ࡱ> 463q` RMbjbjqPqP2::M  6*LLLLLLL$`h* LL LL rLL   L p0ztT_ " 06   0L| v d LLL LLL6  Title:Giant cell granuloma of the temporal bone - A case report with immunohistochemical, enzyme histochemical, and in vitro studies Author(s): HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Tian+XF&curr_doc=6/1&Form=FullRecordPage&doc=6/1" \o "one-click search" Tian XF,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Li+TJ&curr_doc=6/1&Form=FullRecordPage&doc=6/1" \o "one-click search" Li TJ,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Yu+SF&curr_doc=6/1&Form=FullRecordPage&doc=6/1" \o "one-click search" Yu SF Source:ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE 127 (9): 1217-1220 SEP 2003 Document Type:Article Language:English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=PagedCitedRefList&UT=000185240300030&doc=6/1&rec_id=131159736" Cited References: 10 Times Cited: 0  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=EasyRelated&UT=000185240300030&doc=6/1&rec_id=131159736"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:A case of giant cell granuloma (GCG) that occurred in the right temporal bone is reported. The lesion showed histologic features identical to GCG. The multinuclear giant cells (MGCs) in the lesion showed strong reactivity with CD68, but patchy staining for myeloid/histiocyte antigen, alpha-1-antitrypsin, alpha-1-antichymotrypsine, and lysozyme. Activity of tartrate-resistant acid phosphatase was also consistently detected in the MGCs. Some of the mononuclear cells of the lesion exhibited similar immunocytochemical and histochemical reactivity as the MGCs. Ki-67 staining, however, was only detected in the mononuclear cells. The MGCs isolated from the lesion presented characteristic morphology of osteoclasts and possessed the ability to excavate bone in vitro. Thus, the MGCs in GCG appeared to express both macrophage- and osteoclast-associated phenotypes. The mononuclear cells were the major proliferative elements in the lesion and a subpopulation of these cells may represent precursors of the MGCs. KeyWords Plus:REPARATIVE GRANULOMA; LESIONS Addresses:Li TJ (reprint author), Peking Univ, Sch Stomatol, Dept Oral Pathol, 22 Zhongguancun S Ave, Beijing, 100081 Peoples R China Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing, 100081 Peoples R China Publisher:COLLEGE AMER PATHOLOGISTS, C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA Subject Category:MEDICINE, RESEARCH & EXPERIMENTAL; MEDICAL LABORATORY TECHNOLOGY; PATHOLOGY IDS Number:720BF ISSN:0003-9985 F G N O Q R    & 0 9 C D  жККККiККiжККiж,h!$h!$>*B*CJKHOJQJ^Jph2h!$h!$5>*B*CJKHOJQJ\^Jph6jh!$h!$B*CJKHOJQJU^JaJph3h!$h!$5B*CJKHOJQJ\^JaJph-h!$h!$B*CJKHOJQJ^JaJph/h!$h!$5B*CJKHOJQJ\^Jph)  0 C ] ]`)<LMgd!$ $1$a$gd!$ $1$9Da$gd!$M  W X Y Z [ ] f ]k`j)4<ALM䱚䱚~fffffff^h!$h o(/h!$h!$5B*CJKHOJQJ\^Jph6jh!$h!$B*CJKHOJQJU^JaJph-h!$h!$B*CJKHOJQJ^JaJph6jh!$h!$B*CJKHOJQJU^JaJph-h!$h!$B*CJKHOJQJ^JaJph6jh!$h!$B*CJKHOJQJU^JaJph!0182P. 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