ࡱ> ?A>q` RbjbjqPqP2 ::  _$*x x x x x x x #######$%h'$$ x x   $x x $ x x # #x   #/$0_$))R)V#x hr T Hx x x $$ x x x _$    DHDH Title:Leukocyte functions in 2 cases of Papillon-Lefevre syndrome Author(s): HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Liu+RK&curr_doc=45/1&Form=FullRecordPage&doc=45/1" \o "one-click search" Liu RK,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Cao+CF&curr_doc=45/1&Form=FullRecordPage&doc=45/1" \o "one-click search" Cao CF,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Meng+HX&curr_doc=45/1&Form=FullRecordPage&doc=45/1" \o "one-click search" Meng HX,  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Tang+ZH&curr_doc=45/1&Form=FullRecordPage&doc=45/1" \o "one-click search" Tang ZH Source:JOURNAL OF CLINICAL PERIODONTOLOGY 27 (1): 69-73 JAN 2000 Document Type:Article Language:English  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=PagedCitedRefList&UT=000084576700010&doc=45/1&rec_id=113210871" Cited References: 29  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=DispCitingRec&doc=45/1&isickref=113210871" Times Cited: 9  HYPERLINK "http://wos15.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=EasyRelated&UT=000084576700010&doc=45/1&rec_id=113210871"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:Aim: To investigate the role of leukocytes in the pathogenesis of Papillon-Lefevre syndrome (PLS). Methods: Peripheral blood polymorphonuclear neutrophils (PMNs), monocytes (MNs) and gingival crevicular fluid (GCF) were obtained from 2 cases of PLS with typical features. The chemotaxis of PMNs and MNs were evaluated using a modified Boyden chamber. The adherence of PMNs was determined by adherence of PMNs to petri dishes. Interleukin-8 (IL-8) in GCF was detected by sandwich ELISA. Elastase activity in GCF was measured with a low molecular weight substrate (S-2484) specific for granulocyte elastase. Results: PMNs from both patients showed depressed chemotactic response to FMLP and IL-8. Total amounts of IL-8 in GCF from the 2 patients were much higher than those of the normal controls. Elastase activity was not significantly different from that of the controls. The adherence of PMN and the chemotaxis of MN in the 2 patients were normal. Conclusion: The depressed chemotactic response of PMN leads to decreased recruitment of PMN and/or release of lysozyme from PMN in the diseased gingival tissue, increasing the susceptibility of PLS patients to periodontal infection. Author Keywords:Papillon-Lefevre syndrome; polymorphonuclear leukocyte chemotaxis; monocytes; interleukin-8; elastase KeyWords Plus:EARLY-ONSET PERIODONTITIS; NEUTROPHIL-ACTIVATING FACTOR; GINGIVAL CREVICULAR FLUID; GRANULOCYTE ELASTASE; MOLECULAR-BASIS; DYSFUNCTION; CHEMOTAXIS; RECEPTOR; SIBLINGS; PROTEIN Addresses:Liu RK (reprint author), Beijing Med Univ, Sch Stomatol, Dept Periodontol, BaiShiQiao Rd 38, Beijing, 100081 Peoples R China Beijing Med Univ, Sch Stomatol, Dept Periodontol, Beijing, 100081 Peoples R China Publisher:MUNKSGAARD INT PUBL LTD, 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK Subject Category:DENTISTRY, ORAL SURGERY & MEDICINE IDS Number:271CP ISSN:0303-6979 BDNOP    D E L M O V W y M N жККККiККiККiжКК,hm lhm l>*B*CJKHOJQJ^Jph2hm lhm l5>*B*CJKHOJQJ\^Jph6jhm lhm lB*CJKHOJQJU^JaJph3hm lhm l5B*CJKHOJQJ\^JaJph-hm lhm lB*CJKHOJQJ^JaJph/hm lhm l5B*CJKHOJQJ\^Jph)DO Vx8rgdm l$K-1$9Da$gdm l $1$a$gdm l $1$9Da$gdm lN _ b c i j PQRSTVϳϳiiM6jhm lhm lB*CJKHOJQJU^JaJph-hm lhm lB*CJKHOJQJ^JaJph6jhm lhm lB*CJKHOJQJU^JaJph-hm lhm lB*CJKHOJQJ^JaJph6jhm lhm lB*CJKHOJQJU^JaJph,hm lhm l>*B*CJKHOJQJ^Jph2hm lhm l5>*B*CJKHOJQJ\^JphV_x8Brhm lhDo(-hm lhm lB*CJKHOJQJ^JaJph/hm lhm l5B*CJKHOJQJ\^Jph0182P. 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