аЯрЁБс>ўџ :<ўџџџ9џџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџьЅСq` №RПЁbjbjqPqP2(::ЁџџџџџџЄ№№№№№№№ЬЬЬЬш ъ*ммммммммikkkkkk$h| №W ммW W №№ммЄuuuW ў№м№мiuW iuu№№uмє  ѓ1чiљХЬUuiК0ъu†k†uu膹Mм | ruю \J мммk мммъW W W W фшфш№№№№№№џџџџ Title: Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas Author(s):  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Jen+KY&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Jen KY,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Cheng+J&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Cheng J,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Li+J&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Li J,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Wu+LY&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Wu LY,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Li+YF&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Li YF,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Yu+SF&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Yu SF,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Lin+HL&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Lin HL,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Chen+ZL&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Chen ZL,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Gurtsevitch+V&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Gurtsevitch V,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Saku+T&curr_doc=1/1&Form=FullRecordPage&doc=1/1" \o "one-click search" Saku T Source: INTERNATIONAL JOURNAL OF CANCER 105 (5): 654-660 JUL 10 2003 Document Type: Article Language: English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=PagedCitedRefList&UT=000183474000012&doc=1/1&rec_id=129917312" Cited References: 29       HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=DispCitingRec&doc=1/1&isickref=129917312" Times Cited: 1      Abstract: It is still unknown what kinds of roles Epstein-Barr virus (EBV) infection that are highly specific to salivary gland lymphoepithelial carcinomas (LECs) play in their tumorigenesis. To clarify the significance of EBV in LECs, we paid particular attention to the LMPI gene, which is responsible for triggering several pathways for activating transcription factors. Sixty-one cases of EBV positive LECs confirmed by PCR and in-situ hybridization were collected from various areas of the world and studied immunohistochemically for latent membrane protein-I. Furthermore, PCR for the LMPI carboxyl (C)-terminus region was performed, and the PCR products were sequenced for detection of other mutational events. LMPI gene products were immunohistochemically demonstrated in 51% of the cases, while PCR amplification of the LMPI gene was successful in 41 cases (67%). Among them, a 30 bp deletion in the C-terminus of the LMPI gene, which had been shown to be characteristic to EBV in Chinese nasopharyngeal carcinomas, was found in 20 cases (32%). Most of them were from Guangzhou, Chengdu and Taiwan, while most of the cases from Shanghai and other areas exhibited no 30 bp deletion. In addition, several point mutations including codon 338 of LMPI were commonly shared by the cases with or without the 30 bp deletion. These results indicate that there are 2 major genomic variations of EBV infecting salivary gland LECs. The frequent mutational events in the C-terminus in addition to the 30 bp deletion also seem to be critical for the pathogenesis because such mutational events may possibly promote cellular proliferation. Author Keywords: EBV; LMP1; lymphoepithelial carcinoma; mutation; salivary gland KeyWords Plus: NF-KAPPA-B; NASOPHARYNGEAL CARCINOMA; LATENT MEMBRANE-PROTEIN-1; 30-BP DELETION; HONG-KONG; VARIANT; ASSOCIATION; CHINESE; TUMORS; PREVALENCE Addresses: Saku T (reprint author), Niigata Univ, Div Oral Pathol, Dept Tissue Regenerat & Reconstruct, Grad Sch Med & Dent Sci, 2-5274 Gakkocho Dori, Niigata, 9518514 Japan Niigata Univ, Div Oral Pathol, Dept Tissue Regenerat & Reconstruct, Grad Sch Med & Dent Sci, Niigata, 9518514 Japan Shanghai Med Univ 2, Dept Oral Pathol, Sch Stomatol, Shanghai, Peoples R China W China Univ Med Sci, Dept Oral Pathol, Sch Stomatol, Chengdu, 610041 Peoples R China Kunming Med Coll, Dept Oral Pathol, Fac Stomatol, Kunming, Peoples R China Beijing Univ, Dept Oral Pathol, Sch Stomatol, Beijing, 100871 Peoples R China Sun Yat Sen Univ Med Sci, Dept Pathol, Guangzhou, Peoples R China Natl Taiwan Univ, Dept Pathol, Coll Med, Taipei, 10764 Taiwan NN Blokhin Canc Res Ctr, Viral Carcinogenesis Lab, Moscow, Russia Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USA Subject Category: ONCOLOGY IDS Number: 689CL ISSN: 0020-7136 ikuvw) * 0 1 3 4 ч ш я № ђ ѓ Ѓ Є Ј Љ Ћ Ќ ] ^ c d f g     ! " г д й к чаЖачаšаš€šаšаšišаšаšišаšаšišаšаšišаšаšiš,h…зh…з>*B*CJKHOJQJ^Jphџ2h…зh…з5>*B*CJKHOJQJ\^Jphџ6jh…зh…зB*CJKHOJQJU^JaJph3h…зh…з5B*CJKHOJQJ\^JaJph-h…зh…зB*CJKHOJQJ^JaJph/h…зh…з5B*CJKHOJQJ\^Jph)kр&>Q№Bрa} Ёєєєєєыєєєєєєєєщ $1$a$gd…з $1$9Da$gd…зЁ§к м н   – — ™ š MNUVXY !#$жзнорчш&4>GQRрсђѕіќ§шЬшЬЕЬшЬшЬЕЬшЬшЬЕЬшЬшЬЕЬшшƒшшшЬшЬiЕЬшЬ2h…зh…з5>*B*CJKHOJQJ\^Jphџ3h…зh…з5B*CJKHOJQJ\^JaJph/h…зh…з5B*CJKHOJQJ\^Jph,h…зh…з>*B*CJKHOJQJ^Jphџ6jh…зh…зB*CJKHOJQJU^JaJph-h…зh…зB*CJKHOJQJ^JaJph)§vwƒ…†–№BPръ ar}ˆ• ЁшЬВ›Ьшƒшƒшƒшƒшƒшƒшƒшƒш~ h…зo(/h…зh…з5B*CJKHOJQJ\^Jph,h…зh…з>*B*CJKHOJQJ^Jphџ2h…зh…з5>*B*CJKHOJQJ\^Jphџ6jh…зh…зB*CJKHOJQJU^JaJph-h…зh…зB*CJKHOJQJ^JaJph0182PА‚. АЦA!А"А# $ %ААSАр Љ†œN@ёџN ck‡e $1$a$$CJKHPJ_HaJmH nHsH tH$A@ђџЁ$ иžЄ‹Еk=„W[SOBi@ѓџГB nfhˆ*OJQJo(phџ@ўoЂ@ …з fieldlabel15OJQJ\o(Ё(џџџџkр&>Q №Bрa} Ѓ˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€˜0€€€˜0€€€˜0€€€˜0€€€˜0€€€kр&>Q №Bрa} ЃKШ0ЕKШ0ЕKШ0ЕKШ0ЕKШ0ЕKШ0ЕKШ0ЕKШ0ЕKШ0ЕKШ0ЕKШ0ЕIШ0€IШ0€IШ0€ 0њк §ЁЁЁv)03чяђЃЈЋ]cf!гйм–™MUX #жнQрѕќv … ЁXџŒXџŒXџŒXџŒXџŒXџŒXџŒXџŒXџŒXџŒXџŒXџŒџџ Ѕ,”7 І,T;D Ї,„v Ј,l& Љ,м* Њ,œ* Ћ,d> Ќ,ьЩ ­,ŒК#Ў,С Џ,м!Т Э й ў ў 55DNQ\Ѓ  Ы д п BLP[__Ѓ  :*€urn:schemas-microsoft-com:office:smarttags€Street€>*€urn:schemas-microsoft-com:office:smarttags €PostalCode€9*€urn:schemas-microsoft-com:office:smarttags€State€;*€urn:schemas-microsoft-com:office:smarttags€address€B *€urn:schemas-microsoft-com:office:smarttags€country-region€8 *€urn:schemas-microsoft-com:office:smarttags€City€9*€urn:schemas-microsoft-com:office:smarttags€place€ Д    N^  * . > K s w # ' Ž Ѓ s ˆ  Э д ')chЎА ik BJыя !/8MP\_hpqu–šЅЋЙТзкцщ!'),-5Y]beqwy|}…‡ŽЇЎГЗУЩЫЮЯзйрњў DGHKLPUX_e‚†Ž’™ŸЁЅУЪЫЯагдзЃЃ3Ѓ€fУШbk–nДШbkfV?ШbkЯшШbkвJеШbkџE "ШbkQд(Шbk€-7ШbkЗOZLШbkTџdШbkШbkm $kШbkgfЂoШbkЃ)grШbknrzvШbkх…зџ@v1TП•**Ё`@џџUnknownџџџџџџџџџџџџG‡z €џTimes New Roman5€Symbol3& ‡z €џArial7& ‡ ŸVerdana;†‹[SOSimSun qˆЄhТ+œ&Т+œ& % %!-!),.:;?]}ЈЗЧЩ    & 6"0000 0 0 00000џџџ џ џџџџџ=џ@џ\џ]џ^џрџ([{З  0 0 00000џџ;џ[џсџхџ Дœ‚€2——2ƒHX(№џ?Јџџџџџџџџџџџџџџџџџџџџџ…з2џџjTitle: Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas lxxlxxўџр…ŸђљOhЋ‘+'Гй0Дˆ(8 DP p | ˆ”œЄЌЈlTitle: Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas lxxNormallxx2Microsoft Office Word@@dЇЩiљХ@dЇЩiљХўџеЭеœ.“—+,љЎDеЭеœ.“—+,љЎєА X`px€ˆ ˜ ЈЈtshg% —ц д 8@ _PID_HLINKSЈAŒH#?!lhttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=DispCitingRec&doc=1/1&isickref=129917312ГQhhttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=PagedCitedRefList&UT=000183474000012&doc=1/1&rec_id=129917312Г4http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Saku+T&curr_doc=1/1&Form=FullRecordPage&doc=1/1ГH4–http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Gurtsevitch+V&curr_doc=1/1&Form=FullRecordPage&doc=1/1Гqhttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Chen+ZL&curr_doc=1/1&Form=FullRecordPage&doc=1/1Г[mhttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Lin+HL&curr_doc=1/1&Form=FullRecordPage&doc=1/1Г zŽhttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Yu+SF&curr_doc=1/1&Form=FullRecordPage&doc=1/1Гo Žhttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Li+YF&curr_doc=1/1&Form=FullRecordPage&doc=1/1Гk Žhttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Wu+LY&curr_doc=1/1&Form=FullRecordPage&doc=1/1Гv@http://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Li+J&curr_doc=1/1&Form=FullRecordPage&doc=1/1Г Ehttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Cheng+J&curr_doc=1/1&Form=FullRecordPage&doc=1/1ГBhhttp://wos15.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Jen+KY&curr_doc=1/1&Form=FullRecordPage&doc=1/1Г ўџџџўџџџ !"#$%&'ўџџџ)*+,-./ўџџџ12345678ўџџџ§џџџ;ўџџџўџџџўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџRoot Entryџџџџџџџџ РF9чiљХ=€Data џџџџџџџџџџџџ1Tableџџџџ†WordDocumentџџџџ2(SummaryInformation(џџџџџџџџџџџџ(DocumentSummaryInformation8џџџџџџџџ0ШCompObjџџџџџџџџџџџџmџџџџџџџџџџџџўџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџўџ џџџџ РFMicrosoft Office Word ЮФЕЕ MSWordDocWord.Document.8є9Вq