ࡱ> 8:7q` RbjbjqPqP2$::    $0 *H$ $ $ $ $Fh $ $ g g g 2$ $ g g g g $ < T 1 g 0g G g g _< g ]   Title:Dual effects of histone deacetylase inhibition by trichostatin A on endothelial nitric oxide synthase expression in endothelial cells Author(s): HYPERLINK "http://apps.isiknowledge.com/WoS/CIW.cgi?SID=Z2d97PIg59pbAmiFDId&Func=OneClickSearch&field=AU&val=Gan+YH&curr_doc=1/20&Form=FullRecordPage&doc=1/20" \o "one-click search" Gan YH,  HYPERLINK "http://apps.isiknowledge.com/WoS/CIW.cgi?SID=Z2d97PIg59pbAmiFDId&Func=OneClickSearch&field=AU&val=Shen+YH&curr_doc=1/20&Form=FullRecordPage&doc=1/20" \o "one-click search" Shen YH,  HYPERLINK "http://apps.isiknowledge.com/WoS/CIW.cgi?SID=Z2d97PIg59pbAmiFDId&Func=OneClickSearch&field=AU&val=Utama+B&curr_doc=1/20&Form=FullRecordPage&doc=1/20" \o "one-click search" Utama B,  HYPERLINK "http://apps.isiknowledge.com/WoS/CIW.cgi?SID=Z2d97PIg59pbAmiFDId&Func=OneClickSearch&field=AU&val=Wang+J&curr_doc=1/20&Form=FullRecordPage&doc=1/20" \o "one-click search" Wang J,  HYPERLINK "http://apps.isiknowledge.com/WoS/CIW.cgi?SID=Z2d97PIg59pbAmiFDId&Func=OneClickSearch&field=AU&val=Coselli+J&curr_doc=1/20&Form=FullRecordPage&doc=1/20" \o "one-click search" Coselli J,  HYPERLINK "http://apps.isiknowledge.com/WoS/CIW.cgi?SID=Z2d97PIg59pbAmiFDId&Func=OneClickSearch&field=AU&val=Wang+XL&curr_doc=1/20&Form=FullRecordPage&doc=1/20" \o "one-click search" Wang XL Source:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 340 (1): 29-34 FEB 3 2006 Document Type:Article Language:English  HYPERLINK "http://apps.isiknowledge.com/WoS/CIW.cgi?SID=Z2d97PIg59pbAmiFDId&Func=PagedCitedRefList&UT=000234640600005&doc=1/20&rec_id=148201822" Cited References: 28 Times Cited: 0  HYPERLINK "http://apps.isiknowledge.com/WoS/CIW.cgi?SID=Z2d97PIg59pbAmiFDId&Func=EasyRelated&UT=000234640600005&doc=1/20&rec_id=148201822"  INCLUDEPICTURE "http://images.isiknowledge.com/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK "javascript:void();"  INCLUDEPICTURE "http://images.isiknowledge.com/Images/info.gif" \* MERGEFORMATINET  Abstract:Inhibition of histone deacetylases by trichostatin A (TSA) has pleiotropic effects on gene expression. We demonstrated that at low dose (0.1 mu g) TSA increased the eNOS mRNA levels, which was followed by a time- and dose-dependent down-regulation. Cycloheximide, a protein synthesis inhibitor, completely abolished TSA-induced decrease in eNOS expression, indicating that new protein synthesis is required for the inhibiting effect. Mevastatin-an inhibitor HMG-CoA reductase and geranylgeranylation reaction dose-dependently antagonized TSA-induced reduction. This mevastatin-mediated antagonism was completely abolished by geranylgeranylpyrophosphate, suggesting that geranylgeranyl modification is needed to activate the eNOS mRNA destabilizing factor-a mechanism responsible for statin-mediated eNOS upregulation. (c) 2005 Elsevier Inc. All rights reserved. Author Keywords:histone deacetylase; Sp1; eNOS; gene expression; TSA KeyWords Plus:MESSENGER-RNA; POSTTRANSCRIPTIONAL REGULATION; REPRESS TRANSCRIPTION; CODING REGION; CANCER-CELLS; PROTEIN; MICE; PROMOTER; ELEMENTS; SP1 Addresses:Wang XL (reprint author), Baylor Coll Med, Michael E DeBakey Dept Surg, Div Cardiothorac Surg, Houston, TX 77030 USA Baylor Coll Med, Michael E DeBakey Dept Surg, Div Cardiothorac Surg, Houston, TX 77030 USA St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA Peking Univ, Sch Stomatol, Lab Mol Biol, Beijing, 100081 Peoples R China Peking Univ, Sch Stomatol, Ctr TMJ Disorders, Beijing, 100081 Peoples R China E-mail Addresses: HYPERLINK "mailto:xlwang@bcm.tmc.edu" xlwang@bcm.tmc.edu Publisher:ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA Subject Category:BIOCHEMISTRY & MOLECULAR BIOLOGY; BIOPHYSICS IDS Number:002VS ISSN:0006-291X Q R X Y [ \      ` a j k m n & ' . / 1 8 FGжКККККККККККККК,h5h5>*B*CJKHOJQJ^Jph6jh5h5B*CJKHOJQJU^JaJph3h5h55B*CJKHOJQJ\^JaJph-h5h5B*CJKHOJQJ^JaJph/h5h55B*CJKHOJQJ\^Jph31 F'+gd5 $1$a$gd5 $1$9Da$gd5GX[\bnvw[^_`aϳfOffOf-h5h5B*CJKHOJQJ^JaJph6jh5h5B*CJKHOJQJU^JaJph3h5h55B*CJKHOJQJ\^JaJph-h5h5B*CJKHOJQJ^JaJph6jh5h5B*CJKHOJQJU^JaJph,h5h5>*B*CJKHOJQJ^Jph2h5h55>*B*CJKHOJQJ\^JphFV'1CIJNu{Ȭ}}}}cccccc}3h5h55B*CJKHOJQJ\^JaJph/h5h55B*CJKHOJQJ\^Jph-h5h5B*CJKHOJQJ^JaJph6jh5h5B*CJKHOJQJU^JaJph6jh5h5B*CJKHOJQJU^JaJph6jh5h5B*CJKHOJQJU^JaJph()+5Ͷh5hh%o(/h5h55B*CJKHOJQJ\^Jph-h5h5B*CJKHOJQJ^JaJph6jh5h5B*CJKHOJQJU^JaJph,h5h5>*B*CJKHOJQJ^Jph 0182P. 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