ࡱ> @B?q` RbjbjqPqP2&:: ,*$V h"o o o  o  o    ȓ  0, # # n#+h: J <  ,o o o o  Title:The effects of 5-hydroxydopamine on salivary flow rates and protein secretion by the submandibular and parotid glands of rats Author(s): HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Abe+K&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Abe K,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Itoh+T&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Itoh T,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Tashiro+M&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Tashiro M,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Okina+A&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Okina A,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Gao+C&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Gao C,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Nakamura+H&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Nakamura H,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Nose+T&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Nose T,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Inoue+H&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Inoue H,  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=OneClickSearch&field=AU&val=Yu+SF&curr_doc=84/1&Form=FullRecordPage&doc=84/1" \o "one-click search" Yu SF Source:EXPERIMENTAL PHYSIOLOGY 81 (4): 645-653 JUL 1996 Document Type:Article Language:English  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=PagedCitedRefList&UT=A1996VA25800008&doc=84/1&rec_id=96912446" Cited References: 34  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=DispCitingRec&doc=84/1&isickref=96912446" Times Cited: 2  HYPERLINK "http://wos23.isiknowledge.com/CIW.cgi?SID=Z2BpEl7c9GkG4GojDN9&Func=EasyRelated&UT=A1996VA25800008&doc=84/1&rec_id=96912446"  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/relrec.gif" \* MERGEFORMATINET  HYPERLINK ""  INCLUDEPICTURE "http://images.isiknowledge.com/WoK3/Images/info.gif" \* MERGEFORMATINET  Abstract:The secretory effects of 5-hydroxydopamine (5-OHDA) were tested in Nembutal-anaesthetized adult male Sprague-Dawley rats injected I.V. over a wide range of doses, with and without various autonomic antagonists and Ca2+ channel blockers. Polyacrylamide disc gel (15 %) and iso-electric focusing (IEF) electrophoresis by the PhastSystem were used to separate and determine the types of protein in submandibular saliva. Amylase activity of parotid saliva was determined by the blue dextran method. Salivation by the submandibular glands following application of 5-OHDA was completely abolished by both prazosin and propranolol, whereas salivation by the parotid glands was completely abolished by propranolol alone. Following application of 5-OHDA, there was a dose-related increase in flow rates and total output of protein, but not in the protein concentration and amylase activity, from both salivary glands. The effect of 5-OHDA on submandibular saliva was significantly reduced by alpha-adrenoceptor blockers, but not by beta-adrenoceptor and cholinergic blockers, nor by any Ca2+ channel blocker. The effect of 5-OHDA on the parotid gland was not significantly altered by atropine and phentolamine. However, after pretreatment with reserpine, a 95 % reduction was observed in the salivation from the submandibular gland. This implies that 5-OHDA is mostly acting indirectly via release of noradrenaline. The proteins in submandibular saliva following treatment with 5-OHDA alone or 5-OHDA in combination with beta-adrenoceptor blockers were mainly of the alpha-type, whereas after treatment with 5-OHDA in combination with alpha-adrenoceptor blockers they were of the beta-type. The alpha-type was found in saliva after treatment with each of three Ca2+ channel blockers. KeyWords Plus:ALPHA-METHYLNORADRENALINE; ELECTROLYTES; NOREPINEPHRINE; TRANSDUCTION; STIMULATION; OCTOPAMINE; RESPONSES; CLONIDINE Addresses:Abe K (reprint author), FUKUOKA DENT COLL, DEPT ORAL BIOCHEM, FUKUOKA, 81401 JAPAN BEIJING MED UNIV, SCH STOMATOL, BEIJING, 100083 PEOPLES R CHINA FUKUOKA DENT COLL, DEPT ORTHODONT, FUKUOKA, 81401 JAPAN FUKUOKA DENT COLL, DEPT CONSERVAT DENT, FUKUOKA, 81401 JAPAN FUKUOKA DENT COLL, DEPT ORAL PATHOL, FUKUOKA, 81401 JAPAN Publisher:CAMBRIDGE UNIV PRESS, 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 Subject Category:PHYSIOLOGY IDS Number:VA258 ISSN:0958-0670 E F K L N O    G H M N P Q   жККККiККiККiККiККi,hn<hn<>*B*CJKHOJQJ^Jph2hn<hn<5>*B*CJKHOJQJ\^Jph6jhn<hn<B*CJKHOJQJU^JaJph3hn<hn<5B*CJKHOJQJ\^JaJph-hn<hn<B*CJKHOJQJ^JaJph/hn<hn<5B*CJKHOJQJ\^Jph)TOIkgdn< $1$a$gdn< $1$9Da$gdn<   KLQRT[\sHIZ]^de̵̵̵ii2hn<hn<5>*B*CJKHOJQJ\^Jph3hn<hn<5B*CJKHOJQJ\^JaJph/hn<hn<5B*CJKHOJQJ\^Jph,hn<hn<>*B*CJKHOJQJ^Jph6jhn<hn<B*CJKHOJQJU^JaJph-hn<hn<B*CJKHOJQJ^JaJph)}~IJKLMOXIW&k|䱚䱚~fffffff^hn<hAXo(/hn<hn<5B*CJKHOJQJ\^Jph6jhn<hn<B*CJKHOJQJU^JaJph-hn<hn<B*CJKHOJQJ^JaJph6jhn<hn<B*CJKHOJQJU^JaJph-hn<hn<B*CJKHOJQJ^JaJph6jhn<hn<B*CJKHOJQJU^JaJph!0182P. 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