ࡱ> <>;q` R`bjbjqPqP2(::`    $0 *H$ $ $ $ $ $ $ $h#6F $ $ F F 6$ $ K F *$ $  F   $ < J p  a0   04$ | N d $ $ $ 66 $ $ $ F F F F  Title:Preparation and characterization of porous beta-tricalcium phosphate collagen composites with an integrated structure Author(s): HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=OneClickSearch&field=AU&val=Zou+C&curr_doc=13/1&Form=FullRecordPage&doc=13/1" \o "one-click search" Zou C,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=OneClickSearch&field=AU&val=Weng+WJ&curr_doc=13/1&Form=FullRecordPage&doc=13/1" \o "one-click search" Weng WJ,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=OneClickSearch&field=AU&val=Deng+XL&curr_doc=13/1&Form=FullRecordPage&doc=13/1" \o "one-click search" Deng XL,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=OneClickSearch&field=AU&val=Cheng+K&curr_doc=13/1&Form=FullRecordPage&doc=13/1" \o "one-click search" Cheng K,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=OneClickSearch&field=AU&val=Liu+XG&curr_doc=13/1&Form=FullRecordPage&doc=13/1" \o "one-click search" Liu XG,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=OneClickSearch&field=AU&val=Du+PY&curr_doc=13/1&Form=FullRecordPage&doc=13/1" \o "one-click search" Du PY,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=OneClickSearch&field=AU&val=Shen+G&curr_doc=13/1&Form=FullRecordPage&doc=13/1" \o "one-click search" Shen G,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=OneClickSearch&field=AU&val=Han+GR&curr_doc=13/1&Form=FullRecordPage&doc=13/1" \o "one-click search" Han GR Source:BIOMATERIALS 26 (26): 5276-5284 SEP 2005 Document Type:Article Language:English  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z42gbC@C47B3DmNLDND&Func=PagedCitedRefList&UT=000228844900002&doc=13/1&rec_id=144106989" Cited References: 31 Times Cited: 0  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z4on8i3kAbOj6mcc521&Func=TransferToPublisher&URL=http%3A//gateway.isiknowledge.com/gateway/Gateway.cgi%3FGWVersion%3D2%26SrcAuth%3DDOISource%26SrcApp%3DWOS%26KeyAID%3D10.1097%252F01.prs.0000177278.65720.d0%26DestApp%3DDOI%26SrcAppSID%3DZ4on8i3kAbOj6mcc521&PublisherID=DOISource&SubFunc=Popup"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/Links/WOK3/Generic_Src.gif" \* MERGEFORMATINET  Abstract:Porous beta-tricalcium phosphate (TCP)/collagen composites with different beta-TCP/collagen weight ratio were prepared. The influences of the preparation conditions on the microstructure of porous composite and the joint status of beta-TCP particles with collagen fibrils were characterized by X-ray diffractometer, scanning electron microscopy and transmission electron microscopy. The results showed: (1) an acid treatment could effectively disassemble collagen fibrils; (2) in the resulting porous composites, beta-TCP particles homogenously existed on the skeleton of the collagen fibril network and bonded tightly to both the fibrils and themselves. The tight bonding formation could be due to the reaction between Ca ions in the particles and carboxyl groups in colla-g-en polypeptide chains and due to the reprecipitation of partially dissolved beta-TCP during synthesis. The tight bonding between beta-TCP particles and collagen fibrils in the composites demonstrated an integrated structure, which was reproducible when beta-TCP/collagen ratio ranged from 2 to 4. Such integrated structure would make significant contributions in reliably tailoring properties of the porous composites by varying beta-TCP content. In addition, the porous composites had large porosity (similar to 95%) and appropriate pore size (similar to 100 mu m), showed no negative impact in cytotoxicity assay and complete bone tissue regeneration after 12 weeks in animal test. (c) 2005 Elsevier Ltd. All rights reserved. Author Keywords:beta-tricalcium phosphate; collagen; porous composite; preparation; microstructure; scaffold KeyWords Plus:BONE-TISSUE; CALCIUM-PHOSPHATE; IN-VITRO; SCAFFOLDS; BIOMATERIALS; NUCLEATION; SYSTEM Addresses:Weng WJ (reprint author), Zhejiang Univ, Dept Mat Sci & Engn, Zheda Rd 38, Hangzhou, 310027 Peoples R China Zhejiang Univ, Dept Mat Sci & Engn, Hangzhou, 310027 Peoples R China Beijing Univ, Sch Stomatol, Beijing, 100081 Peoples R China E-mail Addresses: HYPERLINK "mailto:wengwj@zju.edu.cn" wengwj@zju.edu.cn Publisher:ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND Subject Category:ENGINEERING, BIOMEDICAL; MATERIALS SCIENCE, BIOMATERIALS IDS Number:922NP ISSN:0142-9612 |~= > C D F G     ~  > ? 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