ࡱ> 8:7q` RbjbjqPqP2$:: *x x x x x x x ;======$hN*a x x ax x v x x ; ;  x  ZS  ;0 x x "x,x 0 "  x x x aa x x x  DHDH Title:Effects of estradiol on proliferation and metabolism of rabbit mandibular condylar cartilage cells in vitro Author(s): HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Cheng+P&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Cheng P,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Ma+XC&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Ma XC,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Xue+Y&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Xue Y,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Li+SL&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Li SL,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Zhang+ZY&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Zhang ZY Source:CHINESE MEDICAL JOURNAL 116 (9): 1413-1417 SEP 2003 Document Type:Article Language:English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=PagedCitedRefList&UT=000185645900030&doc=5/1&rec_id=131402538" Cited References: 24 Times Cited: 0  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=EasyRelated&UT=000185645900030&doc=5/1&rec_id=131402538"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:Objective To investigate the effects in vitro of 17beta-estradiol ( E-2) on the proliferation and metabolism of rabbit mandibular condylar cartilage cells. Methods Chondrocytes were derived from neonatal rabbit mandibular condylar cartilage using a modified enzyme method. 17beta-estradiol was added to the culture medium in a variety of concentrations. Cell growth and DNA, collagen, and proteoglycan synthesis were used as indicators of proliferation and differentiation of condylar chondrocytes. These were measured by cell number, H-3-proline and S-35-incorporation, respectively. Results E-2 increased cell number and H-3-thymidine incorporation at 10(-8) to 10(-10) mol/L, and 10(-8) to 10(-11) mol/L in a dose-dependent manner, peaking at 10(-8) mol/L and 10(-9) mol/L, respectively. However, further increase in the concentration of estradiol caused inhibition of both cell number and H-3-thymidine incorporation, and this was significant at 10(-6) mol/L. The effect of E-2 on proteglycan synthesis was similar; the maximum stimulating effect was at 10(-8) mol/L, and inhibition was significant at 10(-6) mol/L. There was no obvious stimulatory effect of E-2 on H-3-thymidine incorporation observed. Conclusions Estradiol affects condylar chondrocyte cell growth, DNA, and proteoglycan synthesis in a biphasic manner depending on its concentration. This indicates that estrogen may be important in the proliferation and differentiation of mandibular condylar chondrocytes, and could be relevant to some aspects of certain tempormandibular joint diseases by modulating the function of the chondrocytes. Author Keywords:estradiol; cartilage; condyle KeyWords Plus:TEMPOROMANDIBULAR-JOINT; YOUNG-ADULTS; ESTROGEN; COLLAGEN; 17-BETA-ESTRADIOL; DIFFERENTIATION; OSTEOARTHRITIS; CHONDROCYTES; EXPRESSION; INVITRO Addresses:Ma XC (reprint author), Peking Univ, Sch Stomatol, Ctr Temporomandibular Disorders, Beijing, 100081 Peoples R China Peking Univ, Sch Stomatol, Ctr Temporomandibular Disorders, Beijing, 100081 Peoples R China Beijing Jishuitan Hosp, Mol Biol Lab, Beijing, 100083 Peoples R China Peking Univ, Sch Stomatol, Lab Oral & Maxillofacial Surg, Beijing, 100081 Peoples R China Publisher:CHINESE MEDICAL ASSOCIATION, 42 DONGSI XIDAJIE, BEIJING 100710, PEOPLES R CHINA Subject Category:MEDICINE, GENERAL & INTERNAL IDS Number:727FB ISSN:0366-6999 rt~3 4 ; < > ? f g l m o p $ % - . 0 7 8 O m { жККККiККiККiККiж,h8h8>*B*CJKHOJQJ^Jph2h8h85>*B*CJKHOJQJ\^Jph6jh8h8B*CJKHOJQJU^JaJph3h8h85B*CJKHOJQJ\^JaJph-h8h8B*CJKHOJQJ^JaJph/h8h85B*CJKHOJQJ\^Jph)t0 m Yu7Tgd8$K-1$9Da$gd8 $1$a$gd8 $1$9Da$gd8{ ' ( 9 < = C O W X =@AB贚iM6M-h8h8B*CJKHOJQJ^JaJph6jh8h8B*CJKHOJQJU^JaJph3h8h85B*CJKHOJQJ\^JaJph,h8h8>*B*CJKHOJQJ^Jph2h8h85>*B*CJKHOJQJ\^Jph6jh8h8B*CJKHOJQJU^JaJph/h8h85B*CJKHOJQJ\^Jph-h8h8B*CJKHOJQJ^JaJphBCQRS7ET^䱚~ffffffff^h8h o(/h8h85B*CJKHOJQJ\^Jph6jh8h8B*CJKHOJQJU^JaJph-h8h8B*CJKHOJQJ^JaJph6jh8h8B*CJKHOJQJU^JaJph-h8h8B*CJKHOJQJ^JaJph6jh8h8B*CJKHOJQJU^JaJph0182P. 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