ࡱ> 685q` RzbjbjqPqP2"::zLLLLh `*\ \ \ \ \ \ \ $h* \ \   \ \  B\ \  \ t 0DOL.00`\ | d \ \ \  \ \ \ `    $($( Title:Effects of cerulenin on the endogenous fatty acid synthetic activity in squamous cell carcinoma of the oral cavity Author(s): HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Guo+CB&curr_doc=2/1&Form=FullRecordPage&doc=2/1" \o "one-click search" Guo CB,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Cui+NB&curr_doc=2/1&Form=FullRecordPage&doc=2/1" \o "one-click search" Cui NB,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Yu+GY&curr_doc=2/1&Form=FullRecordPage&doc=2/1" \o "one-click search" Yu GY,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Liu+DX&curr_doc=2/1&Form=FullRecordPage&doc=2/1" \o "one-click search" Liu DX,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Meng+SC&curr_doc=2/1&Form=FullRecordPage&doc=2/1" \o "one-click search" Meng SC,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=OneClickSearch&field=AU&val=Song+Q&curr_doc=2/1&Form=FullRecordPage&doc=2/1" \o "one-click search" Song Q Source:JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 61 (8): 909-912 AUG 2003 Document Type:Article Language:English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=PagedCitedRefList&UT=000184357200010&doc=2/1&rec_id=130556991" Cited References: 13  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=DispCitingRec&doc=2/1&isickref=130556991" Times Cited: 2  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Y6lGeO7opkg2OKkf4e3&Func=EasyRelated&UT=000184357200010&doc=2/1&rec_id=130556991"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:Purposes: Inhibition of cerulenin on the endogenous fatty acid synthetic activities of oral squamous cell carcinoma (OSCC) and normal oral mucosa was assayed. Methods: Squamous cell carcinoma and normal oral mucosa were collected fresh from surgical specimens. The collected tissues were minced in RPMI 1640 and divided into 3 groups: cerulenin treated, dimethylsuffoxide treated, and control. The tissues were incubated in [1(2)-C-14]acetic acid, sodium salt for the last 2.5 hours of the treatment at 37degreesC in 5% CO2. After labeling, total lipids were extracted and counted for C-14 by scintillation counting. Results: Endogenous fatty acid synthetic activities of oral squamous cell caranoma in the cerulenin-treated group decreased by 19% at 1 hour, 64% at 2 hours, and 87/7% at 4 hours; remained nearly unchanged in the dimethylsulfoxide-treated group; and increased slightly in the control group. The oral mucosa tissues were only mildly affected by cerulenin in fatty acid synthesis. Conclusions: Cerulenin significantly inhibits fatty acid synthetic activity in squamous cell carcinoma and only mildly affected the oral mucosa, indicating that the fatty acid synthetic pathway may be exploited as a target for developing anticancer drugs. (C) 2003 American Association of Oral and Maxillofacial Surgeons. KeyWords Plus:BREAST-CANCER; SYNTHASE FAS; PREDICTOR; INHIBITION; RECURRENCE; DISEASE; TARGET; STAGE Addresses:Guo CB (reprint author), Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing, 100871 Peoples R China Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing, 100871 Peoples R China Peking Univ, Dept Cell Biol, Beijing, 100871 Peoples R China Publisher:W B SAUNDERS CO, INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 USA Subject Category:DENTISTRY, ORAL SURGERY & MEDICINE IDS Number:704TV ISSN:0278-2391 y{9 : @ A C D  n o u v x y , - 4 5 7 8 жККККiККiККiККiККi,hh>*B*CJKHOJQJ^Jph2hh5>*B*CJKHOJQJ\^Jph6jhhB*CJKHOJQJU^JaJph3hh5B*CJKHOJQJ\^JaJph-hhB*CJKHOJQJ^JaJph/hh5B*CJKHOJQJ\^Jph){ @ X k u2Uhyz$K-1$9Da$gd $1$a$gd $1$9Da$gdz % @ N X a k l /01蚀i蚀iM6jhhB*CJKHOJQJU^JaJph,hh>*B*CJKHOJQJ^Jph2hh5>*B*CJKHOJQJ\^Jph6jhhB*CJKHOJQJU^JaJph3hh5B*CJKHOJQJ\^JaJph/hh5B*CJKHOJQJ\^Jph-hhB*CJKHOJQJ^JaJph1 2@0U`hmyz̰}̰eeeeeee` ho(/hh5B*CJKHOJQJ\^Jph6jhhB*CJKHOJQJU^JaJph-hhB*CJKHOJQJ^JaJph6jhhB*CJKHOJQJU^JaJph6jhhB*CJKHOJQJU^JaJph-hhB*CJKHOJQJ^JaJph0182P. 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