ࡱ> CEBq` RhbjbjqPqP2,::h$ *~ 4666666$hG$Z   Z o b  4 4  h"40kkPk@ Z @ 4T  ZZ      Title:Synergistic cytotoxic action of vitamin C and vitamin K-3 Author(s): HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Zhang+W&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Zhang W,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Negoro+T&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Negoro T,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Satoh+K&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Satoh K,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Jiang+J&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Jiang J,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Hashimoto+K&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Hashimoto K,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Kikuchi+H&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Kikuchi H,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Nishikawa+H&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Nishikawa H,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Miyata+T&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Miyata T,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Yamamoto+Y&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Yamamoto Y,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Nakano+K&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Nakano K,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Yasumoto+E&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Yasumoto E,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Nakayachi+T&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Nakayachi T,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Mineno+K&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Mineno K,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Satoh+T&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Satoh T,  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Sakagami+H&curr_doc=26/1&Form=FullRecordPage&doc=26/1" \o "one-click search" Sakagami H Source:ANTICANCER RESEARCH 21 (5): 3439-3444 SEP-OCT 2001 Document Type:Article Language:English  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=PagedCitedRefList&UT=000173740400042&doc=26/1&rec_id=123361243" Cited References: 21  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=DispCitingRec&doc=26/1&isickref=123361243" Times Cited: 9  HYPERLINK "http://wos02.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=EasyRelated&UT=000173740400042&doc=26/1&rec_id=123361243"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:We investigated the combination effect of sodium ascorbate (vitamin Q and menadione (vitamin K-3) on the viability of various cultured cells. Human oral squamous cell carcinoma (HSC-2, HSC-3) and human promyelocytic leukemia (HL-60) cells were more sensitive to these vitamins as compared to normal cells (human gingival fibroblast HGF, human periodontal ligament fibroblast HPLF, human pulp cell HPC). The combination of vitamin C and vitamin K-3 produced synergistic cytotoxicity against all these 6 cell lines. Treatment with vitamin C or vitamin K-3, or their combination, induced internucleosomal DNA fragmentation only in HL-60 cells, but not in the oral tumor cell lines (HSC-2, HSC-3, HSG). ESR spectroscopy showed that vitamins C and K-3 produce radicals under alkaline conditions and that the combination of these two vitamins synergistically enhanced their respective radical intensities. Author Keywords:vitamin C; vitamin K-3; oral tumor cells; cytotoxicity; mechanism KeyWords Plus:RADICAL INTENSITY; ANTITUMOR-ACTIVITY; SODIUM ASCORBATE; CELLS; ANTIOXIDANTS; APOPTOSIS Addresses:Sakagami H (reprint author), Meikai Univ, Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283 Japan Meikai Univ, Sch Dent, Dept Dent Pharmacol, Sakado, Saitama 3500283 Japan Meikai Univ, Sch Dent, Meikai Pharmaco Med Lab, Sakado, Saitama 3500283 Japan Meikai Univ, Sch Dent, Dept Endodont, Sakado, Saitama 3500283 Japan Meikai Univ, Sch Dent, Dept Periodontol, Sakado, Saitama 3500283 Japan Meikai Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Sakado, Saitama 3500283 Japan Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing, 100038 Peoples R China Showa Univ, Sch Pharmaceut Sci, Anal Ctr, Tokyo, 1428555 Japan Publisher:INT INST ANTICANCER RESEARCH, EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22, ATHENS 19014, GREECE Subject Category:ONCOLOGY IDS Number:519RZ ISSN:0250-7005 @BLMN    H I P Q S T      жККККiККiККiККiККi,h h >*B*CJKHOJQJ^Jph2h h 5>*B*CJKHOJQJ\^Jph6jh h B*CJKHOJQJU^JaJph3h h 5B*CJKHOJQJ\^JaJph-h h B*CJKHOJQJ^JaJph/h h 5B*CJKHOJQJ\^Jph)B&9a(DWghgd  $1$a$gd  $1$9Da$gd h abjkmn&'1245xy>?GHJK   ̵̵̵̵̵̵̵̵̵/h h 5B*CJKHOJQJ\^Jph,h h >*B*CJKHOJQJ^Jph6jh h B*CJKHOJQJU^JaJph-h h B*CJKHOJQJ^JaJph9&/9:`amopvwζζΚΚiΚΚiΚΚM6jh h B*CJKHOJQJU^JaJph,h h >*B*CJKHOJQJ^Jph2h h 5>*B*CJKHOJQJ\^Jph6jh h B*CJKHOJQJU^JaJph/h h 5B*CJKHOJQJ\^Jph-h h B*CJKHOJQJ^JaJph3h h 5B*CJKHOJQJ\^JaJph]`abcqrsaq'(9DOW\gh̰}̰eeeeeeee]h hDo(/h h 5B*CJKHOJQJ\^Jph6jh h B*CJKHOJQJU^JaJph-h h B*CJKHOJQJ^JaJph6jh h B*CJKHOJQJU^JaJph6jh h B*CJKHOJQJU^JaJph-h h B*CJKHOJQJ^JaJph0182P. 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