аЯрЁБс>ўџ 79ўџџџ6џџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџьЅСq` №RПšbjbjqPqP2::š џџџџџџЄ№№№№№№№ЬЬЬЬр “*јphhhhC C C $Нh% 8№І C C І І 8№№hhлM888І J№h№h8І 88№№8hь №юŸвoљХЬ№"8c0“8//88–/№ЮDC hЋ J8ѕ <1 uC C C 88. C C C “І І І І фшфш№№№№№№џџџџ Title: Decline of superoxide dismutase activity during antioxidant-induced apoptosis in HL-60 cells Author(s):  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Zhang+W&curr_doc=9/2&Form=FullRecordPage&doc=9/2" \o "one-click search" Zhang W,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Hashimoto+K&curr_doc=9/2&Form=FullRecordPage&doc=9/2" \o "one-click search" Hashimoto K,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Yu+GY&curr_doc=9/2&Form=FullRecordPage&doc=9/2" \o "one-click search" Yu GY,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Sakagami+H&curr_doc=9/2&Form=FullRecordPage&doc=9/2" \o "one-click search" Sakagami H Source: ANTICANCER RESEARCH 22 (1A): 219-224 JAN-FEB 2002 Document Type: Article Language: English  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=PagedCitedRefList&UT=000175351900035&doc=9/2&rec_id=124601923" Cited References: 18       HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=DispCitingRec&doc=9/2&isickref=124601923" Times Cited: 11      Abstract: Possible changes in Mn-containing superoxide dismutase (MnSOD) and Cu- and Zn-containing superoxide dismutase (CuZnSOD) activity during the apoptosis of human promyelocytic leukemia HL-60 cells, induced by three antioxidants, were investigated. Agarose gel electrophoresis of the DNA isolated from cells treated with sodium ascorbate, gallic acid or epigallocatechin gallate (EGCG) showed the internucleosomal DNA fragmentation, a biochemical hallmark of apoptosis. The optimum concentration for induction of DNA fragmentation was narrow and higher concentrations were rather inhibitory. Their effects were detected after 3 hours and reached a maximum level at 6 hours. Polyactylamide gel electrophoresis and activity staining demonstrated that both MnSOD and CuZnSOD activities were significantly reduced at cytotoxic concentrations of all these compounds. Incubation of an intracellular MnSOD-enriched fraction with apoptosis-inducing concentrations of sodium ascorbate, gallic acid or EGCG did not significantly reduce the MnSOD activity, suggesting that their actions might be cell-mediated. These data suggest the mitochondrial dysfunction at the early stages of apoptosis. Author Keywords: antioxidant; prooxidant action; HL-60; apoptosis; DNA fragmentation; mitochondria; MnSOD KeyWords Plus: HYDROGEN-PEROXIDE; INDUCTION; RESISTANCE; ASCORBATE Addresses: Sakagami H (reprint author), Meikai Univ, Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283 Japan Meikai Univ, Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283 Japan Meikai Univ, Sch Dent, Meikai Pharmaco Med Lab, Sakado, Saitama 3500283 Japan Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing, 100038 Peoples R China Publisher: INT INST ANTICANCER RESEARCH, EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE Subject Category: ONCOLOGY IDS Number: 547UZ ISSN: 0250-7005 ceopq$ % , - / 0 ч ш ѓ є і ї Ј Љ Ў Џ Б В h i s t v } ~ ‘ Б П Щ в м н k l чаЖачаšаš€šаšаšišаšаšišаšаšišачаЖачачаšаš,hі,љhі,љ>*B*CJKHOJQJ^Jphџ2hі,љhі,љ5>*B*CJKHOJQJ\^Jphџ6jhі,љhі,љB*CJKHOJQJU^JaJph3hі,љhі,љ5B*CJKHOJQJ\^JaJph-hі,љhі,љB*CJKHOJQJ^JaJph/hі,љhі,љ5B*CJKHOJQJ\^Jph)ev Б Щ м  П*nдZv‰™šєєєєєыєєєєєєєєцgdі,љ $1$a$gdі,љ $1$9Da$gdі,љš§l } €  ‡ ˆ       " ПЯ*8nxдоZkv‰Ž™šцЯГœГœГцЯГœ„œ„œ„œ„œ„œ„œ„œ„œ|hі,љh…зo(/hі,љhі,љ5B*CJKHOJQJ\^Jph-hі,љhі,љB*CJKHOJQJ^JaJph6jhі,љhі,љB*CJKHOJQJU^JaJph,hі,љhі,љ>*B*CJKHOJQJ^Jphџ2hі,љhі,љ5>*B*CJKHOJQJ\^Jphџ0182PА‚. 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