ࡱ> 8:7q` RbjbjqPqP2":: *      $h$-   -B   pz X0>>>, H 1--      Title:Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw Author(s): HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Fu+KY&curr_doc=22/1&Form=FullRecordPage&doc=22/1" \o "one-click search" Fu KY,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Light+AR&curr_doc=22/1&Form=FullRecordPage&doc=22/1" \o "one-click search" Light AR,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Maixner+W&curr_doc=22/1&Form=FullRecordPage&doc=22/1" \o "one-click search" Maixner W Source:JOURNAL OF PAIN 2 (1): 2-11 FEB 2001 Document Type:Article Language:English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=PagedCitedRefList&UT=000166922300001&doc=22/1&rec_id=118662923" Cited References: 55  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=DispCitingRec&doc=22/1&isickref=118662923" Times Cited: 9  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=EasyRelated&UT=000166922300001&doc=22/1&rec_id=118662923"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:Subcutaneous formalin injection is widely used as a nociceptive stimulus in the rat. This procedure evokes overt behaviors that last about 90 minutes. However, little is known about the duration of paw inflammation and alterations in pain sensitivity to noxious stimuli after 2 hours. We studied the nociceptive responses to thermal and mechanical stimuli 2 hours to 4 weeks after formalin injection into the dorsal or plantar side of the hindpaw. Thirty-two adult male Sprague-Dawley rats were divided into 3 groups: In group I, 50 muL of 5% formalin was injected into the plantar side (n = 12); in group II, 50 muL of 5% formalin was injected into the dorsal side (n = 12); in group III, 50 muL saline was injected into the dorsal or plantar side of the hindpaw (n = 8). Nociceptive responses to thermal and mechanical stimuli applied to the dorsal or plantar surfaces of the injected and the contralateral hindpaws were recorded. The injection of formalin into the rat's hindpaw produced a hypoalgesic region around the injection site. In contrast, hyperalgesic responses to thermal and mechanical stimulation were induced on the opposite surface of the injected hindpaw as well as in the contralateral noninjected hindpaw. The hyperalgesic responses, which were observed 2 hours after formalin administration, were enhanced 1 to 3 days after injection and lasted 3 to 4 weeks. These results suggest that peripheral inflammation after subcutaneous formalin injection produces a long-lasting sensitization. Possible mechanisms for these changes in nociception are discussed. Author Keywords:hyperalgesia; inflammation; pain; formalin; rat KeyWords Plus:NITRIC-OXIDE FORMATION; CENTRAL-NERVOUS-SYSTEM; INDUCED TISSUE-INJURY; SUBSTANCE-P; SPINAL-CORD; ACTIVATED MICROGLIA; CYCLOOXYGENASE INHIBITION; PERSISTENT NOCICEPTION; PROSTAGLANDIN E(2); MESSENGER-RNA Addresses:Fu KY (reprint author), Care Of Maixner W, Univ N Carolina, Sch Dent, Dent Res Ctr, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Cell & Mol Physiol, Dent Res Ctr, Chapel Hill, NC USA Beijing Med Univ, Sch Stomatol, Beijing, 100083 Peoples R China Publisher:CHURCHILL LIVINGSTONE, JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND Subject Category:CLINICAL NEUROLOGY; NEUROSCIENCES IDS Number:401HN ISSN:1526-5900 vx7 8 = > @ A       ! 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