ࡱ> =?<q` RbjbjqPqP2*::D4@ @ @ @ $d x*| | | | | | | | ~$)hF| | | | lll| | ~l~lll| p P\@ Fl~0lLllR,|  hlv T "| | | b | | | xxxddxxx$(@ Title:Association analysis between interleukin-1 family polymorphisms and generalized aggressive periodontitis in a Chinese population Author(s): HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Li+QY&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Li QY,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Zhao+HS&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Zhao HS,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Meng+HX&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Meng HX,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Zhang+L&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Zhang L,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Xu+L&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Xu L,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Chen+ZB&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Chen ZB,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Shi+D&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Shi D,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Feng+XH&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Feng XH,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=OneClickSearch&field=AU&val=Zhu+XL&curr_doc=21/1&Form=FullRecordPage&doc=21/1" \o "one-click search" Zhu XL Source:JOURNAL OF PERIODONTOLOGY 75 (12): 1627-1635 DEC 2004 Document Type:Article Language:English  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=PagedCitedRefList&UT=000226535700009&doc=21/1&rec_id=142580837" Cited References: 53  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6D1KGgC3Nkf68d5iEe&Func=DispCitingRec&doc=21/1&isickref=142580837" Times Cited: 2  HYPERLINK "liqiyan2004.pdf" \t "_blank"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/Links/WOK3/Generic_Src.gif" \* MERGEFORMATINET  Abstract:Background: It has been suggested that aggressive periodontitis (AgP) has a genetic basis, but this theory has not been confirmed. The intent of this investigation was to study whether specific interleukin (IL)-1 genotypes and/or alleles could be used to predict susceptibility to generalized AgP (GAgP) in Chinese. Methods: The GAgP group consisted of 122 patients, and the control group included 95 healthy subjects. Single nucleotide polymorphisms at IL-1A (+4845) and IL-1B (-511, +3954) were analyzed by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The polymorphism of a variable number tandem repeat (VNTR) in intron 2 of IL-1RN was detected by PCR amplification and fragment size analysis. Results: There was no significant association of IL-1 polymorphisms with GAgP in the unstratified subjects. However, when cases were stratified by gender, the frequencies of A2(+) genotype and allele 2 at IL-1A +4845 were significantly increased in male patients compared to male controls (genotype: odds ratio [OR] 5.58, 95% confidence interval [CI]: 1.09 to 28.68, P = 0.039; allele: OR 4.97, 95% CI: 1.01 to 24.50, P = 0.049; adjusted for age and smoking status). The frequency of IL-1B -511 A1/A2 heterozygote was significantly increased in male GAgP group compared to male controls (adjusted OR 3.16, 95% CI: 1.01 to 9.89, P = 0.048). In females, no significant differences were found between patients and controls in corresponding analyses at all polymorphic loci. A possible combined effect of IL-1B -511 polymorphism and smoking on the elevated risk to GAgP was observed. The OR of GAgP for combined A2(+) genotype and smoking was 12.45 (95% CI: 1.43 to 108.06, P = 0.022), and for combined allele 2 and smoking was 18.25 (95% CI: 2.32 to 143.86, P = 0.006). Conclusions: The polymorphisms of IL-1A +4845 and IL-1 B -511 may play an important role in determining GAgP susceptibility in Chinese males. Furthermore, a possible combined effect of the polymorphism of IL-1 B -511 and smoking on GAgP susceptibility was suggested. Author Keywords:Chinese; interleukin-1; periodontitis, aggressive/pathogenesis; polymorphism KeyWords Plus:EARLY-ONSET PERIODONTITIS; TUMOR-NECROSIS-FACTOR; ADULT PERIODONTITIS; GENE POLYMORPHISM; CYTOKINE PRODUCTION; GENDER-DIFFERENCES; CIGARETTE-SMOKING; DISEASE SEVERITY; IL-1-BETA GENES; PLASMA-LEVELS Addresses:Meng HX (reprint author), Peking Univ, Sch Stomatol, Dept Periodontol, 22 Zhong Guan Cun Nan Da Jie, Beijing, 100081 Peoples R China Peking Univ, Sch Stomatol, Dept Periodontol, Beijing, 100081 Peoples R China Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing, 100081 Peoples R China Peking Univ, Hlth Sci Ctr, Ctr Human Dis Genomics, Beijing, 100081 Peoples R China E-mail Addresses: HYPERLINK "mailto:kqhxmeng@mail.bjmu.edu.cn" kqhxmeng@mail.bjmu.edu.cn Publisher:AMER ACAD PERIODONTOLOGY, 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 USA Subject Category:DENTISTRY, ORAL SURGERY & MEDICINE IDS Number:890UF ISSN:0022-3492 H I N O Q R       G H L M O P    жККККiККiККiККiККi,ht3ht3>*B*CJKHOJQJ^Jph2ht3ht35>*B*CJKHOJQJ\^Jph6jht3ht3B*CJKHOJQJU^JaJph3ht3ht35B*CJKHOJQJ\^JaJph-ht3ht3B*CJKHOJQJ^JaJph/ht3ht35B*CJKHOJQJ\^Jph)M-~Cy$K-1$9Da$gdt3 $1$a$gdt3 $1$9Da$gdt3   CDJKMTUnGHY\]cd̵̵̵ii2ht3ht35>*B*CJKHOJQJ\^Jph3ht3ht35B*CJKHOJQJ\^JaJph/ht3ht35B*CJKHOJQJ\^Jph,ht3ht3>*B*CJKHOJQJ^Jph6jht3ht3B*CJKHOJQJU^JaJph-ht3ht3B*CJKHOJQJ^JaJph)/012-;~ŪՕmV>V>V>V>V/ht3ht35B*CJKHOJQJ\^Jph-ht3ht3B*CJKHOJQJ^JaJph.jhrhDdB*CJOJQJUaJphhDdB*CJOJQJaJph(jhDdB*CJOJQJUaJph4jh4h4B*CJOJQJUaJphh4B*CJOJQJaJph(jh4B*CJOJQJUaJph*hDdB*CJKHOJQJ^JaJo(ph~CTyȬȬybybybyb^ht3-ht3ht3B*CJKHOJQJ^JaJph/ht3ht35B*CJKHOJQJ\^Jph4h4ht3>*B*CJKHOJQJ^JmHphsH6jht3ht3B*CJKHOJQJU^JaJph5h4ht3B*CJKHOJQJ^JaJmHphsH7h4ht35B*CJKHOJQJ\^JmHphsH0182P. 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