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EE  OOOO Title:Dentonin, a fragment of MEPE, enhanced dental pulp stem cell proliferation Author(s): HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Liu+H&curr_doc=12/1&Form=FullRecordPage&doc=12/1" \o "one-click search" Liu H,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Li+W&curr_doc=12/1&Form=FullRecordPage&doc=12/1" \o "one-click search" Li W,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Gao+C&curr_doc=12/1&Form=FullRecordPage&doc=12/1" \o "one-click search" Gao C,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Kumagai+Y&curr_doc=12/1&Form=FullRecordPage&doc=12/1" \o "one-click search" Kumagai Y,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Blacher+RW&curr_doc=12/1&Form=FullRecordPage&doc=12/1" \o "one-click search" Blacher RW,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=DenBesten+PK&curr_doc=12/1&Form=FullRecordPage&doc=12/1" \o "one-click search" DenBesten PK Source:JOURNAL OF DENTAL RESEARCH 83 (6): 496-499 JUN 2004 Document Type:Article Language:English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=PagedCitedRefList&UT=000226597900012&doc=12/1&rec_id=142688959" Cited References: 22 Times Cited: 0  HYPERLINK "liu%20he2004.pdf"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/Links/WOK3/Generic_Src.gif" \* MERGEFORMATINET  Abstract:Matrix extracellular phosphoglycoprotein ( MEPE) is a SIBLING protein, found in bone and dental tissues. The purpose of this study was to determine whether a 23-amino-acid peptide derived from MEPE ( Dentonin or AC-100) could stimulate dental pulp stem cell ( DPSC) proliferation and/or differentiation. DPSCs were isolated from erupted human molars, and the mitogenic potential of Dentonin in DPSCs was measured by BrdU immunoassay and cell-cycle gene SuperArray. Differentiation of DPSCs with Dentonin was characterized by Western blot and by osteogenesis gene SuperArray. Dentonin enhanced DPSC proliferation by down-regulating P16, accompanied by up-regulation of ubiquitin protein ligase E3A and human ubiquitin-related protein SUMO-1. Enhanced cell proliferation required intact RGD and SGDG motifs in the peptide. This study shows that Dentonin can promote DPSC proliferation, with a potential role in pulp repair. Further studies are required to determine the usefulness of this material in vivo. Author Keywords:MEPE; dental pulp stem cells; proliferation; Dentonin; AC-100 KeyWords Plus:EXTRACELLULAR-MATRIX PROTEINS; RHEUMATOID-ARTHRITIS; BONE-FORMATION; IN-VITRO; GENE; OSTEOMALACIA; EXPRESSION; INTEGRINS; BINDING; VIVO Addresses:DenBesten PK (reprint author), Univ Calif San Francisco, Box 0640, San Francisco, CA 94143 USA Univ Calif San Francisco, San Francisco, CA 94143 USA Peking Univ, Sch Stomatol, Beijing, 100871 Peoples R China Acologix, Emeryville, CA USA E-mail Addresses: HYPERLINK "mailto:pkdb@itsa.ucsf.edu" pkdb@itsa.ucsf.edu Publisher:INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R, 1619 DUKE ST, ALEXANDRIA, VA 22314-3406 USA Subject Category:DENTISTRY, ORAL SURGERY & MEDICINE IDS Number:891RJ ISSN:0022-0345 QS]^_      K L U V X Y      жККККiККiККiККiККi,he*he*>*B*CJKHOJQJ^Jph2he*he*5>*B*CJKHOJQJ\^Jph6jhe*he*B*CJKHOJQJU^JaJph3he*he*5B*CJKHOJQJ\^JaJph-he*he*B*CJKHOJQJ^JaJph/he*he*5B*CJKHOJQJ\^Jph)S ' ? R E{ $1$a$gde* $1$9Da$gde* ' 5 ? 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