ࡱ> 796q` RbjbjqPqP2$::    $0 *H       PRRRRRR$hcv   v  NNN   PN PNNN < O .NP0N1D1NN14 hz JN <    vvD      Title:NF-kappa B activation in human dental pulp stem cells by TNF and LPS Author(s): HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Chang+J&curr_doc=19/1&Form=FullRecordPage&doc=19/1" \o "one-click search" Chang J,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Zhang+C&curr_doc=19/1&Form=FullRecordPage&doc=19/1" \o "one-click search" Zhang C,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Tani-Ishii+N&curr_doc=19/1&Form=FullRecordPage&doc=19/1" \o "one-click search" Tani-Ishii N,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Shi+S&curr_doc=19/1&Form=FullRecordPage&doc=19/1" \o "one-click search" Shi S,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Wang+CY&curr_doc=19/1&Form=FullRecordPage&doc=19/1" \o "one-click search" Wang CY Source:JOURNAL OF DENTAL RESEARCH 84 (11): 994-998 NOV 2005 Document Type:Article Language:English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=PagedCitedRefList&UT=000232801100005&doc=19/1&rec_id=147363412" Cited References: 28 Times Cited: 0  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=EasyRelated&UT=000232801100005&doc=19/1&rec_id=147363412"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:Post-natal human dental pulp stem cells (DPSCs) represent a unique precursor population in the dental pulp, which has multipotential and can regenerate a dentin/pulp-like structure. Because the dental pulp is frequently infected by oral bacteria due to dental decay, in this study, we examined whether lipopolysaccharide (LPS) and tumor necrosis factor (TNF) activated the immunologic transcription factor nuclear factor kappa B (NF-kappa B) in DPSCs. We found that both TNF and LPS activated the I-kappa B kinase complex (IKK) in DPSCs to induce the phosphorylation and degradation Of I kappa B alpha, resulting in the nuclear translocation of NF-kappa B. Consistently, both TNF and LPS rapidly induced the expression of the NF-kappa B-dependent gene interteukin-8 (IL-8). However, unlike in monocytes, we found that LPS could not induce the phosphorylation of the NF-kappa B active subunit p65 in DPSCs. In summary, our studies suggest that DPSCs may be involved in immune responses during pulpal infection through activating NF-kappa B. Author Keywords:NF-kappa B; dental pulp stem cells; tumor necrosis factor; LPS; inflammation KeyWords Plus:PORPHYROMONAS-GINGIVALIS LIPOPOLYSACCHARIDE; GENE-EXPRESSION; INDUCED APOPTOSIS; PHOSPHORYLATION; INHIBITION; INDUCTION; PROFILES; THERAPY; DEATH Addresses:Wang CY (reprint author), Univ Michigan, Lab Mol Signaling & Apoptosis, Dept Biol & Mat Sci, Sch Dent, 1011 N Univ Ave, Ann Arbor, MI 48109 USA Univ Michigan, Lab Mol Signaling & Apoptosis, Dept Biol & Mat Sci, Sch Dent, Ann Arbor, MI 48109 USA Kanagawa Dent Coll, Div Operat Dent & Endodont, Dept Oral Med, Kanagawa, Japan Peking Univ, Hlth Sci Ctr, Sch Stomatol, Beijing, 100871 Peoples R China Natl Inst Dent & Craniofacial Res, Sect Oral Biol, Craniofacial & Skeletal Dis Branch, NIH, Bethesda, MD USA E-mail Addresses: HYPERLINK "mailto:cunywang@umich.edu" cunywang@umich.edu Publisher:INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R, 1619 DUKE ST, ALEXANDRIA, VA 22314-3406 USA Subject Category:DENTISTRY, ORAL SURGERY & MEDICINE IDS Number:977KA ISSN:0022-0345 KMWXY      Y Z _ ` b c   ! # * + E a o жККККiККККККж2huLhuL5>*B*CJKHOJQJ\^Jph,huLhuL>*B*CJKHOJQJ^Jph6jhuLhuLB*CJKHOJQJU^JaJph3huLhuL5B*CJKHOJQJ\^JaJph-huLhuLB*CJKHOJQJ^JaJph/huLhuL5B*CJKHOJQJ\^Jph)M# a y " $1$a$gduL $1$9Da$gduLo y   . 1 2 8 D L M 3678贚iM6M-huLhuLB*CJKHOJQJ^JaJph6jhuLhuLB*CJKHOJQJU^JaJph3huLhuL5B*CJKHOJQJ\^JaJph,huLhuL>*B*CJKHOJQJ^Jph2huLhuL5>*B*CJKHOJQJ\^Jph6jhuLhuLB*CJKHOJQJU^JaJph/huLhuL5B*CJKHOJQJ\^Jph-huLhuLB*CJKHOJQJ^JaJph89GHI"0䱚~ffffLLf3huLhuL5B*CJKHOJQJ\^JaJph/huLhuL5B*CJKHOJQJ\^Jph6jhuLhuLB*CJKHOJQJU^JaJph-huLhuLB*CJKHOJQJ^JaJph6jhuLhuLB*CJKHOJQJU^JaJph-huLhuLB*CJKHOJQJ^JaJph6jhuLhuLB*CJKHOJQJU^JaJph$Ͷ huLo(/huLhuL5B*CJKHOJQJ\^Jph-huLhuLB*CJKHOJQJ^JaJph6jhuLhuLB*CJKHOJQJU^JaJph,huLhuL>*B*CJKHOJQJ^Jph 0182P. A!"#$%S DdJ  s rA*relrecbrelrecFind Related RecordsbA2w@Q}L]QDnA2w@Q}L]QPNG  IHDRo62[PLTE333գTTQøfff===𴴮``]JJIxxtͽߖfff@@@WWVppnΥźrrr||{YYY,Nh/tRNSZ8bKGDHgIFg>U cmPPJCmp0712HsIDATHKVђ0 _ 4aΐwچdtL-V^+q(c(,mu[_ۗnJ"**Jxv"gS@4:̹aM+NŬqӪK#%zOJ)"%QҐq‡뱫|oFQ3:K Rb?5}<PH:*,֨ZKUaImSF<>Ө- |IBNϡN'ixEo@~'$vmԅl+5)MTX,%D7ai.FEݜY7Wzv8YÞWZ"{1>|i{>*e8?h DBe> 9MUV%{ 86-R(tA2θp=`nj!JVsd kdO\?wꗵ |qz~%j-mxoi#~7]_QDIENDB`Ddj  c FA infoInformationb70л"[n 0л"[PNG  IHDR(PLTE333պde^GGGxxqݙqqjԅSSSƺ̣zzz噙WWRtttfffxFa +tRNS#ɧbKGDHgIFg>U cmPPJCmp0712HsIDATWU0 ;'ÁlL`}-?MܗkzsJ'6)3Z[TMLW3A)GiEv A?WvFw\@/!.sק w.Unoqգ|?Oݲ_P_lSIENDB`N@N cke $1$a$$CJKHPJ_HaJmH nHsH tH$A@$ ؞k=W[SOBi@B nfh*OJQJo(ph@o@ uL fieldlabel15OJQJ\o($M#ay " 0000000000000000M#ay " K0K0K0K0K0K0K0K0K0K0K0K0I0I0I0 0o 8  XY_b 1L3568GH XXXXXXXCXCX`a- `a#`atG `a/!`aTG `a<& `a%!/ TTbnq|4 `lp{:*urn:schemas-microsoft-com:office:smarttagsStreetB*urn:schemas-microsoft-com:office:smarttagscountry-region>*urn:schemas-microsoft-com:office:smarttags PostalCode9*urn:schemas-microsoft-com:office:smarttagsState8*urn:schemas-microsoft-com:office:smarttagsCity;*urn:schemas-microsoft-com:office:smarttagsaddress<*urn:schemas-microsoft-com:office:smarttagschmetcnv ( 0165FalseHasSpaceinNegative NumberType SourceValueTCSCTrueUnitName   (6ot 5 : a f " *  ' * , / = A _ c   $ % ( ) , . 1 2 : \ ` z } 3.d sYG /+sYG (sYG^*sYG) -sYG/.sYG!::sYG?sYGsYG3IsYGpDUsYGe-UsYG{[sYGh ^sYG1jsYGXmsYGuL@X•`@UnknownGz Times New Roman5Symbol3& z Arial7&  Verdana;[SOSimSun qhb&b&7 7 !-!),.:;?]}    & 6"0000 0 0 00000 =@\]^([{  0 0 00000;[22HX(?uL2LTitle: NF-kappa B activation in human dental pulp stem cells by TNF and LPS lxxlxxOh+'0  (4 T ` lxPTitle: NF-kappa B activation in human dental pulp stem cells by TNF and LPS lxxNormallxx2Microsoft Office Word@ @XVo@XVo7 ՜.+,D՜.+, X`px tshg  8@ _PID_HLINKSA 0Qrmailto:cunywang@umich.edu!|http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=EasyRelated&UT=000232801100005&doc=19/1&rec_id=147363412|Ohttp://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=PagedCitedRefList&UT=000232801100005&doc=19/1&rec_id=147363412e http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Wang+CY&curr_doc=19/1&Form=FullRecordPage&doc=19/1)G http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Shi+S&curr_doc=19/1&Form=FullRecordPage&doc=19/1ahttp://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Tani-Ishii+N&curr_doc=19/1&Form=FullRecordPage&doc=19/1G1http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Zhang+C&curr_doc=19/1&Form=FullRecordPage&doc=19/1G!http://wos15.isiknowledge.com/CIW.cgi?SID=X2cBGKGN7ihb3hO9MGm&Func=OneClickSearch&field=AU&val=Chang+J&curr_doc=19/1&Form=FullRecordPage&doc=19/1  !"#$%'()*+,-/0123458Root Entry F:Data 1Table1WordDocument2$SummaryInformation(&DocumentSummaryInformation8.CompObjm  FMicrosoft Office Word ĵ MSWordDocWord.Document.89q