ࡱ> :<9q` RbjbjqPqP2":: *$h$+  +@   V0<<<H  lx ++   Title:Bisphosphonate inhibits alveolar bone resorption in experimentally-induced peri-implantitis in dogs Author(s): HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Shibutani+T&curr_doc=28/1&Form=FullRecordPage&doc=28/1" \o "one-click search" Shibutani T,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Inuduka+A&curr_doc=28/1&Form=FullRecordPage&doc=28/1" \o "one-click search" Inuduka A,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Horiki+I&curr_doc=28/1&Form=FullRecordPage&doc=28/1" \o "one-click search" Horiki I,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Luan+QX&curr_doc=28/1&Form=FullRecordPage&doc=28/1" \o "one-click search" Luan QX,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Iwayama+Y&curr_doc=28/1&Form=FullRecordPage&doc=28/1" \o "one-click search" Iwayama Y Source:CLINICAL ORAL IMPLANTS RESEARCH 12 (2): 109-114 APR 2001 Document Type:Article Language:English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=PagedCitedRefList&UT=000167530400003&doc=28/1&rec_id=119093905" Cited References: 23  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=DispCitingRec&doc=28/1&isickref=119093905" Times Cited: 3  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=EasyRelated&UT=000167530400003&doc=28/1&rec_id=119093905"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:The purpose of this study was to determine the effect of bisphosphonate on alveolar bone resorption in experimentally-induced peri-implantitis in beagle dogs. Experimental peri-implantitis was induced by ligation around the abutments, 6 months after placement of a fixture. Pamidronate (0.6 mg/kg) was injected intramuscularly every 3 days into each of 5 dogs. Another 5 dogs served as the control group and were injected with saline only. Peripheral blood and urine samples were collected every week up to 12 weeks after placement of the ligature. Standard X-rays were taken every week. Urinary deoxypyridinoline (DPD) and serum osteocalcin (OC) were evaluated by ELISA as markers of alveolar bone remodeling. X-ray films were analyzed with a computer image analyzer. After 12 weeks, the bone level was measured after removal of the gingival flap. The distance between the top surface of the fixture and the fundus of the defect was significantly lower in the Pamidronate group (1.59+/-0.55 mm, mean+/-SD) than in the control group (2.41+/-0.48 mm). Bone density analyzed from the X-ray films was significantly higher in the bisphosphonate group (69.2+/-8.7%, mean+/-SD) than in the control group (50.3+/-12.8%) after 2 to 8 weeks compared with the baseline value (100%). OC and DPD levels fluctuated during the experimental period. These findings suggest that bisphosphonate inhibits the progression of alveolar bone resorption during ligature-induced peri-implantitis in dogs. Author Keywords:peri-implantitis; biophosphonate; alveolar bone resorption; dogs; bone marker KeyWords Plus:EXPERIMENTAL PERIODONTITIS; BEAGLE DOGS; MONKEYS Addresses:Shibutani T (reprint author), Asahi Univ, Sch Dent, Dept Periodontol, 1851 Hozumi, Gifu, 50102 Japan Asahi Univ, Sch Dent, Dept Periodontol, Gifu, 50102 Japan Beijing Med Univ, Sch Stomatol, Dept Periodontol, Beijing, 100083 Peoples R China Publisher:MUNKSGAARD INT PUBL LTD, 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK Subject Category:DENTISTRY, ORAL SURGERY & MEDICINE; ENGINEERING, BIOMEDICAL IDS Number:411ZW ISSN:0905-7161 jlvwx1 2 = > @ A     ~  A B K L N U V u жККККiККiККiККiж,h>Ah>A>*B*CJKHOJQJ^Jph2h>Ah>A5>*B*CJKHOJQJ\^Jph6jh>Ah>AB*CJKHOJQJU^JaJph3h>Ah>A5B*CJKHOJQJ\^JaJph-h>Ah>AB*CJKHOJQJ^JaJph/h>Ah>A5B*CJKHOJQJ\^Jph)lN T'$sgd>A $1$a$gd>A $1$9Da$gd>A K L ] ` a g h NO贚贚gPggPg-h>Ah>AB*CJKHOJQJ^JaJph6jh>Ah>AB*CJKHOJQJU^JaJph,h>Ah>A>*B*CJKHOJQJ^Jph2h>Ah>A5>*B*CJKHOJQJ\^Jph6jh>Ah>AB*CJKHOJQJU^JaJph/h>Ah>A5B*CJKHOJQJ\^Jph-h>Ah>AB*CJKHOJQJ^JaJphOPQRT]'7$5s~Ȭ}}}}}}}}uh>AhDo(/h>Ah>A5B*CJKHOJQJ\^Jph-h>Ah>AB*CJKHOJQJ^JaJph6jh>Ah>AB*CJKHOJQJU^JaJph6jh>Ah>AB*CJKHOJQJU^JaJph6jh>Ah>AB*CJKHOJQJU^JaJph0182P. 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