ࡱ> 574q` RbjbjqPqP2 ::     ( T*@~h     4 P  $0T( 4 | gT     Title:Clinicopathologic study of 24 cases of cherubism Author(s): HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Meng+XM&curr_doc=6/1&Form=FullRecordPage&doc=6/1" \o "one-click search" Meng XM,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Yu+SF&curr_doc=6/1&Form=FullRecordPage&doc=6/1" \o "one-click search" Yu SF,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Yu+GY&curr_doc=6/1&Form=FullRecordPage&doc=6/1" \o "one-click search" Yu GY Source:INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 34 (4): 350-356 JUN 2005 Document Type:Article Language:English  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=PagedCitedRefList&UT=000229449100003&doc=6/1&rec_id=144592650" Cited References: 35 Times Cited: 0 HYPERLINK "X.M.Meng2005.pdf" \t "_blank" INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/Links/WOK3/Generic_Src.gif" \* MERGEFORMATINET  Abstract:The authors reviewed 24 cases of familial or nonfamilial cherubism. The age at onset was between 6 and 10 years. It was characterized by bilateral painless swelling of jaws and eyes-to-heaven appearance was visible when the maxillae were affected as well. Radiographs showed well-defined multilocular radiolucencies and with age, thick sclerotic borders were visible. A malocclusive and abnormal dentition, worse in the mandible can be seen. Histopathologically, numerous randomly distributed multinucleated giant cells and vascular spaces within a fibrous connective tissue stroma with or without eosinophilic collagen perivascular cuffing were apparent. Multinucleated giant cells were positive for osteoclastic specific markers, tartrate-resistant acid phosphatase and human alpha V beta 3 integrin, 23C6. Results after follow-up were available for 14 cases. Of these, no treatment was carried out in five cases, cherubism resolved (three cases) or grew slowly (two cases); curettage or surgical contouring was performed in seven cases, during the rapid growth of the lesions. This not only gave good immediate results, but also arrested active growth of remnant cherubic lesions and even stimulated bone regeneration. Segmental mandibulectomy followed by reconstruction was performed in two cases with extensive lesion and the risk of pathologic fracture of the mandible, and excellent results were obtained. Author Keywords:cherubism; jaw; giant cell lesion KeyWords Plus:GIANT-CELL GRANULOMAS; GENE; JAWS; MUTATION; THERAPY; LESIONS Addresses:Meng XM (reprint author), Peking Univ, Sch Stomatol, Dept Oral Pathol, 22 S Zhongguancun Ave, Beijing, 100081 Peoples R China Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing, 100081 Peoples R China Peking Univ, Dept Oral & Maxillofacial Surg, Sch Stomatol, Beijing, 100081 Peoples R China E-mail Addresses: HYPERLINK "mailto:m.xm@163.com" m.xm@163.com Publisher:CHURCHILL LIVINGSTONE, JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND Subject Category:DENTISTRY, ORAL SURGERY & MEDICINE; SURGERY IDS Number:930WZ ISSN:0901-5027 79CDE    p q v w y жККККiККiжККiж,h8h8>*B*CJKHOJQJ^Jph2h8h85>*B*CJKHOJQJ\^Jph6jh8h8B*CJKHOJQJU^JaJph3h8h85B*CJKHOJQJ\^JaJph-h8h8B*CJKHOJQJ^JaJph/h8h85B*CJKHOJQJ\^Jph)9y m 1 $1$a$gd8 $1$9Da$gd8 g h i j k m v  1?ŪՕmV>V>V>V>V>V/h8h85B*CJKHOJQJ\^Jph-h8h8B*CJKHOJQJ^JaJph.jhrh~B*CJOJQJUaJphh~B*CJOJQJaJph(jh~B*CJOJQJUaJph4jhtA&htA&B*CJOJQJUaJphhtA&B*CJOJQJaJph(jh2OVB*CJOJQJUaJph*h~B*CJKHOJQJ^JaJo(ph͚͞͞͞͞h8/h8h85B*CJKHOJQJ\^Jph,h8h8>*B*CJKHOJQJ^Jph-h8h8B*CJKHOJQJ^JaJph6jh8h8B*CJKHOJQJU^JaJph0182P. 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