*5le-þU-osm͍+Ya~4XLGX>0@[}ID!lCRjNZvn* Bc4z* endstream endobj 152 0 obj <>stream 8;Z\7CRTku%-0,Aj8N]5FV]7W&-rki]3C&OC9<1L9SNiBiW?2E/F%"\);Ng&1+k=l 6XLdH0.OCo/$uL1A),^U4:tO.Y5!)4C%,d?niCF7hP\o)7/&bK(3>:71mW ^Ms-"pK3MD$MbM[QYV,$SI!K;=\YF?fK/.]^,T/LXMgF!#ZnK[abpM_]--eL*=!UL ?H9.7Aed\16'N_A`gF$"=C+)qU_e6.=B112MWa`Q`pl1W.u5Eb?tA"VRqB%F5:(S+L60@&hjRbSkQ[5DSB ^5+/8erd!G1)nF5Rc`q!^97#qj&1j_k\Fg9gDS_0O,th3W^3N-On>u$J(.luecTW9 jB[8hfDZHE)ZI2q>1NLZo!M4\K(Af,g#tWc#J?@'T95[oER6q'Dp5]rn1t&%G9qh~> endstream endobj 87 0 obj <>stream 8;Z]"?*])*%#%uGDsVs*g!6]l1#tPbkJ!1@doOs<5#*4%r*#r)]lmW7>AFabH)kf, qLI82/]P49$*iIgk.8brgLi_"_s)Af!E+^L,dN?@d"hg2eTh9emi8kZS.V4h5;l!) ?(#gU7s&q39=*Ejd_-_1f6GBSk)KH4bUdm!*ZI^INrRsWMS9Y67 f6CiMcBA^pI1%a=Rd3qfCTdN0VH=hbS(Y8IZ9E-7$7 h]S;)qFrDG3VseFQ],T5Z7p7t'\LPfV`ttIX37FcH;.FgIfu:(aaB'6O'^@F[Mi2K DJ/X/7*XaLO]pCm((6J&TZ>G85Wlr[[$)EuPZ`M/qg#44(4dB)3\h[XcqOV=A a>H0Br$C['Hg,n%etV^:`Eu*SJb)oA*eMS5)65d"^Xta8nuDTQf7*,ArWW?YMZ07~> endstream endobj 92 0 obj <>stream 8;Z\7>EZlH%-'&>l2G>S3Xs`Sgm3c74-Q57GP2V>KiSJu8a0=.$i3Ru>YPG$hH5(a \\W',l[sIkK@edC@>!1;$83d2""(kkbOE)s>4s[EQ^;]M^H?e\l1-UtK%Dn]iRL.M g325fS*+co1GAWD))Y3ilXc(g^[OTW2.Ea]ME!!:)-Wb'hfu9+2YeNU'C>id#ZrNH9AGfeU8P Nqik!r/-6\kbWS4g&/]kC?_=ejtCin,JF//IGIKK`:49WteW27J=hb4/)f?M,#HrO'S$dXS[[ MO71Jb:d]5U(dE!5um0OS?O")/",S\XY]&5*."dVduW*U4nQ:ub--6N J'Wt"hg=OQds:k(jjj8+C9#kcHA.@f~> endstream endobj 96 0 obj <>stream 8;Z\7>EZoI#im]=p&34rFZ'Ho'i@Y%]D5Q@VT_G\S[LhCn_[XkmdHXcVDmanYN[k8 ;-^pP(Z+(J-D3<-'ORHAJr8k.n-[dHYGAAX93OnXqU4NHd-b_HY@."MbcTp"1SWAIR$aV#Vg0>]M#.ANT^m04A<>[nlMn64;4f;,U3gftAK OVtsM!_;Vn)<;OqI$'Ami(>P+ZX5qS(n;bU,\&C8d[[g+OaaeODWM8M$CICRkUZ$4 /j'mj79)7[LfqPt?SLe=_\LpK1rQN[lXDA!f(Wa9/q$%C'ma-_dJ:*->1GW_S\Jd9 M]:&JAeOLE3N`ZHk,IQ.0>^0qAUd*B3uh!Q$L8PI'mkOjZUL:MRYWBX37VDHU)hfd ef/BW7k/&nXhb9+on0TKjKG".o)C+3<=RBH2sTt#6tMS.DMRm+kHm6)oW/"rcO?u>%a4[q?Jk3kg%@4'&T(n4)Wl.jrTEKn+()d_0<;4! ]JEdVldS%:H0ads\/ZXIk,U/mrDCgH6e/cgVjsVs&SN"!6H6ZXo~> endstream endobj 100 0 obj <>stream 8;Z]"iK?MN#_dO@s7-*7ip1D/lE-=mTpTT(QtDeV#+p-.DQR9Xf=67Gs4J=HiJ[%> erXTAi[Rf42A\Z^8-6:VoG's5B5lho0eQTU*-YW9(\!^3'sUde^d>nC8_1D/_kCQM W@Z+mW2Pb&UJ.RhClZ#"hStgZ_*$mGM=c3A7U.]4\<+&"0.rU5A\.s$\W#jn:seI' *g<^nSQP(r>U8"\*du5V3iAEfB&)+NWjP>jFc>(eX]$MJ"`TGpQ:<9jZak=\a2lk, :15/Nai%%;_=%/l% aMkQ%;j1+'34-&cSQqooXPMt21esa6X(eJ[cVqqcT0"F'%S*[II!DD4TY0/a:!(n! k(t&'W]_cWKVf<+?-eDZM>^$%E#kZ;Q7k;a95-e,=.+-t,H(9C 8X.k AaZ>-5D!ma-0p#gCld<6U[<&N)!N(kd$V<:d^Y[ff1YbGg,4D#5M,23*p9!jQ=7Ma 9B2',T`hOTJ!jGRrKrr;s7]m2pWsSa1@*Q8qQH*/+1\3b endstream endobj 104 0 obj <>stream 8;Z]";0Kl##XqmTJ*_Y:DPp@IW*gn#O*4^\F#l[JhRkrWk56=;_#!pddV:B?&JtNl 0)Lfq>j3XQ#.R\aJ6jKd8sc+08k6GAV*WPh06Luj[.qh\jWZ;U;S+H\f/^!3-e)DY d*"5j3>^72%_k%@hJ*X^R0fQTVI3.o36sS\K..MSu?cq27@AeB)o0Pj:HAi_k(/c(sKVl\F)q .2(K^hCNq:hga69G(Ya\E4D/EL"MtF0[(XF\Q+.;lc>=f.ZYl p",cCKe'X,4B*okg@dnHgIU\>$ZfCuqB_a9E8#Yag4f"*Umfc=Ot+dMhHZW7em-n, #q"9L(0mMf>(o?B]'j$NPN&MiX2dA!6P8YQm5S2qA-\\336Pn.-:TJu`0:_UjmDMB EKZ6lKmA5t`eZk/h`HQQ#!(Nnfu^r]EW3b%*Ht#jKDr/;d&=^\'2Fq\o6h-iY!&uh >45!Y2s#BN,+fm2"\K:ibi[F@5*IGTOmCsO,RDb>Vik#W*acYhW*^W#[O%*kcIJO/ >>h#<\0p$NAZZbmLjd:\eb*94Cs@rESj*#2q_.Dba?,_Y*I%IfP*%a"*8+]J!jPK4 XV8[^,1rT(QVI#0rHO'TlISV1.>#n9pVlj=p`GXn)?AZX_;b~> endstream endobj 108 0 obj <>stream 8;Z\7?#IY)%-'%Sq>P$c3r;IbpaJet(/:5S*i`8*@#Qg3.KAd`6Rg^WK\s7Q8]#bX P2EbG4c5Li`VMGsRDfobNPpMHJ-lL"Y\nC`leh`6h#Reg[qQSD]?"(N\.!eYY;C^A `75)D3,!^\`AJ(>V3Am[:W2PtUET)&d^iM&VtMF_e8XsSW^B\o.6op4/sPcK'T7^H //^47YNkDOVc%JF$WoJnI3C%H8G6q>MMpL&W2EBcSh*[O/I8jT)@"EqN%%Z*&@SUY @.1s;2I)c%_9hE&[C9dr$"LhMJ[2-YFWr/3e!Ffc@'35Bi>VAhR_BJ;k$m#8fpS?A *qh6f?Us\o@q@I_62m-g8Hm%Z*r/4(*nG92FuPP"omQ29G>hYl'1(ToW37u?Sn-#l U:F=hrhYQnP-@kuE`M7jFMT\dmU'PBAa3q';Qm*u&2:5cJ'#gnnuqLFRr4sD$ZLL0 mRLAEEW3f'Qo0&*QaZ$:]RRJ_&+VB',&/25/diV.Z20>s;1,@/HsB(BrCY2J($G=U-uSHC9!"r^Habf0/N57MHPIU+c0pdL_MNHNLUsD33CFpR \J'7@Mp1WWI?Aorr^H*9#IlaAS]qNsIuY34pJBc]SF6!9B.Z+,r-hVt_@MQ?nu+tY XFHpD[Q8_p7J[-@jB7ifU?fiTi*+XMq`VNGC$++sH;pg8YA#1%QeQdBs'd2.D#<2f OnCBBPHQ'\M%8ZTj?A endstream endobj 113 0 obj <>stream 8;Z\7>E6WE%%G0,0D@\(Y-ZYr+-8I::lo:cB#X,80Z>o0PH)>O'!dMq9K!KNN+H": K`*?jrHohBE3K5G*2EF\N+62]ojdni^)Tb$9)b&`O%N&P/,9gt b!^[.m.n$sT5g`X79V^LWP70QOGu0$:/Qs\>DV?4qd-_8J))Y=_j0129u95%ls>LE L?:sFl&?6nQea.M?a8bb-Umt?q,^Q>Ea)DCq8IL$X8B)"-c,@*bu^Y=4Ud-*>YNfO qB?m51FapJ%"4E?`O_&*Fdr."Umq#liQtGmKhUgm5*63?VocNpqfe3c?8?W[YN$"' _;u`iN8][UHJRbrliaijg+cVH^=)Q0*PR65&YDk@bh:Z26k39k?^^aM1Xbr9:4M`9 >$UKdYcBr;dT:kWLO<,#HL1PmrI(WIM](Lh(70177Y`^$?_MD+HFSIVQG2dr,g9?- pI"ls^chZsH<0B>1S`?INU&*DCW#KjHq'A!h \@A[[qUtqP;8/Jj,f?#clnsHsYrV:Wi;K,D^)pNH^R3,hKYe1 56Cm.'&+i~> endstream endobj 117 0 obj <>stream 8;Z\7>IMEl#jc$skPj)MG&H_>@MEE>N,=&2:JMt.@2oJ>OiJfMP]n8U*p`h&1Y=-, 0CXn>lgH@6L2b\3fUG+<2f5gPN.l(/9o;LYUZJDX`E-AFStGsT+.53L+p,jdJ* ,oRq_XZpN\XoI`LNoOFu-MRD%ATWDU5kNMf2p@,8F!%%QM-Sitk$U%]ehF)dPc'Np '5@.53HN8B6/rcn)Ah"IT!+g0#Pq*(9'aY\VYn;I,k[)S$@QX.\pK?n?t-C;\59%[ RQA9]p`_]UC;B+_A6d46ojCJ+%"0Q&e:Te_`SDjrb7+e5to6MfuE:?U.9AfKV\L_`6X7"Q:8t?d9^U iPPI8Hf)QHKJ."9SG\3:hkKrZS=u_S6@@TD?'@&:.oPq9`!q($Iaq`PbQeC/#4&#< D7KIHb6H>C[-fG#"8W?c^Qa:e6HJi*r?GX`e[nSb\Wsn]DI\Ef=j-"Zr)QYO>.`O1 V+fKdBmU7EMn$N?FOk5inq"rT2.4>'^`$4Ze;UGPa7q^kaRJlTA(CP_!*d#uRK~> endstream endobj 123 0 obj <>stream 8;Z\74*'(0&7ld+Ue'St-quC0iY9+\/(73>9oe.OA%<0j;k9u!MCM4-^`laW$eQ3P L3oIB^`S@C6-?L^BJF:"poN=94=k/rU[;Q%[bihq,D7$RbBmAp]/8XecR6Z*0o=p? =FiaG,>bOpZ#*+AH&sZTQc9^aS-(9Adiu%KP'5=es.eM'HKAh9U4]_ X^QMlLea(0;I*V=Os(l+qh`Xu6tWT]#[iSUL>7t+7a4NQR/U40_jl;Z8EV%u\E^/V JE;GhfsnDdHDGFbN*5oR:hia-?\65*nZ=M7Im2,jc%@`NX=:ni6'`D$?cN1Ymh`u #@Gj,=$mK5.s0IE%U?*ZT:3ccqHi/b`=Ni&K=U?a"Qstf'$hQW#\)GRZ$Q;'iLW"e 'oS!jh='1;C>JHg_*I3T;aM7>@MO@j1b*pY3[p**C54.X.bLD#F^*m0jG5t71XET% G&5!X9d4BESE6Br`k'W@I47-28bp0?1PS?-.M1%M(:&q=[mJCpCpp[)jsUNbNU[fr A#d0YB=(RM[?%cT/L6^r1<;dM[k_;C14J'E9EgV@)hY1h'qu9V+qdHSi``E)9ECU2EB.+qdG(#h)OT>P^,XH*#B VU_iLiqMobW*eEjIp60aT'J<8JXJBucS8o%lb0rhHM=r&A'FQFoY#TG0F&X.#IkAV mShL#8"2Ma"5&%u]Ks7g*&&Db+`6^m#B>=>QV0Op>;4"NbTq!e/dKBTkK>r'T8!5` 25^tTN&kr=\a"/42gtLC43CQE9pokfgp\[%D][ (EV"N^Mdk&.UQ]XjZBkgQm3KO?c2W5OlWath=ojTNY\pM!s$7#Xd/~> endstream endobj 128 0 obj <>stream 8;Z\76'?jS%-'(Ujo98HGBOcN`/ZFi+dBlF*G1ap@\Ll'"+2hR;I7>QloFUna(VAI (ADmo_molm,J7&hN)rUA._gK'0?QtIY`/s5*S9it%Ze`$eMs>UU02sUS6(_BUJR54 IgKbfq#N=DJJbR7o_U.pe[Y(l!hGC[8iCUs^>5k1b;cTgJ]t#93PMijOf@kkr,l=O EJJqFr6kA`;$rZg-.P>bISGVKl5,D:Hd5-[Ddh=tQR7S*n\,BnTCg8tm?4`1>%E+> ZpDU*?a"[.ktLDj#Jgb/Hucm0J')>PZ$!_]?H7A:iR"@^)!T$kjQc=_D+C;46$,lA]DOY D!n1n8QL7%eDHJgdB*9?l"-fI;].G'qi#fU?K(nXMrH\fZs(-A[a"AL,,orbpc1V#Ors1gk!$OIHCB~> endstream endobj 132 0 obj <>stream 8;Z]">B[n,$q.E=s0;U3b]]FaN8DW8d/J\hJ> 3(\A\-jaQJF[Ac<AS*jEKMUci#^/Mm&o96*9I7K]MZp E%%H4mKB^bp*3aFr"\U&X(su%::ORA9]l2%=8%;`A,gkTLqa$t&4E[;$HfEs^>ORa 9=_h01$8.k^MXYLIO\*Y^TC0.79MUmX/WkjhspC>iq966#.fU,1;uia@c+-65j&aC MP$$5VpL1WYP+"h:H^S9Kd6U\<@'`79$?^EIIk)Uk/q4_7'n'-qM6i?R7FpOHWPuJ KMH.tPq\H/L?jIa"3m8G:eON@,smCp3**cja&\l7Lkdrf%H7 Y]<8!ra,AWr^W'b1]qdH)=/[820YG<`SQ9@hMOSo/Md43iR0JAMs;MXS@R6?5kQrs J(Y;:!AF2,W1Uu#^W5or7Hqtl0;=f7k&Ap&L6+Dr:M0TXki8-8jh96J]D^@8iUpA; Z]G!1PJ>QB#dufN>q/'q[F3Z;f:c2qP)n"_[Kft4A#mKMf:)65OeE-F+ endstream endobj 136 0 obj <>stream 8;Z\7=gGpf%*N)Ua8O>Ylb"QpOVaO!b3Mioa^cOu=3.ZVr9T!"ng]hZ*`KiPRbPkbe3UD;emk1>(>r#i.JSc5mb0Y">7EfKRg-oI$9OK.cc r:4LYf8)t#H0h\"0fRK,6lH9XZK!"s*c&TaTn0f>Ju3L)E73!R_NTh."T'Sq_4nAF X'`&Da4=JT';Rg*dK"3##+$^Ea9uDLl.dNnb4`*)e410%T!HlVj#Oib4RH a8&Nj;t;.91JtM53\-O:^P_.iT`m).$8?@TAc=oP/Yu)QgPFfE7)X:ldfO(p=O2_=2T[Lf6Gd3>VaJ FqM%:YGqUQ?gBaCO8LZGM!MF/Y0Puh%eV@4c^\@9?V13*j%qPuA(^R!3?)l."G>;0 IK@gk&!fGG=/jnh:Gb,j.nhchIcVSGdOd$ZmO/DI@b%Z`g+_ZRBtP=3/U^&*+95qo 6)XPK5Z]GdFa2k;rH5eo+AE+WZJB?Ff+*@tNl]`=hr,BEl?UXZc7d)?,U0WS6.^pD :1QM)_&SS endstream endobj 140 0 obj <>stream 8;Z\7?(-Bg%.l6fjo/n\lYI:;q#to;0>$I]X^EFbP@4Ijj%7Vslu06EdEB)%M@CMU NplR5iXFWEeTUq)D.]#^52@EXXdqIn)kZrYZJuos[DDPaH%fsRn(VeTU>g]XLR?%E O0VQgq3O&PA(1p57sFoYeF,2_cJu-Y*Fa1K"2Q*5o;%6D(_(Qs_=.hR@LVero7oH3 PP9EII(Ie@ebU#$VZX`"-S#gW2J>CM@*lfnGrud*7g,p[jhNfTro?d3RR.WZ^YnbM 6jQsJlfSR\#ER$[N/6HElVLgn')L)iJOKehg+/'K=`FU+]WBC&k?"65%4_'GI*Ag. >[`V,LdgX)7/!Y;K+'r4Iol9c-bbq)N-3?T"mHi!LRI]3Jn4m2L3as&20p&*lokON e92gsW[ehs]"7Ig\0IPHaAk$GL/UZMl-kCQTD1"cb5D5!m=e/K2Xe,j#sthVf&>Z* qM<-==FJ>^7OVS1rWqAgCUED]GcA@Pkah`J5oPLVDMo9Pjk]K7DO$%?a7;E^:%sY^ mVI2.)%ZE\br\dEL_1;HKLY0/85O_:hSE=pT,'gKO55:-nk%_lVQ99Xc2D>`*rC1m!Ke)r[$i9;!A]V Ln!_j06k5I0ukWWV*$DU?T9VM8tC^_Wk2`(=`CM2%Hl-LK`2oUZl617\ endstream endobj 144 0 obj <>stream 8;Z\t>nVc4%"r\h^?,?,g$@-R5a8>a>Ga(N1&)^4-A2BY!U_Tg1OaQEp2@77E.b\A a6a:"ScncS==UF$5ue'Qf*8gpoeA?0[T$ endstream endobj 153 0 obj <> endobj 154 0 obj <> endobj 155 0 obj <> endobj 79 0 obj <> endobj 126 0 obj <> endobj 157 0 obj <> endobj 156 0 obj <>/XObject<>/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]/Font<>>>/Thumb 152 0 R/MediaBox[0 0 612 792]/Rotate 0>> endobj 168 0 obj <>/ProcSet[/PDF/Text]/Font<>>> endobj 166 0 obj <> endobj 167 0 obj <> endobj 82 0 obj <> endobj 171 0 obj <> endobj 81 0 obj <> endobj 158 0 obj <>stream HUN1}WS%*A *RPnm5 tl'!$4k3.$Yu|4 IrD$֌$]f$ *YoFiHBSlCeanZY a76mk*]EHwOϿ(fЧ9 .4Ep-kDH\ ]m֦GG`)K^(O0f00G>Cg.#u 6K PyvAfAm@&Jh"ƊQ5حR\9 I((1$ጃ\bAN  2M"O>KJe2Dk%:<ׁO01u(n n4ST}s!|+Cw[bAT JL%JL` 8F88>i)8XrF1qLÔf 4jO=R]e\@?]DmIS2W4?I'M; Mt+Hxݡi*ӀJohf;=ho]ג)k$txh fl;"SJRphV07|_z~7K"2Ga4Z?a$;ڮwm8`wRZa2ߢa=Za.} !:hwY[3lWI W0aEYOpf">?؛0r;8ׂ~ظ6~j ^qx 50W>R_S<5hhϱ!+juYץm=BKC+/( endstream endobj 83 0 obj <> endobj 173 0 obj <> endobj 159 0 obj <>stream HtUMo8WH-A&):@9ohHC웡md7oތ>&oCA3]hh\Unļ\ Lw=C^?3qڂu][Ty)NKyd\%^|K"32?kRtC)^le?k Sۻ I ȼ\trJyԚ"by@%Zz*2ŧbXʲf*J,]ſpZ{'? URJ}ƏdWeI̭=љz2Mc;8plfP&Oe mFqYpT;RWyR* e<d3osk"EQZTp!//AăGb]jVAUorcH2"ltkUF jo ZjCWmR~QesNgۺm(F]7(+>Y0ݥA 7Od*ĩE9lĽkI|}%h9kjkFA]5(7+7";܁Õ) woKfM[, lUp!7lVam-팑$'OvmooYIM @'Ò.MڹiaJ LijS Dw?u;_><'aGJMgJӞNJh !.דhVůh} nu"HӆY]z?j11eZ.> endobj 122 0 obj <> endobj 91 0 obj <> endobj 175 0 obj <> endobj 177 0 obj <> endobj 176 0 obj <> endobj 160 0 obj <>stream HdTM8 hR5J%[R{ĘYɆ[ғ˷;ۯD"K0Oo+k8qIGEklAYL0gYvNOmsڐ']Ev<\)ŜOÄ;M`sW2\+Bf3bm-4}]zKz7&tE1[vh,`yd cB@;wgn&P:c@;yQPb:UBe>d7nC*]| F'V-BF1ґ9kꊴ=h0;=Mm7]d@|aXgFܺGfhkLjeސ6cQal5g|kv?`Jk~ET.!I0d>a/>stream HdU= +\B!Tf*3WXƖ}x,+I ޮЅ͋XZF ,X #MWM<ֺq?*_akF 9+XzdNZT-PTN\4*`'m[*ld endstream endobj 162 0 obj <>stream HlUn0+tS-6@O-AX-4?o.40 Q~WI]Ȣ\JY;喅+c6n-;js!'T`=sܰtTh@.%e!<[|T ,\@5g`,]BǕaxIJxY2FB4kԅnMStǝ(aTڵ1dO+)[.`nlTJ:=nεT(!^iMәeԭS47>L@mg >`%w7^fbQZs ooob{=O4;<䏗os9 iM =8#M}R.l\e\njD^ʷ 'Z(--Ɇw)' ǀwg<_ߢi5hA(2x6VܱPQ+2 %C'/ٍ,'8WppPg$e@jQG n0u5¡1?iVp٪[muVWI,Maq|'ˊo̵|, 0 endstream endobj 163 0 obj <>stream HlUˮ8W4i_`͕"*/m-FmMr>)p_)+v=N96/'YWIYSeť?JMՈV-BiUWYۈ3>~#к< :9*/_Ngi*:]e%loXӶtüGG(FJeMKX6Q v u4aE߶rb~sL\8ʳj WTmW{5"~(ӧM!p2VL+qHUj33HĴ~<7W[k8l0N~k#:{2;0B&Hyn#lŞW߈/0cE|/JRL+`Ӏnv"s3OT|1k:?Q:eE>})+- 7 zlV;ը8'DRj#gdjUIo z}H"r։C?Щ&0|Y\{Iƒ>)^V.&.tQ C"RɌ T|+A p ND?$?_1鬃\oy[+шzB/xjx)m3C4XJGYwIkD0׊A@P]KHSh#n]@L_\Z!A[ x Qrs}0{FL7>1 ȉ9G0cK+ws¡˝S~'Bc 4E^ N_'3!B(?ZdVb̞v)ј'g[Df&7s^x4U 0[ |Ђ')k'nto52CR-Oq%rT`û endstream endobj 86 0 obj <> endobj 184 0 obj <>stream hbd`ab`ddp vL) {XH d؁103122x122+}WVǂC-^%wI?ߣ1 1?߫X} &Hբi~.](-{ Ҿ߁6.^mKWg ݡe3ڽg]|҄Dɩ./λj㙻&;su]` EP6}. 6 o q9{DV endstream endobj 183 0 obj <> endobj 182 0 obj <>stream hTMo ;@jM;)}hv'dH Bu뱍צusn@?-Q';{ (-e+Gv-0FgLN/{y~,{^v;ٹh9( _{#Me`prBf@`4<]/'ϢΜ̼ʗBd>#ONbKV q|,9't%m_ss endstream endobj 181 0 obj <> endobj 164 0 obj <>stream HtUMH +86[KAS{즒^-΁^<{ʩܨ%==鵦q*3)K׏g?%Jь׊OR]LeMܲ8r\\$5y)&)sԆüӽ* N]0ĩͰjRYf( ,h9㾄ϯIХn$Xpdh㊖M>q V=laAOcے7`3YY"!i9 Oh(R(j0ĸa?4]^g.}{7j3.KGVU1z^)!U޴D +q}fyg'B-t%ey3[}+gp}bd˭jM%ٜ{FޞߺlӼ*>F $օ=5JH"Gny~8/pXpH.yްV!ٿҵ|;2˪wZ"SXࢬ~nΧ4!9tc$ڡkиܽ4k.G3[YKL@iI"o֖23x‡ _EP2%7$،Ь(6IfW[훞 6W}9)FR9v}yJЎK7>F>Ea*;hN]/S@ ⫔ Rh;z%lv i+*EU?dő%ڒY}GO:* endstream endobj 165 0 obj <>stream HTR0)tT[)) %iJL{`88A$ ԧrB´r&*Ee,1Jn_O( C@!6yh`T-e"-%d|$K P$B"S&3eY/O^ 'Ti,'ZL{f|; ujmb:kd2i0m%Cz(UHZMUVݷ7A|իiՂW܃=9&$8ZEsһ_#5DhaZ|evZAT= wXjS.4NDG;n" 8װlj=3Xבa).M]njDo1+]z%XCy;N@FQ"RtdrՏ3?:pDcH2OT4Ƹ/U^8sz=S9Q &Lv5 ?3]t hL1-oM^1<3hWAl 3JMq|i4nJ,xuMiWj-iEnZXrծ4&Kr endstream endobj 172 0 obj <>stream htXiTTWރh&8YqEE@y**j`bgpByb'11m']䐵-ouުǭ}w}j8+kkk{<<.t틈q IZ~{X};d1ȧBٴwV㬭K#…wXfNj,߫^|YW$ Irp KK /qppv $9x$$|"!IIĀ(P8$>yC@lҸDĈ%Q5"l[Mj+V1㬼x&UYXaֽ_Yg=nڸ=ۏwo NXII5ڍ7OO\?Q29O4[k2pʢ))4SWLzw>i6ܦ}=ezwG.,}&ȻwِKn=R;؀58n w`PiEƺY9שͲ+?NJl0ԙָBT"m8ɘ*lv:eiݜTM!&<1!+Fi;rtnv0uͣ\iөÝ8<9odA #LKj*zcbB:e5`#Ys% RQ:}gx2<5N $pH)0)awNlHn:V:ę2uuj/i4eL&AčDΡjO5+0{I K}6]b aOBa3ꖮA-,sN7[z\g¬8zXo=neW@wDӉa?L:FA1h6<}g&e Rjoy;}k_!:B,2{Bf~JYZ)sdY*}vV9^Ac; Mlzؠ 8¸_9+lfMVf x>BWal{@^"rkOf_[Ƅ&Ӓ.HRzL|GU5bH;FBh@3PG 7xv_wƟ!ᖧ/臻c:ʙu~jC _xk$au<WDV\p.OŶk_s}BUIVNKMlWLIT y:" D2'ć_}kE_yuW5m( ({rG(O/U'񟰂oA)׍/شv}>Q$x1Q{)k;54֙#qB|$z0^"NQKsmkBCR!;  0 H)ʊyk|IͼVΤ1(1HY#HC+8:UZORŰ$oەy54 7OI^k6L0 lA[Y'[>8nQeQ+7Ʉ̌(wtn,:p^NI-.x*2H_/?p,SBP-p =G`8\'&elB1/U1 KG[V$Sv(18r1xkh,Q?5tIKO^dgRG#@`1,&?Wg,A3{x6'CMckϷ稷eMs&F4~Fc QLPvBNZ&}^h/` W68G\l n\<~7būW0 qG< ~we*\,;E#\& =v u)eWYq1 /`ŕ$v:J'a‹0 įĎRW롞Á6`UK~x$;Kd%'` 4S^8'%8Xj,6D꒪p ؝+ziX8EL2fC"' &6/t2g|LZ /LY^Z d/?:4Rs|^L~8r}\EZBm=Y7_y5,k;5li?J0ݤE5K̆ gd6@ԓ`]dqtV Yv Y8;XWS@:)OfzE{Y Ґ;5G7=-i`S J㣢 &{]@Zfx!|GItIw&1TW)A);# OZ Cz{o-H!TuӢ̘L~ d}J kpm~PgWS:>B-F( {{E6rKN'8kB-m0)nI!O!;7Ʋlnמ貲F / ;_ M/^ & շӦF&Ç/Q!/5U5!cx4r y^KqbWJxHdgJiKbt*Ǩ1ÛFpr.[;|[vu[Kwڜ,ށg24%cuH47ˮ,1_ 3TAiT25||5˸яAzؖJ8,ktF~jbhxR1*EUfD˓ضA~r, ϲrHXMK S_|ls%HZhaF#[:ݍ+"ѮÆ/^a]r6g=>jg랽M"Jt)VI_®+ۿ{S6fjH*u~)~r{)h Q ?ܚ?eOD-̪mmދ " 2Qgߪ0U"1wm9}/ 9'+*,38)qrf{̥3Q 9X(W67|Iѿ2PKd(',Ga~Ow? !TNW U/P펌S?lUp0B4󋙵xٗi+SXD"կU O'Ev0S]Wyi/v{5Q_䆔 7+r#Zm @vZjzZ*3Gx'Î-ԍ+0t޾>',9Mm@RH™ dN+ :c s6ؕþhX#‘`#?myJ~SeHW^30\]*wJlnmiN E]q#Xha0bLzZ| gGJ1oUgj B[cZ"R\O?؝(K)ȢrU&+Ap4k.0F|4 eedR}ajyH9Fr@zj4[H3˴x_ hDOu_L4pm ](n,A; (PHC>{W0S>GQ8Rmbt?YvIi;Q=(KrHvHntE%otOy(5ؚ3 '9U[Bp8LJgp)PV-Rs/CQ{/7Ɖ8u~b?M1ӥO RQBy8rߡ11z6XXi8~J." 7 p$o6rTfʍH6Yq ~ %w_Q{}!9Ō|fV[-tcMœDsj- i`lҩt&5q˸๩UݮC|caP^o{ԃa?-%X B:/X΁bBUm,j:ֈ}d::# 3ŵM̀W +:|zeuNȎOKdĵɏ^٥UtK#<"CҬL,~v0颛, PH^ ~iiO/d K&@w87貊 Xؓ_RSho]G)2Zm9F׆\3UTzBkoĎ2T[+Ӳ3vĊ[?ktU|A2ԡ-϶$^埪W`'TRCMA1sJFFk+t<*=]1BUUQN7uiB#߀uvJGfG`Z|ˆTxQEuc%il>?uMf^IďȭL_ FWrCO q%ڣ漉ɓܤv6GOdG er2fզk~Ϊ aJ_3uoJq7&]92"O}vig~^!rI ܙ>stream hlWgt皖fd Ȥ X30#B=!q ز,EU,ٖ{/BtL( Bnb?߳;&{rwOz<™qqqڵ}-6FK.F %N9iCﺗ dC3޼&ťasRB+,8PsͪկO傍QIB^T&L 'L$'I"d¨FH;  BI*-P* "2ID0!BrH-KL)[Q˒$8ҔHi\T\$N(]ะW89+睉..8]89{'p8UlC888g{1rRkkk+_k &xOƖc$ _pWs7ۍ܉ G&MtkɟuϧNw.Z2' -_\'$q]6OFNˤyR"%*o qAQm?.nJHH 2jˉo;Xinڼ }CjvNzdXaD/ A44b,All AL&^0cŭCʐ z,;3aw. LN!_`Saj rtY4]ѵZޱ];{-dP4aS`>>BnCĄW1JGH@7{/s2/Χ0uKp?r.psF a$4 @V.q܊Ec6˷aP-}|yΪt1 DVI5?뿁u;*3 :àҩzG)GIr2n ? M0^j^ j:xe(}\z~$q:/y?hSȕOi}7 皊7?%}j4Lrz7z}Ӵ%x}bzw&W$`W$,X{gT4M>jG3P TҹgD%+J"j']Weo1Q$X1?J4$?Xb'rK>_h`! B5_ >vk+(h/6.kU&UyP믧C% 3y *cQ]8 3̟3f]5FJMRre4rIߙaVa% lF;רtkKk C {ixYETZ-1[r4۰t)$C0re> )@^HPn0?3XH'}a:tdf ^A7HFdkJq8NXԎÎDZy.>']A7C作E*qX2[sА/N *|,|.D~8^fJVL RiPvnBšNS)\5Ze*G6-jZ8/AuJM* zիx5vn9GZ j'NCXNfP1UXa4u> /,P'[eT ϗ/%2*G%Bh/+bEx+/]cN®kֳV(úC"Ae,Q@`W'0/^ģLU" dRfC,IsC0W_?a붰MJ)}3Kvau0x@/)VeϚ\?["x8Su:N6݀ocB"wQ> C~ `ZCgIY]rj5ZhYPt4>L.T=D0)L.D8{Tή,`dhtt?J4It8Zi4buzm^AȿӇx4zL-؍M|1؈LJoKR5:v##. "#V˴X17AQC[{hݱOKiN_9;#7-*bJMUd\GMByhf;n[nJ s/?]^1C9M-]Tя1jFݓJ6;wkmM1(VcBH "91@q7ف”s@m4[V7Yum:2 ov8 +p._Ǻ 6m:iҥd9Jv > ޶fֽv(-4z{ѾpmdgxE&1iLI٨Ao=F$we:l˰=Iw;(5IBe* X23yc5d5~N2^/PeT1@m'kJ҇U? S녫eA w!`ޟ?/E?YɦꉺۙQ0.5e*.7%mAyw٣VFNu;~QX?BɤԹ=5%Qedھ/k8fb6`3pIvF6)B((8v|w'9d9pЍSlw; 45Uh]7uhSuau z. kh xIiӑ>M>ߓ̠O|>&KA&7y?JXhp+f;t+NX)RlвS~PmʢZ{CFUc:%y&ng4r$̡ݙZ(ͥRݦTsr 9z>EupaE#Ɏh;S]nNz*Z+bExecyҹXf.2k|YbCI\Ag7LL [rg :,IbCTb2[ؙkybbӨR[e`gx ;hp*P[náYj~Rq֘䏑- Q<þc7i .V昡SMOGYu'n%{I)tg7:yX/W2h(2p-컛 P U&9WR×73U~hGIqj"%F`2tN:G-NU1K#E-st7l+>RjYކ 0 endstream endobj 178 0 obj <>stream hތViTW.uEƪVPAPYEK nQ%%Q48j\+ &Kt4۞Wd̏9Ns_W~{τ2&&&3{Fg+YjKtŤBj/(]hsIĤh.9;5.&6]34jqX{/ǏxF"tmb?)JKHFh<444mj&MԦEEh4ԈhmbDjFXKNj<4I#u86-#2-.:."5N6:d^ ی`dhR0,"gƍV1rƆf=$)1u0-0mַ[T5wUf.[ [!$%+{ώb!VdI"XyCaVU*ޙfff%fݭv7tEOzHqZ1>w6ig*WTAGXC8!lmb^ÞT3Axšn- Anr4`c w<(qxq%+Ar2;7,B~sKuCyna1h1B([?fBsF:{Y_[SX` YWBn=h qXc׳8` LYq_=4u oU[{Ov=ǿ`I*6=hjȉ# vs0Xn 44"W§b35ݨ"F^ϞwF[X8):xʴcuTYp|IA)nq9WDW+ǺnORc~6A5֠Àoa{_`=vIR!>O x>/:lK.KrbEtΘKrќdFNxT6+`qCB EWnFUGn8T%hJo) gA eA\?K]LХEdWbbvC I]Gwjߓߨ8}߀)!Q3,4}ICkCk:Q { $r@g {GkE{ CGv72T}ȤHWO:DGH^PI&;70H_VV=.~ά$!)(7hZvRe- *~v`aG/75R;]$x&2twRTx'_&:85_SC{LW\%R/yxHrj zx$%anF+01$U~Q^Br!.>؇Łģpa$_POo}%C F(v8Ƒ0ʼnp'c9 SǰIa %h F땣,Lj^O2yjP aTMYN-oN܁ endstream endobj 179 0 obj <>stream hlUkPWF[6nR1,|,fzdx #"5ŨIE]Mib&Vmڤ6֩?n}U5R%cc2s 9zzu̩ #||E$'!*hC٨T 0];+l^H }yyϰQ:mT1ics7ycF.M6jmMҙtƭʭΤ՛cF.'øYkب y:mRmFnLQWLML}Q3Jb @!wjbH SzAhDUʬPWP?3lSqŚ" %WGRH?tC7;U.[;blP_ [?,o[p~X]sxCj 䐽W8');,Y\w]NW+m=-ƯyakH!1PHn+w 6<`'DC߃Z&sDQ_` 'N,O> /Pg o{ԗ{^ֵ&FV$0;Zc>{3?ŧq͎5^ fjZ3sQo @B,ôˏA{. ,2Tf+6L&ÕBN a5=j%@:<]ζPQNSMVND4ɷ/1k-LN[ +>@e6CUBr"U T-USQoU)Z {mW՛x EI‹EU[9$ej:wנϾ.Ʃ$ߘd|P>Oݰ[Y=v6#hfNPߞII3Ʈ݂MKM]}'7pe[؂1@X6[~~w$#f`x/ḁ/F25 kz칧=C(Zh+jzZH1g0!`H9:li,08bnV%WI<yO%؏*5 P:h<'Z|ȡI"uxU?BqQ(YD-0c[jx]lM{|{u4L,r}thoKvJP%UVSafW C%x#ZgGݒ>%, bI]*Zks _KE_lYb[{B풳}\SspnwQ_OEJ, < +0N "B}D?~u4(HċD\u{yU IH(e JwJ|%9ꓚ.(IJMɡ O'G[V>Rt#1OTW# At_<8 ca$X{`&}o(f{rا+Vy۔5-5UU+wg* 4vR4;<9/}Uٞ<TUH(pUn p1 %Jhn>}`MיWBMqlp{y )|.ENx3& Q2TߚNX$PjuSPIڹQe <>stream ht{LWgtΚP|P, `.teavEQBֲ ((jQDYUikjHlmk|ܛ{K$ $qKRRGJLhKd\emCw$ )M12W 6OPu lhYh)*Mۄ)SفC:o Ұ`!`YeRK6*$Z" AUP ~ :(ȧ2*^zѬ~P)p$9ۤYii?W '2K[s_{b &'BFG×k^Gn{ϫbW(Eej7_9\ W~åtǩ _5Ƥ/_kAP08+~NPh_򀞏/ 5 ɢWc~K^}zۙ9ɺL4~naa4HdWC0ވ a$(w5:jFƆt\^\_ ] endstream endobj 185 0 obj <>stream hތV P#!=i\@uDYE6(HQPFDtX↉ԸH55ъ&Bp ƄhmR!O~_{u=Q2͠Y!'نLnBWL4ro[Sf2YqE@CJLqn}֣p%'59 MHZbayAOrh-13l:],[ӤdhtL.I3,դ/LIKYktiI.M䛑33%>j5̌PH5FF({rSZ9寠BT9CQ&AA)FLyPoSrM K2`+0]͟ɧC ZWO(ONĬf.3/(W)v) pBf`1bR)W.h]>T=(Fi Ex0iDtl^d!tQ>6/_` ߡ$XqKmOly%`O;# ɇ p7w0J*em7a9iS s"C|vj&W~;'z"XqQ^#- wْ҂\9ZaJzVzKP̚: s{Bxqտy6r~_`'tڐVb- 6fnp}/ l!l  L2 lɧOw{r3V;;GHrH\*mI,aaȜpQ4٥TK܋SU5¹u/bxc!t€o9xm= #nsB&{+\q7(t̼?_j\:eMNpy(/{phW^%N# :G49/ֿ63k|o}ǫOCΈ ֲ/U FΚ$ Wwdbı>H<*>>K BaBv']%~yhq{z 00s_n!|P! _TF}5 򨹫%flV@ctF\zn%= 4ۛ@wfXit!ƛR=V,jӵӝ ,|M@]4ȂZQMiB][ylL$ȇ*8I  8K3ӝC[]1C<Ƣ}XSGFrqJ7AOapL2e匙Ѽ.d#=Bx+`:eTs1l\}5ߟq^L#e 'M?Oʫ=\hzM 4 74>kP3:Kq5[mfyYŻ42}.w (3ݥA֓$3E'$V>R чRd`%Vz`#4@%T>[3؊&Ns_:Q9]\ 6&`Kr XXK@Q<-|yJxcI-+xoߕqBvjpD>+9s?@s9f)na7sf(AK `BEhbs\+^#7Au .\-u\( h%R~, 8b E8=F&mdhM ,=>{>̾O7@`^o~ѩ,;zT;K7ng V)XùE'{ o(N}#VºKp^asaVJtԺJ ›$hւ¸1G<']bDF; Vөۏ+by]zYԁXjMD]ޥև zU_ԗG{;f765 Y;΀́1R8qNqa &wXHF^2JsͶXWPA\ j Z@p`^6TUkBUP T5ZU ?ߒ'fPZH]ruL O#PWؖ#H\.$6!l`|3lhVgvLEwr_ t{V676l'EeMȁ@ҟD~A._㴺`^_=;3lh 33wͅ˘śjQUbk%|v6&K|燮UҕH–ξ!Sh;Q#R孉2rl%ۋ!U|5UeJUA!=?Im endstream endobj 169 0 obj <> endobj 186 0 obj <>stream hތkTT<.2ރ^Kp͌ToNe5mec<,*҄&]1hT F I&NV/]Ygw9F82bf9$eͣg4V&o +N4j#Ѩ2 - ӒH ӐDB%VB25Ħ% Y@H>!EP*$;)###NmͿVkt:AgՕ~{711 !6,ot{Be9EXu}ɡӇ=Kd+G?Nuwϖ+7npii7]lU! 0aRrC'?S4ZZM~͠Md{n?`xvʎ$"ML@*& M,Mi/KagWYˇ7|ŵp:g1ݼx\pm\9ٞ]\bFb|D#,L~ uh8U!SͥJ1&>> Q{hq櫟U>)'7{M6+( Ka1.VX ywE3XdWM@ r`L++\-) 7šv_.\ ![T JIlW#Iȅ€"y-Ngy]Jqr71+m.(3ė$,)ar PnB{>Czߏ1\E 9z?S p+>p< ~)qS-۔W! 2DSP%{GI1DaתjRZ,YQ/  SB >-Ç:,%0^v+Ѡ7gլ\U89\yʜ5*)bKBh\i\:AuM'Z 8=mt䛍\<./m^vCmu;w[ӣ\A-Gp/B\||r`Uj躚%\SkPϊA&":w PͅH`>3IVS8Hps6L:dixg39+ C%J@)jc_^}=#Q@ܪ*D;SHײe3%L3p$5ȣEʰ{Rz+Aa;LeuEpqmvOwX%tCHݡSKrߟ+.YVPL#aqp=^=i4;e5K  ΄q8 ͩIZ wuH0 sW?)\ӄ譗Ҁw' 80&O~vʩ-}&k;U0)5'^TIsvܓaЁ?pHړA~eGKݥv̩> endobj 187 0 obj <> endobj xref 0 188 0000000000 65535 f 0000006950 00000 n 0000000015 00000 n 0000004760 00000 n 0000008046 00000 n 0000005306 00000 n 0000001749 00000 n 0000001200 00000 n 0000011606 00000 n 0000005033 00000 n 0000001474 00000 n 0000008867 00000 n 0000006128 00000 n 0000003937 00000 n 0000000927 00000 n 0000010237 00000 n 0000009687 00000 n 0000009140 00000 n 0000012153 00000 n 0000007497 00000 n 0000011333 00000 n 0000003390 00000 n 0000000105 00000 n 0000003664 00000 n 0000010785 00000 n 0000006402 00000 n 0000008320 00000 n 0000007772 00000 n 0000007222 00000 n 0000002569 00000 n 0000009413 00000 n 0000004485 00000 n 0000003117 00000 n 0000008593 00000 n 0000005853 00000 n 0000002296 00000 n 0000010511 00000 n 0000002842 00000 n 0000004212 00000 n 0000002022 00000 n 0000009962 00000 n 0000000380 00000 n 0000000653 00000 n 0000011878 00000 n 0000006677 00000 n 0000011059 00000 n 0000005578 00000 n 0000012427 00000 n 0000015901 00000 n 0000015978 00000 n 0000016090 00000 n 0000016167 00000 n 0000016278 00000 n 0000016355 00000 n 0000016466 00000 n 0000016543 00000 n 0000016654 00000 n 0000016731 00000 n 0000016842 00000 n 0000016919 00000 n 0000017030 00000 n 0000017107 00000 n 0000017217 00000 n 0000017294 00000 n 0000017405 00000 n 0000017482 00000 n 0000017592 00000 n 0000017669 00000 n 0000017779 00000 n 0000017856 00000 n 0000017967 00000 n 0000018044 00000 n 0000018155 00000 n 0000018232 00000 n 0000018344 00000 n 0000018421 00000 n 0000018532 00000 n 0000018609 00000 n 0000018720 00000 n 0000338326 00000 n 0000019170 00000 n 0000341424 00000 n 0000340213 00000 n 0000342430 00000 n 0000344159 00000 n 0000319545 00000 n 0000350086 00000 n 0000325475 00000 n 0000019046 00000 n 0000041237 00000 n 0000041688 00000 n 0000345040 00000 n 0000326342 00000 n 0000041564 00000 n 0000045840 00000 n 0000046275 00000 n 0000327175 00000 n 0000046161 00000 n 0000051030 00000 n 0000051468 00000 n 0000328076 00000 n 0000051353 00000 n 0000055305 00000 n 0000055745 00000 n 0000328899 00000 n 0000055630 00000 n 0000061062 00000 n 0000061502 00000 n 0000329883 00000 n 0000061387 00000 n 0000065561 00000 n 0000066005 00000 n 0000321989 00000 n 0000330821 00000 n 0000065888 00000 n 0000087830 00000 n 0000088314 00000 n 0000331634 00000 n 0000088177 00000 n 0000106113 00000 n 0000106642 00000 n 0000117080 00000 n 0000344786 00000 n 0000332490 00000 n 0000106473 00000 n 0000244450 00000 n 0000338464 00000 n 0000244935 00000 n 0000333942 00000 n 0000244798 00000 n 0000263017 00000 n 0000263460 00000 n 0000334742 00000 n 0000263344 00000 n 0000279546 00000 n 0000279989 00000 n 0000335717 00000 n 0000279873 00000 n 0000297744 00000 n 0000298187 00000 n 0000336766 00000 n 0000298071 00000 n 0000315493 00000 n 0000315936 00000 n 0000337788 00000 n 0000315820 00000 n 0000318982 00000 n 0000319032 00000 n 0000321471 00000 n 0000319857 00000 n 0000321694 00000 n 0000322412 00000 n 0000324739 00000 n 0000338187 00000 n 0000338225 00000 n 0000338251 00000 n 0000338650 00000 n 0000338566 00000 n 0000341526 00000 n 0000343210 00000 n 0000346298 00000 n 0000347282 00000 n 0000348217 00000 n 0000349125 00000 n 0000351635 00000 n 0000352565 00000 n 0000339226 00000 n 0000339842 00000 n 0000339068 00000 n 0000373469 00000 n 0000375560 00000 n 0000340910 00000 n 0000353399 00000 n 0000342848 00000 n 0000359602 00000 n 0000345364 00000 n 0000346006 00000 n 0000345738 00000 n 0000364068 00000 n 0000367110 00000 n 0000369169 00000 n 0000351522 00000 n 0000351207 00000 n 0000350949 00000 n 0000350536 00000 n 0000370625 00000 n 0000373838 00000 n 0000375848 00000 n trailer <<5bef4a0736efbd2dcb276ea53dd043e1>]/Info 187 0 R/Size 188>> startxref 376380 %%EOF