аЯрЁБс>ўџ 8:ўџџџ7џџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџџьЅСq` №RПпbjbjqPqP2$::пџџџџџџЄ№№№№№№№LLLLh Ю*€И8 8 8 8    MOOOOOO$јh` s№+   + + s№№8 8 лˆе е е + Š№8 №8 Mе + Mе е №№е 8 t 0WmљХLЕ е Mž0Юе jЫ jе е Lj№!, L_ 6е • ,С j   ssЫ    Ю+ + + + $($(№№№№№№џџџџ Title: Relationship between vitamin D receptor gene polymorphism and periodontitis Author(s):  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Sun+JL&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Sun JL,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Meng+HX&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Meng HX,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Cao+CF&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Cao CF,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Tachi+Y&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Tachi Y,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Shinohara+M&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Shinohara M,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Ueda+M&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Ueda M,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Imai+H&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Imai H,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=OneClickSearch&field=AU&val=Ohura+K&curr_doc=5/1&Form=FullRecordPage&doc=5/1" \o "one-click search" Ohura K Source: JOURNAL OF PERIODONTAL RESEARCH 37 (4): 263-267 AUG 2002 Document Type: Article Language: English  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=PagedCitedRefList&UT=000177316600005&doc=5/1&rec_id=125965892" Cited References: 22       HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Y6E34lK9hCc8NejJNi8&Func=DispCitingRec&doc=5/1&isickref=125965892" Times Cited: 11      Abstract: Recent studies have shown that vitamin D receptor (VDR) gene polymorphism had regulatory effects on bone mineral density (BMD) and bone turnover. The VDR gene has also been indicated as a candidate gene for the susceptibility of osteoporosis. However, it is unclear whether VDR genotypes could be associated with alveolar bone loss of patients with periodontitis. or whether vitamin D receptor gene could be a candidate gene for susceptibility to periodontitis. The purpose of this Study was to answer these two questions. Methods: Twenty-four cases of adult periodontitis (AP). 37 cases of early onset periodontitis (EOP) and 39 healthy controls were recruited for the study. Individual samples of venous blood and DNA were obtained from each subject. Genotypes of the TaqI VDR gene were determined by PCR and TaqI restriction endonuclease digestion. Results: One out of 24 AP patients, nine out of 37 EOP patients and two out of 39 healthy controls were detected with Tt genotype, while the rest had the TT genotype. The detected frequency of Tt genotype was significantly higher in EOP patients (24.3%) than in AP patients (4.2%) and healthy controls (5.1%). The frequency of t allele was also significantly higher in EOP patients. There was no statistical difference in the distribution of TaqI VDR genotypes between AP patients and healthy controls. The study suggests that Tt genotype might be a risk indicator for the susceptibility to EOP. Carriage of the allele (t) of the TaqI VDR gene may increase the risk of developing EOP. Author Keywords: polymorphism; periodontitis; susceptibility; VDR gene KeyWords Plus: EARLY-ONSET PERIODONTITIS; MESSENGER-RNA STABILITY; D-RESISTANT RICKETS; GENOTYPE; ASSOCIATION; INHERITANCE; MUTATION; CHINESE; DENSITY Addresses: Meng HX (reprint author), Peking Univ, Sch Stomatol, Dept Periodontol, 22 Zhong Guan Cun Nan Da Jie, Beijing, 100081 Peoples R China Peking Univ, Sch Stomatol, Dept Periodontol, Beijing, 100081 Peoples R China Osaka Dent Univ, Dept Pharmacol, Osaka, Japan Osaka Dent Univ, Dept Periodontol, Osaka, Japan Publisher: BLACKWELL MUNKSGAARD, 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK Subject Category: DENTISTRY, ORAL SURGERY & MEDICINE IDS Number: 581WE ISSN: 0022-3484 RT^_`      а б и й л м Ž  • – ˜ ™ L M T U W X       б в и й чаЖачаšаš€šаšаšišаšаšišаšаšišаšаšišаšаšiš,hyhy>*B*CJKHOJQJ^Jphџ2hyhy5>*B*CJKHOJQJ\^Jphџ6jhyhyB*CJKHOJQJU^JaJph3hyhy5B*CJKHOJQJ\^JaJph-hyhyB*CJKHOJQJ^JaJph/hyhy5B*CJKHOJQJ\^Jph)TW™БФ` Uэ)…ЛЮопєєєєєыєммєєєєєєєзgdy$ЄKЄ-1$9Da$gdy $1$a$gdy $1$9Da$gdyп§й л м Ž  • – ˜ ™ LMTUW^_~™ЇБКФХSTehiopщъіљњ  UcэшЬшЬЕЬшЬшЬЕЬшшƒшшшЬшЬiЕЬшЬшЬiЕЬшшшш2hyhy5>*B*CJKHOJQJ\^Jphџ3hyhy5B*CJKHOJQJ\^JaJph/hyhy5B*CJKHOJQJ\^Jph,hyhy>*B*CJKHOJQJ^Jphџ6jhyhyB*CJKHOJQJU^JaJph-hyhyB*CJKHOJQJ^JaJph)эї)3…–ЛЦЮгопчачачачачаШhyh…зo(-hyhyB*CJKHOJQJ^JaJph/hyhy5B*CJKHOJQJ\^Jph 0182PА‚. 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